Strain Information | |
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Image | |
BRC No. | RBRC02847 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | 129S6/SvEvTac-Dkk3<tm1Tfur> |
Former Common name | DKK3 K.O. |
H-2 Haplotype | |
ES Cell line | TC1 [129S6/SvEvTac] |
Background strain | 129S6/SvEvTac |
Appearance | light-bellied agouti [A<w>/A<w> B/B C/C] |
Strain development | Developed by Dr. Takahisa Furukawa, Osaka Bioscience Institute in 2007. |
Strain description | Dkk3 knockout mice. Homozygous mutant mice show no obvious phenotype. |
Colony maintenance | Sibling Mating (Homozygote x Homozygote) |
References |
Health Report | |
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Examination Date / Room / Rack |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Dkk3dickkopf homolog 3 (Xenopus laevis)7Dkk3<tm1Tfur>targeted mutation 1, Takahisa Furukawadickkopf homolog 3 (Xenopus laevis) Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter neoneomycin resistance gene (E. coli)7neo; neomycin;mouse phosphoglycerate kinase promoter (PGK promoter) Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter SV40 polyA signal7 |
Ordering Information | |
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Donor DNA | mouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, SV40 pA, mouse Dkk3 genomic DNA |
Research application | |
Specific Term and Conditions | In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. |
Depositor | Takahisa Furukawa (Osaka Bioscience Institute) |
Strain Status | Frozen embryos Frozen sperm |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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Habuta M, Fujita H, Sato K, Bando T, Inoue J, Kondo Y, Miyaishi S, Kumon H, Ohuchi H. Dickkopf3 (Dkk3) is required for maintaining the integrity of secretory vesicles in the mouse adrenal medulla. Cell Tissue Res 379(1) 157-167(2020) 31673758 Zhu Y, Demidov ON, Goh AM, Virshup DM, Lane DP, Bulavin DV. Phosphatase WIP1 regulates adult neurogenesis and WNT signaling during aging. J Clin Invest 124(7) 3263-73(2014) 24911145 Inoue J, Fujita H, Bando T, Kondo Y, Kumon H, Ohuchi H. Expression analysis of Dickkopf-related protein 3 (Dkk3) suggests its pleiotropic roles for a secretory glycoprotein in adult mouse. J Mol Histol 48(1) 29-39(2017) 27866302 |