Strain Information | |
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Image | |
BRC No. | RBRC10094 |
Type | Targeted Mutation Congenic |
Species | Mus musculus |
Strain name | B6.Cg-Irf3<tm2.2Ttg> |
Former Common name | IRF3 KO |
H-2 Haplotype | |
ES Cell line | TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1] |
Background strain | C57BL/6JJcl |
Appearance | |
Strain development | Developed by Tadatsugu Taniguchi and Hideyuki Yanai, University of Tokyo in 2017. TT2 ES cells derived from C57BL/6 x CBA F1 were used. The neo gene was deleted by crossing the CAG-cre mice. Mice were backcrossed to C57BL/6J for 10 generations. C57BL/6J congenic strain. |
Strain description | IRF-3(Irf3:interferon regulatory factor)knockout mice. Homozygous mice are viable, susceptible to viral infection and exhibit lower serum interferon levels in response to viral infection. This strain has normal expression of Bcl2L12, an adjacent gene of the Irf-3. |
Colony maintenance | |
References | Proc. Natl. Acad .Sci. USA, 115(20), 5253-5258 (2018). 29712834 |
Health Report | |
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Examination Date / Room / Rack | 2024/03/11Room:3-2Rack:C 2023/12/11Room:3-2Rack:C 2023/09/11Room:3-2Rack:C 2023/06/13Room:3-2Rack:C 2023/03/13Room:3-2Rack:C 2022/12/12Room:3-2Rack:C 2022/09/12Room:3-2Rack:C 2022/06/13Room:3-2Rack:C |
Gene | |
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Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter loxPphage P1 loxP7loxP |
Ordering Information | |
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Donor DNA | phage P1 loxP site, mouse Irf3 genomic DNA |
Research application | Cre/loxP system Immunology and Inflammation Research |
Specific Term and Conditions | Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Proc. Natl. Acad .Sci. USA, 115(20), 5253-5258 (2018).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The availability of the BIOLOGICAL RESOURCE is limited to a RECIPIENT of a not-for profit institution for a not-for-profit research. For use of the BIOLOGICAL RESOURCE by a for-profit institution, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and must obtain a prior written consent from the DEPOSITOR. |
Depositor | Tadatsugu Taniguchi (The University of Tokyo) |
Strain Status | Live mice Frozen embryos Frozen sperm |
Strain Availability | Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) Live mouse (1 to 3 months) |
Additional Info. | Mouse of the Month Nov 2020 Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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No Data |