Strain Information | |
---|---|
Image | |
BRC No. | RBRC11161 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | C57BL/6N-Arg1<tm1.1(KikGR)Ksho> |
Former Common name | Arg1-KikGR |
H-2 Haplotype | |
ES Cell line | JM8A3.N1 [C57BL/6N-A<tm1Brd>] |
Background strain | |
Appearance | |
Strain development | Developed by Tsuneyasu Kaisho, Research Center for Allergy and Immunologuy, RIKEN around 2009. |
Strain description | Arginase 1, ARG1, is an enzyme in urea cycle and generates ornithine and urea from arginine. In type 2 inflammation, ARGI expression is known to be increased in macrophages. ArgI-KikGR mice were generated by knocking a gene encoding a photoconvertible green-to-red fluorescent protein KikGR into the murine ArgI gene locus. |
Colony maintenance | |
References |
Health Report | |
---|---|
Examination Date / Room / Rack |
Gene | |
---|---|
Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Frtyeast FRT (flippase recombination target) site10Frt Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter GHGrowth hormone polyA (Bovine)10GH Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter kikGRGreen-Red Fluorescent Protein (Favia favus)10kikGR |
Ordering Information | |
---|---|
Donor DNA | Favia favus KikGR cDNA, Bos taurus bGH polyA, Saccharomyces cerevisiae FRT site, mouse Arg1 genomic DNA |
Research application | FLP/frt system Fluorescent Proteins/lacZ System Immunology and Inflammation Research Metabolism Research |
Specific Term and Conditions | Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. (will be announced.) The availability of the BIOLOGICAL RESOURCE is limited to a RECIPIENT of a not-for profit organization for a not-for-profit research. For use of the BIOLOGICAL RESOURCE by a for-profit organization, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and a right holder for phKikGRl-S1, Medical & Biological Laboratories (MBL) Co., Ltd., and must obtain a prior written consent from the DEPOSITOR and MBL. The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEVELOPER of the kikGR using Approval form (form V) (Lab Contact: Laboratory for Cell Function Dynamics, RIKEN CBS: mta-cfds@ml.riken.jp). |
Depositor | Tsuneyasu Kaisho (RIKEN) |
Strain Status | Frozen sperm |
Strain Availability | Recovered litters from cryopreserved sperm (2 to 4 months) Cryopreserved sperm (within 1 month) |
Additional Info. | Genotyping protocol -PCR- Necessary documents for ordering: |
BRC mice in Publications |
---|
No Data |