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Cryopreservation of Mouse Embryos by Ethylene Glycol-Based Vitrification

JoVE 3155 11/18/2011

RIKEN BioResource Center Mouse E-mail Message No. 62

  RIKEN BioResource Center (BRC) is pleased to update you with 
all the latest information, including newly deposited mouse strains.

=======  content  ======================================================
- Special topic: Mouse of the Month,
  "Sox2: An essential factor for maintaining neural stem cells"
- Distribution of Germ Cell Competent C57BL/6N ES Cell Lines
- Publication by users
- Newly deposited mouse strains
- Newly available mouse strains
- Mouse strains for freeze preservation

|  Special topic: Mouse of the Month    Sep. 2009

  Sox2: An essential factor for maintaining neural stem cells

      RBRC01897   Floxed Sox2 mice

    Depositor: Dr. Akihiko Okuda (Saitama Medical University)

    Mouse of the Month archive

|  Distribution of Germ Cell Competent C57BL/6N ES Cell Lines

  Genetic modification by transgenesis and gene targeting has become a 
well-established method to generate mouse models for the study of gene 
functions.  Functional annotation of these models is one of the biggest 
challenges in the current biomedical sciences.  Accurate phenotyping of 
these models in the uniform genetic background is essential for this 
purpose.  The C57BL/6N strain is one of the major C57BL/6 substrains.  
In recent years, efforts have been made worldwide to generate knockout 
mouse resources of the C57BL/6N background.
  The Cell Engineering Division of RIKEN BRC distributes a number of germ 
cell competent C57BL/6N ES cell lines suitable for generating knockout mice.
Please contact to obtain these useful resources.

    Read more.

|  Publication by users

  The following publication is newly reported by the following users.

Hatanaka Y., Matsumoto T., Yanagawa Y., Fujisawa H., Murakami F. and 
Masu M. Distinct roles of neuropilin 1 signaling for radial and tangential 
extension of callosal axons. J Comp Neurol. 514(3):215-25, 2009.

|   Newly deposited mouse strains

  These mice have been newly deposited to RIKEN BRC. They will be available 
soon after rederivation. We appreciate depositors for their contributions 
to the scientific community.

  Mitsubishi Kagaku Institute of Life Sciences (MITILS) has deposited 244 
valuable mouse strains including genetically engineered mice to RIKEN 
BioResource Center.  These strains were generated at MITILS and cryopreserved 
in the Mouse Embryo Bank of MITILS.  Since MITILS is soon to cease operations, 
RIKEN BioResource Center has accepted deposition of all the strains and 
will ensure that researchers continue to have access to these valuable 
genetic resources.  We thank the developer scientists of the strains and 
MITILS for their contribution to the research community.

  Terms and conditions of use

1.  The BIOLOGICAL RESOURCE shall be used only for academic research purposes 
    by a non-profit organization.
2.  The RECIPIENT of a non-profit organization must make prior contact with 
    RIKEN BRC and negotiate with Mitsubishi Chemical Corporation to use the 
    BIOLOGICAL RESOURCE non-academic research purposes.
3.  In publishing the research results to be obtained by use of the BIOLOGICAL 
    RESOURCE in relevant journals and meetings, the RECIPIENT must stipulate 
    the source of the BIOLOGICAL RESOURCE and acknowledge Mitsubishi Chemical 
4.  The RECIPIENT agrees to the condition that RIKEN BRC shall inform 
    Mitsubishi Chemical Corporation annually of the RECIPIENT organization, 
    the RECIPIENT name, the specific research purpose and the date of 

|  Newly available mouse strains

  These mice just have been rederived into our barrier facility. 
They are now available for distribution.

|  Mouse strains for freeze preservation

  The preservation of a sufficient number of embryos means that the live 
mice of these strains will be closed soon. It will take more than 3 months 
to recover live mice from frozen stock. Please let us know as soon as 
possible if you plan to use these mice and request them alive.

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*These contents are subject to change without notice.

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RIKEN BioResource Center
Experimental Animal Division
3-1-1 Koyadai, Tsukuba-shi
Ibaraki, 305-0074 Japan