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Cryopreservation of Mouse Embryos by Ethylene Glycol-Based Vitrification
JoVE 3155 11/18/2011

RIKEN BioResource Center Mouse Mail News (電子メール版) No. 138


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RIKEN BioResource Center Mouse Mail News (電子メール版) No. 138
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サクラ前線も順調に北上しているようで、つくばでも満開の桜がみられるようになりました。
春爛漫の心地よい季節の到来に心躍ります。
理研BRC・実験動物開発室から最新情報をお届けします。

━━━━ 目 次 ━━━━━━━━━━━━━━━━━━━━━━━━━━━
● 特集 今月のマウス  “A knock-in mouse strain with R124H human TGFBI mutation”
● 利用者の成果
● 新規寄託マウス系統
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┏━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
┃ 特集 今月のマウス  2016年3月
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A knock-in mouse strain with R124H human TGFBI mutation
  RBRC09538 B6-B6-Tgfbi<tm1(TGFBI)Ccbko>
 寄託者:榛村重人先生(慶応義塾大学 医学部)

詳細はこちら
http://mus.brc.riken.jp/ja/mouse_of_month/mar_2016_mm

今月のマウス・バックナンバー
http://mus.brc.riken.jp/ja/mouse_of_month

今月のマウスへの掲載をご希望される場合は、実験動物開発室
(animal@brc.riken.jp)までお問い合わせください。

┏━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
┃ 利用者の成果
┗━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━

理研BRCから提供したマウスを用いた研究成果が次々と発表されております。
理研BRCでは皆様の成果をご紹介することで、新たな発見のお手伝いをしたいと
考えております。論文発表・特許取得などありました折りには是非ご連絡をお待
ちしております。

RBRC-GD000099  Srr<Rgsc01872>
Jiang H, Wang X, Zhang H, Chang Y, Feng M, Wu S. Loss-of-function 
mutation of serine racemase attenuates excitotoxicity by intravitreal 
injection of N-methyl-D-aspartate. J Neurochem.;136(1):186-93, 2016.
http://www.ncbi.nlm.nih.gov/pubmed/26485193

RBRC00207  M.MUS-NJL 
Bamunusinghe D, Naghashfar Z, Buckler-White A, Plishka R, Baliji S, 
Liu Q, Kassner J, Oler A, Hartley J2 Kozak CA. Sequence diversity, 
intersubgroup relationships, and origins of the mouse leukemia 
gammaretroviruses of laboratory and wild mice. J Virol., 
pii: JVI.03186-15, 2016.
http://www.ncbi.nlm.nih.gov/pubmed/26865715

RBRC00213  PWK
Morita S, Nakabayashi K, Kawai T, Hayashi K, Horii T, Kimura M, 
Kamei Y, Ogawa Y, Hata K, Hatada I. Gene expression profiling 
of white adipose tissue reveals paternal transmission of proneness 
to obesity. Sci Rep.;6:21693, 2016.
http://www.ncbi.nlm.nih.gov/pubmed/26868178

RBRC00267  C57BL/6-Tg(CAG-EGFP)C14-Y01-FM131Osb [C57BL/6-TgN(act-EGFP)OsbC14-Y01-FM131]
Kobayashi Y, Kiguchi N, Fukazawa Y, Saika F, Maeda T, Kishioka S.
Macrophage-T cell interactions mediate neuropathic pain through 
the glucocorticoid-induced tumor necrosis factor ligand system.
J Biol Chem.;290(20):12603-13, 2015.
http://www.ncbi.nlm.nih.gov/pubmed/25787078

RBRC00806  GFP-LC3#53
Chang AL, Ulrich A, Suliman HB, Piantadosi CA. Redox regulation 
of mitophagy in the lung during murine Staphylococcus aureus sepsis.
Free Radic Biol Med.;78:179-89, 2015. 
http://www.ncbi.nlm.nih.gov/pubmed/25450328

RBRC00806  GFP-LC3#53
Chrisam M, Pirozzi M, Castagnaro S, Blaauw B, Polishchuck R, 
Cecconi F, Grumati P, Bonaldo P. Reactivation of autophagy by 
spermidine ameliorates the myopathic defects of collagen VI-null mice. 
Autophagy.;11(12):2142-52, 2015.
http://www.ncbi.nlm.nih.gov/pubmed/26565691

RBRC00806  GFP-LC3#53
Gubbiotti MA, Neill T, Frey H, Schaefer L, Iozzo RV. Decorin is 
an autophagy-inducible proteoglycan and is required for proper 
in vivo autophagy. Matrix Biol;48:14-25, 2015. 
http://www.ncbi.nlm.nih.gov/pubmed/26344480

RBRC00806  GFP-LC3#53
Kanamori H, Takemura G, Goto K, Tsujimoto A, Mikami A, Ogino A, 
Watanabe T, Morishita K, Okada H, Kawasaki M, Seishima M, 
Minatoguchi S. Autophagic adaptations in diabetic cardiomyopathy 
differ between type 1 and type 2 diabetes. Autophagy;11(7):1146-60, 2015.
http://www.ncbi.nlm.nih.gov/pubmed/26042865

RBRC00806  GFP-LC3#53
Klinman E, Holzbaur EL. Stress-Induced CDK5 Activation Disrupts Axonal 
Transport via Lis1/Ndel1/Dynein. Cell Rep.;12(3):462-73, 2015.
http://www.ncbi.nlm.nih.gov/pubmed/26166569

RBRC00806  GFP-LC3#53
Kwok J, Onuma H, Olmer M, Lotz MK, Grogan SP, D'Lima DD.
Histopathological analyses of murine menisci: implications for joint 
aging and osteoarthritis. Osteoarthritis Cartilage;24(4):709-18, 2016.
http://www.ncbi.nlm.nih.gov/pubmed/26585241

RBRC00806  GFP-LC3#53
Mintern JD, Macri C, Chin WJ, Panozza SE, Segura E, Patterson NL, 
Zeller P, Bourges D, Bedoui S, McMillan PJ, Idris A, Nowell CJ, 
Brown A, Radford KJ, Johnston AP, Villadangos JA. Differential use 
of autophagy by primary dendritic cells specialized in cross-presentation.
Autophagy;11(6):906-17, 2015. 
http://www.ncbi.nlm.nih.gov/pubmed/25950899

RBRC00806  GFP-LC3#53
Mukherjee R, Mareninova OA, Odinokova IV, Huang W, Murphy J, 
Chvanov M, Javed MA, Wen L, Booth DM, Cane MC, Awais M, 
Gavillet B, Pruss RM, Schaller S, Molkentin JD, Tepikin AV, 
Petersen OH, Pandol SJ, Gukovsky I, Criddle DN, Gukovskaya AS, 
Sutton R; and NIHR Pancreas Biomedical Research Unit.
Mechanism of mitochondrial permeability transition pore induction 
and damage in the pancreas: inhibition prevents acute pancreatitis 
by protecting production of ATP. Gut., pii: gutjnl-2014-308553, 
doi: 10.1136/gutjnl-2014-308553, 2015.
http://www.ncbi.nlm.nih.gov/pubmed/26071131

RBRC00806  GFP-LC3#53
Terawaki S, Camosseto V, Prete F, Wenger T, Papadopoulos A, 
Rondeau C, Combes A, Rodriguez Rodrigues C, Vu Manh TP, Fallet M, 
English L, Santamaria R, Soares AR, Weil T, Hammad H, Desjardins M, 
Gorvel JP, Santos MA, Gatti E, Pierre P. RUN and FYVE domain-containing 
protein 4 enhances autophagy and lysosome tethering in response to 
Interleukin-4. J Cell Biol.;210(7):1133-52, 2015.
http://www.ncbi.nlm.nih.gov/pubmed/26416964

RBRC00806  GFP-LC3#53
Komeya M, Kimura H, Nakamura H, Yokonishi T, Sato T, Kojima K, Hayashi K, 
Katagiri K, Yamanaka H, Sanjo H, Yao M, Kamimura S, Inoue K, Ogonuki N, 
Ogura A, Fujii T, Ogawa T. Long-term ex vivo maintenance of testis tissues 
producing fertile sperm in a microfluidic device. Sci Rep.;6:21472, 2016.
http://www.ncbi.nlm.nih.gov/pubmed/26892171

RBRC00915  C.Cg-Irf9<tm1Ttg>/TtgRbrc [IRF-9 KO/BALB/c, BALB/cAJcl-Isgf3g<tm1>]
Martinet V1, Tonon S1, Torres D1, Azouz A1, Nguyen M1, Kohler A1, 
Flamand V1, Mao CA2, Klein WH2, Leo O1, Goriely S1. Type I interferons 
regulate eomesodermin expression and the development of unconventional 
memory CD8(+) T cells. Nat Commun.;6:7089, 2015.
http://www.ncbi.nlm.nih.gov/pubmed/25953241

RBRC01081  B6.129S-Drd2<tm1Mok> [D2R KO, B6-D2R KO]
Wakabayashi C, Numakawa T, Ooshima Y, Hattori K, Kunugi H
Possible role of the dopamine D1 receptor in the sensorimotor 
gating deficits induced by high-fat diet.
Psychopharmacology (Berl).;232(24):4393-400, 2015. 
http://www.ncbi.nlm.nih.gov/pubmed/26359228

RBRC01351  B6.129S-Grm2<tm1Nak>/NakRbrc [C57BL/6-Grm2 tm (Nov.2011), GluR2 KO, mGluR2 KO]
Moreno JL, Miranda-Azpiazu P, García-Bea A, Younkin J, Cui M, 
Kozlenkov A, Ben-Ezra A, Voloudakis G, Fakira AK, Baki L, Ge Y, 
Georgakopoulos A, Morón JA, Milligan G, López-Giménez JF, 
Robakis NK, Logothetis DE, Meana JJ, González-Maeso J.
Allosteric signaling through an mGlu2 and 5-HT2A heteromeric 
receptor complex and its potential contribution to schizophrenia.
Sci Signal.;9(410):ra5, 2016.
http://www.ncbi.nlm.nih.gov/pubmed/26758213

RBRC01390  B6.129P2-Nfe2l2<tm1Mym>/MymRbrc [Nrf2 kO/C57BL6J]
Marques L, Negre-Salvayre A, Costa L, Canonne-Hergaux F.
Iron gene expression profile in atherogenic Mox macrophages.
Biochim Biophys Acta., doi: 10.1016/j.bbadis.2016.03.004, 2016.
http://www.ncbi.nlm.nih.gov/pubmed/26972048

RBRC01828  B6.Cg-Tg(CAG-Cre)CZ-MO2Osb [CAG-cre]
Ogoh H, Tanuma N, Matsui Y, Hayakawa N, Inagaki A, Sumiyoshi M, 
Momoi Y, Kishimoto A, Suzuki M, Sasaki N, Ohuchi T, Nomura M, 
Teruya Y, Yasuda K, Watanabe T, Shima H.
The protein phosphatase 6 catalytic subunit (Ppp6c) is 
indispensable for proper post-implantation embryogenesis.
Mech Dev.;139:1-9, 2016.
http://www.ncbi.nlm.nih.gov/pubmed/26868000

RBRC01834  C57BL/6-Tg(CAG-flpe)36Ito/ItoRbrc [B6-Tg(CAG-FLPe)36, C57BL/6-Tg(CAG-FLPe)36Ito/ItoRbrc]
Kai T, Tsukamoto Y, Hijiya N, Tokunaga A, Nakada C, Uchida T, 
Daa T, Iha H, Takahashi M, Nomura T, Sato F, Mimata H, Ikawa M, 
Seto M, Matsuura K, Moriyama M.
Kidney-specific knockout of Sav1 in the mouse promotes 
hyper-proliferation of renal tubular epithelium through 
suppression of the Hippo pathway. J Pathol., 
doi: 10.1002/path.4706, 2016.
http://www.ncbi.nlm.nih.gov/pubmed/26913567

RBRC02192  B6.129-Mapk14<tm1.2Otsu>
Schnöder L, Hao W, Qin Y, Liu S, Tomic I, Liu X, Fassbender K, 
Liu Y. Deficiency of Neuronal p38α MAPK Attenuates Amyloid Pathology 
in Alzheimer Disease Mouse and Cell Models through Facilitating 
Lysosomal Degradation of BACE1. J Biol Chem., ;291(5):2067-79, 2016.
http://www.ncbi.nlm.nih.gov/pubmed/26663083

RBRC02298  C.Cg-Il3<tm1Glli> [IL-3 KO]
Weber GF, Chousterman BG, He S, Fenn AM, Nairz M, Anzai A, 
Brenner T, Uhle F, Iwamoto Y, Robbins CS, Noiret L, Maier SL, 
Zönnchen T, Rahbari NN, Schölch S, Klotzsche-von Ameln A, 
Chavakis T, Weitz J, Hofer S, Weigand MA, Nahrendorf M, 
Weissleder R, Swirski FK.
Interleukin-3 amplifies acute inflammation and is a potential 
therapeutic target in sepsis. Science.;347(6227):1260-5, 2015.
http://www.ncbi.nlm.nih.gov/pubmed/25766237

RBRC02332  B6.Cg-Tg(Drd2-YFP)364-5
RBRC03111  C57BL/6J-Tg(mDrd1-YFP)680-1Koba
RBRC04720  B6;129S-Rap1a<tm1Morz> Rap1b<tm1Morz> [B6-Rap1a/Rap1b floxed]
Nagai T, Nakamuta S, Kuroda K, Nakauchi S, Nishioka T, Takano T, 
Zhang X, Tsuboi D, Funahashi Y, Nakano T, Yoshimoto J, Kobayashi K, 
Uchigashima M, Watanabe M, Miura M, Nishi A, Kobayashi K, Yamada K, 
Amano M, Kaibuchi K. Phosphoproteomics of the Dopamine Pathway 
Enables Discovery of Rap1 Activation as a Reward Signal In Vivo.
Neuron.;89(3):550-65, 2016.
http://www.ncbi.nlm.nih.gov/pubmed/26804993

RBRC02388  B6.129P2-Ly96<tm1Kmiy> [C57BL/6-MD-2 KO]
Wang Y, Shan X, Chen G, Jiang L, Wang Z, Fang Q, Liu X, Wang J, 
Zhang Y, Wu W, Liang G. MD-2 as the target of a novel small molecule, 
L6H21, in the attenuation of LPS-induced inflammatory response and sepsis.
Br J Pharmacol.;172(17):4391-405, 2015. 
http://www.ncbi.nlm.nih.gov/pubmed/26076332

RBRC02344  FVB.129P2-Nf2<tm2Gth> [Nf2flox2 (FVB)]
Ahmad I, Fernando A, Gurgel R, Clark JJ, Xu L, Hansen MR.
Merlin status regulates p75(NTR) expression and apoptotic 
signaling in Schwann cells following nerve injury.
Neurobiol Dis;82:114-22, 2015.
http://www.ncbi.nlm.nih.gov/pubmed/26057084

RBRC02975  B6.129S-Atg5<tm1Myok> [Atg5flox]
Akoumianaki T, Kyrmizi I, Valsecchi I, Gresnigt MS, Samonis G, 
Drakos E, Boumpas D, Muszkieta L, Prevost MC, Kontoyiannis DP, 
Chavakis T, Netea MG, van de Veerdonk FL, Brakhage AA, El-Benna J, 
Beauvais A, Latge JP, Chamilos G.
Aspergillus Cell Wall Melanin Blocks LC3-Associated Phagocytosis 
to Promote Pathogenicity. Cell Host Microbe.;19(1):79-90, 2016.
http://www.ncbi.nlm.nih.gov/pubmed/26749442

RBRC03163  B6J.129P2-Hmox1<tm1Mym> [HO-1 floxed mouse]
Parada E, Buendia I, Navarro E, Avendaño C, Egea J, López MG.
Microglial HO-1 induction by curcumin provides antioxidant, 
antineuroinflammatory, and glioprotective effects.
Mol Nutr Food Res.;59(9):1690-700, 2015.
http://www.ncbi.nlm.nih.gov/pubmed/26047311

RBRC03731  B6;129S4-Dnmt3a<tm3.1Enl> [Dnmt3a<tm3.1Enl>, Dnmt3a conditional KO, Dnmt3a-2lox]
Sharma A, Klein SS, Barboza L, Lohdi N, Toth M.
Principles Governing DNA Methylation during Neuronal Lineage 
and Subtype Specification. J Neurosci.;36(5):1711-22, 2016.
http://www.ncbi.nlm.nih.gov/pubmed/26843651

RBRC04138   B6;129-Ace3<tm1Osb> [ACE3 KO]
Yu CJ, Tang LL, Liang C, Chen X, Song SY, Ding XQ, Zhang KY, 
Song BL, Zhao D, Zhu XY, Li HL, Zhang ZR.
Angiotensin-Converting Enzyme 3 (ACE3) Protects Against 
Pressure Overload-Induced Cardiac Hypertrophy.
J Am Heart Assoc.;5(2), 2016.
http://www.ncbi.nlm.nih.gov/pubmed/26892527

RBRC04874  C57BL/6N-Gt(ROSA)26Sor<tm1(CAG-EGFP/tDsRed)Utr>/Rbrc
Shibata M, Banno R, Sugiyama M, Tominaga T, Onoue T, Tsunekawa T, 
Azuma Y, Hagiwara D, Lu W, Ito Y, Goto M, Suga H, Sugimura Y, Oiso Y, 
Arima H. AgRP Neuron-Specific Deletion of Glucocorticoid Receptor 
Leads to Increased Energy Expenditure and Decreased Body Weight in 
Female Mice on a High Fat Diet. Endocrinology.:en20151430, 2016. 
http://www.ncbi.nlm.nih.gov/pubmed/26889940

RBRC04878  B6;129-Tg(CMV-EGFP,U6-shNanog)1Ttada [NRi-Tg]
Chen CL, Uthaya Kumar DB, Punj V, Xu J, Sher L, Tahara SM, Hess S, 
Machida K. NANOG Metabolically Reprograms Tumor-Initiating Stem-like 
Cells through Tumorigenic Changes in Oxidative Phosphorylation and 
Fatty Acid Metabolism. Cell Metab.;23(1):206-19, 2016.
http://www.ncbi.nlm.nih.gov/pubmed/26724859

┏━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━
┃ 新規寄託マウス系統
┗━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━

下記のマウス系統が新たに寄託登録されました。寄託していただいた先生には、
室員一同、心より感謝いたしております。

Dr. Shin Kobayashi, Tokyo Medical and Dental University
RBRC09531 C57BL/6N-Ftx<tm1Koba>

Dr. Masayuki Yamamoto, Tohoku University
RBRC09595 B6.129P2-Keap1<tm2Mym>
RBRC09596 B6.BD-Keap1<em1(C151S)Mym>
RBRC09597 B6.BD-Keap1<em1(C288E)Mym>

Dr. Masahide Takahashi, Nagoya University
RBRC09599 FVB.129S6-Cd109<tm1Mat>

Dr. Yusuke Okubo, National Institute of Health Sciences
RBRC09611 MCH.B6C3F1-Tg(CAG-cat,-Dll1)Yoku
RBRC09612 MCH.B6C3F1-Dll1<em1Yoku>

詳細はこちら
http://mus.brc.riken.jp/ja/mailnews/kitaku_list/20160304_k

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 2016.03.30.