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Cryopreservation of Mouse Embryos by Ethylene Glycol-Based Vitrification
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RIKEN BioResource Center Mouse E-mail News No. 109

RIKEN BioResource Center (BRC) is pleased to update you with the latest

======= Contents ===============================================
- Special topic: Mouse of the Month "Conditional ablation of HMGB1 in
- Participation report of the Munich repository workshop
- Participation Report of the 13th China Western Experimental Animal
  Management and Academic Seminar Conference
- Announcement: The Third RIKEN BRC/Nanjing University MARC
  International Summer Intensive Course of the Mouse
- User publications
- Newly deposited mouse strains
- Newly available mouse strains
- Mouse strains for freeze preservation

|  Special topic: Mouse of the Month    June 2014

Conditional ablation of HMGB1 in mice
  RBRC06240  B6.129P2-Hmgb1<tm1Ttg>/TtgRbrc

  Depositor: Tadatsugu Taniguchi, Ph.D.
             Department of Molecular Immunology, Institute of Industrial
             The University of Tokyo

Mouse of the Month archive

|  Participation report of the Munich repository workshop

  The INFRAFRONTIER IMPC workshop entitled "Promoting the international
exchange of mouse mutant resources," was held in Munich, Germany on May
8-9, 2014. Regarding the discussions we had at this workshop, an
editorial has been published in NATURE as follows:

|  Participation report of the 13th China Western Experimental Animal
|  Management and Academic Seminar Conference

  The 13th China Western Experimental Animal Management and Academic
Seminar Conference was held in Xi'an, China from May 28 to 30, 2014.
Dr. Kazuyuki Mekada, Senior Research Scientist, Experimental Animal
Division, RIKEN BioResource Center was invited to the conference by Dr.
Enqi Liu, Director and Professor, Laboratory Animal Center, Xi'an
Jiaotong University Health Science Center and talked on the Collection,
Preservation and Distribution of the Mouse Resources by RIKEN
BioResource Center and Genetic Variation of Mouse Inbred Strains.

|  Announcement: The Third RIKEN BRC/Nanjing University MARC
|  International Summer Intensive Course of the Mouse

  The 3rd RIKEN BRC/Nanjing University MARC International Summer
Intensive Course of the Mouse will be held at RIKEN BioResource Center
from July 28 to 30. It is aiming to provide short and intensive
educational program about using laboratory mouse, and to train young
scientists with international vision and innovative spirits for
biomedical research and developmental biology. The registration will
start at 8:30 am on July 28.

  Place: RIKEN BioResource Center(BRC)
  Date: July 28-30, 2014
  Official Language: English
  Registration Fee: Free
  Application Deadline has been extended: July 15, 2014

|  User publications

  The following results have been newly reported by users. We are
honored to introduce new publications to the science community.
Therefore, we look forward to receiving your publications too.

RBRC-GSC0080 B6(D2)-Gdf5<Rgsc451>/RgscRbrc «M100451»
Hinoi E., IezakiT, Fujita H, Watanabe T, Odaka Y, Ozaki K, Yoneda Y.
PI3K/Akt is involved in brown adipogenesis mediated by growth
differentiation factor-5 in association with activation of the Smad
pathway. Biochem. Biophys. Res. Commun., doi:10.1016/j.bbrc.2014.05.108,

RBRC00144 B6.SJL-Ptprc<a>/Rbrc «C57BL/6-Ly-5.1»
Mise-Omata S, Alles N, Fukazawa T, Aoki K, Ohya K, Jimi E, Obata Y,
Doi T. NF-{kappa}B RELA-deficient bone marrow macrophages fail to
support bone formation and to maintain hematopoietic niche after lethal
irradiation and stem cell transplantation. Int. Immunol.,
10.1093/intimm/dxu062, 2014.

RBRC00267 C57BL/6-Tg(CAG-EGFP)C14-Y01-FM131Osb/OsbRbrc
Vogelgesang A, Scapin C, Barone C, Tam E, Blumental Perry A, Dammann CE.
Cigarette Smoke Exposure during Pregnancy Alters Fetomaternal Cell
Trafficking Leading to Retention of Microchimeric Cells in the Maternal
Lung. PLoS One, 15;9(5):e88285. doi: 10.1371/journal.pone.0088285.
eCollection 2014, 2014.

RBRC00639 JF1/MsRbrc
Obata Y, Wakai T, Hara S, Kono T. Long exposure to mature ooplasm can
alter DNA methylation at imprinted loci in non-growing oocytes but not
in prospermatogonia. Reproduction; 147(1):H1-6, doi: 10.1530/REP-13-0359,

RBRC00639 JF1/MsRbrc
Hara S, Takano T, Fujikawa T, Yamada M, Wakai T, Kono T, Obata Y. Forced
expression of DNA methyltransferases during oocyte growth accelerates
the establishment of methylation imprints but not functional genomic
imprinting. Hum. Mol. Genet.

RBRC00980 B6C3-Tg(CAG-EGFP)CX-FM038Osb/OsbRbrc
Watanabe-Takano H, Takano K, Sakamoto A, Matsumoto K, Tokuhisa T, Endo T,
Hatano M. DA-Raf-dependent inhibition of the Ras-ERK signaling pathway
in type 2 alveolar epithelial cells controls alveolar formation. Proc
Natl Acad Sci U S A, pii: 201321574, 2014.

RBRC01023 129S2/SvPasRbrc
Aoki K, Shimada S, Simantini DS, Tun MM, Buerano CC, Morita K,
Hayasaka D. Type-I interferon response affects an inoculation
dose-independent mortality in mice following Japanese encephalitis virus
infection. Virol J.;11(1):105.

RBRC01908 B6.C3-Tg(Mt1-Il5)6Ato/KtkRbrc
Tani Y, Isobe Y, Imoto Y, Segi-Nishida E, Sugimoto Y, Arai H, Arita M.
Eosinophils control the resolution of inflammation and draining lymph
node hypertrophy through the proresolving mediators and CXCL13 pathway
in mice. FASEB J., pii: fj.14-251132, 2014.

RBRC02339 B6.B6D2-Tg(Tec-p210 BCR/ABL1)1Homy/HomyRbrc
«B6.Cg-Tg(Tec-p210 BCR/ABL1)1Homy»
Sanchez-Sanchez B, Gutierrez-Herrero S, Lopez-Ruano G, Prieto-Bermejo R,
Romo-Gonzalez M, Llanillo M, Pandiella A, Guerrero C, San Miguel JF,
Sanchez-Guijo F, Del Canizo MC, Hernandez-Hernandez A. NADPH oxidases as
therapeutic targets in chronic myeloid leukemia. Clin Cancer Res., pii:
clincanres.3044.2013, 2014.

RBRC02704 B6.Cg-Tg(FucciS/G2/M)#474Bsi/BsiRbrc
RBRC02709 B6.Cg-Tg(FucciG1)#639Bsi/BsiRbrc
Shand FH, Ueha S, Otsuji M, Koid SS, Shichino S, Tsukui T,
Kosugi-Kanaya M, Abe J, Tomura M, Ziogas J, Matsushima K. Tracking of
intertissue migration reveals the origins of tumor-infiltrating
monocytes. Proc Natl Acad Sci U S A, pii: 201402914, 2014.

RBRC02759 B6.Cg-Atg7<tm1Tchi>/TchiRbrc
Wang H, Wan H, Li X, Liu W, Chen Q, Wang Y, Yang L, Tang H, Zhang X,
Duan E, Zhao X, Gao F, Li W. Atg7 is required for acrosome biogenesis
during spermatogenesis in mice. Cell Res., doi: 10.1038/cr.2014.70, 2014.

|  Newly deposited mouse strains

  The following mice have been newly deposited with RIKEN BRC and will
be available shortly after rederivation.
  We appreciate the contributions of the depositors to the science

  Dr. Hidenori Senpuku, National Institute of Infectious Diseases
    RBRC06336  NOD.Cg-Prkdc<scid> E2f1<tm1Meg>

|  Newly available mouse strains

  The following mice have recently been rederived into our barrier
facility and are now available for distribution.

    RBRC03626  B6.B6D2-Tg(EF1A-BCL2)1Ymat
    RBRC05525  B6.B6D2-Tg(Prrx1-Sox9,-lacZ)1Haak
    RBRC06027  A.SM-(D11Mit106-D11Mit173)
    RBRC06146  FVB.Cg-Tg(HSA-Slk*K63R)3405
    RBRC06183  SL/Stm
    RBRC06194  A.SM-Par1 Par3
    RBRC06219  C57BL/6-Frmpd1<tm1Tfur>

|  Mouse strains for freeze preservation

  Since a sufficient number of frozen stocks have been preserved, live
mice of the following strains will be discontinued soon.
  It will take more than 3 months to recover live mice from frozen stock.
Therefore, please inform us as soon as possible if you plan to use the
mice and request them alive.

    RBRC04916  B6.129P2-Gnb1<Gt(prvSStrap)4B8Yiw>
    RBRC05562  B6.Cg-Tg(Crx-rtTA)G2Tfur
    RBRC05660  B6.B6D2-Tg(CAG-CAT,SpH)5Yyan
    RBRC05702  C57BL/6J-Tg(CAG-XBP1/luc)23Tiw
    RBRC05703  B6;129S4-Gt(ROSA)26Sor<tm1.1Tiw>
    RBRC05753  B6.129S4-Map3k5<tm1Hijo>
    RBRC05761  B6.Cg-Rftn1<tm1Ayos>
    RBRC05822  C57BL/6J-Tg(hSMA-NCX1*trun)1
    RBRC05825  C57BL/6J-Tg(hSMA-NCX1.3*del)2
    RBRC05842  C57BL/6-Tg(tetO-ArchT/EGFP)1Ahky
    RBRC05920  C57BL/6J-Tg(Cdh5-rtTA)1
    RBRC05921  B6;129P2-Eed<tm1(L240Q)Homy>
    RBRC05924  B6.Cg-Atpif1<tm1>

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RIKEN BioResource Center
Experimental Animal Division
3-1-1 Koyadai, Tsukuba-shi
Ibaraki, 305-0074 Japan