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Cryopreservation of Mouse Embryos by Ethylene Glycol-Based Vitrification
JoVE 3155 11/18/2011

RIKEN BioResource Center Mouse E-mail News No. 112

RIKEN BioResource Center (BRC) is pleased to update you with the latest

======= Contents ===============================================
- Special topic: Mouse of the Month 
  "App knock-in mouse strains: new models for Alzheimer's disease"
- Quality Examination and Information Release Policy on Our Bioresources
- Banking on biological tools for research innovation
- Announcement: The 37th Annual Meeting of the Molecular Biology Society
  of Japan
- User publications
- Newly deposited mouse strains
- Newly available mouse strains
- Mouse strains for freeze preservation

|  Special topic: Mouse of the Month    September 2014

App knock-in mouse strains: new models for Alzheimer's disease
  RBRC06342  C57BL/6-App<tm1(NL)Tcs>/TcsRbrc
  RBRC06343  C57BL/6-App<tm2(NL-F)Tcs>/TcsRbrc
  RBRC06344  C57BL/6-App<tm3(NL-G-F)Tcs>/TcsRbrc

Depositor: Takaomi C. Saido, RIKEN Brain Science Institute

Mouse of the Month archive

|  Quality Examination and Information Release Policy on Our
|  Bioresources

  RIKEN BioResource Center (BRC) has strived to offer bioresources of
the highest quality with secured reproducibility. In spite of all our
efforts, however, we happened to have unintentionally and regrettably
distributed some resources with defects. This has caused great troubles
to our valued users who have spent their precious time and resources on
such materials. We expressed our sincere apology to the users involved
and made the utmost effort to meet their needs. We would also like to
apologize to all citizens as well as the research community for
tremendous concerns and anxieties.
  Every time our Center faced with such defects, we clarified what had
caused the troubles, established measures to prevent a recurrence of
incidents, and put the remedy into actions. Main causes of the present
cases include: (1) There was no method to examine the materials properly
when we distributed them, (2) The range of our tests was not sufficient
to cover the materials fully, (3) Communication between the depositors
and our staff was inadequate, and (4) Simple mistakes. From now on, we
will make every effort not to let these happen again and never to
distribute bioresources with any defects.

Read more

|  Banking on biological tools for research innovation

  Repositories of biological materials and information play an essential
role in managing the unprecedented growth in knowledge about living
systems that is being generated by genomics, genetics and molecular
biology. To help ensure that research in these fields continues to make
a positive contribution to humanity, RIKEN is engaging in international
collaborations and targeted research.

Read more

|  Announcement: The 37th Annual Meeting of the Molecular Biology
|  Society of Japan

  The 37th Annual Meeting of the Molecular Biology Society of Japan will
be held at PACIFICO Yokohama from Tuesday, November 25th to Thursday,
November 27th. We are pleased to welcome you to visit our booth in the
exhibition hall during the annual meeting.

The 37th Annual Meeting of the Molecular Biology Society of Japan

|  User publications

  The following results have been newly reported by users. We are
honored to introduce new publications to the science community.
Therefore, we look forward to receiving your publications too.

RBRC01828  B6.Cg-Tg(CAG-Cre)CZ-M02Osb/OsbRbrc
Liu T, Yamaguchi Y, Shirasaki Y, Shikada K, Yamagishi M, Hoshino K,
Kaisho T, Takemoto K, Suzuki T, Kuranaga E, Ohara O, Miura M.
Single-Cell Imaging of Caspase-1 Dynamics Reveals an All-or-None
Inflammasome Signaling Response.
Cell Rep.; 8(4):974-82, doi: 10.1016/j.celrep.2014.07.012, 2014.

RBRC02095  B6.Cg-Tg(Th-EGFP)21-31Koba/KobaRbrc
Suzuki Y, Kiyokage E, Sohn J, Hioki H, Toida K, Structural basis for
serotonergic regulation of neural circuits in the mouse olfactory bulb.
J Comp Neurol. doi: 10.1002/cne.23680, 2014.

RBRC02370  B6.129-Grn<tm1Mni>
Hafler BP, Klein ZA, Jimmy Zhou Z, Strittmatter SM, Progressive retinal
degeneration and accumulation of autofluorescent lipopigments in
Progranulin deficient mice.
Brain Res. pii: S0006-8993(14)01234-7. doi: 10.1016/j.brainres.2014.09.
023, 2014.

RBRC02892  B6.Cg-Tg(FucciS/G2/M)#504Bsi Tg(FucciG1)#596Bsi/Rbrc
Imayoshi I, Isomura A, Harima Y, Kawaguchi K, Kori H, Miyachi H,
Fujiwara T, Ishidate F, Kageyama R. Oscillatory control of factors
determining multipotency and fate in mouse neural progenitors.
Science; 342(6163):1203-8, doi: 10.1126/science.1242366, 2013.

|  Newly deposited mouse strains

  The following mice have been newly deposited with RIKEN BRC and will
be available shortly after rederivation.
  We appreciate the contributions of the depositors to the science

Dr. Takao Shimizu, The University of Tokyo, Graduate School of Medicine
  RBRC05641    B6.129P2-Pla2g4a<tm1Tksh>

Dr. Takaomi C. Saido, RIKEN
  RBRC06342    C57BL/6-App<tm1(NL)Tcs>

Dr. Jun Wada, Okayama University Graduate School of Medicine, Dentistry
and Pharmaceutical Sciences
  RBRC06436    C57BL/6-Pemt<tm1>
  RBRC06443    C57BL/6-Tg(Fabp4-Clmp)4Jwada
  RBRC06444    C57BL/6-Tg(Fabp4-Clmp)11Jwada
  RBRC06445    C57BL/6-Tg(Fabp4-Clmp)22Jwada
  RBRC06446    B6.129-Clmp<tm1Jwada>
  RBRC06447    ICR.129-Clmp<tm1Jwada>
  RBRC06448    STOCK Clmp<tm1Jwada>

Dr. Fumihiro Sugiyama, University of Tsukuba
  RBRC06458    C57BL/6J-Tyr<em1Utr>
  RBRC06459    C57BL/6J-Tyr<em2Utr>

Dr. Seiji Shiota, Showa University
  RBRC06462    C57BL/6-Prkcd<tm1Shb>
  RBRC06463    C57BL/6-Prkcd<tm1.1Shb>

Dr. Makoto Kinoshita, Nagoya University
  RBRC06467    C57BL/6-Tg(Prnp-Sirt1,Cryaa-EGFP)1Ksh

|  Newly available mouse strains

  The following mice have recently been rederived into our barrier
facility and are now available for distribution.

  RBRC06233    DS/Shi-Trpv3<Nh>/Shi
  RBRC06294    B6;129-Aqp7<tm1Tfun>
  RBRC06303    NEAT2(lacZ)(Acc.No.CDB0837K)
  RBRC06313    B6.129-Sparc<tm1Hwe>
  RBRC06317    C.Cg-Cables1<Tg(CAG-rtTA,CAG-tTS)138Utr>
  RBRC06318    BALB/c-Cables1<tm1Utr>
  RBRC06330    C57BL/6-Tg(Ly6a-KDM1A*v2)6Fscr

|  Mouse strains for freeze preservation

  Since a sufficient number of frozen stocks have been preserved, live
mice of the following strains will be discontinued soon.
It will take more than 3 months to recover live mice from frozen stock.
Therefore, please inform us as soon as possible if you plan to use the
mice and request them alive.

  RBRC05282    LMIR5 (Acc. No. CDB0539K)
  RBRC05525    B6.B6D2-Tg(Prrx1-Sox9,-lacZ)1Haak
  RBRC05556    B6J.MSM-Aanat<MSM>
  RBRC05765    B6.Cg-H2az1<tm1.1Hko> H2az2<tm1.1Hko>
  RBRC05822    C57BL/6J-Tg(hSMA-NCX1*trun)1
  RBRC05825    C57BL/6J-Tg(hSMA-NCX1.3*del)2
  RBRC05924    B6.Cg-Atpif1<tm1>
  RBRC05926    B6.Cg-Map3k5<tm1Hijo> Map3k6<tm1Hijo>
  RBRC05945    ICR.Cg-Pax6<tm1Ued>
  RBRC05949    B6.129P2-Rbm3<tm1Ttg>
  RBRC06173    ICR;FVB-Invs<inv>
  RBRC06178    B6;KOR1-Pitx3<+/->
  RBRC06238    ICR.Cg-Capn6<tm1Hiso>

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RIKEN BioResource Center
Experimental Animal Division
3-1-1 Koyadai, Tsukuba-shi
Ibaraki, 305-0074 Japan