{"id":6575,"date":"2007-05-31T17:04:40","date_gmt":"2007-05-31T08:04:40","guid":{"rendered":"http:\/\/mus.brc.riken.jp:7301\/?page_id=6575"},"modified":"2022-07-12T14:29:27","modified_gmt":"2022-07-12T05:29:27","slug":"may_2007_mm","status":"publish","type":"page","link":"http:\/\/mus.brc.riken.jp\/en\/mouse_of_month\/may_2007_mm","title":{"rendered":"Lefty & Nodal"},"content":{"rendered":"\n\n\n
\"RIKEN<\/td>\nMay 2007<\/span>
\nMouse of the Month<\/span><\/a>\n <\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n\n\n\n
\n

Lefty & Nodal
\nThe principal players in left-right patterning<\/h2>\n

BRC No. 02106_B6.129-lefty1<\/a>
\nBRC No. 02107_B6.129-nodal<\/a>
\nBRC No. 02108_B6;C3;129-Tg(NodalASE-lacZ)H8Hmd<\/a>
\nBRC No. 01861_C57BL\/6-Tg(NodalNDE-Cre)16Hmd<\/a>
\nResearch Application : Developmental Biology<\/h5>\n

\n\"mn0705_0101\"
\nFigure. Lefty1 restricts Nodal expression to the left side.<\/b>
\nThe expressing areas of nodal (orange dot), lefty1 (blue line)
\nand lefty2 (light blue dot) in a ventral view of embryo (E8.0)
\nare summarized. A: anterior; P: posterior<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

\u00a0The internal organs of vertebrates show left-right (L-R) asymmetry in their anatomy and physiology. L-R patterning is determined early during development. Lefty and Nodal have been found to be expressed asymmetrically in developing mouse embryo. Both of these proteins are expressed in the lateral plate mesoderm exclusively on the left side; Nodal acts as the left-side determinant, whereas Lefty functions as a feedback inhibitor of Nodal. Lefty1-deficient and Nodal-deficient mice showed a variety of L-R positional defects in visceral organs including left and right isomerism, respectively.<\/strong>\n<\/div>\n

 <\/p>\n\n\n\n\n
Depositor<\/td>\n:<\/td>\nDr. Hiroshi Hamada
\n(Osaka University)<\/td>\n<\/tr>\n
References<\/td>\n:<\/td>\n(1) Meno C, Shimono A, Saijoh Y, Yashiro K, Mochida K, Ohishi S, Noji S, Kondoh H, Hamada H.
\nCell<\/i>\u00a01998 Aug 7;94(3):287-97<\/a>
\n(2) Adachi H, Saijoh Y, Mochida K, Ohishi S, Hashiguchi H, Hirao A, Hamada H.
\nGenes Dev<\/i>1999 Jun 15;13(12):1589-600<\/a>
\n(3) Saijoh Y, Oki S, Ohishi S, Hamada H.
\nDev Biol<\/i>\u00a02003 Apr 1;256(1):160-72.<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"

May 2007 Mouse of the Month   Lefty & Nodal The principal players in left-right patterning BRC No. 02106_B6.129-lefty1 BRC No. 02107_B6.129-nodal BRC No. 02108_B6;C3;129-Tg(NodalASE-lacZ)H8Hmd BRC No. 01861_C57BL\/6-Tg(NodalNDE-Cre)16Hmd Research Application : Developmental Biology Figure. Lefty1 restricts Nodal expression to the left side. The expressing areas of nodal (orange dot), lefty1 (blue line) and lefty2 (light blue dot) in a ventral view of embryo (E8.0) are summarized. A: anterior; P: posterior   \u00a0The internal organs of vertebrates show left-right (L-R) asymmetry in their anatomy and physiology. L-R patterning is determined early during development. Lefty and Nodal have been found to be expressed asymmetrically in developing mouse embryo. Both of these proteins are expressed in the lateral plate mesoderm exclusively on the left side; Nodal acts as the left-side determinant, whereas Lefty functions as a feedback inhibitor of Nodal. Lefty1-deficient and Nodal-deficient mice showed a variety of L-R positional defects in visceral organs including left and right isomerism, respectively.   Depositor : Dr. Hiroshi Hamada (Osaka University) References : (1) Meno C, Shimono A, Saijoh Y, Yashiro K, Mochida K, Ohishi S, Noji S, Kondoh H, Hamada H. Cell\u00a01998 Aug 7;94(3):287-97 (2) Adachi H, Saijoh Y, Mochida K, Ohishi S, Hashiguchi H, […]<\/p>\n","protected":false},"author":8,"featured_media":0,"parent":198,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_seopress_robots_follow":"","_seopress_robots_imageindex":"","_seopress_robots_snippet":"","_seopress_robots_primary_cat":"","_seopress_robots_breadcrumbs":"","_seopress_robots_freeze_modified_date":"","_seopress_robots_custom_modified_date":"","_seopress_robots_canonical":"","_seopress_social_fb_title":"","_seopress_social_fb_desc":"","_seopress_social_fb_img":"","_seopress_social_fb_img_attachment_id":0,"_seopress_social_fb_img_width":0,"_seopress_social_fb_img_height":0,"_seopress_social_twitter_title":"","_seopress_social_twitter_desc":"","_seopress_social_twitter_img":"","_seopress_social_twitter_img_attachment_id":0,"_seopress_social_twitter_img_width":0,"_seopress_social_twitter_img_height":0,"_seopress_redirections_value":"","_seopress_redirections_enabled":"","_seopress_redirections_enabled_regex":"","_seopress_redirections_logged_status":"both","_seopress_redirections_param":"","_seopress_redirections_type":301,"_seopress_analysis_target_kw":"","footnotes":"","_wp_rev_ctl_limit":""},"class_list":["post-6575","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"http:\/\/mus.brc.riken.jp\/en\/wp-json\/wp\/v2\/pages\/6575","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/mus.brc.riken.jp\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/mus.brc.riken.jp\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/en\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/en\/wp-json\/wp\/v2\/comments?post=6575"}],"version-history":[{"count":11,"href":"http:\/\/mus.brc.riken.jp\/en\/wp-json\/wp\/v2\/pages\/6575\/revisions"}],"predecessor-version":[{"id":19159,"href":"http:\/\/mus.brc.riken.jp\/en\/wp-json\/wp\/v2\/pages\/6575\/revisions\/19159"}],"up":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/en\/wp-json\/wp\/v2\/pages\/198"}],"wp:attachment":[{"href":"http:\/\/mus.brc.riken.jp\/en\/wp-json\/wp\/v2\/media?parent=6575"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}