<\/a><\/p>\n
Visualizing the neuronal activity-regulated gene Arc<\/em><\/span><\/p>\nC57BL\/6-Tg(Arc-EGFP\/Arc)3Hbto\/HbtoRbrc (RBRC06086)<\/a><\/h5>\n<\/a>Courtesy of Haruhiko Bito, M.D., Ph.D.<\/p>\nNeuronal activity-regulated induction of EGFP-Arc in the hippocampus<\/strong><\/p>\nFluorescence images taken from the hippocampus of a transgenic (Tg) mouse kept in a home cage (left panel, na\u00efve) or a Tg mouse that received an electro-convulsive shock 3 hours earlier (right panel, ECS). \u00a0The framed areas in the upper panels are expanded and shown in the lower panels.<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n <\/p>\n\n\n\nActivity-dependent gene expression and protein synthesis in mature neurons are required for long-term memory formation. \u00a0In particular, Arc (also called Arg3.1) has emerged recently as an attractive candidate of cognitive function-related gene products whose induction correlates with physiological neuronal activity. \u00a0In the postsynaptic density, Arc protein regulates the surface expression of AMPA-type glutamate receptors at excitatory synapses [1]. \u00a0This function is implicated in several forms of protein translation-dependent synaptic long-term depression and homeostatic plasticity\/synaptic scaling. \u00a0To examine Arc dynamics in living neurons, the expression of a monomeric EGFP-tagged Arc was driven under the control of the 7 kb Arc promoter [2, 3]. \u00a0Neuronal activity-triggered Arc protein was found to \u00a0rather accumulate in synapses with low activity, and thus may play a role in an \u2018\u2018inverse” tagging process, to prevent the undesired enhancement of weak synapses in potentiated neurons [3]. \u00a0Genomic mutations in the Arc gene were recently proposed to be associated with several neurological and psychiatric disorders, including schizophrenia [4].<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\nDepositor<\/td>\n:<\/td>\nHaruhiko Bito, M.D., Ph.D.\nDepartment of Neurochemistry\nThe University of Tokyo Graduate School of Medicine<\/b><\/span><\/td>\n<\/tr>\n\nStrain name<\/td>\n:<\/td>\nC57BL\/6-Tg(Arc-EGFP\/Arc)3Hbto\/HbtoRbrc<\/b><\/span><\/td>\n<\/tr>\n\nRBRC No.<\/td>\n:<\/td>\nRBRC06086<\/td>\n<\/tr>\n\n<\/td>\n<\/td>\n<\/td>\n<\/tr>\n\nReferences<\/td>\n:<\/td>\n[1]<\/td>\nChowdhury S, Shepherd JD, Okuno H, Lyford G, Petralia RS, Plath N, Kuhl D, Huganir RL, Worley PF. Arc\/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking.\u00a0\u00a0<\/i><\/b>Neuron<\/em>; 52:445-459, 2006.<\/a><\/td>\n<\/tr>\n\n[2]<\/td>\nKawashima T, Okuno H, Nonaka M, Adachi-Morishima A, Kyo N, Okamura M, Takemoto-Kimura S, Worley PF, Bito H. Synaptic activity-responsive element in the Arc\/Arg3.1 promoter essential for synapse-to-nucleus signaling in activated neurons.\u00a0Proc Natl Acad Sci U S A.<\/em>; 106(1):316-321, 2009.<\/a><\/td>\n<\/tr>\n\n[3]<\/td>\nOkuno H, Akashi K, Ishii Y, Yagishita-Kyo N, Suzuki K, Nonaka M, Kawashima T, Fujii H, Takemoto-Kimura S, Abe M, Natsume R, Chowdhury S, Sakimura K, Worley PF, Bito H. Inverse synaptic tagging of inactive synapses via dynamic interaction of Arc\/Arg3.1 with CaMKII\u03b2.\u00a0Cell<\/em>; 149(4):886-898, 2012. <\/a><\/td>\n<\/tr>\n\n[4]<\/td>\nFromer M, Pocklington AJ, Kavanagh DH, et al., De novo mutations in schizophrenia implicate synaptic networks.\u00a0Nature<\/em>; 506(7487):179-184, 2014. <\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n <\/p>\n\n\n\nJuly 2014\nContact: Shinya Ayabe, Ph.D.<\/a>\nExperimental Animal Division, RIKEN BioResource Center\nAll materials contained on this site may not be reproduced, distributed, displayed, published or broadcast without the prior permission of the owner of that content.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n <\/map>\n<\/p>\n <\/p>\n","protected":false},"excerpt":{"rendered":"Visualizing the neuronal activity-regulated gene Arc C57BL\/6-Tg(Arc-EGFP\/Arc)3Hbto\/HbtoRbrc (RBRC06086) Courtesy of Haruhiko Bito, M.D., Ph.D. Neuronal activity-regulated induction of EGFP-Arc in the […]<\/p>\n","protected":false},"author":19,"featured_media":0,"parent":198,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_seopress_robots_follow":"","_seopress_robots_imageindex":"","_seopress_robots_snippet":"","_seopress_robots_primary_cat":"","_seopress_robots_breadcrumbs":"","_seopress_robots_freeze_modified_date":"","_seopress_robots_custom_modified_date":"","_seopress_robots_canonical":"","_seopress_social_fb_title":"","_seopress_social_fb_desc":"","_seopress_social_fb_img":"","_seopress_social_fb_img_attachment_id":0,"_seopress_social_fb_img_width":0,"_seopress_social_fb_img_height":0,"_seopress_social_twitter_title":"","_seopress_social_twitter_desc":"","_seopress_social_twitter_img":"","_seopress_social_twitter_img_attachment_id":0,"_seopress_social_twitter_img_width":0,"_seopress_social_twitter_img_height":0,"_seopress_redirections_value":"","_seopress_redirections_enabled":"","_seopress_redirections_enabled_regex":"","_seopress_redirections_logged_status":"","_seopress_redirections_param":"","_seopress_redirections_type":301,"_seopress_analysis_target_kw":"","footnotes":"","_wp_rev_ctl_limit":""},"class_list":["post-10643","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/10643","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/users\/19"}],"replies":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/comments?post=10643"}],"version-history":[{"count":20,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/10643\/revisions"}],"predecessor-version":[{"id":18577,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/10643\/revisions\/18577"}],"up":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/198"}],"wp:attachment":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/media?parent=10643"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
<\/a>Courtesy of Haruhiko Bito, M.D., Ph.D.<\/p>\nNeuronal activity-regulated induction of EGFP-Arc in the hippocampus<\/strong><\/p>\nFluorescence images taken from the hippocampus of a transgenic (Tg) mouse kept in a home cage (left panel, na\u00efve) or a Tg mouse that received an electro-convulsive shock 3 hours earlier (right panel, ECS). \u00a0The framed areas in the upper panels are expanded and shown in the lower panels.<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n <\/p>\n\n\n\nActivity-dependent gene expression and protein synthesis in mature neurons are required for long-term memory formation. \u00a0In particular, Arc (also called Arg3.1) has emerged recently as an attractive candidate of cognitive function-related gene products whose induction correlates with physiological neuronal activity. \u00a0In the postsynaptic density, Arc protein regulates the surface expression of AMPA-type glutamate receptors at excitatory synapses [1]. \u00a0This function is implicated in several forms of protein translation-dependent synaptic long-term depression and homeostatic plasticity\/synaptic scaling. \u00a0To examine Arc dynamics in living neurons, the expression of a monomeric EGFP-tagged Arc was driven under the control of the 7 kb Arc promoter [2, 3]. \u00a0Neuronal activity-triggered Arc protein was found to \u00a0rather accumulate in synapses with low activity, and thus may play a role in an \u2018\u2018inverse” tagging process, to prevent the undesired enhancement of weak synapses in potentiated neurons [3]. \u00a0Genomic mutations in the Arc gene were recently proposed to be associated with several neurological and psychiatric disorders, including schizophrenia [4].<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\nDepositor<\/td>\n:<\/td>\nHaruhiko Bito, M.D., Ph.D.\nDepartment of Neurochemistry\nThe University of Tokyo Graduate School of Medicine<\/b><\/span><\/td>\n<\/tr>\n\nStrain name<\/td>\n:<\/td>\nC57BL\/6-Tg(Arc-EGFP\/Arc)3Hbto\/HbtoRbrc<\/b><\/span><\/td>\n<\/tr>\n\nRBRC No.<\/td>\n:<\/td>\nRBRC06086<\/td>\n<\/tr>\n\n<\/td>\n<\/td>\n<\/td>\n<\/tr>\n\nReferences<\/td>\n:<\/td>\n[1]<\/td>\nChowdhury S, Shepherd JD, Okuno H, Lyford G, Petralia RS, Plath N, Kuhl D, Huganir RL, Worley PF. Arc\/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking.\u00a0\u00a0<\/i><\/b>Neuron<\/em>; 52:445-459, 2006.<\/a><\/td>\n<\/tr>\n\n[2]<\/td>\nKawashima T, Okuno H, Nonaka M, Adachi-Morishima A, Kyo N, Okamura M, Takemoto-Kimura S, Worley PF, Bito H. Synaptic activity-responsive element in the Arc\/Arg3.1 promoter essential for synapse-to-nucleus signaling in activated neurons.\u00a0Proc Natl Acad Sci U S A.<\/em>; 106(1):316-321, 2009.<\/a><\/td>\n<\/tr>\n\n[3]<\/td>\nOkuno H, Akashi K, Ishii Y, Yagishita-Kyo N, Suzuki K, Nonaka M, Kawashima T, Fujii H, Takemoto-Kimura S, Abe M, Natsume R, Chowdhury S, Sakimura K, Worley PF, Bito H. Inverse synaptic tagging of inactive synapses via dynamic interaction of Arc\/Arg3.1 with CaMKII\u03b2.\u00a0Cell<\/em>; 149(4):886-898, 2012. <\/a><\/td>\n<\/tr>\n\n[4]<\/td>\nFromer M, Pocklington AJ, Kavanagh DH, et al., De novo mutations in schizophrenia implicate synaptic networks.\u00a0Nature<\/em>; 506(7487):179-184, 2014. <\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n <\/p>\n\n\n\nJuly 2014\nContact: Shinya Ayabe, Ph.D.<\/a>\nExperimental Animal Division, RIKEN BioResource Center\nAll materials contained on this site may not be reproduced, distributed, displayed, published or broadcast without the prior permission of the owner of that content.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n <\/map>\n<\/p>\n <\/p>\n","protected":false},"excerpt":{"rendered":"Visualizing the neuronal activity-regulated gene Arc C57BL\/6-Tg(Arc-EGFP\/Arc)3Hbto\/HbtoRbrc (RBRC06086) Courtesy of Haruhiko Bito, M.D., Ph.D. Neuronal activity-regulated induction of EGFP-Arc in the […]<\/p>\n","protected":false},"author":19,"featured_media":0,"parent":198,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_seopress_robots_follow":"","_seopress_robots_imageindex":"","_seopress_robots_snippet":"","_seopress_robots_primary_cat":"","_seopress_robots_breadcrumbs":"","_seopress_robots_freeze_modified_date":"","_seopress_robots_custom_modified_date":"","_seopress_robots_canonical":"","_seopress_social_fb_title":"","_seopress_social_fb_desc":"","_seopress_social_fb_img":"","_seopress_social_fb_img_attachment_id":0,"_seopress_social_fb_img_width":0,"_seopress_social_fb_img_height":0,"_seopress_social_twitter_title":"","_seopress_social_twitter_desc":"","_seopress_social_twitter_img":"","_seopress_social_twitter_img_attachment_id":0,"_seopress_social_twitter_img_width":0,"_seopress_social_twitter_img_height":0,"_seopress_redirections_value":"","_seopress_redirections_enabled":"","_seopress_redirections_enabled_regex":"","_seopress_redirections_logged_status":"","_seopress_redirections_param":"","_seopress_redirections_type":301,"_seopress_analysis_target_kw":"","footnotes":"","_wp_rev_ctl_limit":""},"class_list":["post-10643","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/10643","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/users\/19"}],"replies":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/comments?post=10643"}],"version-history":[{"count":20,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/10643\/revisions"}],"predecessor-version":[{"id":18577,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/10643\/revisions\/18577"}],"up":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/198"}],"wp:attachment":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/media?parent=10643"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Neuronal activity-regulated induction of EGFP-Arc in the hippocampus<\/strong><\/p>\nFluorescence images taken from the hippocampus of a transgenic (Tg) mouse kept in a home cage (left panel, na\u00efve) or a Tg mouse that received an electro-convulsive shock 3 hours earlier (right panel, ECS). \u00a0The framed areas in the upper panels are expanded and shown in the lower panels.<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n <\/p>\n\n\n\nActivity-dependent gene expression and protein synthesis in mature neurons are required for long-term memory formation. \u00a0In particular, Arc (also called Arg3.1) has emerged recently as an attractive candidate of cognitive function-related gene products whose induction correlates with physiological neuronal activity. \u00a0In the postsynaptic density, Arc protein regulates the surface expression of AMPA-type glutamate receptors at excitatory synapses [1]. \u00a0This function is implicated in several forms of protein translation-dependent synaptic long-term depression and homeostatic plasticity\/synaptic scaling. \u00a0To examine Arc dynamics in living neurons, the expression of a monomeric EGFP-tagged Arc was driven under the control of the 7 kb Arc promoter [2, 3]. \u00a0Neuronal activity-triggered Arc protein was found to \u00a0rather accumulate in synapses with low activity, and thus may play a role in an \u2018\u2018inverse” tagging process, to prevent the undesired enhancement of weak synapses in potentiated neurons [3]. \u00a0Genomic mutations in the Arc gene were recently proposed to be associated with several neurological and psychiatric disorders, including schizophrenia [4].<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\nDepositor<\/td>\n:<\/td>\nHaruhiko Bito, M.D., Ph.D.\nDepartment of Neurochemistry\nThe University of Tokyo Graduate School of Medicine<\/b><\/span><\/td>\n<\/tr>\n\nStrain name<\/td>\n:<\/td>\nC57BL\/6-Tg(Arc-EGFP\/Arc)3Hbto\/HbtoRbrc<\/b><\/span><\/td>\n<\/tr>\n\nRBRC No.<\/td>\n:<\/td>\nRBRC06086<\/td>\n<\/tr>\n\n<\/td>\n<\/td>\n<\/td>\n<\/tr>\n\nReferences<\/td>\n:<\/td>\n[1]<\/td>\nChowdhury S, Shepherd JD, Okuno H, Lyford G, Petralia RS, Plath N, Kuhl D, Huganir RL, Worley PF. Arc\/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking.\u00a0\u00a0<\/i><\/b>Neuron<\/em>; 52:445-459, 2006.<\/a><\/td>\n<\/tr>\n\n[2]<\/td>\nKawashima T, Okuno H, Nonaka M, Adachi-Morishima A, Kyo N, Okamura M, Takemoto-Kimura S, Worley PF, Bito H. Synaptic activity-responsive element in the Arc\/Arg3.1 promoter essential for synapse-to-nucleus signaling in activated neurons.\u00a0Proc Natl Acad Sci U S A.<\/em>; 106(1):316-321, 2009.<\/a><\/td>\n<\/tr>\n\n[3]<\/td>\nOkuno H, Akashi K, Ishii Y, Yagishita-Kyo N, Suzuki K, Nonaka M, Kawashima T, Fujii H, Takemoto-Kimura S, Abe M, Natsume R, Chowdhury S, Sakimura K, Worley PF, Bito H. Inverse synaptic tagging of inactive synapses via dynamic interaction of Arc\/Arg3.1 with CaMKII\u03b2.\u00a0Cell<\/em>; 149(4):886-898, 2012. <\/a><\/td>\n<\/tr>\n\n[4]<\/td>\nFromer M, Pocklington AJ, Kavanagh DH, et al., De novo mutations in schizophrenia implicate synaptic networks.\u00a0Nature<\/em>; 506(7487):179-184, 2014. <\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n <\/p>\n\n\n\nJuly 2014\nContact: Shinya Ayabe, Ph.D.<\/a>\nExperimental Animal Division, RIKEN BioResource Center\nAll materials contained on this site may not be reproduced, distributed, displayed, published or broadcast without the prior permission of the owner of that content.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n <\/map>\n<\/p>\n <\/p>\n","protected":false},"excerpt":{"rendered":"Visualizing the neuronal activity-regulated gene Arc C57BL\/6-Tg(Arc-EGFP\/Arc)3Hbto\/HbtoRbrc (RBRC06086) Courtesy of Haruhiko Bito, M.D., Ph.D. Neuronal activity-regulated induction of EGFP-Arc in the […]<\/p>\n","protected":false},"author":19,"featured_media":0,"parent":198,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_seopress_robots_follow":"","_seopress_robots_imageindex":"","_seopress_robots_snippet":"","_seopress_robots_primary_cat":"","_seopress_robots_breadcrumbs":"","_seopress_robots_freeze_modified_date":"","_seopress_robots_custom_modified_date":"","_seopress_robots_canonical":"","_seopress_social_fb_title":"","_seopress_social_fb_desc":"","_seopress_social_fb_img":"","_seopress_social_fb_img_attachment_id":0,"_seopress_social_fb_img_width":0,"_seopress_social_fb_img_height":0,"_seopress_social_twitter_title":"","_seopress_social_twitter_desc":"","_seopress_social_twitter_img":"","_seopress_social_twitter_img_attachment_id":0,"_seopress_social_twitter_img_width":0,"_seopress_social_twitter_img_height":0,"_seopress_redirections_value":"","_seopress_redirections_enabled":"","_seopress_redirections_enabled_regex":"","_seopress_redirections_logged_status":"","_seopress_redirections_param":"","_seopress_redirections_type":301,"_seopress_analysis_target_kw":"","footnotes":"","_wp_rev_ctl_limit":""},"class_list":["post-10643","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/10643","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/users\/19"}],"replies":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/comments?post=10643"}],"version-history":[{"count":20,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/10643\/revisions"}],"predecessor-version":[{"id":18577,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/10643\/revisions\/18577"}],"up":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/198"}],"wp:attachment":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/media?parent=10643"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Fluorescence images taken from the hippocampus of a transgenic (Tg) mouse kept in a home cage (left panel, na\u00efve) or a Tg mouse that received an electro-convulsive shock 3 hours earlier (right panel, ECS). \u00a0The framed areas in the upper panels are expanded and shown in the lower panels.<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
<\/p>\n
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![\"Title201407\"](\"\/ja\/wp-content\/uploads\/2014\/07\/271c75d9fcaad2ee1619cc2cc2e6d581.png\")
<\/a><\/p>\n![\"201407\"](\"\/ja\/wp-content\/uploads\/2014\/07\/201407.png\")
<\/a>Courtesy of Haruhiko Bito, M.D., Ph.D.<\/p>\n