<\/a><\/p>\n
Clarifying the role of Fbxw7 in cancer<\/b><\/span><\/p>\nB6;129P2-Fbxw7<\/i><tm1Kei><\/i>\u00a0(RBRC06393, floxed mouse)<\/a><\/h5>\nB6;129P2-Fbxw7<tm1Kin>\u00a0<\/i>(RBRC06394, knockout mouse)<\/a><\/h5>\n<\/a><\/p>\nCourtesy of \u00a0Keiichi Nakayama, M.D., Ph.D.<\/p>\nGross appearance of the lungs of wild-type mice that had been reconstituted with bone marrow (BM) cells from CAG-EGFP\/Fbxw7<\/em>F\/F <\/sup>(Control) or CAG–<\/i>EGFP\/Mx1-Cre\/Fbxw7<\/i>F\/F<\/sup> (Fbxw7 cKO) mice and injected with pIpC and mouse B16F10 melanoma cells (2.0 \u00d7 105<\/sup>). After 2 weeks, the animals were killed and the lungs were removed and fixed in Bouin\u2019s solution. Scale bar, 10 mm.<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n <\/p>\n\n\n\nF-box and WD-40 domain protein 7 (Fbxw7, also known as Fbw7) is an E3 ubiquitin ligase and the component of an F-box protein of the Skp, Cullin, F-box containing complex (SCF complex). Fbxw7 targets substrate proteins including c-Myc, cyclin E, and Notch for ubiquitination and degradation. Nakayama and colleagues generated mice with Fbxw7 conditionally deleted in the T cell lineage and showed that loss of Fbxw7 resulted in c-Myc accumulation, which led to hyperproliferation of immature T cells but apoptosis of mature T cells [1, 2].<\/td>\n<\/tr>\n\nCancer-initiating cells (CICs) are quiescent cells that are required for cancer initiation and maintenance. As most anti-cancer drugs target dividing cells, CICs are resistant to such therapies, resulting in disease relapse. Using a mouse model of chronic myeloid leukemia, the group revealed that ablation of Fbxw7 in leukemia-initiating cells abrogated their quiescence via c-Myc accumulation and increased their sensitivity to anti-cancer drugs. Combination therapy with Fbxw7 ablation and anti-cancer drugs was effective for leukemia-initiating cell depletion in mice [3, 4]. A recent report focused on the host environment and revealed the suppressive role of Fbxw7 in cancer metastasis via C-C motif chemokine 2 [5], showing Fbxw7 to be a therapeutic target of many kinds of human cancer.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n <\/p>\n\n\n\nDepositor<\/td>\n:<\/td>\nKeiichi Nakayama,\u00a0M.D., Ph.D.\nDepartment of Molecular and Cellular Biology\nMedical Institute of Bioregulation, Kyushu University<\/td>\n<\/tr>\n\nStrain name<\/td>\n:<\/td>\nB6;129P2-Fbxw7<tm1Kei><\/i><\/b><\/td>\n<\/tr>\n\nRBRC No.<\/td>\n:<\/td>\nRBRC06393<\/td>\n<\/tr>\n\nStrain name<\/td>\n:<\/td>\nB6;129P2-Fbxw7<tm1Kin><\/i><\/b><\/td>\n<\/tr>\n\nRBRC No.<\/td>\n:<\/td>\nRBRC06394<\/td>\n<\/tr>\n\nRelated strains<\/td>\n:<\/td>\nB6;129P2-Fbxw7<tm2.1Kei><\/i><\/b><\/td>\n<\/tr>\n\nRBRC No.<\/td>\n:<\/td>\nRBRC06395<\/td>\n<\/tr>\n\nReferences<\/td>\n:<\/td>\n[1]<\/td>\nTsunematsu R, Nakayama K, Oike Y, Nishiyama M, Ishida N, Hatakeyama S, Bessho Y, Kageyama R, Suda T, Nakayama KI. Mouse Fbw7\/Sel-10\/Cdc4 is required for notch degradation during vascular development.\u00a0J Biol Chem.<\/em>; 279(10):9417-23, 2004.<\/a><\/td>\n<\/tr>\n\n[2]<\/td>\nOnoyama I, Tsunematsu R, Matsumoto A, Kimura T, de Albor\u00e1n IM, Nakayama K, Nakayama KI. Conditional inactivation of Fbxw7 impairs cell-cycle exit during T cell differentiation and results in lymphomatogenesis.\u00a0J Exp Med.<\/em>; 204(12):2875-88, 2007.<\/a><\/td>\n<\/tr>\n\n[3]<\/td>\nTakeishi S, Matsumoto A, Onoyama I, Naka K, Hirao A, Nakayama KI. Ablation of Fbxw7 eliminates leukemia-initiating cells by preventing quiescence.\u00a0Cancer Cell<\/em>; 23(3):347-61, 2013.<\/a><\/td>\n<\/tr>\n\n[4]<\/td>\nReavie L, Buckley SM, Loizou E, Takeishi S, Aranda-Orgilles B, Ndiaye-Lobry D, Abdel-Wahab O, Ibrahim S, Nakayama KI, Aifantis I. Regulation of c-Myc ubiquitination controls chronic myelogenous leukemia initiation and progression.\u00a0Cancer Cell<\/em>; 23(3):362-75, 2013. <\/a><\/td>\n<\/tr>\n\n[5]<\/td>\nYumimoto K, Akiyoshi S, Ueo H, Sagara Y, Onoyama I, Ueo H, Ohno S, Mori M, Mimori K, Nakayama KI. F-box protein FBXW7 inhibits cancer metastasis in a non-cell-autonomous manner.\u00a0J Clin Invest.<\/em>; in press, 2015.\u00a0<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n <\/p>\n\n\n\n\u00a0January 2015\nContact: Shinya Ayabe, Ph.D.<\/a>\nExperimental Animal Division, RIKEN BioResource Center\nAll materials contained on this site may not be reproduced, distributed, displayed, published or broadcast without the prior permission of the owner of that content.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n <\/p>\n\n\n\n <\/map>\n<\/p>\n <\/p>\n","protected":false},"excerpt":{"rendered":"Clarifying the role of Fbxw7 in cancer B6;129P2-Fbxw7<tm1Kei>\u00a0(RBRC06393, floxed mouse) B6;129P2-Fbxw7<tm1Kin>\u00a0(RBRC06394, knockout mouse) Courtesy of \u00a0Keiichi Nakayama, M.D., Ph.D. Gross […]<\/p>\n","protected":false},"author":19,"featured_media":0,"parent":198,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_seopress_robots_follow":"","_seopress_robots_imageindex":"","_seopress_robots_snippet":"","_seopress_robots_primary_cat":"","_seopress_robots_breadcrumbs":"","_seopress_robots_freeze_modified_date":"","_seopress_robots_custom_modified_date":"","_seopress_robots_canonical":"","_seopress_social_fb_title":"","_seopress_social_fb_desc":"","_seopress_social_fb_img":"","_seopress_social_fb_img_attachment_id":0,"_seopress_social_fb_img_width":0,"_seopress_social_fb_img_height":0,"_seopress_social_twitter_title":"","_seopress_social_twitter_desc":"","_seopress_social_twitter_img":"","_seopress_social_twitter_img_attachment_id":0,"_seopress_social_twitter_img_width":0,"_seopress_social_twitter_img_height":0,"_seopress_redirections_value":"","_seopress_redirections_enabled":"","_seopress_redirections_enabled_regex":"","_seopress_redirections_logged_status":"","_seopress_redirections_param":"","_seopress_redirections_type":301,"_seopress_analysis_target_kw":"","footnotes":"","_wp_rev_ctl_limit":""},"class_list":["post-12262","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/12262","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/users\/19"}],"replies":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/comments?post=12262"}],"version-history":[{"count":20,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/12262\/revisions"}],"predecessor-version":[{"id":18586,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/12262\/revisions\/18586"}],"up":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/198"}],"wp:attachment":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/media?parent=12262"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
<\/a><\/p>\nCourtesy of \u00a0Keiichi Nakayama, M.D., Ph.D.<\/p>\nGross appearance of the lungs of wild-type mice that had been reconstituted with bone marrow (BM) cells from CAG-EGFP\/Fbxw7<\/em>F\/F <\/sup>(Control) or CAG–<\/i>EGFP\/Mx1-Cre\/Fbxw7<\/i>F\/F<\/sup> (Fbxw7 cKO) mice and injected with pIpC and mouse B16F10 melanoma cells (2.0 \u00d7 105<\/sup>). After 2 weeks, the animals were killed and the lungs were removed and fixed in Bouin\u2019s solution. Scale bar, 10 mm.<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n <\/p>\n\n\n\nF-box and WD-40 domain protein 7 (Fbxw7, also known as Fbw7) is an E3 ubiquitin ligase and the component of an F-box protein of the Skp, Cullin, F-box containing complex (SCF complex). Fbxw7 targets substrate proteins including c-Myc, cyclin E, and Notch for ubiquitination and degradation. Nakayama and colleagues generated mice with Fbxw7 conditionally deleted in the T cell lineage and showed that loss of Fbxw7 resulted in c-Myc accumulation, which led to hyperproliferation of immature T cells but apoptosis of mature T cells [1, 2].<\/td>\n<\/tr>\n\nCancer-initiating cells (CICs) are quiescent cells that are required for cancer initiation and maintenance. As most anti-cancer drugs target dividing cells, CICs are resistant to such therapies, resulting in disease relapse. Using a mouse model of chronic myeloid leukemia, the group revealed that ablation of Fbxw7 in leukemia-initiating cells abrogated their quiescence via c-Myc accumulation and increased their sensitivity to anti-cancer drugs. Combination therapy with Fbxw7 ablation and anti-cancer drugs was effective for leukemia-initiating cell depletion in mice [3, 4]. A recent report focused on the host environment and revealed the suppressive role of Fbxw7 in cancer metastasis via C-C motif chemokine 2 [5], showing Fbxw7 to be a therapeutic target of many kinds of human cancer.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n <\/p>\n\n\n\nDepositor<\/td>\n:<\/td>\nKeiichi Nakayama,\u00a0M.D., Ph.D.\nDepartment of Molecular and Cellular Biology\nMedical Institute of Bioregulation, Kyushu University<\/td>\n<\/tr>\n\nStrain name<\/td>\n:<\/td>\nB6;129P2-Fbxw7<tm1Kei><\/i><\/b><\/td>\n<\/tr>\n\nRBRC No.<\/td>\n:<\/td>\nRBRC06393<\/td>\n<\/tr>\n\nStrain name<\/td>\n:<\/td>\nB6;129P2-Fbxw7<tm1Kin><\/i><\/b><\/td>\n<\/tr>\n\nRBRC No.<\/td>\n:<\/td>\nRBRC06394<\/td>\n<\/tr>\n\nRelated strains<\/td>\n:<\/td>\nB6;129P2-Fbxw7<tm2.1Kei><\/i><\/b><\/td>\n<\/tr>\n\nRBRC No.<\/td>\n:<\/td>\nRBRC06395<\/td>\n<\/tr>\n\nReferences<\/td>\n:<\/td>\n[1]<\/td>\nTsunematsu R, Nakayama K, Oike Y, Nishiyama M, Ishida N, Hatakeyama S, Bessho Y, Kageyama R, Suda T, Nakayama KI. Mouse Fbw7\/Sel-10\/Cdc4 is required for notch degradation during vascular development.\u00a0J Biol Chem.<\/em>; 279(10):9417-23, 2004.<\/a><\/td>\n<\/tr>\n\n[2]<\/td>\nOnoyama I, Tsunematsu R, Matsumoto A, Kimura T, de Albor\u00e1n IM, Nakayama K, Nakayama KI. Conditional inactivation of Fbxw7 impairs cell-cycle exit during T cell differentiation and results in lymphomatogenesis.\u00a0J Exp Med.<\/em>; 204(12):2875-88, 2007.<\/a><\/td>\n<\/tr>\n\n[3]<\/td>\nTakeishi S, Matsumoto A, Onoyama I, Naka K, Hirao A, Nakayama KI. Ablation of Fbxw7 eliminates leukemia-initiating cells by preventing quiescence.\u00a0Cancer Cell<\/em>; 23(3):347-61, 2013.<\/a><\/td>\n<\/tr>\n\n[4]<\/td>\nReavie L, Buckley SM, Loizou E, Takeishi S, Aranda-Orgilles B, Ndiaye-Lobry D, Abdel-Wahab O, Ibrahim S, Nakayama KI, Aifantis I. Regulation of c-Myc ubiquitination controls chronic myelogenous leukemia initiation and progression.\u00a0Cancer Cell<\/em>; 23(3):362-75, 2013. <\/a><\/td>\n<\/tr>\n\n[5]<\/td>\nYumimoto K, Akiyoshi S, Ueo H, Sagara Y, Onoyama I, Ueo H, Ohno S, Mori M, Mimori K, Nakayama KI. F-box protein FBXW7 inhibits cancer metastasis in a non-cell-autonomous manner.\u00a0J Clin Invest.<\/em>; in press, 2015.\u00a0<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n <\/p>\n\n\n\n\u00a0January 2015\nContact: Shinya Ayabe, Ph.D.<\/a>\nExperimental Animal Division, RIKEN BioResource Center\nAll materials contained on this site may not be reproduced, distributed, displayed, published or broadcast without the prior permission of the owner of that content.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n <\/p>\n\n\n\n <\/map>\n<\/p>\n <\/p>\n","protected":false},"excerpt":{"rendered":"Clarifying the role of Fbxw7 in cancer B6;129P2-Fbxw7<tm1Kei>\u00a0(RBRC06393, floxed mouse) B6;129P2-Fbxw7<tm1Kin>\u00a0(RBRC06394, knockout mouse) Courtesy of \u00a0Keiichi Nakayama, M.D., Ph.D. Gross […]<\/p>\n","protected":false},"author":19,"featured_media":0,"parent":198,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_seopress_robots_follow":"","_seopress_robots_imageindex":"","_seopress_robots_snippet":"","_seopress_robots_primary_cat":"","_seopress_robots_breadcrumbs":"","_seopress_robots_freeze_modified_date":"","_seopress_robots_custom_modified_date":"","_seopress_robots_canonical":"","_seopress_social_fb_title":"","_seopress_social_fb_desc":"","_seopress_social_fb_img":"","_seopress_social_fb_img_attachment_id":0,"_seopress_social_fb_img_width":0,"_seopress_social_fb_img_height":0,"_seopress_social_twitter_title":"","_seopress_social_twitter_desc":"","_seopress_social_twitter_img":"","_seopress_social_twitter_img_attachment_id":0,"_seopress_social_twitter_img_width":0,"_seopress_social_twitter_img_height":0,"_seopress_redirections_value":"","_seopress_redirections_enabled":"","_seopress_redirections_enabled_regex":"","_seopress_redirections_logged_status":"","_seopress_redirections_param":"","_seopress_redirections_type":301,"_seopress_analysis_target_kw":"","footnotes":"","_wp_rev_ctl_limit":""},"class_list":["post-12262","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/12262","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/users\/19"}],"replies":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/comments?post=12262"}],"version-history":[{"count":20,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/12262\/revisions"}],"predecessor-version":[{"id":18586,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/12262\/revisions\/18586"}],"up":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/198"}],"wp:attachment":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/media?parent=12262"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Courtesy of \u00a0Keiichi Nakayama, M.D., Ph.D.<\/p>\n
Gross appearance of the lungs of wild-type mice that had been reconstituted with bone marrow (BM) cells from CAG-EGFP\/Fbxw7<\/em>F\/F <\/sup>(Control) or CAG–<\/i>EGFP\/Mx1-Cre\/Fbxw7<\/i>F\/F<\/sup> (Fbxw7 cKO) mice and injected with pIpC and mouse B16F10 melanoma cells (2.0 \u00d7 105<\/sup>). After 2 weeks, the animals were killed and the lungs were removed and fixed in Bouin\u2019s solution. Scale bar, 10 mm.<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n <\/p>\n\n\n\nF-box and WD-40 domain protein 7 (Fbxw7, also known as Fbw7) is an E3 ubiquitin ligase and the component of an F-box protein of the Skp, Cullin, F-box containing complex (SCF complex). Fbxw7 targets substrate proteins including c-Myc, cyclin E, and Notch for ubiquitination and degradation. Nakayama and colleagues generated mice with Fbxw7 conditionally deleted in the T cell lineage and showed that loss of Fbxw7 resulted in c-Myc accumulation, which led to hyperproliferation of immature T cells but apoptosis of mature T cells [1, 2].<\/td>\n<\/tr>\n\nCancer-initiating cells (CICs) are quiescent cells that are required for cancer initiation and maintenance. As most anti-cancer drugs target dividing cells, CICs are resistant to such therapies, resulting in disease relapse. Using a mouse model of chronic myeloid leukemia, the group revealed that ablation of Fbxw7 in leukemia-initiating cells abrogated their quiescence via c-Myc accumulation and increased their sensitivity to anti-cancer drugs. Combination therapy with Fbxw7 ablation and anti-cancer drugs was effective for leukemia-initiating cell depletion in mice [3, 4]. A recent report focused on the host environment and revealed the suppressive role of Fbxw7 in cancer metastasis via C-C motif chemokine 2 [5], showing Fbxw7 to be a therapeutic target of many kinds of human cancer.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n <\/p>\n\n\n\nDepositor<\/td>\n:<\/td>\nKeiichi Nakayama,\u00a0M.D., Ph.D.\nDepartment of Molecular and Cellular Biology\nMedical Institute of Bioregulation, Kyushu University<\/td>\n<\/tr>\n\nStrain name<\/td>\n:<\/td>\nB6;129P2-Fbxw7<tm1Kei><\/i><\/b><\/td>\n<\/tr>\n\nRBRC No.<\/td>\n:<\/td>\nRBRC06393<\/td>\n<\/tr>\n\nStrain name<\/td>\n:<\/td>\nB6;129P2-Fbxw7<tm1Kin><\/i><\/b><\/td>\n<\/tr>\n\nRBRC No.<\/td>\n:<\/td>\nRBRC06394<\/td>\n<\/tr>\n\nRelated strains<\/td>\n:<\/td>\nB6;129P2-Fbxw7<tm2.1Kei><\/i><\/b><\/td>\n<\/tr>\n\nRBRC No.<\/td>\n:<\/td>\nRBRC06395<\/td>\n<\/tr>\n\nReferences<\/td>\n:<\/td>\n[1]<\/td>\nTsunematsu R, Nakayama K, Oike Y, Nishiyama M, Ishida N, Hatakeyama S, Bessho Y, Kageyama R, Suda T, Nakayama KI. Mouse Fbw7\/Sel-10\/Cdc4 is required for notch degradation during vascular development.\u00a0J Biol Chem.<\/em>; 279(10):9417-23, 2004.<\/a><\/td>\n<\/tr>\n\n[2]<\/td>\nOnoyama I, Tsunematsu R, Matsumoto A, Kimura T, de Albor\u00e1n IM, Nakayama K, Nakayama KI. Conditional inactivation of Fbxw7 impairs cell-cycle exit during T cell differentiation and results in lymphomatogenesis.\u00a0J Exp Med.<\/em>; 204(12):2875-88, 2007.<\/a><\/td>\n<\/tr>\n\n[3]<\/td>\nTakeishi S, Matsumoto A, Onoyama I, Naka K, Hirao A, Nakayama KI. Ablation of Fbxw7 eliminates leukemia-initiating cells by preventing quiescence.\u00a0Cancer Cell<\/em>; 23(3):347-61, 2013.<\/a><\/td>\n<\/tr>\n\n[4]<\/td>\nReavie L, Buckley SM, Loizou E, Takeishi S, Aranda-Orgilles B, Ndiaye-Lobry D, Abdel-Wahab O, Ibrahim S, Nakayama KI, Aifantis I. Regulation of c-Myc ubiquitination controls chronic myelogenous leukemia initiation and progression.\u00a0Cancer Cell<\/em>; 23(3):362-75, 2013. <\/a><\/td>\n<\/tr>\n\n[5]<\/td>\nYumimoto K, Akiyoshi S, Ueo H, Sagara Y, Onoyama I, Ueo H, Ohno S, Mori M, Mimori K, Nakayama KI. F-box protein FBXW7 inhibits cancer metastasis in a non-cell-autonomous manner.\u00a0J Clin Invest.<\/em>; in press, 2015.\u00a0<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n <\/p>\n\n\n\n\u00a0January 2015\nContact: Shinya Ayabe, Ph.D.<\/a>\nExperimental Animal Division, RIKEN BioResource Center\nAll materials contained on this site may not be reproduced, distributed, displayed, published or broadcast without the prior permission of the owner of that content.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n <\/p>\n\n\n\n <\/map>\n<\/p>\n <\/p>\n","protected":false},"excerpt":{"rendered":"Clarifying the role of Fbxw7 in cancer B6;129P2-Fbxw7<tm1Kei>\u00a0(RBRC06393, floxed mouse) B6;129P2-Fbxw7<tm1Kin>\u00a0(RBRC06394, knockout mouse) Courtesy of \u00a0Keiichi Nakayama, M.D., Ph.D. Gross […]<\/p>\n","protected":false},"author":19,"featured_media":0,"parent":198,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_seopress_robots_follow":"","_seopress_robots_imageindex":"","_seopress_robots_snippet":"","_seopress_robots_primary_cat":"","_seopress_robots_breadcrumbs":"","_seopress_robots_freeze_modified_date":"","_seopress_robots_custom_modified_date":"","_seopress_robots_canonical":"","_seopress_social_fb_title":"","_seopress_social_fb_desc":"","_seopress_social_fb_img":"","_seopress_social_fb_img_attachment_id":0,"_seopress_social_fb_img_width":0,"_seopress_social_fb_img_height":0,"_seopress_social_twitter_title":"","_seopress_social_twitter_desc":"","_seopress_social_twitter_img":"","_seopress_social_twitter_img_attachment_id":0,"_seopress_social_twitter_img_width":0,"_seopress_social_twitter_img_height":0,"_seopress_redirections_value":"","_seopress_redirections_enabled":"","_seopress_redirections_enabled_regex":"","_seopress_redirections_logged_status":"","_seopress_redirections_param":"","_seopress_redirections_type":301,"_seopress_analysis_target_kw":"","footnotes":"","_wp_rev_ctl_limit":""},"class_list":["post-12262","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/12262","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/users\/19"}],"replies":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/comments?post=12262"}],"version-history":[{"count":20,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/12262\/revisions"}],"predecessor-version":[{"id":18586,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/12262\/revisions\/18586"}],"up":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/198"}],"wp:attachment":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/media?parent=12262"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
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