{"id":13929,"date":"2016-10-04T15:06:04","date_gmt":"2016-10-04T06:06:04","guid":{"rendered":"http:\/\/mus.brc.riken.jp\/ja\/?page_id=13929"},"modified":"2021-04-07T13:07:46","modified_gmt":"2021-04-07T04:07:46","slug":"info20161004","status":"publish","type":"page","link":"http:\/\/mus.brc.riken.jp\/ja\/info20161004","title":{"rendered":"\u30de\u30a6\u30b9\u306e\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u306e\u5f79\u5272\u3092\u89e3\u660e\u3059\u308b\u305f\u3081\u306e\u30c4\u30fc\u30eb"},"content":{"rendered":"

2016\u5e74\u306e\u30ce\u30fc\u30d9\u30eb\u533b\u5b66\u30fb\u751f\u7406\u5b66\u8cde\u306f\u3001\u300c\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u306e\u4ed5\u7d44\u307f\u306e\u89e3\u660e\u300d\u3067\u5927\u9685\u826f\u5178\u5148\u751f\uff08\u6771\u4eac\u5de5\u696d\u5927\u5b66\u6804\u8a89\u6559\u6388\uff09\u304c\u53d7\u8cde\u3055\u308c\u307e\u3057\u305f[1]\u3002
\n\u7406\u7814BRC\u306b\u306f\u6c34\u5cf6\u6607\u5148\u751f\uff08\u6771\u4eac\u5927\u5b66\u5927\u5b66\u9662\u6559\u6388\uff09\u306a\u3089\u3073\u306b\u5c0f\u677e\u96c5\u660e\u5148\u751f\uff08\u65b0\u6f5f\u5927\u5b66\u5927\u5b66\u9662\u6559\u6388\uff09\u304c\u5927\u9685\u826f\u5178\u5148\u751f\u3068\u306e\u5171\u8457[2, 3, 4]\u306b\u3088\u308a\u3054\u767a\u8868\u3055\u308c\u305f\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u7814\u7a76\u306b\u6709\u7528\u306a\u30de\u30a6\u30b9\u7cfb\u7d71\u304c\u5bc4\u8a17\u3055\u308c\u3001\u3053\u308c\u307e\u3067\u306b\u4e16\u754c\u306e240\u6a5f\u95a2\u4ee5\u4e0a\u306b\u63d0\u4f9b\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u7686\u69d8\u306e\u3054\u5229\u7528\u3092\u304a\u5f85\u3061\u3044\u305f\u3057\u3066\u304a\u308a\u307e\u3059\u3002<\/p>\n

\u7cfb\u7d71\u306e\u30ea\u30b9\u30c8<\/strong><\/p>\n\n\n\n\n\n\n\n
BRC No.<\/th>\nStrain Name<\/th>\n\u5bc4\u8a17\u8005<\/th>\n\u6587\u732e<\/th>\n<\/tr>\n
RBRC00806<\/a><\/td>\nGFP-LC3#53<\/td>\n\u6c34\u5cf6\u6607\u5148\u751f<\/td>\n2, 3<\/td>\n<\/tr>\n
RBRC02231<\/a><\/td>\nB6;129-Atg5<tm1Nmz><\/td>\n\u6c34\u5cf6\u6607\u5148\u751f<\/td>\n3<\/td>\n<\/tr>\n
RBRC02759<\/a><\/td>\nB6.Cg-Atg7<tm1Tchi><\/td>\n\u5c0f\u677e\u96c5\u660e\u5148\u751f<\/td>\n4<\/td>\n<\/tr>\n
RBRC02760<\/a><\/td>\nB6.Cg-Atg7<tm1.1Tchi><\/td>\n\u5c0f\u677e\u96c5\u660e\u5148\u751f<\/td>\n4<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n



\n\u6587\u732e<\/strong>
\n[1]\tThe 2016 Nobel Prize in Physiology or Medicine
\nhttp:\/\/www.nobelprize.org\/nobel_prizes\/medicine\/laureates\/2016\/<\/a>
\n[2]\tMizushima N, Yamamoto A, Matsui M, Yoshimori T, Ohsumi Y<\/u>. In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol Biol Cell 15(3):1101-1111, 2004.
\n[3]\tKuma, A., Hatano, M., Matsui, M., Yamamoto, A., Nakaya, H., Yoshimori, T., Ohsumi, Y<\/u>., Tokuhisa, T., and Mizushima, N. The role of autophagy during the early neonatal starvation period. Nature 432, 1032\u20131036, 2004.
\n[4]\tKomatsu M, Waguri S, Ueno T, Iwata J, Murata S, Tanida I, Ezaki J, Mizushima N, Ohsumi Y<\/u>, Uchiyama Y, Kominami E, Tanaka K, Chiba T. Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol 169(3):425-434, 2005.
\n

\n\u305d\u306e\u4ed6\u306e\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u95a2\u9023\u7cfb\u7d71<\/strong><\/p>\n\n\n\n\n\n\n\n\n
BRC No.<\/th>\nStrain Name<\/th>\n\u5bc4\u8a17\u8005<\/th>\n\u6587\u732e<\/th>\n<\/tr>\n
RBRC02761<\/a><\/td>\nB6.Cg-Atg3<tm1><\/td>\n\u5c0f\u677e\u96c5\u660e\u5148\u751f<\/td>\nMol. Biol. Cell 19:4762-4775 (2008).<\/td>\n<\/tr>\n
RBRC02975<\/a><\/td>\nB6.129S-Atg5<tm1Myok><\/td>\n\u6c34\u5cf6\u6607\u5148\u751f<\/td>\nNature 441, 885-889 (2006).<\/td>\n<\/tr>\n
RBRC03914<\/a><\/td>\nC57BL\/6-Tg(Myh6-mCherry\/LC3)1Acvm<\/td>\n\u91ce\u5800\u6f54\u5148\u751f<\/td>\nCirc. J. 74, 203-206 (2010).<\/td>\n<\/tr>\n
RBRC05545<\/a><\/td>\nC.129S4-Tecpr1<tm1><\/td>\n\u7b39\u5ddd\u5343\u5c0b\u5148\u751f, \u5c0f\u5ddd\u9053\u6c38\u5148\u751f<\/td>\nCell Host Microbe, 9, 376-389 (2011). Mol. Cell, 45, 629-641 (2012).<\/td>\n<\/tr>\n
RBRC09404<\/a><\/td>\nB6.CBA-Park2<tm1Tchi><\/td>\n\u5343\u8449\u667a\u6a39\u5148\u751f<\/td>\nJ. Neurosci. Res., 84:1350-1357 (2006). <\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n



\n\u95a2\u9023\u8a18\u4e8b\uff08\u4eca\u6708\u306e\u30de\u30a6\u30b9\uff09<\/strong><\/p>\n