{"id":14634,"date":"2017-12-12T09:27:05","date_gmt":"2017-12-12T00:27:05","guid":{"rendered":"http:\/\/mus.brc.riken.jp\/ja\/?page_id=14634"},"modified":"2021-01-29T14:11:32","modified_gmt":"2021-01-29T05:11:32","slug":"dec_2017","status":"publish","type":"page","link":"http:\/\/mus.brc.riken.jp\/ja\/current_tech\/dec_2017","title":{"rendered":"BRC Current Technology December 2017"},"content":{"rendered":"\n\n\n\n\n\n
\n\"RIKEN<\/td>\n
\nBRC Current Technology<\/span>
\nDecember 2017<\/span><\/a><\/td>\n<\/tr>\n
\n

11. \u521d\u306e\u91ce\u751f\u7531\u6765MSM\/Ms \u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u7cfb\u7d71\u3092\u958b\u767a<\/h1>\n

\u91ce\u751f\u30de\u30a6\u30b9\u3092\u304a\u3068\u306a\u3057\u304f<\/h2>\n
\n\"\u907a\u4f1d\u5b50\u6539\u5909\u524d\u3068\u6539\u5909\u5f8c\u306e\u30de\u30a6\u30b9\u5199\u771f\"<\/a>\n<\/div>\n

\u56f31 \u907a\u4f1d\u5b50\u6539\u5909\u524d\u306e\u30de\u30a6\u30b9\u3068\u907a\u4f1d\u5b50\u6539\u5909\u5f8c\u306e\u30de\u30a6\u30b9<\/p>\n

\u5de6\uff1a\u907a\u4f1d\u5b50\u6539\u5909\u524d\u306e\u91ce\u751fMSM\u30de\u30a6\u30b9\u3002\u7406\u7814\u30d0\u30a4\u30aa\u30ea\u30bd\u30fc\u30b9\u30bb\u30f3\u30bf\u30fc\u30db\u30fc\u30e0\u30da\u30fc\u30b8\u3088\u308a\u8ee2\u8f09\u3002
\n\u53f3\uff1a\u30a2\u30b0\u30fc\u30c1\u30bf\u30f3\u30d1\u30af\u8cea\u907a\u4f1d\u5b50\u30ce\u30c3\u30af\u30a2\u30a6\u30c8MSM\u30de\u30a6\u30b9\u3002\u30a2\u30b0\u30fc\u30c1\u30bf\u30f3\u30d1\u30af\u8cea\u907a\u4f1d\u5b50\u30ce\u30c3\u30af\u30a2\u30a6\u30c8MSM\u30de\u30a6\u30b9\u306f\u9ed2\u8272\u306b\u5909\u5316\u3057\u305f\u3002\u307e\u305f\u3001\u4eba\u306e\u624b\u306b\u4e57\u3063\u305f\u307e\u307e\u306b\u306a\u308b\u500b\u4f53\u3082\u73fe\u308c\u305f\u3002<\/p>\n

RIKEN BRC \u3067\u306f\u3001\u91ce\u751f\u7531\u6765\u30de\u30a6\u30b9\u7cfb\u7d71\u3078\u306e\u767a\u751f\u5de5\u5b66\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u307e\u3067\u306b40\u7cfb\u7d71\u4ee5\u4e0a\u306b\u304a\u3088\u3076\u91ce\u751f\u7531\u6765\u7cfb\u7d71\u306e\u904e\u6392\u5375\u304a\u3088\u3073\u80da\u79fb\u690d\u306e\u6280\u8853\u958b\u767a\u304c\u5b8c\u4e86\u3057\u3001\u7cfb\u7d71\u306e\u5b89\u5b9a\u7684\u306a\u7dad\u6301\u30fb\u4fdd\u5b58\u30fb\u63d0\u4f9b\u306b\u7528\u3044\u3089\u308c\u3066\u3044\u307e\u3059[1, 2]\u3002\u3053\u306e\u305f\u3073\u3001CRISPR\/Cas9 \u6280\u8853\u3092\u91ce\u751f\u7531\u6765 MSM\/Ms \u30de\u30a6\u30b9\u3078\u5fdc\u7528\u3057\u3001\u521d\u306eMSM\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u30de\u30a6\u30b9\u306e\u4f5c\u51fa\u306b\u6210\u529f\u3057\u307e\u3057\u305f[3]\u3002\u30db\u30e2\u7cfb\u7d71\u5316\u304c\u7d42\u4e86\u3044\u305f\u3057\u307e\u3057\u305f\u306e\u3067\u3001\u65b0\u305f\u306a\u7cfb\u7d71\u3068\u3057\u3066BRC\u3088\u308a\u63d0\u4f9b\u3092\u958b\u59cb\u3044\u305f\u3057\u307e\u3057\u305f\u3002
\n
\nRBRC10151 MSM-A<em1Ogu>
\nRBRC10152 MSM-A<em2Ogu>
\n
\n\u3044\u305a\u308c\u3082 a (nonagouti)<\/i> \u907a\u4f1d\u5b50\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u3067\u3001\u9ed2\u3044\u88ab\u6bdb\u3068\u3068\u3082\u306b\u3001\u91ce\u751f\u578b\u306b\u6bd4\u3079\u3066\u304a\u3068\u306a\u3057\u3044\u6027\u8cea\u3092\u6301\u3063\u3066\u3044\u308b\u306e\u304c\u7279\u5fb4\u3067\u3059\u3002\u4f53\u91cd\u3084\u8840\u6e05\u751f\u5316\u5b66\u5024\u306a\u3069\u306e\u4e3b\u306a\u5f62\u8cea\u306f\u3001\u91ce\u751f\u578b\u3068\u76f8\u9055\u306f\u3042\u308a\u307e\u305b\u3093\u306e\u3067\u3001\u53d6\u308a\u6271\u3044\u306e\u5bb9\u6613\u306aMSM\u30de\u30a6\u30b9\u3068\u3057\u3066\u5e83\u304f\u3054\u5229\u7528\u3092\u3044\u305f\u3060\u3051\u307e\u3059\u3002\n<\/td>\n<\/tr>\n
\u7406\u7814\u30d7\u30ec\u30b9\u767a\u8868\uff1ahttp:\/\/www.riken.jp\/pr\/press\/2017\/20170214_3\/<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n\n\n\n
References<\/td>\n[1]<\/td>\nHasegawa A, Mochida K, Matoba S, Yonezawa K, Ohta A, Watanabe G, Taya K, Ogura A. Efficient production of offspring from Japanese wild-derived strains of mice (Mus musculus molossinus) by improved assisted reproductive technologies. Biol Reprod.<\/em>; 86(5):167, 1-7, 2012.<\/a><\/td>\n<\/tr>\n[2]<\/td>\nMochida K, Hasegawa A, Otaka N, Hama D, Furuya T, Yamaguchi M, Ichikawa E, Ijuin M, Taguma K, Hashimoto M, Takashima R, Kadota M, Hiraiwa N, Mekada K, Yoshiki A, Ogura A. Devising assisted reproductive technologies for wild-derived strains of mice: 37 strains from five subspecies of Mus musculus. PLoS One.<\/em>; 9(12):e114305, 2014.<\/a><\/td>\n<\/tr>\n[3]<\/td>\nHonda A, Kawano Y, Izu H, Choijookhuu N, Honsho K, Nakamura T, Yabuta Y, Yamamoto T, Takashima Y, Hirose M2, Sankai T9, Hishikawa Y3, Ogura A2, Saitou M. Discrimination of Stem Cell Status after Subjecting Cynomolgus Monkey Pluripotent Stem Cells to Na\u00efve Conversion. Sci Rep.<\/em>; 7:45285, 2017<\/a><\/td>\n<\/tr>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"

BRC Current Technology December 2017 11. \u521d\u306e\u91ce\u751f\u7531\u6765MSM\/Ms \u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u7cfb\u7d71\u3092\u958b\u767a \u91ce\u751f\u30de\u30a6\u30b9\u3092\u304a\u3068\u306a\u3057\u304f \u56f31 \u907a\u4f1d\u5b50\u6539\u5909\u524d\u306e\u30de\u30a6\u30b9\u3068\u907a\u4f1d\u5b50\u6539\u5909\u5f8c\u306e\u30de\u30a6\u30b9 \u5de6\uff1a\u907a\u4f1d\u5b50\u6539\u5909\u524d\u306e\u91ce\u751fMSM\u30de\u30a6\u30b9\u3002\u7406\u7814\u30d0\u30a4\u30aa\u30ea\u30bd\u30fc\u30b9\u30bb\u30f3\u30bf\u30fc\u30db\u30fc\u30e0\u30da\u30fc\u30b8\u3088\u308a\u8ee2\u8f09\u3002 \u53f3\uff1a\u30a2\u30b0\u30fc\u30c1\u30bf\u30f3\u30d1\u30af\u8cea\u907a\u4f1d\u5b50\u30ce\u30c3\u30af\u30a2\u30a6\u30c8MSM\u30de\u30a6\u30b9\u3002\u30a2\u30b0\u30fc\u30c1\u30bf\u30f3\u30d1\u30af\u8cea\u907a\u4f1d\u5b50\u30ce\u30c3\u30af\u30a2\u30a6\u30c8MSM\u30de\u30a6\u30b9\u306f\u9ed2\u8272 […]<\/p>\n","protected":false},"author":19,"featured_media":0,"parent":3268,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_seopress_robots_follow":"","_seopress_robots_imageindex":"","_seopress_robots_snippet":"","_seopress_robots_primary_cat":"","_seopress_robots_breadcrumbs":"","_seopress_robots_freeze_modified_date":"","_seopress_robots_custom_modified_date":"","_seopress_robots_canonical":"","_seopress_social_fb_title":"","_seopress_social_fb_desc":"","_seopress_social_fb_img":"","_seopress_social_fb_img_attachment_id":0,"_seopress_social_fb_img_width":0,"_seopress_social_fb_img_height":0,"_seopress_social_twitter_title":"","_seopress_social_twitter_desc":"","_seopress_social_twitter_img":"","_seopress_social_twitter_img_attachment_id":0,"_seopress_social_twitter_img_width":0,"_seopress_social_twitter_img_height":0,"_seopress_redirections_value":"","_seopress_redirections_enabled":"","_seopress_redirections_enabled_regex":"","_seopress_redirections_logged_status":"","_seopress_redirections_param":"","_seopress_redirections_type":301,"_seopress_analysis_target_kw":"","footnotes":"","_wp_rev_ctl_limit":""},"class_list":["post-14634","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/14634","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/users\/19"}],"replies":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/comments?post=14634"}],"version-history":[{"count":10,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/14634\/revisions"}],"predecessor-version":[{"id":17896,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/14634\/revisions\/17896"}],"up":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/3268"}],"wp:attachment":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/media?parent=14634"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}