{"id":16028,"date":"2019-07-18T11:58:17","date_gmt":"2019-07-18T02:58:17","guid":{"rendered":"http:\/\/mus.brc.riken.jp\/ja\/?page_id=16028"},"modified":"2021-04-07T13:20:58","modified_gmt":"2021-04-07T04:20:58","slug":"aug_2019_mm","status":"publish","type":"page","link":"http:\/\/mus.brc.riken.jp\/ja\/mouse_of_month\/aug_2019_mm","title":{"rendered":"\u9020\u8840\u5e79\u7d30\u80de\u306e\u81ea\u5df1\u8907\u88fd\u3092\u5236\u5fa1\u3059\u308bPHF6"},"content":{"rendered":"

\"title201908\"<\/a><\/p>\n\n\n\n
\n

\u9020\u8840\u5e79\u7d30\u80de\u306e\u81ea\u5df1\u8907\u88fd\u3092\u5236\u5fa1\u3059\u308bPHF6<\/b><\/span><\/p>\n

C57BL\/6-Phf6<\/i><em1Utr<\/i>> (RBRC10186)<\/a><\/h5>\n

\n\"MMfig_201908A\"<\/a>
\n\"MMfig_201908B\"<\/a>\n<\/p>\n

Courtesy of Satoru Miyagi, Ph.D.<\/p>\n

(A) Mx1-Cre\u30b7\u30b9\u30c6\u30e0\u3092\u7528\u3044\u305f\u7af6\u5408\u7684\u9aa8\u9ac4\u518d\u69cb\u7bc9\u6cd5(competitive repopulating assays)\u306e\u6982\u8981\u3002Mx1-Cre<\/i>\u304a\u3088\u3073Mx1-Cre;Phf6fl\/y<\/i>\u30de\u30a6\u30b9\u3092\u7528\u3044\u3066\u30017\u9031\u9f62\u3067pIpC\u6295\u4e0e\u3092\u884c\u3044\u300112\u9031\u9f62\u3067\u7af6\u5408\u7684\u9aa8\u9ac4\u79fb\u690d\u3092\u884c\u3063\u305f\u3002\u540c\u6570\u306e\u3001Ly5.1\u7531\u6765\u306e\u91ce\u751f\u578b\u53ca\u3073Ly5.2\u7531\u6765\u306e\u9aa8\u9ac4\u7d30\u80de\u3092\u30c9\u30ca\u30fc\u7d30\u80de\u3068\u3057\u3001\u81f4\u6b7b\u91cf\u306e\u653e\u5c04\u7dda\u7167\u5c04\u3092\u884c\u3063\u305fLy5.1\u7531\u6765\u30ec\u30b7\u30d4\u30a8\u30f3\u30c8\u30de\u30a6\u30b9\u306b\u79fb\u690d\u3057\u305f\u3002 (B) \u79fb\u690d\u5f8c\u306e\u672b\u68a2\u8840\u3067\u89b3\u5bdf\u3055\u308c\u305f\u30c9\u30ca\u30fc\u7d30\u80de\u306e\u5272\u5408\u3002<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n\n\n\n
\n

Phf6<\/i>(plant homeodomain-like finger gene 6)\u306f\u3001\u30af\u30ed\u30de\u30c1\u30f3\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u30b3\u30fc\u30c9\u3059\u308bX\u67d3\u8272\u4f53\u4e0a\u306b\u4f4d\u7f6e\u3059\u308b\u907a\u4f1d\u5b50\u3067\u3059\u3002Zinc-finger domain\u3092\u6301\u3064\u3053\u3068\u304b\u3089\u3001\u8ee2\u5199\u5236\u5fa1\u3092\u62c5\u3063\u3066\u3044\u308b\u3068\u8a00\u308f\u308c\u3066\u3044\u307e\u3059[1]\u3002\u3053\u308c\u307e\u3067\u306bX\u9023\u9396\u7cbe\u795e\u9045\u6ede\u75c7\u5019\u7fa4\u306e1\u3064\u3001Börjeson-Forssman-Lehmann\u75c7\u5019\u7fa4(OMIM#301900)\u306e\u539f\u56e0\u907a\u4f1d\u5b50\u3068\u3057\u3066\u540c\u5b9a\u3055\u308c\u3066\u3044\u308b\u3060\u3051\u3067\u306a\u304f[2]\u3001T\u7d30\u80de\u6027\u6025\u6027\u30ea\u30f3\u30d1\u6025\u82bd\u6027\u767d\u8840\u75c5\u3001\u6025\u6027\u9aa8\u9ac4\u6027\u767d\u8840\u75c5\u3001\u9aa8\u9ac4\u6027\u7570\u5f62\u6210\u75c7\u5019\u7fa4\u3068\u3044\u3063\u305f\u9020\u8840\u5e79\u7d30\u80de\u75be\u60a3\u306b\u304a\u3044\u3066\u3082PHF6<\/i>\u907a\u4f1d\u5b50\u306e\u4e0d\u6d3b\u6027\u5316\u5909\u7570\u3092\u751f\u3058\u308b\u30b1\u30fc\u30b9\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059[3-5]\u3002
\n \u4eca\u56de\u3054\u7d39\u4ecb\u3059\u308bPhf6<\/i>\u907a\u4f1d\u5b50\u306e\u30b3\u30f3\u30c7\u30a3\u30b7\u30e7\u30ca\u30eb\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u30de\u30a6\u30b9(RBRC10186)\u306f\u3001zinc-finger domain\u306e1\u3064\u3092\u542b\u3080exon4\u3068exon5\u3092loxP\u914d\u5217\u3067\u631f\u3093\u3060\u30de\u30a6\u30b9\u3067\u3001CRISPR\/Cas9\u30b7\u30b9\u30c6\u30e0\u3092\u7528\u3044\u3066\u4f5c\u88fd\u3055\u308c\u307e\u3057\u305f[6]\u3002\u5bc4\u8a17\u8005\u306e\u5bae\u57ce\u5148\u751f\u3089\u306f\u3001\u672c\u7cfb\u7d71\u3092\u7528\u3044\u3066\u3001\u69d8\u3005\u306a\u767a\u751f\u30b9\u30c6\u30fc\u30b8\u3067\u3001\u9020\u8840\u7d30\u80de\u5185\u306ePhf6<\/i>\u907a\u4f1d\u5b50\u3092\u6b20\u5931\u3055\u305b\u3001\u9020\u8840\u5206\u5316\u306b\u304a\u3051\u308bPHF6\u306e\u6a5f\u80fd\u89e3\u6790\u3092\u884c\u3044\u307e\u3057\u305f\u3002\u305d\u3057\u3066\u3001PHF6\u304c\u9020\u8840\u5e79\u7d30\u80de\u306e\u81ea\u5df1\u8907\u88fd\u3092\u5236\u5fa1\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002\u672c\u7814\u7a76\u3067\u306f\u3001Phf6<\/i>\u907a\u4f1d\u5b50\u306e\u6b20\u5931\u3060\u3051\u3067\u306f\u9020\u8840\u5e79\u7d30\u80de\u306e\u5f62\u8cea\u8ee2\u63db\u304c\u8d77\u304d\u306a\u3044\u3053\u3068\u3082\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u304a\u308a\u3001\u4eca\u5f8c\u3001PHF6\u95a2\u9023\u75be\u60a3\u306e\u767a\u75c7\u30fb\u75c5\u614b\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u63a2\u6c42\u3059\u308b\u4e0a\u3067\u3082\u3001\u672c\u7cfb\u7d71\u306f\u6709\u7528\u3067\u3042\u308b\u3068\u3044\u3048\u307e\u3059\u3002\n<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n\n\n\n\n\n\n\n\n\n\n\n
Depositor<\/td>\n:<\/td>\n\u5bae\u57ce \u8061 \u5148\u751f
\u5343\u8449\u5927\u5b66\u5927\u5b66\u9662\u533b\u5b66\u7814\u7a76\u9662 \u7d30\u80de\u5206\u5b50\u533b\u5b66 (\u5bc4\u8a17\u5f53\u6642)<\/td>\n<\/tr>\n
Strain name<\/td>\n:<\/td>\nC57BL\/6-Phf6<\/i><em1Utr<\/i>><\/td>\n<\/tr>\n
RBRC No.<\/td>\n:<\/td>\nRBRC10186<\/td>\n<\/tr>\n
References<\/td>\n:<\/td>\n[1]<\/td>\nTodd MA, Ivanochko D, Picketts DJ.
\nPHF6 Degrees of Separation: The Multifaceted Roles of a Chromatin Adaptor Protein.
\nGenes (Basel).<\/em>; 6(2):325-52, 2015.<\/a><\/td>\n<\/tr>\n
[2]<\/td>\nLower KM, Turner G, Kerr BA, Mathews KD, Shaw MA, Gedeon AK, Schelley S, Hoyme HE, White SM, Delatycki MB, Lampe AK, Clayton-Smith J, Stewart H, van Ravenswaay CM, de Vries BB, Cox B, Grompe M, Ross S, Thomas P, Mulley JC, Gécz J.
\nMutations in PHF6 are associated with Börjeson-Forssman-Lehmann syndrome.
\nNat Genet.<\/em>; 32(4):661-5, 2002.<\/a><\/td>\n<\/tr>\n
[3]<\/td>\nVan Vlierberghe P, Palomero T, Khiabanian H, Van der Meulen J, Castillo M, Van Roy N, De Moerloose B, Philippé J, González-García S, Toribio ML, Taghon T, Zuurbier L, Cauwelier B, Harrison CJ, Schwab C, Pisecker M, Strehl S, Langerak AW, Gecz J, Sonneveld E, Pieters R, Paietta E, Rowe JM, Wiernik PH, Benoit Y, Soulier J, Poppe B, Yao X, Cordon-Cardo C, Meijerink J, Rabadan R, Speleman F, Ferrando A.
\nPHF6 mutations in T-cell acute lymphoblastic leukemia.
\nNat Genet.<\/em>; 42(4):338-42, 2010.<\/a><\/td>\n<\/tr>\n
[4]<\/td>\nVan Vlierberghe P, Patel J, Abdel-Wahab O, Lobry C, Hedvat CV, Balbin M, Nicolas C, Payer AR, Fernandez HF, Tallman MS, Paietta E, Melnick A, Vandenberghe P, Speleman F, Aifantis I, Cools J, Levine R, Ferrando A.
\nPHF6 mutations in adult acute myeloid leukemia.
\nLeukemia.<\/em>; 25(1):130-4, 2011.<\/a><\/td>\n<\/tr>\n
[5]<\/td>\nMori T, Nagata Y, Makishima H, Sanada M, Shiozawa Y, Kon A, Yoshizato T, Sato-Otsubo A, Kataoka K, Shiraishi Y, Chiba K, Tanaka H, Ishiyama K, Miyawaki S, Mori H, Nakamaki T, Kihara R, Kiyoi H, Koeffler HP, Shih LY, Miyano S, Naoe T, Haferlach C, Kern W, Haferlach T, Ogawa S, Yoshida K.
\nSomatic PHF6 mutations in 1760 cases with various myeloid neoplasms.
\nLeukemia.<\/em>; 30(11):2270-2273, 2016.<\/a><\/td>\n<\/tr>\n
[6]<\/td>\nMiyagi S, Sroczynska P, Kato Y, Nakajima-Takagi Y, Oshima M, Rizq O, Takayama N, Saraya A, Mizuno S, Sugiyama F, Takahashi S, Matsuzaki Y, Christensen J, Helin K, Iwama A.
\nThe chromatin-binding protein Phf6 restricts the self-renewal of hematopoietic stem cells.
\nBlood.<\/em>; 133(23):2495-2506, 2019.<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n\n\n\n
August 2019
\nContact: Saori Mizuno, Ph.D.<\/a>
\nExperimental Animal Division, RIKEN BioResource Research Center
\nAll materials contained on this site may not be reproduced, distributed, displayed, published or broadcast without the prior permission of the owner of that content.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"

\u9020\u8840\u5e79\u7d30\u80de\u306e\u81ea\u5df1\u8907\u88fd\u3092\u5236\u5fa1\u3059\u308bPHF6 C57BL\/6-Phf6<em1Utr> (RBRC10186) Courtesy of Satoru Miyagi, Ph.D. (A) Mx1-Cre\u30b7\u30b9\u30c6\u30e0\u3092\u7528\u3044\u305f\u7af6\u5408\u7684\u9aa8\u9ac4\u518d\u69cb\u7bc9\u6cd5(competitive repopulating assays)\u306e\u6982\u8981\u3002Mx1-Cre\u304a\u3088\u3073Mx1-Cre;Phf6fl\/y\u30de\u30a6\u30b9\u3092\u7528\u3044\u3066\u30017\u9031\u9f62\u3067pIpC\u6295 […]<\/p>\n","protected":false},"author":19,"featured_media":0,"parent":198,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_seopress_robots_follow":"","_seopress_robots_imageindex":"","_seopress_robots_snippet":"","_seopress_robots_primary_cat":"","_seopress_robots_breadcrumbs":"","_seopress_robots_freeze_modified_date":"","_seopress_robots_custom_modified_date":"","_seopress_robots_canonical":"","_seopress_social_fb_title":"","_seopress_social_fb_desc":"","_seopress_social_fb_img":"","_seopress_social_fb_img_attachment_id":0,"_seopress_social_fb_img_width":0,"_seopress_social_fb_img_height":0,"_seopress_social_twitter_title":"","_seopress_social_twitter_desc":"","_seopress_social_twitter_img":"","_seopress_social_twitter_img_attachment_id":0,"_seopress_social_twitter_img_width":0,"_seopress_social_twitter_img_height":0,"_seopress_redirections_value":"","_seopress_redirections_enabled":"","_seopress_redirections_enabled_regex":"","_seopress_redirections_logged_status":"","_seopress_redirections_param":"","_seopress_redirections_type":301,"_seopress_analysis_target_kw":"","footnotes":"","_wp_rev_ctl_limit":""},"class_list":["post-16028","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/16028","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/users\/19"}],"replies":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/comments?post=16028"}],"version-history":[{"count":17,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/16028\/revisions"}],"predecessor-version":[{"id":18645,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/16028\/revisions\/18645"}],"up":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/198"}],"wp:attachment":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/media?parent=16028"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}