{"id":17361,"date":"2020-03-09T13:13:00","date_gmt":"2020-03-09T04:13:00","guid":{"rendered":"http:\/\/mus.brc.riken.jp\/ja\/?page_id=17361"},"modified":"2022-03-01T09:41:32","modified_gmt":"2022-03-01T00:41:32","slug":"mar_2020_mm","status":"publish","type":"page","link":"http:\/\/mus.brc.riken.jp\/ja\/mouse_of_month\/mar_2020_mm","title":{"rendered":"\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u5b9f\u884c\u56e0\u5b50: \u30ac\u30b9\u30c0\u30fc\u30df\u30f3D"},"content":{"rendered":"\n\n\n
\"RIKEN<\/td>\nMarch 2020<\/span>
\nMouse of the Month<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n
\n

\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u5b9f\u884c\u56e0\u5b50: \u30ac\u30b9\u30c0\u30fc\u30df\u30f3D<\/b><\/span><\/p>\n

\nB6.B6CB-Gsdmd<\/i><tm1.1Tshir<\/i>>\/Ms<\/i> (RBRC10761)<\/a>
\nB6.B6CB-Gsdmd<\/i><tm1.2Tshir<\/i>>\/Ms<\/i> (RBRC10762)<\/a>
\nB6.B6CB-Gsdma<\/i><tm1Tshir<\/i>>\/Ms<\/i> (RBRC10760)<\/a><\/h5>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n\n\n\n
\n

\u751f\u4f53\u5185\u3067\u306f\u3001\u907a\u4f1d\u7684\u30d7\u30ed\u30b0\u30e9\u30e0\u306b\u3088\u3063\u3066\u5236\u5fa1\u3055\u308c\u305f\u7d30\u80de\u6b7b\u304c\u3001\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u306b\u9650\u3089\u305a\u3001\u8907\u6570\u5b58\u5728\u3057\u307e\u3059\u3002\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u3082\u305d\u306e1\u3064\u3067\u3059\u3002\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u306f\u3001\u75c5\u539f\u7d30\u83cc\u306b\u611f\u67d3\u3057\u305f\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u3067\u898b\u3089\u308c\u308b\u7d30\u80de\u819c\u7834\u58ca\u3092\u4f34\u3046\u7d30\u80de\u6b7b\u3068\u3057\u3066\u6700\u521d\u3001\u5831\u544a\u3055\u308c\u307e\u3057\u305f1)2)3)<\/sup>\u3002\u708e\u75c7\u8a98\u5c0e\u6027\u7d30\u80de\u6b7b\u3068\u3057\u3066\u77e5\u3089\u308c\u3001\u514d\u75ab\u62c5\u5f53\u7d30\u80de(\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u3001\u6a39\u72b6\u7d30\u80de\u3001T\u7d30\u80de\u306a\u3069)\u304c\u75c5\u539f\u5fae\u751f\u7269\u306a\u3069\u306b\u611f\u67d3\u3059\u308b\u3068\u3001\u30ab\u30b9\u30d1\u30fc\u30bc1\u304c\u6d3b\u6027\u5316\u3057\u3001\u7d30\u80de\u8cea\u306e\u5909\u6027\u3092\u4f34\u3063\u305f\u3001\u30cd\u30af\u30ed\u30fc\u30b7\u30b9\u306b\u985e\u4f3c\u3057\u305f\u5f62\u614b\u5b66\u7684\u7279\u5fb4(\u7d30\u80de\u819c\u306e\u5b54\u5f62\u6210\u3001\u7d30\u80de\u306e\u81a8\u6f64\u3068\u7834\u88c2)\u3092\u793a\u3057\u307e\u3059\u3002\u305d\u306e\u7d50\u679c\u3001\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3092\u542b\u3080\u7d30\u80de\u5185\u5bb9\u7269\u304c\u3001\u75c5\u539f\u5fae\u751f\u7269\u3068\u5171\u306b\u7d30\u80de\u5916\u3078\u3068\u653e\u51fa\u3055\u308c\u3001\u5468\u8fba\u7d30\u80de\u306b\u708e\u75c7\u3092\u60f9\u8d77\u3059\u308b\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n

\u4eca\u56de\u6ce8\u76ee\u3059\u308b\u30ac\u30b9\u30c0\u30fc\u30df\u30f3D(Gsdmd \/ GSDMD<\/i>)\u306f\u3001\u5bc4\u8a17\u8005\u306e\u57ce\u77f3\u5148\u751f(\u907a\u4f1d\u7814\u5728\u7c4d\u6642)\u3089\u304c\u767a\u898b\u3057\u3001\u547d\u540d\u3057\u305f\u65b0\u898f\u907a\u4f1d\u5b50\u30d5\u30a1\u30df\u30ea\u30fc\u306e\u69cb\u6210\u30e1\u30f3\u30d0\u30fc\u306e1\u3064\u30674)5)<\/sup>\u3001\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u306e\u904e\u7a0b\u306b\u304a\u3044\u3066\u3001\u30ab\u30b9\u30d1\u30fc\u30bc1\u3092\u542b\u3080\u7279\u5b9a\u306e\u30ab\u30b9\u30d1\u30fc\u30bc\u306e\u4e0b\u6d41\u3067\u57fa\u8cea\u3068\u3057\u3066\u50cd\u304f\u7d30\u80de\u8cea\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u30596)7)8)<\/sup>\u3002\u30ac\u30b9\u30c0\u30fc\u30df\u30f3D\u306f\u975e\u523a\u6fc0\u6642\u306b\u306f\u3001\u7d30\u80de\u8cea\u5185\u3067\u4e0d\u6d3b\u6027\u578b\u524d\u99c6\u4f53\u3068\u3057\u3066\u5b58\u5728\u3057\u3001\u5fae\u751f\u7269\u611f\u67d3\u5f8c\u3001\u30ab\u30b9\u30d1\u30fc\u30bc\u306b\u3088\u3063\u3066\u5207\u65ad\u3055\u308c\u308b\u3068\u3001\u6d3b\u6027\u578b\u306eN\u672b\u7aef\u65ad\u7247\u304c\u591a\u91cf\u4f53\u5316\u3057\u3001\u7d30\u80de\u819c\u306b\u633f\u5165\u3055\u308c\u3066\u3001\u5927\u304d\u306a\u5b54\u3092\u5f62\u6210\u3057\u307e\u30599)<\/sup>\u3002\u3053\u308c\u306b\u3088\u3063\u3066\u3001\u7d30\u80de\u819c\u7834\u58ca\u3092\u5b9f\u884c\u3057\u307e\u3059\u3002<\/p>\n

\u7406\u7814BRC\u5b9f\u9a13\u52d5\u7269\u958b\u767a\u5ba4\u304b\u3089\u306f\u3001\u30ac\u30b9\u30c0\u30fc\u30df\u30f3D\u907a\u4f1d\u5b50\u6b20\u640d\u30de\u30a6\u30b9(RBRC10761)\u304a\u3088\u3073\u30ac\u30b9\u30c0\u30fc\u30df\u30f3D\u907a\u4f1d\u5b50\u306efloxed\u30de\u30a6\u30b9(RBRC10762)\u304c\u63d0\u4f9b\u53ef\u80fd\u3067\u305910)<\/sup>\u3002\u672c\u7cfb\u7d71\u306f\u3001\u6700\u8fd1\u5831\u544a\u3055\u308c\u305f\u201d\u30ac\u30b9\u30c0\u30fc\u30df\u30f3D\u306e\u6709\u7121\u306b\u5fdc\u3058\u3066\u3001\u30ab\u30b9\u30d1\u30fc\u30bc1\u304c\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u3068\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3068\u3044\u30462\u3064\u306e\u7570\u306a\u308b\u7d30\u80de\u6b7b\u3092\u8a98\u5c0e\u3057\u3066\u3044\u308b\u201d\u3068\u3044\u3046\u7814\u7a76\u6210\u679c\u306b\u3082\u8ca2\u732e\u3057\u3066\u3044\u307e\u305911)<\/sup>\u3002\u81ea\u7136\u514d\u75ab\u5fdc\u7b54\u3068\u3057\u3066\u3001\u30ac\u30b9\u30c0\u30fc\u30df\u30f3D\u304c\u5b58\u5728\u3059\u308b\u514d\u75ab\u62c5\u5f53\u7d30\u80de\u3067\u306f\u30ab\u30b9\u30d1\u30fc\u30bc\uff11\u304c\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u3092\u5f15\u304d\u8d77\u3053\u3059\u306e\u306b\u5bfe\u3057\u3001\u30ac\u30b9\u30c0\u30fc\u30df\u30f3D\u304c\u5b58\u5728\u3057\u306a\u3044\u795e\u7d4c\u7d30\u80de\u7b49\u3067\u306f\u3001\u30ab\u30b9\u30d1\u30fc\u30bc1\u306f\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u3053\u308c\u304c\u795e\u7d4c\u5909\u6027\u75be\u60a3(\u8133\u6897\u585e\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3001\u7b4b\u840e\u7e2e\u6027\u5074\u7d22\u786c\u5316\u75c7\u306a\u3069)\u306e\u767a\u75c7\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u30ac\u30b9\u30c0\u30fc\u30df\u30f3D\u306f\u751f\u547d\u73fe\u8c61\u306e\u7406\u89e3\u3068\u3068\u3082\u306b\u3001\u75be\u60a3\u306b\u5bfe\u3059\u308b\u65b0\u898f\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u3068\u3044\u3046\u89b3\u70b9\u304b\u3089\u3082\u6ce8\u76ee\u306e\u5b58\u5728\u3067\u3059\u3002<\/p>\n

\u307e\u305f\u3001\u5f53\u5ba4\u306b\u306f\u3001\u30ac\u30b9\u30c0\u30fc\u30df\u30f3\u907a\u4f1d\u5b50\u30d5\u30a1\u30df\u30ea\u30fc\u306b\u5c5e\u3059\u308b\u30ac\u30b9\u30c0\u30fc\u30df\u30f3A\u306eLacZ\u30ce\u30c3\u30af\u30a4\u30f3\u30de\u30a6\u30b9(RBRC10760)\u3082\u5bc4\u8a17\u3055\u308c\u3066\u3044\u307e\u305912)<\/sup>\u3002\u30ac\u30b9\u30c0\u30fc\u30df\u30f3A\u306f\u4e0a\u76ae\u7d44\u7e54\u3067\u767a\u73fe\u304c\u898b\u3089\u308c\u3001\u73fe\u6642\u70b9\u3067\u306f\u30d1\u30a4\u30ed\u30c8\u30fc\u30b7\u30b9\u3068\u306e\u95a2\u9023\u306b\u3064\u3044\u3066\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u305b\u3093\u304c\u3001\u30ac\u30b9\u30c0\u30fc\u30df\u30f3A\u306eN\u672b\u7aef\u65ad\u7247\u306e\u914d\u5217\u306f\u30ac\u30b9\u30c0\u30fc\u30df\u30f3D\u306eN\u672b\u7aef\u65ad\u7247\u3068\u540c\u69d8\u3001\u7d30\u80de\u819c\u5b54\u5f62\u6210\u6a5f\u80fd\u3092\u6709\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u305913)<\/sup>\u3002\n<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Depositor<\/td>\n:<\/td>\n\u57ce\u77f3 \u4fca\u5f66 \u5148\u751f
\u5927\u5b66\u5171\u540c\u5229\u7528\u6a5f\u95a2\u6cd5\u4eba \u60c5\u5831\u30fb\u30b7\u30b9\u30c6\u30e0\u7814\u7a76\u6a5f\u69cb \u56fd\u7acb\u907a\u4f1d\u5b66\u7814\u7a76\u6240 (\u5bc4\u8a17\u5f53\u6642)<\/td>\n<\/tr>\n
Strain name<\/td>\n:<\/td>\nB6.B6CB-Gsdmd<\/i><tm1.1Tshir<\/i>>\/Ms<\/i>
(Gsdmd<\/i>\u907a\u4f1d\u5b50\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u30de\u30a6\u30b9)<\/td>\n<\/tr>\n
RBRC No.<\/td>\n:<\/td>\nRBRC10761<\/td>\n<\/tr>\n
Strain name<\/td>\n:<\/td>\nB6.B6CB-Gsdmd<\/i><tm1.2Tshir<\/i>>\/Ms<\/i>
(Gsdmd<\/i>\u907a\u4f1d\u5b50floxed\u30de\u30a6\u30b9)<\/td>\n<\/tr>\n
RBRC No.<\/td>\n:<\/td>\nRBRC10762<\/td>\n<\/tr>\n
Strain name<\/td>\n:<\/td>\nB6.B6CB-Gsdma<\/i><tm1Tshir<\/i>>\/Ms<\/i>
(Gsdma<\/i>\u907a\u4f1d\u5b50LacZ\u30ce\u30c3\u30af\u30a4\u30f3\u30de\u30a6\u30b9)<\/td>\n<\/tr>\n
RBRC No.<\/td>\n:<\/td>\nRBRC10760<\/td>\n<\/tr>\n
References<\/td>\n:<\/td>\n[1]<\/td>\nFriedlander AM.
\nMacrophages are sensitive to anthrax lethal toxin through an acid-dependent process.
\nJ Biol Chem.<\/em>; 1986 Jun 5;261(16):7123-6.<\/a><\/td>\n<\/tr>\n
[2]<\/td>\nZychlinsky A, Prevost MC, Sansonetti PJ.
\nShigella flexneri induces apoptosis in infected macrophages.
\nNature.<\/em> 1992 Jul 9;358(6382):167-9.<\/a><\/td>\n<\/tr>\n
[3]<\/td>\nCookson BT, Brennan MA.
\nPro-inflammatory programmed cell death.
\nTrends Microbiol.<\/em> 2001 Mar;9(3):113-4.<\/a><\/td>\n<\/tr>\n
[4]<\/td>\nSaeki N, Kuwahara Y, Sasaki H, Satoh H, Shiroishi T.
\nGasdermin (Gsdm) localizing to mouse chromosome 11 is predominantly expressed in upper gastrointestinal tract but significantly suppressed in human gastric cancer cells.
\nMamm. Genome<\/em> 2000 Sep; 11(9):718-724.<\/a><\/td>\n<\/tr>\n
[5]<\/td>\nTamura M, Tanaka S, Fujii T, Aoki A, Komiyama H, Ezawa K, Sumiyama K, Sagai T, Shiroishi T.
\nMembers of a novel gene family, Gsdm, are expressed exclusively in the epithelium of the skin and gastrointestinal tract in a highly tissue-specific manner.
\nGenomics.<\/em> 2007 May;89(5):618-29.<\/a><\/td>\n<\/tr>\n
[6]<\/td>\nKayagaki N, Stowe IB, Lee BL, O’Rourke K, Anderson K, Warming S, Cuellar T, Haley B, Roose-Girma M, Phung QT, Liu PS, Lill JR, Li H, Wu J, Kummerfeld S, Zhang J, Lee WP, Snipas SJ, Salvesen GS, Morris LX, Fitzgerald L, Zhang Y, Bertram EM, Goodnow CC, Dixit VM.
\nCaspase-11 cleaves gasdermin D for non-canonical inflammasome signalling.
\nNature.<\/em> 2015 Oct 29;526(7575):666-71.<\/a><\/td>\n<\/tr>\n
[7]<\/td>\nShi J, Zhao Y, Wang K, Shi X, Wang Y, Huang H, Zhuang Y, Cai T, Wang F, Shao F.
\nCleavage of GSDMD by inflammatory caspases determines pyroptotic cell death.
\nNature.<\/em> 2015 Oct 29;526(7575):660-5.<\/a><\/td>\n<\/tr>\n
[8]<\/td>\nBroz P, Pelegr\u00edn P, Shao F.
\nThe gasdermins, a protein family executing cell death and inflammation.
\nNat Rev Immunol.<\/em> 2020 Mar;20(3):143-157<\/a><\/td>\n<\/tr>\n
[9]<\/td>\nDing J, Wang K, Liu W, She Y, Sun Q, Shi J, Sun H, Wang DC, Shao F.
\nPore-forming activity and structural autoinhibition of the gasdermin family.
\nNature.<\/em> 2016 Jul 7;535(7610):111-6.<\/a><\/td>\n<\/tr>\n
[10]<\/td>\nFujii T, Tamura M, Tanaka S, Kato Y, Yamamoto H, Mizushina Y, Shiroishi T.
\nGasdermin D (Gsdmd) is dispensable for mouse intestinal epithelium development.
\nGenesis.<\/em> 2008 Aug;46(8):418-23.<\/a><\/td>\n<\/tr>\n
[11]<\/td>\nTsuchiya K, Nakajima S, Hosojima S, Thi Nguyen D, Hattori T, Manh Le T, Hori O, Mahib MR, Yamaguchi Y, Miura M, Kinoshita T, Kushiyama H, Sakurai M, Shiroishi T, Suda T.
\nCaspase-1 initiates apoptosis in the absence of gasdermin D.
\nNat Commun.<\/em> 2019 May 7;10(1):2091.<\/a><\/td>\n<\/tr>\n
[12]<\/td>\nTanaka S, Mizushina Y, Kato Y, Tamura M, Shiroishi T.
\nFunctional conservation of Gsdma cluster genes specifically duplicated in the mouse genome.
\nG3 (Bethesda).<\/em> 2013 Oct 3;3(10):1843-50.<\/a><\/td>\n<\/tr>\n
[13]<\/td>\nRuan J, Xia S, Liu X, Lieberman J, Wu H.
\nCryo-EM structure of the gasdermin A3 membrane pore.
\nNature. 2018<\/em> May;557(7703):62-67.<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n\n\n\n
March 2020
\nSaori Mizuno, Ph.D.
\nContact: Experimental Animal Division, RIKEN BioResource Research Center (animal.brc@riken.jp)<\/a>
\nAll materials contained on this site may not be reproduced, distributed, displayed, published or broadcast without the prior permission of the owner of that content.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"

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