{"id":19193,"date":"2022-07-27T14:37:42","date_gmt":"2022-07-27T05:37:42","guid":{"rendered":"http:\/\/mus.brc.riken.jp\/ja\/?page_id=19193"},"modified":"2022-07-27T14:38:32","modified_gmt":"2022-07-27T05:38:32","slug":"aug_2022_mm","status":"publish","type":"page","link":"http:\/\/mus.brc.riken.jp\/ja\/mouse_of_month\/aug_2022_mm","title":{"rendered":"\u30aa\u30ad\u30b7\u30c8\u30b7\u30f3\u7523\u751f\u30cb\u30e5\u30fc\u30ed\u30f3 Cre\u30c9\u30e9\u30a4\u30d0\u30fc\u30de\u30a6\u30b9"},"content":{"rendered":"\n\n\n
\"RIKEN<\/td>\nAugust 2022<\/span>
\nMouse of the Month<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n
\n

\u30aa\u30ad\u30b7\u30c8\u30b7\u30f3\u7523\u751f\u30cb\u30e5\u30fc\u30ed\u30f3Cre\u30c9\u30e9\u30a4\u30d0\u30fc\u30de\u30a6\u30b9<\/span><\/p>\n

\n C57BL\/6-Oxt<tm1.1(Cre)Ksak> (RBRC11316)<\/a>
\n <\/h5>\n

\n \"Fig.A<\/a>\n <\/p>\n

A. \u4e0a\u306f\u30de\u30a6\u30b9\u306e\u30aa\u30ad\u30b7\u30c8\u30b7\u30f3\u907a\u4f1d\u5b50(Oxt)\u306e\u30b2\u30ce\u30e0\u69cb\u9020\u3001\u4e0b\u306fOxt-iCre knock-in (KI)\u30a2\u30ec\u30eb\u3092\u793a\u3059\u3002Oxt-iCre KI\u30de\u30a6\u30b9(C57BL\/6-Oxttm1.1(Cre)Ksak)\u3067\u306f\u3001OXT\u30bf\u30f3\u30d1\u30af\u8cea\u30b3\u30fc\u30c9\u914d\u5217\u306e\u5f8c\u306b\u81ea\u5df1\u30d7\u30ed\u30bb\u30b7\u30f3\u30b0\u914d\u5217furin-2A\u3092\u524d\u306b\u6301\u3064improved Cre recombinase (iCre)\u304c\u633f\u5165\u3055\u308c\u3066\u3044\u308b\uff08\u69cb\u7bc9\u904e\u7a0b\u3067\u4f7f\u308f\u308c\u305fFrt\u914d\u5217\u304c\u5f8c\u308d\u306b\u6b8b\u3063\u3066\u3044\u308b\uff09\u3002
\nB. Oxt-iCre\u30de\u30a6\u30b9\u8996\u5e8a\u4e0b\u90e8\u306e\u5ba4\u508d\u6838\u306e\u514d\u75ab\u7d44\u7e54\u5316\u5b66\u67d3\u8272\u50cf\u3002\u6297OXT (\u7dd1\u8272)\u3068\u6297Cre (\u8d64\u8272)\u6297\u4f53\u306e\u514d\u75ab\u967d\u6027\u30b7\u30b0\u30ca\u30eb\u306f\u307b\u307c\u30de\u30fc\u30b8\u3059\u308b\u3053\u3068\u304b\u3089\u3001Cre\u306f\u30aa\u30ad\u30b7\u30c8\u30b7\u30f3\u7523\u751f\u30cb\u30e5\u30fc\u30ed\u30f3\u306b\u7279\u7570\u7684\u306b\u767a\u73fe\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u3002\u30b9\u30b1\u30fc\u30eb: 100 \u03bcm\u30023v\u306f\u7b2c\u4e09\u8133\u5ba4\u3002\n <\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n
\u30aa\u30ad\u30b7\u30c8\u30b7\u30f3\uff08OXT\uff09\u306f\u3001\u8996\u5e8a\u4e0b\u90e8\u3067\u7523\u751f\u3055\u308c\u308b\u795e\u7d4c\u30da\u30d7\u30c1\u30c9\u3067\u3059\u3002OXT\u7523\u751f\u30cb\u30e5\u30fc\u30ed\u30f3\u306f\u8ef8\u7d22\u3092\u795e\u7d4c\u4e0b\u5782\u4f53\u5f8c\u8449\u3001\u3064\u307e\u308a\u4e0b\u5782\u4f53\u5f8c\u8449\u306b\u6295\u5c04\u3057\u3001\u30da\u30d7\u30c1\u30c9\u30db\u30eb\u30e2\u30f3\u3068\u3057\u3066\u672b\u68a2\u7684\u306bOXT\u3092\u8840\u6db2\u5faa\u74b0\u306b\u653e\u51fa\u3057\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u30cb\u30e5\u30fc\u30ed\u30f3\u306f\u307e\u305f\u3001\u3044\u304f\u3064\u304b\u306e\u8133\u9818\u57df\u3092\u795e\u7d4c\u652f\u914d\u3057\u3001\u305d\u3053\u3067\u795e\u7d4c\u30da\u30d7\u30c1\u30c9\u3068\u3057\u3066OXT\u3092\u653e\u51fa\u3057\u307e\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u3001OXT\u306f\u3001\u5b50\u5bae\u53ce\u7e2e\u3084\u6388\u4e73\u306a\u3069\u306e\u672b\u68a2\u6027\u6a5f\u80fd\u3060\u3051\u3067\u306a\u304f\u3001\u793e\u4f1a\u7684\u3001\u653b\u6483\u7684\u3001\u6050\u6016\u3001\u6bcd\u6027\u884c\u52d5\u306a\u3069\u306e\u4e2d\u67a2\u6027\u6a5f\u80fd\u306e\u8abf\u7bc0\u306b\u3082\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002
\n\u4eca\u56de\u3054\u7d39\u4ecb\u3059\u308bOxt-iCre KI\u30de\u30a6\u30b9(RBRC11316)\u306f\u3001Oxt\u907a\u4f1d\u5b50\u306e\u5185\u5728\u6027\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u5236\u5fa1\u4e0b\u3067\u3001iCre\u7d44\u63db\u3048\u9175\u7d20\u3092\u767a\u73fe\u3059\u308bCre\u30c9\u30e9\u30a4\u30d0\u30fc\u30de\u30a6\u30b9\u3067\u3059\u3002\u5b9f\u969b\u306b\u5bc4\u8a17\u8005\u306e\u53e4\u5e02\u5148\u751f\u3089\u306f\u3001Oxt-iCre KI\u30de\u30a6\u30b9\u3068\u3001Caps2(Ca<\/u>2+<\/sup>-dependent a<\/u>ctivator p<\/u>rotein for s<\/u>ecretion 2<\/u>)\u907a\u4f1d\u5b50\u306efloxed\u30de\u30a6\u30b9(C57BL\/6-Cadps2<tm1.1Ksak>; RBRC11315)\u3092\u4ea4\u914d\u3057\u3066\u3001\u89e3\u6790\u3092\u884c\u3044\u3001\u795e\u7d4c\u30da\u30d7\u30c1\u30c9\u3084\u30da\u30d7\u30c1\u30c9\u30db\u30eb\u30e2\u30f3\u3001\u304a\u3088\u3073\u30a2\u30df\u30f3\u7cfb\u795e\u7d4c\u4f1d\u9054\u7269\u8cea(\u30c9\u30fc\u30d1\u30df\u30f3\u3084\u30ce\u30eb\u30a8\u30d4\u30cd\u30d5\u30ea\u30f3\u306a\u3069)\u306a\u3069\u3092\u5185\u5305\u3059\u308b\u6709\u82af\u5c0f\u80de\u306e\u30a8\u30ad\u30bd\u30b5\u30a4\u30c8\u30fc\u30b7\u30b9\u306e\u8abf\u7bc0\u3092\u62c5\u3046CAPS2\u304cOXT\u306e\u5206\u6ccc\u5236\u5fa1\u3092\u8abf\u7bc0\u3057\u3001\u305d\u306e\u7d50\u679c\u3001\u793e\u4f1a\u6027\u884c\u52d5\u306e\u5236\u5fa1\u306b\u3082\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u5831\u544a\u3057\u307e\u3057\u305f\u3002
\nOXT\u306f\u3001\u672b\u68a2\u6027\u3068\u4e2d\u67a2\u6027\u3001\u3069\u3061\u3089\u306e\u6a5f\u80fd\u9762\u306b\u304a\u3044\u3066\u3082\u6ce8\u76ee\u306e\u30da\u30d7\u30c1\u30c9\u30db\u30eb\u30e2\u30f3\u3067\u3042\u308a\u3001Oxt-iCre KI\u30de\u30a6\u30b9\u3092\u7528\u3044\u3066\u3001\u69d8\u3005\u306a\u751f\u7406\u73fe\u8c61\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u89e3\u660e\u3084\u3001\u793e\u4f1a\u6027\u884c\u52d5\u969c\u5bb3\u306e\u6cbb\u7642\u6cd5\u958b\u767a\u7b49\u306b\u3064\u306a\u304c\u308b\u3053\u3068\u3092\u671f\u5f85\u3057\u307e\u3059\u3002\n <\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n\n\n\n\n\n\n\n\n
Depositor<\/td>\n:<\/td>\n\u53e4\u5e02 \u8c9e\u4e00 \u5148\u751f
\u6771\u4eac\u7406\u79d1\u5927\u5b66<\/td>\n<\/tr>\n
Developer<\/td>\n:<\/td>\n\ufa11\u6751 \u5065\u53f8 \u5148\u751f
\u65b0\u6f5f\u5927\u5b66<\/td>\n<\/tr>\n
Strain name<\/td>\n:<\/td>\n C57BL\/6-Oxt <tm1.1(Cre)Ksak> (Oxt-iCre KI)<\/td>\n<\/tr>\n
RBRC No.<\/td>\n:<\/td>\nRBRC11316<\/td>\n<\/tr>\n
References<\/td>\n:<\/td>\n[1]<\/td>\nFujima S, Yamaga R, Minami H, Mizuno S, Shinoda Y, Sadakata T, Abe M, Sakimura K, Sano Y, Furuichi T.
\nCAPS2 Deficiency Impairs the Release of the Social Peptide Oxytocin, as Well as Oxytocin-Associated Social Behavior.
\nJ Neurosci.<\/em> 2021 May 19;41(20):4524-4535.<\/a><\/td>\n<\/tr>\n
[2]<\/td>\n\u30aa\u30ad\u30b7\u30c8\u30b7\u30f3\u306e\u5206\u6ccc\u3092\u5236\u5fa1\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u767a\u898b\uff01
\uff5e\u81ea\u9589\u75c7\u306e\u65e9\u671f\u5206\u5b50\u8a3a\u65ad\u6cd5\u3084\u6cbb\u7642\u6cd5\u958b\u767a\u306b\u5149\uff5e
\u6771\u4eac\u7406\u79d1\u5927\u5b662021.05.17\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n\n\n\n
August 2022
\nSaori Mizuno, Ph.D.
\nContact: Experimental Animal Division, RIKEN BioResource Research Center (animal.brc@riken.jp)<\/a>
\nAll materials contained on this site may not be reproduced, distributed, displayed, published or broadcast without the prior permission of the owner of that content.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"

August 2022 Mouse of the Month \u30aa\u30ad\u30b7\u30c8\u30b7\u30f3\u7523\u751f\u30cb\u30e5\u30fc\u30ed\u30f3Cre\u30c9\u30e9\u30a4\u30d0\u30fc\u30de\u30a6\u30b9 C57BL\/6-Oxt<tm1.1(Cre)Ksak> (RBRC11316) A. \u4e0a\u306f\u30de\u30a6\u30b9\u306e\u30aa\u30ad\u30b7\u30c8\u30b7\u30f3\u907a\u4f1d\u5b50(Oxt)\u306e\u30b2\u30ce\u30e0\u69cb\u9020\u3001\u4e0b\u306fOxt-iCre knock-in (KI)\u30a2\u30ec\u30eb\u3092\u793a\u3059\u3002Oxt-iCre KI\u30de\u30a6\u30b9(C57BL\/6-Oxttm1.1(Cre)K […]<\/p>\n","protected":false},"author":19,"featured_media":0,"parent":198,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_seopress_robots_follow":"","_seopress_robots_imageindex":"","_seopress_robots_snippet":"","_seopress_robots_primary_cat":"","_seopress_robots_breadcrumbs":"","_seopress_robots_freeze_modified_date":"","_seopress_robots_custom_modified_date":"","_seopress_robots_canonical":"","_seopress_social_fb_title":"","_seopress_social_fb_desc":"","_seopress_social_fb_img":"","_seopress_social_fb_img_attachment_id":0,"_seopress_social_fb_img_width":0,"_seopress_social_fb_img_height":0,"_seopress_social_twitter_title":"","_seopress_social_twitter_desc":"","_seopress_social_twitter_img":"","_seopress_social_twitter_img_attachment_id":0,"_seopress_social_twitter_img_width":0,"_seopress_social_twitter_img_height":0,"_seopress_redirections_value":"","_seopress_redirections_enabled":"","_seopress_redirections_enabled_regex":"","_seopress_redirections_logged_status":"both","_seopress_redirections_param":"","_seopress_redirections_type":301,"_seopress_analysis_target_kw":"","footnotes":"","_wp_rev_ctl_limit":""},"class_list":["post-19193","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/19193","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/users\/19"}],"replies":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/comments?post=19193"}],"version-history":[{"count":1,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/19193\/revisions"}],"predecessor-version":[{"id":19194,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/19193\/revisions\/19194"}],"up":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/198"}],"wp:attachment":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/media?parent=19193"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}