{"id":21047,"date":"2026-06-30T09:45:16","date_gmt":"2026-06-30T00:45:16","guid":{"rendered":"http:\/\/mus.brc.riken.jp\/ja\/?page_id=21047"},"modified":"2026-07-29T14:50:34","modified_gmt":"2026-07-29T05:50:34","slug":"jun_2026_mm","status":"publish","type":"page","link":"http:\/\/mus.brc.riken.jp\/ja\/mouse_of_month\/jun_2026_mm","title":{"rendered":"\u984e\u9854\u9762\u9aa8\u5f62\u6210\u4e0d\u5168\u75c7\u30e2\u30c7\u30eb\u30de\u30a6\u30b9"},"content":{"rendered":"\n\n\n\n\n\n\n
\"RIKEN<\/td>\nJune 2026<\/span>
\nMouse of the Month<\/span><\/a><\/td>\n<\/tr>\n<\/thead>\n
\n

\u984e\u9854\u9762\u9aa8\u5f62\u6210\u4e0d\u5168\u75c7\u30e2\u30c7\u30eb\u30de\u30a6\u30b9<\/p>\n

ICR-Ednra<em1(E303K)Hku> (RBRC12041)
\n ICR-Ednra<em2(Y129F)Hku> (RBRC12042)<\/a>
\n<\/h5>\n

\"\u6b63\u5e38\u3000\u5909\u7570\"<\/a>\n <\/p>\n

ETAR_Y129F\u5909\u7570\u3067\u306f\u3001\u5916\u898b\u4e0a\u3001\u8033\u4ecb\u3068\u773c\u77bc\u306e\u7570\u5e38\u304c\u898b\u3089\u308c\u308b\u3002\u307e\u305f\u3001\u65b0\u751f\u5150\u306e\u9aa8\u8edf\u9aa8\u67d3\u8272\u3067\u306f\u4e0a\u984e(mx, jg)\u306e\u4f4d\u7f6e\u306b\u4e0b\u984e\u69d8\u306e\u95a2\u7bc0\u8edf\u9aa8\u3092\u6301\u3064\u68d2\u72b6\u306e\u9aa8\u304c\u51fa\u73fe\u3057\u3001\u65b9\u5f62\u9aa8(sq)\u306f\u7a81\u8d77(zp, rp) \u304c\u6d88\u5931\u3057\u3066\u3044\u308b\u3002ETAR_E303K\u5909\u7570\u3067\u3082\u540c\u3058\u8868\u73fe\u578b\u304c\u5168\u4f8b\u306b\u898b\u3089\u308c\u308b\u3002\n <\/p>\n<\/td>\n<\/td>\n<\/tr>\n<\/tbody>\n

\u984e\u9854\u9762\u9aa8\u5f62\u6210\u4e0d\u5168\u75c7\u306f\u3001\u907a\u4f1d\u5b50\u5909\u7570\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u5148\u5929\u6027\u5e0c\u5c11\u75be\u60a3\u3067\u3059\u3002\u5bc4\u8a17\u8005\u306e\u6817\u539f\u7531\u7d00\u5b50\u5148\u751f\u3089\u306f\u3001\u3053\u308c\u307e\u3067\u306e\u5148\u884c\u7814\u7a76\u53ca\u3073\u30d2\u30c8\u3067\u306e\u75c7\u4f8b\u5831\u544a\u306b\u57fa\u3065\u3044\u3066\u3001\u8840\u7ba1\u53ce\u7e2e\u3084\u5f62\u614b\u5f62\u6210\u306b\u91cd\u8981\u306a\u30a8\u30f3\u30c9\u30bb\u30ea\u30f31(Edn1\/ET1)\uff0f\u30a8\u30f3\u30c9\u30bb\u30ea\u30f3A\u53d7\u5bb9\u4f53(Ednra\/ETAR)\u30b7\u30b0\u30ca\u30eb\u306b\u6ce8\u76ee\u3057\u3001\u30b2\u30ce\u30e0\u7de8\u96c6CRISPR\/Cas9\u30b7\u30b9\u30c6\u30e0\u3092\u7528\u3044\u3066\u3001\u30a8\u30f3\u30c9\u30bb\u30ea\u30f3A\u53d7\u5bb9\u4f53\u30a2\u30df\u30ce\u9178\u5909\u7570\u30de\u30a6\u30b9\u30922\u7cfb\u7d71\u4f5c\u88fd\u3057\u307e\u3057\u305f\u3002\u30b0\u30eb\u30bf\u30df\u30f3\u9178\u304b\u3089\u30ea\u30b8\u30f3\u3078\u5909\u7570\u3055\u305b\u305fETAR E303K\u5909\u7570\u30de\u30a6\u30b9(RBRC12401)\u3068\u3001\u30c1\u30ed\u30b7\u30f3\u304b\u3089\u30d5\u30a7\u30cb\u30eb\u30a2\u30e9\u30cb\u30f3\u3078\u5909\u7570\u3055\u305b\u305fETAR Y129F\u5909\u7570\u30de\u30a6\u30b9(RBRC12402)\u306f\u3001\u3068\u3082\u306b\u8033\u4ecb\u306e\u5f62\u614b\u7570\u5e38\u3001\u4e0a\u984e\u9aa8\u306e\u5f62\u614b\u7570\u5e38\u3001\u96e3\u8074\u3092\u63a8\u6e2c\u3055\u305b\u308b\u8033\u5c0f\u9aa8\u306e\u4f4e\u5f62\u6210\u304c\u898b\u3089\u308c\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u3001\u8033\u4ecb\u3001\u9854\u9762\u306e\u5f62\u614b\u7570\u5e38\u3084\u96e3\u8074\u3092\u793a\u3059\u8131\u6bdb\u75c7\u3092\u4f34\u3046\u984e\u9854\u9762\u9aa8\u5f62\u6210\u4e0d\u5168\u75c7\u3067\u3082\u898b\u3089\u308c\u5f97\u308b\u8868\u73fe\u578b\u3067\u3059\u3002\u307e\u305f\u3001\u6817\u539f\u5148\u751f\u3089\u306f\u3001\u3053\u306e\u907a\u4f1d\u5b50\u6539\u5909\u30de\u30a6\u30b9\u3092\u7528\u3044\u3066\u3001\u85ac\u7406\u5b9f\u9a13\u3068\u30b9\u30fc\u30d1\u30fc\u30b3\u30f3\u30d4\u30e5\u30fc\u30bf\u30fc\u3092\u7528\u3044\u305f\u5206\u5b50\u52d5\u529b\u5b66(MD)\u30b7\u30df\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u3092\u884c\u3044\u3001\u539f\u5b50\u30ec\u30d9\u30eb\u3067\u30a8\u30f3\u30c9\u30bb\u30ea\u30f3A\u53d7\u5bb9\u4f53\u5909\u7570\u304c\u984e\u9854\u9762\u9aa8\u5f62\u6210\u4e0d\u5168\u75c7\u3092\u5f15\u304d\u8d77\u3053\u3059\u767a\u75c7\u6a5f\u5e8f\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f [1, 2]\u3002
\n\u7406\u7814BRC\u304b\u3089\u306f\u3001\u984e\u9854\u9762\u9aa8\u5f62\u6210\u4e0d\u5168\u75c7\u30e2\u30c7\u30eb\u30de\u30a6\u30b92\u7cfb\u7d71(RBRC12041\u3068RBRC12042)\u306e\u4ed6\u3001\u672c\u7814\u7a76\u3067\u4f7f\u308f\u308c\u305f\u30a8\u30f3\u30c9\u30bb\u30ea\u30f33(Edn3\/ET3)\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u30de\u30a6\u30b9(RBRC12043)\u3001RBRC12041\u7cfb\u7d71\u3068RBRC12043\u7cfb\u7d71\u306e\u4ea4\u914d\u306b\u3088\u308a\u3001ETAR E303K\u5909\u7570\u306b\u3088\u308b\u8868\u73fe\u578b\u3092ET3\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u3067\u30ec\u30b9\u30ad\u30e5\u30fc\u3057\u305f\u30de\u30a6\u30b9(RBRC12044)\u3082\u63d0\u4f9b\u53ef\u80fd\u3067\u3059\u3002\u3053\u308c\u3089\u306e\u7cfb\u7d71\u306f\u3001\u984e\u9854\u9762\u9aa8\u5f62\u6210\u4e0d\u5168\u75c7\u306e\u6cbb\u7642\u958b\u767a\u306b\u6709\u7528\u306a\u3060\u3051\u3067\u306a\u304f\u3001\u30a8\u30f3\u30c9\u30bb\u30ea\u30f3A\u53d7\u5bb9\u4f53\u304c\u5c5e\u3059\u308bG\u30bf\u30f3\u30d1\u30af\u8cea\u5171\u5f79\u578b\u53d7\u5bb9\u4f53\uff08GPCR\uff09\u306e\u5909\u7570\u306f\u69d8\u3005\u306a\u30d2\u30c8\u75be\u60a3\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u304a\u308a\u3001\u672c\u7814\u7a76\u3092\u304d\u3063\u304b\u3051\u306b\u3001\u75be\u60a3\u30e1\u30ab\u30cb\u30ba\u30e0\u89e3\u660e\u304c\u9032\u3080\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\n <\/td>\n<\/tr>\n<\/tfoot>\n<\/table>\n

 <\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Keywords<\/td>\n:<\/td>\n\u984e\u9854\u9762\u9aa8\u5f62\u6210\u4e0d\u5168\u75c7(MFDA)\u3001\u5148\u5929\u6027\u5e0c\u5c11\u75be\u60a3\u3001\u30a2\u30df\u30ce\u9178\u5909\u7570\u3001\u30d2\u30c8\u75be\u60a3\u30e2\u30c7\u30eb\u3001G\u30bf\u30f3\u30d1\u30af\u8cea\u5171\u5f79\u578b\u53d7\u5bb9\u4f53(GPCR)<\/td>\n<\/tr>\n
Depositor<\/td>\n:<\/td>\n\u6817\u539f\u7531\u7d00\u5b50\u5148\u751f (\u5bc4\u8a17\u5f53\u6642\u30fb\u6771\u4eac\u5927\u5b66)<\/td>\n<\/tr>\n
Strain name<\/td>\n:<\/td>\nICR-Ednra<em1(E303K)Hku><\/td>\n<\/tr>\n
RBRC No.<\/td>\n:<\/td>\nRBRC12041<\/td>\n<\/tr>\n
Strain name<\/td>\n:<\/td>\nICR-Ednra<em2(Y129F)Hku><\/td>\n<\/tr>\n
RBRC No.<\/td>\n:<\/td>\nRBRC12042<\/td>\n<\/tr>\n
Strain name<\/td>\n:<\/td>\nICR-Edn3<em1Hku><\/td>\n<\/tr>\n
RBRC No.<\/td>\n:<\/td>\nRBRC12043<\/td>\n<\/tr>\n
Strain name<\/td>\n:<\/td>\nICR-Ednra<em1(E303K)Hku>Edn3<em1Hku><\/td>\n<\/tr>\n
RBRC No.<\/td>\n:<\/td>\nRBRC12044<\/td>\n<\/tr>\n
References<\/td>\n:<\/td>\n[1]<\/td>\nKurihara Y, Ekimoto T, Gordon CT, Uchijima Y, Sugiyama R, Kitazawa T, Iwase A, Kotani R, Asai R, Pingault V, Ikeguchi M, Amiel J, Kurihara H.
\nMandibulofacial dysostosis with alopecia results from ETAR gain-of-function mutations via allosteric effects on ligand binding
\nJ Clin Invest. 2023 Feb 15;133(4):e151536.\n <\/td>\n<\/tr>\n
[2]<\/td>\n\u305f\u3063\u305f\u4e00\u3064\u306e\u30a2\u30df\u30ce\u9178\u5909\u7570\u3067\u5148\u5929\u6027\u5e0c\u5c11\u75be\u60a3\u3092\u8d77\u3053\u3059\u6a5f\u5e8f\u3092\u539f\u5b50\u306e\u30ec\u30d9\u30eb\u304b\u3089\u89e3\u660e
\n2023\u5e741\u670814\u65e5\u6771\u4eac\u5927\u5b66\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n\n\n\n
June 2026
\nSaori Mizuno, Ph.D.
\nContact: Experimental Animal Division, RIKEN BioResource Research Center (animal.brc@riken.jp)<\/a>
\nAll materials contained on this site may not be reproduced, distributed, displayed, published or broadcast without the prior permission of the owner of that content.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":19,"featured_media":0,"parent":198,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_seopress_robots_follow":"","_seopress_robots_imageindex":"","_seopress_robots_snippet":"","_seopress_robots_primary_cat":"","_seopress_robots_breadcrumbs":"","_seopress_robots_freeze_modified_date":"","_seopress_robots_custom_modified_date":"","_seopress_robots_canonical":"","_seopress_social_fb_title":"","_seopress_social_fb_desc":"","_seopress_social_fb_img":"","_seopress_social_fb_img_attachment_id":0,"_seopress_social_fb_img_width":0,"_seopress_social_fb_img_height":0,"_seopress_social_twitter_title":"","_seopress_social_twitter_desc":"","_seopress_social_twitter_img":"","_seopress_social_twitter_img_attachment_id":0,"_seopress_social_twitter_img_width":0,"_seopress_social_twitter_img_height":0,"_seopress_redirections_value":"","_seopress_redirections_enabled":"","_seopress_redirections_enabled_regex":"","_seopress_redirections_logged_status":"","_seopress_redirections_param":"","_seopress_redirections_type":0,"_seopress_analysis_target_kw":"","footnotes":"","_wp_rev_ctl_limit":""},"class_list":["post-21047","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/21047","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/users\/19"}],"replies":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/comments?post=21047"}],"version-history":[{"count":2,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/21047\/revisions"}],"predecessor-version":[{"id":21081,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/21047\/revisions\/21081"}],"up":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/198"}],"wp:attachment":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/media?parent=21047"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}