{"id":21131,"date":"2026-09-03T10:57:42","date_gmt":"2026-09-03T01:57:42","guid":{"rendered":"http:\/\/mus.brc.riken.jp\/ja\/?page_id=21131"},"modified":"2026-09-03T14:25:34","modified_gmt":"2026-09-03T05:25:34","slug":"sep_2026_mm","status":"publish","type":"page","link":"http:\/\/mus.brc.riken.jp\/ja\/mouse_of_month\/sep_2026_mm","title":{"rendered":"Per1<\/i>\u907a\u4f1d\u5b50E0\u2013E1 E-box\u3092\u6b20\u640d\u3057\u305f \u6982\u65e5\u6642\u8a08\u7814\u7a76\u306b\u6709\u7528\u306a\u30de\u30a6\u30b9"},"content":{"rendered":"\n\n\n\n\n\n\n
\"RIKEN<\/td>\nSeptember 2026<\/span>
\nMouse of the Month<\/span><\/a><\/td>\n<\/tr>\n<\/thead>\n
\n

Per1<\/i>\u907a\u4f1d\u5b50E0\u2013E1 E-box\u3092\u6b20\u640d\u3057\u305f
\u6982\u65e5\u6642\u8a08\u7814\u7a76\u306b\u6709\u7528\u306a\u30de\u30a6\u30b9<\/p>\n

B6.B6D2-Per1<em2(delEbox)Ytaka> (RBRC12802)<\/a>
\n<\/h5>\n

\"\"<\/a>\n <\/p>\n

\u56f31. Mic-628\u306b\u3088\u308b\u6982\u65e5\u6642\u8a08\u306e\u524d\u9032\u30e1\u30ab\u30cb\u30ba\u30e0\u3068Per1<\/i>\u0394(E0E1)\u30de\u30a6\u30b9\u306e\u8868\u73fe\u578b
\n(a)Mic-628\u306e\u5316\u5b66\u69cb\u9020\u3002Mic-628\u306fPer1\u8ee2\u5199\u3092\u9078\u629e\u7684\u306b\u8a98\u5c0e\u3057\u3001\u6982\u65e5\u6642\u8a08\u306e\u4f4d\u76f8\u3092\u524d\u9032\u3055\u305b\u308b\u65b0\u898f\u4f4e\u5206\u5b50\u5316\u5408\u7269\u3067\u3042\u308b\u3002(b)Per1\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u306b\u5b58\u5728\u3059\u308bDual E-box\u306e\u6a21\u5f0f\u56f3\u3002Per1\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u306b\u306f\u7d0410 bp\u306e\u9593\u9694\u3067\u914d\u7f6e\u3055\u308c\u305f2\u3064\u306eE-box\uff08E0\u304a\u3088\u3073E1\uff09\u304c\u5b58\u5728\u3057\u3001Mic-628\u306b\u3088\u308b\u8ee2\u5199\u6d3b\u6027\u5316\u306b\u5fc5\u9808\u306e\u5236\u5fa1\u914d\u5217\u3068\u3057\u3066\u6a5f\u80fd\u3059\u308b\u3002(c)Mic-628\u306b\u3088\u308bPer1\u8ee2\u5199\u6d3b\u6027\u5316\u6a5f\u69cb\u306e\u6a21\u5f0f\u56f3\u3002\u901a\u5e38\u3001CRY\u8907\u5408\u4f53\u306fDual E-box\u4e0a\u3067Per1\u8ee2\u5199\u3092\u6291\u5236\u3057\u3066\u3044\u308b\u3002Mic-628\u304c\u4f5c\u7528\u3059\u308b\u3068CRY\u8907\u5408\u4f53\u304c\u8ee2\u5199\u6d3b\u6027\u578b\u3078\u6a5f\u80fd\u8ee2\u63db\u3057\u3001Dual E-box\u3092\u4ecb\u3057\u3066Per1\u8ee2\u5199\u304c\u9078\u629e\u7684\u306b\u6d3b\u6027\u5316\u3055\u308c\u308b\u3002
\n\u56f3.2 Dual E-box\u306fMic-628\u306b\u3088\u308b\u6982\u65e5\u6642\u8a08\u524d\u9032\u4f5c\u7528\u306b\u5fc5\u9808\u3067\u3042\u308b
\n\u91ce\u751f\u578b\u30de\u30a6\u30b9\u3067\u306fMic-628\u6295\u4e0e\u306b\u3088\u308aPer1\u767a\u73fe\u304c\u8a98\u5c0e\u3055\u308c\u3001\u884c\u52d5\u30ea\u30ba\u30e0\u306e\u4f4d\u76f8\u524d\u9032\u304c\u8a8d\u3081\u3089\u308c\u308b\u3002\u4e00\u65b9\u3001Per1\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u306eDual E-box\u3092\u6b20\u640d\u3057\u305f\u30de\u30a6\u30b9\u3067\u306fPer1\u8a98\u5c0e\u304a\u3088\u3073\u4f4d\u76f8\u524d\u9032\u4f5c\u7528\u306f\u8457\u3057\u304f\u6e1b\u5f31\u3059\u308b\u3002Dual E-box\u304cMic-628\u5fdc\u7b54\u6027\u3092\u898f\u5b9a\u3059\u308b\u91cd\u8981\u306a\u30b7\u30b9\u5236\u5fa1\u914d\u5217\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u308b\u3002\n <\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n

\u54fa\u4e73\u985e\u306e\u6982\u65e5\u6642\u8a08\u907a\u4f1d\u5b50\u3068\u3057\u3066\u77e5\u3089\u308c\u308bPeriod1<\/i>(Per1<\/i>)\u907a\u4f1d\u5b50\u306e\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u9818\u57df\u306b\u306f\u3001\u8ee2\u5199\u3092\u5236\u5fa1\u3059\u308bCLOCK\u2013BMAL1\u8907\u5408\u4f53\u304c\u7d50\u5408\u3059\u308b2\u3064\u306e\u30bf\u30f3\u30c7\u30e0E-box\uff08E0\u304a\u3088\u3073E1\uff09\u304c\u4e26\u3093\u3067\u5b58\u5728\u3057\u307e\u3059\u3002\u4eca\u56de\u3054\u7d39\u4ecb\u3059\u308bPer1\u0394(E0E1)<\/sup>\u30de\u30a6\u30b9(RBRC12802)\u306f\u3001\u3053\u306eE0-E1 E-box \u30a8\u30ec\u30e1\u30f3\u30c8\u3092CRISPR\/Cas9\u30b7\u30b9\u30c6\u30e0\u3092\u7528\u3044\u3066\u6b20\u640d\u3055\u305b\u305f\u30de\u30a6\u30b9\u3067\u3059\u3002\u672c\u7cfb\u7d71\u306b\u304a\u3044\u3066\u3001CLOCK\u2013BMAL1\u8907\u5408\u4f53\u306f\u4ed6\u306eE-box\uff08E3, E4, E5\u306a\u3069\uff09\u306b\u7d50\u5408\u3057\u3066\u4f5c\u7528\u3059\u308b\u305f\u3081\u3001Per1<\/i>\u907a\u4f1d\u5b50\u306e\u57fa\u790e\u7684\u306a\u8ee2\u5199\u6d3b\u6027\u306f\u7dad\u6301\u3055\u308c\u3066\u3044\u307e\u3059\u3002
\n\u5bc4\u8a17\u8005\u306e\u9ad8\u7551\u4f73\u53f2\u5148\u751f\u3089\u306f\u3001Per1<\/i>\u907a\u4f1d\u5b50\u306eE0-E1 E-box \u30a8\u30ec\u30e1\u30f3\u30c8\u3092\u4ecb\u3057\u3066\u3001Per1<\/i>\u907a\u4f1d\u5b50\u306e\u8ee2\u5199\u3092\u7279\u7570\u7684\u306b\u8a98\u5c0e\u3059\u308b\u4f4e\u5206\u5b50\u5316\u5408\u7269Mic-628\u3092\u767a\u898b\u3057\u307e\u3057\u305f\u3002Mic-628\u306f\u8ee2\u5199\u6291\u5236\u56e0\u5b50CRY1\u306b\u7d50\u5408\u3057\u3066\u3001CLOCK-BMAL1-CRY1-Mic-628\u8907\u5408\u4f53\u306e\u5f62\u6210\u3092\u4fc3\u9032\u3057\u307e\u3059\u3002\u3053\u306e\u8907\u5408\u4f53\u304c\u524d\u8ff0\u306eE0-E1 E-box \u30a8\u30ec\u30e1\u30f3\u30c8\u306b\u7279\u7570\u7684\u306b\u4f5c\u7528\u3057\u3066Per1<\/i>\u907a\u4f1d\u5b50\u8ee2\u5199\u3092\u8a98\u5c0e\u3057\u3001\u305d\u306e\u5f8c\u3001PER1\u306b\u3088\u308b\u81ea\u5df1\u6291\u5236\u30d5\u30a3\u30fc\u30c9\u30d0\u30c3\u30af\u304c\u50cd\u304f\u3053\u3068\u3067\u3001\u5e38\u306b\u6982\u65e5\u6642\u8a08\u3092\u524d\u9032\u65b9\u5411\u306b\u4f4d\u76f8\u30b7\u30d5\u30c8\u3055\u305b\u308b\u3068\u3044\u3046\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002
\n\u91ce\u751f\u578b\u30de\u30a6\u30b9\u306bMic-628\u3092\u7d4c\u53e3\u6295\u4e0e\u3059\u308b\u3068\u3001\u6295\u4e0e\u6642\u523b\u306b\u4f9d\u5b58\u3059\u308b\u3053\u3068\u306a\u304f\u3001\u6982\u65e5\u6642\u8a08\u4e2d\u67a2\u3067\u3042\u308b\u8133\u306e\u8996\u4ea4\u53c9\u4e0a\u6838\u3068\u3001\u80ba\u306a\u3069\u306e\u5168\u8eab\u306e\u672b\u68a2\u7d44\u7e54\u306e\u6982\u65e5\u6642\u8a08\u304c\u540c\u6642\u306b\u524d\u9032\u3057\u3001\u884c\u52d5\u30ea\u30ba\u30e0\u3082\u524d\u9032\u3057\u307e\u3059\u3002\u4e00\u65b9\u3001Per1\u0394(E0E1)\u30de\u30a6\u30b9\u306bMic-628\u3092\u7d4c\u53e3\u6295\u4e0e\u3059\u308b\u3068\u3001Mic-628\u306b\u3088\u308b\u4f4d\u76f8\u524d\u9032\u4f5c\u7528\u306e\u5927\u90e8\u5206\u304c\u5931\u308f\u308c\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002
\nPer1<\/i>\u907a\u4f1d\u5b50\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u306eE0-E1 E-box \u30a8\u30ec\u30e1\u30f3\u30c8\u304c\u6982\u65e5\u6642\u8a08\u306e\u4f4d\u76f8\u5236\u5fa1\u306b\u91cd\u8981\u3067\u3042\u308b\u3053\u3068\u304b\u3089\u3001Per1\u0394(E0E1)<\/sup>\u30de\u30a6\u30b9\u306f\u6982\u65e5\u6642\u8a08\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u5236\u5fa1\u6a5f\u69cb\u3084\u3001\u6982\u65e5\u6642\u8a08\u306e\u524d\u9032\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u89e3\u6790\u3059\u308b\u4e0a\u3067\u6709\u7528\u306a\u30de\u30a6\u30b9\u7cfb\u7d71\u3068\u3057\u3066\u5e83\u304f\u5229\u7528\u3055\u308c\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002\n <\/td>\n<\/tr>\n<\/tfoot>\n<\/table>\n

 <\/p>\n\n\n\n\n\n\n\n\n
Keywords<\/td>\n:<\/td>\n\u6982\u65e5\u6642\u8a08\u3001\u907a\u4f1d\u5b50\u8ee2\u5199\u5236\u5fa1\u3001\u81ea\u5df1\u6291\u5236\u30d5\u30a3\u30fc\u30c9\u30d0\u30c3\u30af\u3001\u4f4e\u5206\u5b50\u5316\u5408\u7269\u3001\u4f4d\u76f8\u524d\u9032\n <\/td>\n<\/tr>\n
Depositor<\/td>\n:<\/td>\n\u9ad8\u7551\u4f73\u53f2\u5148\u751f (\u5927\u962a\u5927\u5b66) <\/td>\n<\/tr>\n
Strain name<\/td>\n:<\/td>\nB6.B6D2-Per1<em2(delEbox)Ytaka><\/td>\n<\/tr>\n
RBRC No.<\/td>\n:<\/td>\nRBRC12802<\/td>\n<\/tr>\n
References<\/td>\n:<\/td>\n[1]<\/td>\nTakahata Y, Kasashima Y, Yoshioka T, Yashiki S, Kulikauskaite J, Matsuura T, Ohba Y, Hasegawa H, Yuri N, Iwai N, Otsu N, Kitakata M, Kitaguchi Y, Furune H, Omori C, Mukai M, Komamura-Kohno Y, Huang YY, Hirose M, Koike N, Yamada Y, Nakazawa K, Ui-Tei K, Sakaki Y, Numano R, Uriu K, Tei H.
\nA Period1<\/i> inducer specifically advances circadian clock in mice.
\nProc Natl Acad Sci U S A. 2026 Jan 27;123(4):e2509943123.<\/a>\n <\/td>\n<\/tr>\n
[2]<\/td>\n\u7d4c\u53e3\u6295\u4e0e\u3067\u4f53\u5185\u6642\u8a08\u3092\u300c\u9032\u3081\u308b\u300d\u65b0\u5316\u5408\u7269\u3092\u767a\u898b: \u6642\u5dee\u307c\u3051\u3084\u6982\u65e5\u30ea\u30ba\u30e0\u969c\u5bb3\u306e\u6cbb\u7642\u306b\u65b0\u305f\u306a\u5149
\n2026\u5e741\u670826\u65e5\u5927\u962a\u5927\u5b66\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9<\/a>\n <\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n\n\n\n
September 2026
\nSaori Mizuno, Ph.D.
\nContact: Experimental Animal Division, RIKEN BioResource Research Center (animal.brc@riken.jp)<\/a>
\nAll materials contained on this site may not be reproduced, distributed, displayed, published or broadcast without the prior permission of the owner of that content.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":19,"featured_media":0,"parent":198,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_seopress_robots_follow":"","_seopress_robots_imageindex":"","_seopress_robots_snippet":"","_seopress_robots_primary_cat":"","_seopress_robots_breadcrumbs":"","_seopress_robots_freeze_modified_date":"","_seopress_robots_custom_modified_date":"","_seopress_robots_canonical":"","_seopress_social_fb_title":"","_seopress_social_fb_desc":"","_seopress_social_fb_img":"","_seopress_social_fb_img_attachment_id":0,"_seopress_social_fb_img_width":0,"_seopress_social_fb_img_height":0,"_seopress_social_twitter_title":"","_seopress_social_twitter_desc":"","_seopress_social_twitter_img":"","_seopress_social_twitter_img_attachment_id":0,"_seopress_social_twitter_img_width":0,"_seopress_social_twitter_img_height":0,"_seopress_redirections_value":"","_seopress_redirections_enabled":"","_seopress_redirections_enabled_regex":"","_seopress_redirections_logged_status":"","_seopress_redirections_param":"","_seopress_redirections_type":0,"_seopress_analysis_target_kw":"","footnotes":"","_wp_rev_ctl_limit":""},"class_list":["post-21131","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/21131","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/users\/19"}],"replies":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/comments?post=21131"}],"version-history":[{"count":2,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/21131\/revisions"}],"predecessor-version":[{"id":21135,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/21131\/revisions\/21135"}],"up":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/198"}],"wp:attachment":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/media?parent=21131"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}