{"id":3607,"date":"2013-02-22T16:37:18","date_gmt":"2013-02-22T07:37:18","guid":{"rendered":"http:\/\/mus.brc.riken.jp:8001\/?page_id=3607"},"modified":"2023-08-03T14:06:04","modified_gmt":"2023-08-03T05:06:04","slug":"nomen_strain","status":"publish","type":"page","link":"http:\/\/mus.brc.riken.jp\/ja\/manual\/nomen_strain","title":{"rendered":"\u30de\u30a6\u30b9\u7cfb\u7d71\u306e\u5b66\u8853\u547d\u540d\u898f\u7d04"},"content":{"rendered":"
\n

Rules for Nomenclature of Mouse Strains
\n\uff08\u30de\u30a6\u30b9\u7cfb\u7d71\u306e\u5b66\u8853\u547d\u540d\u898f\u7d04\uff09<\/strong><\/p>\n

\u3000\u30ca\u30b7\u30e7\u30ca\u30eb\u30d0\u30a4\u30aa\u30ea\u30bd\u30fc\u30b9\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u300c\u30e9\u30c3\u30c8\u300d\u30fb\u771f\u4e0b\u77e5\u58eb\u535a\u58eb\u306b\u3088\u308a\u548c\u8a33\u3055\u308c\u305f\u300cRules for Nomenclature of Mouse and Rat Strains<\/a>\u300d\u304b\u3089\u30de\u30a6\u30b9\u90e8\u5206\u3092\u629c\u7c8b\u3057\uff0c\u82e5\u5e72\u306e\u7de8\u96c6\u3092\u52a0\u3048\u305f\u3082\u306e\u3067\u3042\u308b\uff0e
\n2004\u5e743\u670810\u65e5<\/p>\n

1.\u3000\u5e8f\u8ad6<\/strong>
\n\u5b9f\u9a13\u306b\u7528\u3044\u308b\u30de\u30a6\u30b9\u306e\u7531\u6765\u306f\u3055\u307e\u3056\u307e\u3067\u3042\u308b\uff0e\u8fd1\u4ea4\u7cfb\u3092\u6a39\u7acb\u3059\u308b\u3053\u3068\u306f\uff0c\u305d\u308c\u3089\u306e\u80cc\u666f\u3092\u660e\u78ba\u306b\u3059\u308b\u3053\u3068\u3092\u610f\u5473\u3057\uff0c\u305d\u306e\u305f\u3081\u306e\u5b66\u8853\u547d\u540d\u898f\u7d04\u3092\u5fc5\u8981\u3068\u3059\u308b\uff0eGenetic Drift\uff08\u907a\u4f1d\u7684\u6d6e\u52d5\uff09\uff0c\u3064\u307e\u308a\u7cfb\u7d71\u5185\u306e\u500b\u4f53\u9593\u3067\u672a\u77e5\u306e\u907a\u4f1d\u7684\u5dee\u7570\u304c\u751f\u3058\u3066\u3044\u308b\u304b\u3082\u3057\u308c\u306a\u3044\u3068\u3044\u3046\u3053\u3068\u3092\u5fc3\u306b\u7559\u3081\u3066\u304a\u304f\u3079\u304d\u3067\u3042\u308b\uff0e<\/p>\n

\u307b\u3068\u3093\u3069\u306e\u5b9f\u9a13\u7528\u30de\u30a6\u30b9\u306f\uff0cMus musculus musculus<\/em>\u3068\uff0cM. m. domesticus<\/em>\u306b\u7531\u6765\u3059\u308b\u304c\uff0cM. m. molossinus<\/em>\u3084M. m. castaneus<\/em>\u304b\u3089\u3082\u307e\u305f\uff0c\u3042\u308b\u7a2e\u306e\u5b9f\u9a13\u7528\u30de\u30a6\u30b9\u306f\u7531\u6765\u3057\u3066\u3044\u308b\uff0e\u5f93\u3063\u3066\uff0c\u305d\u308c\u3089\u306e\u540d\u524d\u306b\u306f\uff0c\u7a2e\u540d\u3067\u306f\u306a\u304f\uff0c\u305d\u308c\u305e\u308c\u7279\u5b9a\u306e\u7cfb\u7d71\u540d\u3084\u30b9\u30c8\u30c3\u30af\u540d\uff0c\u3042\u308b\u3044\u306f\u5b9f\u9a13\u7528\u30de\u30a6\u30b9\u540d\u3092\u4f7f\u7528\u3059\u3079\u304d\u3067\u3042\u308b\uff0e\uff08\u8fd1\u5e74\uff0c\u5b9f\u9a13\u7528\u30de\u30a6\u30b9\u3068\u3057\u3066\u958b\u767a\u3055\u308c\u305f\u7cfb\u7d71\u306e\u3044\u304f\u3064\u304b\u306f\uff0c\u3082\u3063\u3071\u3089M. spretus<\/em>\u306e\u3088\u3046\u306a\u4ed6\u306eMus<\/em>\u5c5e\u306e\u7a2e\u3084M. musculus<\/em>\u306e\u4e9c\u7a2e\u306b\u7531\u6765\u3057\u3066\u3044\u308b\uff0e\uff09<\/p>\n

\u30de\u30a6\u30b9\u306e\u7cfb\u7d71\u540d\u306fMouse Genome Database\uff08MGD\uff09\u304b\u3089\u767b\u9332\u3059\u308b\uff0e<\/p>\n

https:\/\/www.informatics.jax.org\/submit.shtml<\/a><\/blockquote>\n

2.\u3000\u65bd\u8a2d\u8a18\u53f7(\u30e9\u30dc\u30b3\u30fc\u30c9)<\/strong>
\n\u30de\u30a6\u30b9\u306e\u547d\u540d\u8868\u8a18\u306e\u4e3b\u8981\u306a\u90e8\u5206\u306f\u65bd\u8a2d\u767b\u9332\u8a18\u53f7\u307e\u305f\u306f\u30e9\u30dc\u30b3\u30fc\u30c9\u3067\u3042\u308a\uff0c\u30de\u30a6\u30b9\u7cfb\u7d71\u3092\u7dad\u6301\uff0c\u3042\u308b\u3044\u306f\u751f\u7523\u3059\u308b\u65bd\u8a2d\uff0c\u7814\u7a76\u5ba4\uff0c\u307e\u305f\u306f\u7814\u7a76\u8005\u3092\u8b58\u5225\u3059\u308b\u305f\u3081\u306b\uff0c\u901a\u5e383\uff0c4\u6587\u5b57\u306e\u8a18\u53f7\u3067\u8868\u3059\uff08\u982d\u6587\u5b57\u306f\u5927\u6587\u5b57\u3068\u3057\uff0c\u5f8c\u306b\u5c0f\u6587\u5b57\u304c\u7d9a\u304f\uff09\uff0e\u4e9c\u7cfb\u7d71\u306f\uff0c\u3053\u306e\u30e9\u30dc\u30b3\u30fc\u30c9\u306b\u3088\u308a\u533a\u5225\u3059\u308b\uff0e\u30b3\u30f3\u30b8\u30a7\u30cb\u30c3\u30af\u7cfb\u7d71\u3084\uff0c\u3044\u304f\u3064\u304b\u306e\u30bf\u30a4\u30d7\u304c\u5b58\u5728\u3059\u308b\u304c\uff0c\u533a\u5225\u3059\u308b\u3053\u3068\u304c\u4e0d\u53ef\u80fd\u306a\u7cfb\u7d71\u306a\u3069\u3082\uff0c\u3053\u306e\u30e9\u30dc\u30b3\u30fc\u30c9\u3092\u7528\u3044\u308b\uff0e\u30e9\u30dc\u30b3\u30fc\u30c9\u306fIinstitute for Laboratory Animal Research\uff08ILAR\uff09\u3067\u767b\u9332\u3059\u308b\uff0e<\/p>\n

\uff08https:\/\/www.nationalacademies.org\/ilar\/lab-code-database<\/a>\uff09<\/p>\n

\u4f8b\uff1a<\/strong><\/p>\n\n\n\n\n\n
J<\/td>\n\u30b8\u30e3\u30af\u30bd\u30f3\u7814\u7a76\u6240<\/td>\n<\/tr>\n
Mit<\/td>\nMassachusetts Institute of Technology<\/td>\n<\/tr>\n
Ms<\/td>\n\u56fd\u7acb\u907a\u4f1d\u5b66\u7814\u7a76\u6240<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p><\/blockquote>\n

3.\u3000\u8fd1\u4ea4\u7cfb\u304a\u3088\u3073\u4ea4\u96d1\u4ed4\uff08Inbred Strains and Hybrids\uff09<\/strong>
\n3.1.\u3000\u5b9a\u7fa9
\n<\/strong>\u3000\u5144\u59b9\u4ea4\u914d\u309220\u4e16\u4ee3\uff0c\u3082\u3057\u304f\u306f\u305d\u308c\u4ee5\u4e0a\u7d99\u4ee3\u3057\u305f\u7cfb\u7d71\u3092\u8fd1\u4ea4\u7cfb\u3068\u3059\u308b\uff0e\u3053\u306e\u7cfb\u7d71\u306e\u5404\u500b\u4f53\u306f\uff0c\u4e00\u7d44\u306e\u5171\u901a\u306e\u7956\u5148\u306b\u9061\u308b\u3053\u3068\u304c\u3067\u304d\u308b\uff0e\u8fd1\u4ea4\u7cfb\u3068\u306a\u3063\u305f\u6642\u70b9\u3067\uff0c\u305d\u308c\u305e\u308c\u306e\u500b\u4f53\u306e\u30b2\u30ce\u30e0\u306b\u306f\uff0c\u5e73\u5747\u3057\u3066\u50c5\u304b0.01\u306e\u30d8\u30c6\u30ed\u63a5\u5408\u6027\u3057\u304b\u6b8b\u3063\u3066\u3044\u306a\u3044\uff08Genetic Drift\u306e\u5834\u5408\u3092\u9664\u304f\uff09\uff0e\u5f93\u3063\u3066\uff0c\u3042\u3089\u3086\u308b\u5229\u7528\u306b\u304a\u3044\u3066\uff0c\u907a\u4f1d\u7684\u306b\u540c\u4e00\u3068\u898b\u306a\u3059\u3053\u3068\u304c\u3067\u304d\u308b\uff0e\u8fd1\u4ea4\u7cfb\u306f\uff0c\u5144\u59b9\u4ea4\u914d\u3042\u308b\u3044\u306f\uff08\u305d\u308c\u306b\u76f8\u5f53\u3059\u308b\u65b9\u6cd5\uff09\u3067\u7dad\u6301\u3057\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044\uff0e<\/p>\n

\u8fd1\u4ea4\u7cfb\u3092\u4f5c\u88fd\u3059\u308b\u4ed6\u306e\u4ea4\u914d\u65b9\u6cd5\u3068\u3057\u3066\u306f\uff0c\u7d99\u7d9a\u7684\u306a\u89aa\u4ed4\u4ea4\u914d\u304c\u3042\u308a\uff0c\u4ea4\u914d\u3057\u305f\u89aa\u306e\u3046\u3061\uff0c\u3044\u3064\u3082\u82e5\u3044\u65b9\u3092\u6b21\u306e\u4ea4\u914d\u306b\u4f7f\u7528\u3059\u308b\u5834\u5408\u3067\u3042\u308b\uff08\u4f8b\uff1a\u89aa\u4ed4\u4ea4\u914d\u3092\u3055\u305b\u305f\u30da\u30a2\u30fc\u306e\u4ed4\u306e\u65b9\u3092\uff0c\u6b21\u306f\u89aa\u306e\u65b9\u3068\u3057\u3066\uff0c\u7523\u307e\u308c\u3066\u304d\u305f\u4ed4\u3068\u4ea4\u914d\u3055\u305b\u308b\uff09\uff0e\u7d99\u7d9a\u3057\u305f20\u4e16\u4ee3\u4ee5\u4e0a\u306e\u8fd1\u89aa\u4ea4\u914d\u306b\u76f8\u5f53\u3059\u308b\u4ea4\u914d\u65b9\u6cd5\u306a\u3089\uff0c\u4ed6\u306e\u4ea4\u914d\u65b9\u6cd5\u3082\u4f7f\u7528\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\uff0e<\/p>\n

3.2.\u3000\u8fd1\u4ea4\u7cfb\u306e\u547d\u540d<\/strong>
\n\u8fd1\u4ea4\u7cfb\u540d\u306f\uff0c\u5927\u6587\u5b57\u306e\u30ed\u30fc\u30de\u5b57\u304b\uff0c\u6587\u5b57\u3068\u6570\u5b57\u3092\u7d44\u307f\u5408\u308f\u305b\u305f\u6587\u5b57\u306e\u7565\u53f7\u3067\u8868\u8a18\u3059\u308b\uff0e\u65e2\u5b58\u306e\u7cfb\u7d71\u306b\u306f\uff0c\u3053\u306e\u898f\u7d04\u306b\u5f53\u3066\u306f\u307e\u3089\u306a\u3044\u7cfb\u7d71\u3082\u3042\u308b\uff08\u4f8b\uff1a129P1\/J\uff09\uff0e<\/p>\n

\u7cfb\u7d71\u306e\u540d\u79f0\u306f\uff0c\u30de\u30a6\u30b9\u3068\u30e9\u30c3\u30c8\u3067\u91cd\u8907\u3057\u306a\u3044\u3088\u3046\u306b\u6ce8\u610f\u3059\u308b\uff08\u30de\u30a6\u30b9\uff0c\u30e9\u30c3\u30c8\u7cfb\u7d71\u306e\u4e2d\u306b\u306f\u540c\u3058\u7cfb\u7d71\u540d\u3092\u6301\u3064\u3082\u306e\u304c\u3042\u308b\u304c\uff0c\u305d\u308c\u3089\u306f\u4e9c\u7cfb\u7d71\u540d\u306e\u8868\u8a18\u306b\u3088\u308a\u533a\u5225\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\uff09\uff0e
\n\u5171\u901a\u306e\u7956\u5148\u3092\u3082\u3061\uff0c20\u4e16\u4ee3\u306b\u306a\u308b\u4ee5\u524d\u306b\u5206\u5c90\u3057\u305f\u95a2\u9023\u6027\u304c\u3042\u308b\u8fd1\u4ea4\u7cfb\u306f\uff0c\u3053\u306e\u95a2\u4fc2\u3092\u8868\u3059\u7cfb\u7d71\u540d\u3092\u4ed8\u3051\u308b\uff0e<\/p>\n

\u4f8b\uff1a<\/strong>
\nNZB\uff0cNZC\uff0cNZO<\/blockquote>\n

3.3.\u3000\u4e16\u4ee3\u6570\u306e\u8868\u793a<\/strong>
\n\u5144\u59b9\u4ea4\u914d\u306e\u4e16\u4ee3\u6570\u306f\uff0c\u5fc5\u8981\u306a\u3089\u3070\u62ec\u5f27\u306e\u4e2d\u306b\u201cF\u201d\u3068\uff0c\u305d\u306e\u5f8c\u306b\u4e16\u4ee3\u6570\u3092\u3064\u3051\u3066\u8868\u793a\u3059\u308b\uff0e<\/p>\n

\u4f8b\uff1a<\/strong>
\nMSM\/Ms\uff08F81\uff09<\/blockquote>\n

\u4ee5\u524d\u306e\u4e16\u4ee3\u6570\u306b\u3064\u3044\u3066\u306e\u60c5\u5831\u304c\u7121\u304f\uff0c\u6700\u8fd1\u306e\u8fd1\u4ea4\u4e16\u4ee3\u6570\u3060\u3051\u304c\u5224\u660e\u3057\u3066\u3044\u308b\u5834\u5408\u306b\u306f\uff0c\u30af\u30a8\u30b9\u30c1\u30e7\u30f3\u30de\u30fc\u30af\u201c?\u201d\u201c\uff0b\u201d\u3068\uff0c\u305d\u306e\u5f8c\u306b\u65e2\u77e5\u306e\u5144\u59b9\u4e16\u4ee3\u6570\u3092\u4ed8\u3051\u3066\u8868\u793a\u3059\u308b\uff0e<\/p>\n

\u4f8b\uff1a<\/strong>
\nC3H\/HeJ-ruf<\/em>\/+\uff08F?+25\uff09<\/blockquote>\n

3.4.\u3000\u4e9c\u7cfb\u7d71<\/strong>
\n\u8fd1\u4ea4\u7cfb\u306f\uff0c\u6642\u304c\u7d4c\u3064\u3068\u3068\u3082\u306b\u74b0\u5883\u306e\u5909\u5316\u306b\u3088\u3063\u3066\uff0c\u907a\u4f1d\u7684\u306b\u4e9c\u7cfb\u7d71\uff08Substrains\uff09\u306b\u5206\u304b\u308c\u308b\uff0e<\/p>\n

    \n
  • \u5144\u59b9\u4ea4\u914d\u304c20\u4e16\u4ee3\u4ee5\u4e0a40\u4e16\u4ee3\u672a\u6e80\u30672\u3064\u306e\u7cfb\u7d71\u306b\u5206\u304b\u308c\u305f\u5834\u5408\uff0e\u672a\u3060\u30d8\u30c6\u30ed\u9818\u57df\u304c\u6b8b\u3063\u3066\u3044\u308b\u304b\u3082\u3057\u308c\u306a\u3044\u306e\u3067\uff0c2\u3064\u306e\u907a\u4f1d\u7684\u306b\u7570\u306a\u308b\u4e9c\u7cfb\u7d71\u3068\u3059\u308b\uff08Green, 1981\uff09\uff0e<\/li>\n
  • \u5171\u901a\u306e\u7956\u5148\u304b\u3089\u5206\u304b\u308c\u306620\u4e16\u4ee3\u4ee5\u4e0a\u3092\u7d4c\u305f\u5834\u5408\uff0e\u7a81\u7136\u5909\u7570\u3084Genetic Drift\u306b\u3088\u308a\u7cfb\u7d71\u9593\u306b\u907a\u4f1d\u7684\u5dee\u7570\u304c\u751f\u3058\u3066\u3044\u308b\u304b\u3082\u3057\u308c\u306a\u3044\uff0e<\/li>\n
  • \u907a\u4f1d\u89e3\u6790\u306b\u3088\u3063\u3066\uff0c\u7cfb\u7d71\u5185\u3067\u907a\u4f1d\u7684\u5dee\u7570\u304c\u751f\u3058\u305f\u3068\u793a\u3055\u308c\u305f\u5834\u5408\uff0e<\/li>\n<\/ul>\n

    \u4e9c\u7cfb\u7d71\u3092\u8868\u8a18\u3059\u308b\u3068\u304d\u306f\uff0c\u89aa\u7cfb\u7d71\u306e\u3082\u3068\u306e\u540d\u524d\u306e\u5f8c\u306b\uff0c\u30b9\u30e9\u30c3\u30b7\u30e5\u3068\u4e9c\u7cfb\u7d71\u8a18\u53f7\u3092\u4ed8\u8a18\u3059\u308b\uff0e\u4e9c\u7cfb\u7d71\u8a18\u53f7\u306b\u306f\uff0c\u901a\u5e38\uff0c\u7cfb\u7d71\u3092\u4f5c\u88fd\u3057\u305f\u500b\u4eba\u3084\u7814\u7a76\u6240\u306e\u30e9\u30dc\u30b3\u30fc\u30c9\u3092\u7528\u3044\u308b\uff0e<\/p>\n

    \u4f8b\uff1a<\/strong><\/p>\n\n\n\n
    A\/He<\/td>\n\u30de\u30a6\u30b9A\u7cfb\u7d71\u306e\u4e9c\u7cfb\u7d71\u3067\uff0cWalter Heston\u306b\u3088\u3063\u3066\u4f5c\u51fa\u3055\u308c\u305f\u3082\u306e\uff0e<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/blockquote>\n

    \u3072\u3068\u3064\u306e\u7814\u7a76\u6240\u304c\uff0c\u8907\u6570\u306e\u4e9c\u7cfb\u7d71\u3092\u4f5c\u51fa\u3057\u305f\u5834\u5408\u306f\uff0c\u30e9\u30dc\u30b3\u30fc\u30c9\u306b\u901a\u3057\u756a\u53f7\u3092\u3075\u308b\uff0e<\/p>\n

    \u4f8b\uff1a<\/strong>
    \nFL\/1Re\uff0cFL\/2Re<\/p>\n

    \uff08\u6ce8\uff1a\u65e2\u5b58\u306e\u7cfb\u7d71\u306b\u306f\u3053\u306e\u30eb\u30fc\u30eb\u306b\u5f53\u3066\u306f\u307e\u3089\u306a\u3044\u3082\u306e\u3082\u3042\u308b\uff0e\u4f8b\u3048\u3070\uff0cBALB\/c\u306f\u4e9c\u7cfb\u7d71\u3067\u306f\u306a\u3044\uff0eDBA\/1\u3068DBA\/2\u3082\u5225\u3005\u306e\u7cfb\u7d71\u3067\u3042\u308a\uff0c\u4e9c\u7cfb\u7d71\u306e\u95a2\u4fc2\u3067\u306f\u306a\u3044\uff0e\uff09<\/p><\/blockquote>\n

    \u4ed6\u306e\u7814\u7a76\u8005\u304c\u7dad\u6301\u3092\u5f15\u304d\u7d99\u3044\u3060\u308a\uff0c\u65b0\u3057\u3044\u30b3\u30ed\u30cb\u30fc\u306e\u78ba\u7acb\u306b\u3088\u3063\u3066\uff0c\u3055\u3089\u306a\u308b\u4e9c\u7cfb\u7d71\u304c\u751f\u3058\u308b\uff0e\u307e\u305f\uff0c\u30aa\u30ea\u30b8\u30ca\u30eb\u306e\u7cfb\u7d71\u304b\u3089\u660e\u3089\u304b\u306a\u907a\u4f1d\u7684\u5dee\u7570\u304c\u898b\u3064\u304b\u3063\u305f\u5834\u5408\u3082\u307e\u305f\uff0c\u4e9c\u7cfb\u7d71\u3068\u306a\u308b\uff0e\u3069\u3061\u3089\u306e\u5834\u5408\u306b\u3082\uff0c\u3055\u3089\u306b\u30b9\u30e9\u30c3\u30b7\u30e5\u3092\u52a0\u3048\u3066\u30e9\u30dc\u30b3\u30fc\u30c9\u8868\u8a18\u3092\u3059\u308b\u306e\u3067\u306f\u306a\u304f\uff0c\u30e9\u30dc\u30b3\u30fc\u30c9\u306e\u307f\u3092\u8ffd\u52a0\u3059\u308b\uff0e<\/p>\n

    \u4f8b\uff1a<\/strong><\/p>\n\n\n\n\n
    C3H\/HeH<\/td>\nC3H\u7cfb\u7d71\u306e\u4e9c\u7cfb\u7d71\u3067\uff0cHeston\uff08He\uff09\u306e\u3042\u3068\u306bHarwell\uff08H\uff09\u3067\u7dad\u6301\u3055\u308c\u3066\u3044\u308b\uff0e<\/td>\n<\/tr>\n
    CBA\/StmMs<\/td>\nCBA\u7cfb\u7d71\u306e\u4e9c\u7cfb\u7d71\u3067\uff0c\u57fc\u7389\u304c\u3093\u30bb\u30f3\u30bf\u30fc\uff08Stm\uff09\u306e\u3042\u3068\u306b\uff0c\u56fd\u7acb\u907a\u4f1d\u5b66\u7814\u7a76\u6240\uff08Ms\uff09\u3067\u7dad\u6301\u3055\u308c\u3066\u3044\u308b\uff0e<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/blockquote>\n

    \u30e9\u30dc\u30b3\u30fc\u30c9\u306f\u84c4\u7a4d\u3055\u308c\u308b\uff0e\u306a\u305c\u306a\u3089\u3070\uff0c\u907a\u4f1d\u7684\u5dee\u7570\u306f\u6642\u306e\u7d4c\u904e\u3068\u3068\u3082\u306b\u84c4\u7a4d\u3055\u308c\u308b\u3082\u306e\u3067\u3042\u308a\uff0c\u7cfb\u7d71\u3084\u4e9c\u7cfb\u7d71\u3092\u7dad\u6301\u30fb\u80b2\u6210\u3057\u3066\u3044\u308b\u6a5f\u95a2\u306e\u54c1\u8cea\u7ba1\u7406\u30ec\u30d9\u30eb\u306b\u3088\u3063\u3066\uff0c\u305d\u306e\u901f\u5ea6\u3082\u5909\u308f\u3063\u3066\u3044\u304f\uff0e\u30de\u30a6\u30b9\u3092\u63d0\u4f9b\u3059\u308b\u969b\u306b\u306f\uff0c\u7cfb\u7d71\u306b\u95a2\u3059\u308b\u60c5\u5831\u306e\u4e2d\u306b\uff0c\u3082\u3068\u306e\u7cfb\u7d71\u304b\u3089\u5206\u5c90\u3057\u3066\u4f55\u4e16\u4ee3\u7d4c\u3066\u3044\u308b\u306e\u304b\u3092\u8868\u8a18\u3059\u3079\u304d\u3067\u3042\u308b\uff0e\u51fa\u7248\u7269\u306b\u95a2\u3057\u3066\u306f\uff0c\u6700\u521d\u306b\u5b8c\u5168\u306a\u7cfb\u7d71\u540d\u3092\u660e\u793a\u3057\u3066\u304a\u3051\u3070\uff0c\u5f8c\u306f\u7701\u7565\u3057\u3066\u3082\u3088\u3044\uff0e<\/p>\n

    3.5.\u3000\u4ea4\u96d1\u4ed4\uff08Hybrid\uff09<\/strong>
    \n2\u3064\u306e\u8fd1\u4ea4\u7cfb\u3092\u4ea4\u914d\u3057\u305f\u4ed4\u3067\uff0c\u7236\u6bcd\u306b\u3082\u3061\u3044\u308b\u8fd1\u4ea4\u7cfb\u3092\u305d\u308c\u305e\u308c\u305d\u308d\u3048\u3066\u4ea4\u914d\u3057\u3066\u3044\u308b\u30de\u30a6\u30b9\u306f\uff0c\u907a\u4f1d\u7684\u306b\u540c\u4e00\u3067\u3042\u308a\uff0c\u4e21\u65b9\u306e\u89aa\u7cfb\u7d71\u306e\u982d\u6587\u5b57\u3092\u7528\u3044\u3066\u8868\u8a18\u3057\uff08\u6bcd\u89aa\u306e\u7cfb\u7d71\u306e\u65b9\u3092\u5148\u306b\u8868\u8a18\uff09\uff0c\u305d\u306e\u5f8c\u308d\u306b\u201cF1\u201d\u3092\u4ed8\u8a18\u3059\u308b\uff0e\u7236\u6bcd\u3092\u9006\u306b\u3057\u3066\u4ea4\u914d\u3057\u305fF1\u4ea4\u96d1\u4ed4\u306f\uff0c\u3053\u308c\u3068\u306f\u907a\u4f1d\u7684\u306b\u540c\u4e00\u3067\u306f\u306a\u304f\uff0c\u305d\u306e\u8868\u8a18\u3082\u7570\u306a\u308b\uff0e<\/p>\n

    \u4f8b\uff1a<\/strong><\/p>\n\n\n\n\n
    D2B6F1<\/td>\n\u6bcd\u89aa\u3092DBA\/2\uff0c\u7236\u89aa\u3092C57BL\/6J\u7cfb\u7d71\u306e\u4ed4\u30de\u30a6\u30b9<\/td>\n<\/tr>\n
    B6D2F1<\/td>\n\u4e0a\u8a18\u3068\u306f\u53cd\u5bfe\u306e\u4ea4\u914d\u3067\u7523\u307e\u308c\u305f\u4ed4\u30de\u30a6\u30b9<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/blockquote>\n

    \u3055\u3089\u306a\u308b\u4ea4\u914d\u306b\u3088\u308a\u4ed4\u3092\u4f5c\u308b\u3053\u3068\u306f\u53ef\u80fd\u3067\u3042\u308b\u304c\uff0c\u3082\u306f\u3084\u907a\u4f1d\u7684\u306b\u306f\u540c\u4e00\u3067\u306f\u306a\u3044\u305f\u3081\uff0cF1\u4ea4\u96d1\u4ed4\u306e\u3088\u3046\u306b\u4ea4\u914d\u69d8\u5f0f\u3092\u8868\u3059\u540d\u524d\u3092\u3064\u3051\u305f\u65b9\u304c\u3088\u3044\uff0e<\/p>\n

    \u4f8b\uff1a<\/strong><\/p>\n\n\n\n\n
    D2B6F2<\/td>\nD2B6F1\u540c\u58eb\u306e\u4ea4\u914d\u306b\u3088\u308a\u7523\u307e\u308c\u305f\u4ed4\u30de\u30a6\u30b9<\/td>\n<\/tr>\n
    B6(D2AKRF1)<\/td>\n(DBA\/2\u00d7AKR\/J)\u306eF1\u4ed4\u3092C57BL\/6J\u306e\u96cc\u306b\u623b\u3057\u4ea4\u914d\u3057\u305f\u4ed4<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

    \u51fa\u7248\u7269\u306b\u304a\u3044\u3066\u4ea4\u96d1\u4ed4\u3084\u4ea4\u914d\u69d8\u5f0f\u306b\u3064\u3044\u3066\u8ff0\u3079\u308b\u3068\u304d\u306f\uff0c\u6700\u521d\u306b\u4e0a\u8a18\u306e\u3088\u3046\u306a\u5b8c\u5168\u306a\u7cfb\u7d71\u540d\u3092\u8868\u8a18\u3059\u308b\uff0e\u3082\u3057\u4ea4\u96d1\u4ed4\u3092\u4f5c\u88fd\u3059\u308b\u969b\u306b\uff0c\u907a\u4f1d\u7684\u306b\u3042\u308b\u3044\u306f\u5f62\u8cea\u304c\u3082\u3068\u306e\u7cfb\u7d71\u3068\u7570\u306a\u308b\u4e9c\u7cfb\u7d71\u3092\u7528\u3044\u3066\u3044\u308b\u5834\u5408\uff0c\u305d\u306e\u4e9c\u7cfb\u7d71\u540d\u3092\u540d\u524d\u306e\u4e2d\u306b\u3044\u308c\u308b\u3079\u304d\u3067\u3042\u308b\uff0e\uff08\u4f8b\uff1aBALB\/cBy\u306e\u5834\u5408\uff0cC\u3067\u306f\u306a\u304fCby\u3092\u7528\u3044\u308b\uff0eC3H\/HeSn\u306e\u5834\u5408\uff0cC3H\u3067\u306f\u306a\u304fC3Sn\u3092\u7528\u3044\u308b\uff0e\uff09<\/p><\/blockquote>\n

    \u4e00\u822c\u7684\u306a\u30de\u30a6\u30b9\u7cfb\u7d71\u306b\u8a8d\u3081\u3089\u308c\u3066\u3044\u308b\u7565\u53f7\u306f\uff0c\u4e0b\u8a18\u306b\u6319\u3052\u308b\u3068\u304a\u308a\uff0e<\/p>\n

    \u4f8b\uff1a<\/strong><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
    129<\/td>\n129\uff08\u30b5\u30d6\u30bf\u30a4\u30d7\u3092\u542b\u3080\u5834\u5408\u3082\u3042\u308b\uff0e\u4f8b\uff1a129S7\uff09<\/td>\n<\/tr>\n
    129P<\/td>\n129P3<\/td>\n<\/tr>\n
    129S<\/td>\n129S1<\/td>\n<\/tr>\n
    A<\/td>\nA<\/td>\n<\/tr>\n
    A\/He<\/td>\nAHe<\/td>\n<\/tr>\n
    AK<\/td>\nAKR<\/td>\n<\/tr>\n
    B<\/td>\nB57BL<\/td>\n<\/tr>\n
    B6<\/td>\nC57BL\/6<\/td>\n<\/tr>\n
    B6Ei<\/td>\nC57BL\/6Ei<\/td>\n<\/tr>\n
    B10<\/td>\nC57BL\/10<\/td>\n<\/tr>\n
    BR<\/td>\nC57BR\/cd<\/td>\n<\/tr>\n
    C<\/td>\nBALB\/c<\/td>\n<\/tr>\n
    CBy<\/td>\nBALB\/cBy<\/td>\n<\/tr>\n
    CB<\/td>\nCBA<\/td>\n<\/tr>\n
    CBACa<\/td>\nCBA\/Ca<\/td>\n<\/tr>\n
    C3<\/td>\nC3H<\/td>\n<\/tr>\n
    D1<\/td>\nDBA\/1<\/td>\n<\/tr>\n
    D2<\/td>\nDBA\/2<\/td>\n<\/tr>\n
    HR<\/td>\nHRS\/J<\/td>\n<\/tr>\n
    L<\/td>\nC57L\/J<\/td>\n<\/tr>\n
    NZB<\/td>\nNZB<\/td>\n<\/tr>\n
    NZW<\/td>\nNZW<\/td>\n<\/tr>\n
    R3<\/td>\nRIIIS\/J<\/td>\n<\/tr>\n
    J or SJL<\/td>\nSJL<\/td>\n<\/tr>\n
    SW<\/td>\nSWR<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

     <\/p><\/blockquote>\n

    4.\u3000\u8907\u6570\u306e\u8fd1\u4ea4\u7cfb\u304b\u3089\u4f5c\u51fa\u3055\u308c\u305f\u7cfb\u7d71<\/strong>
    \n\u907a\u4f1d\u7684\u80cc\u666f\u304c\u660e\u78ba\u3067\uff0c2\u3064\u4ee5\u4e0a\u306e\u8fd1\u4ea4\u7cfb\u304b\u3089\u4f5c\u51fa\u3055\u308c\u305f\u7cfb\u7d71\u306f\uff0c\u907a\u4f1d\u7684\u306b\u540c\u4e00\u3067\u3042\u308b\u5834\u5408\u3068\uff0c\u7570\u306a\u308b\u5834\u5408\u3068\u304c\u3042\u308b\uff0e\u305d\u306e\u4f5c\u51fa\u3055\u308c\u305f\u4ea4\u914d\u65b9\u6cd5\u306b\u5f93\u3063\u3066\uff0c\u9069\u5207\u306b\u8868\u8a18\u3059\u308b\uff0e<\/p>\n

    4.1.\u3000\u30ea\u30b3\u30f3\u30d3\u30ca\u30f3\u30c8\u8fd1\u4ea4\u7cfb\uff08Recombinant Inbred Strain\uff09<\/strong>
    \n\u30ea\u30b3\u30f3\u30d3\u30ca\u30f3\u30c8\uff08RI\uff09\u7cfb\u7d71\u306f\uff0c2\u3064\u306e\u8fd1\u4ea4\u7cfb\u3092\u4ea4\u914d\u3057\uff0c\u305d\u306e\u5f8c\uff0c20\u4e16\u4ee3\u4ee5\u4e0a\u306e\u5144\u59b9\u4ea4\u914d\u3092\u7d9a\u3051\u308b\u3053\u3068\u306b\u3088\u308a\u4f5c\u51fa\u3059\u308b\uff08Bailey, 1971; Taylor, 1978\uff09\uff0e\u30ea\u30b3\u30f3\u30d3\u30ca\u30f3\u30c8\u7cfb\u7d71\u306f\uff0c\u4e21\u65b9\u306e\u89aa\u7cfb\u7d71\u306e\u7565\u8a9e\uff081\uff0c2\u6587\u5b57\uff09\u3092\u7528\u3044\u3066\uff0c\u6bcd\u89aa\u7cfb\u7d71\u3092\u5148\u306b\u3057\u3066\u8868\u8a18\u3059\u308b\uff0e\u9593\u306b\u306f\u30b9\u30da\u30fc\u30b9\u3092\u5165\u308c\u305a\u306b\u5927\u6587\u5b57\u306e\u201cX\u201d\u3067\u4e21\u89aa\u7cfb\u7d71\u3092\u5206\u3051\u308b\uff0e<\/p>\n

    \u4f8b\uff1a<\/strong><\/p>\n\n\n\n
    CXB<\/td>\nBALB\/c\u00d7C57BL\/6J\u306e\u4ea4\u96d1\u306b\u7531\u6765<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/blockquote>\n

    \u8907\u6570\u306e\u30ea\u30b3\u30f3\u30d3\u30ca\u30f3\u30c8\u7cfb\u7d71\u306b\u306f\uff0c\u901a\u3057\u756a\u53f7\u3092\u4ed8\u8a18\u3059\u308b\uff0e<\/p>\n

    \u4f8b\uff1a<\/strong>
    \nBXD1\uff0cBXD2\uff0cBXD3
    \n\uff1aC57BL\/6\u00d7DBA\/2\u306e\u4ea4\u96d1\u304b\u3089\u751f\u3058\u305f\u30ea\u30b3\u30f3\u30d3\u30ca\u30f3\u30c8\u8fd1\u4ea4\u7cfb\u30de\u30a6\u30b9\u3067\uff0cBXD\u30bb\u30c3\u30c8\u306e\u30e1\u30f3\u30d0\u30fc\uff0e<\/p>\n

    SMXA1\uff0cSMXA2\uff0cSMXA3
    \n\uff1aSM\/J\u00d7A\/J\u306e\u4ea4\u96d1\u304b\u3089\u751f\u3058\u305f\u30ea\u30b3\u30f3\u30d3\u30ca\u30f3\u30c8\u8fd1\u4ea4\u7cfb\u30de\u30a6\u30b9\u3067\uff0cSMXA\u30bb\u30c3\u30c8\u306e\u30e1\u30f3\u30d0\u30fc\uff0e<\/p>\n

    \u3082\u30572\u756a\u76ee\uff08\u7236\u89aa\uff09\u306e\u7cfb\u7d71\u306e\u7565\u53f7\u304c\u6570\u5b57\u3067\u7d42\u308f\u308b\u5834\u5408\uff08\u4f8b\uff1aCX8 RI\u7cfb\u7d71\uff09\uff0c\u7cfb\u7d71\u306e\u7565\u53f7\u3068\u901a\u3057\u756a\u53f7\u3092\u5206\u3051\u308b\u305f\u3081\u306b\u30cf\u30a4\u30d5\u30f3\u201c\uff0d\u201d\u3092\u7528\u3044\u308b\uff08\u4f8b\uff1aCX8-1\uff09\uff0e<\/p><\/blockquote>\n

    \u30ea\u30b3\u30f3\u30d3\u30ca\u30f3\u30c8\u7cfb\u7d71\u306f\uff0c\u591a\u56e0\u5b50\u5f62\u8cea\u306e\u907a\u4f1d\u89e3\u6790\u306e\u305f\u3081\u306b\uff0c\u4e92\u3044\u306b\u4ea4\u914d\u3059\u308b\u3053\u3068\u304c\u3042\u308b\uff0e\u305d\u306e\u5834\u5408\u306eF1\u4e16\u4ee3\u306f\uff0cRecombinant inbred intercrosses\uff08RIX\uff09\u3068\u547c\u3070\u308c\uff0c\u4ed6\u306e\u8fd1\u4ea4\u7cfb\u9593\u306eF1\u4e16\u4ee3\u3068\u540c\u3058\u3088\u3046\u306b\u8868\u8a18\u3059\u308b\uff0e<\/p>\n

    \u4f8b\uff1a<\/strong><\/p>\n\n\n\n
    (BXD1\/Ty\u00d7AXB19\/Pgn)F1<\/td>\n\u96cc\u306eBXD1\/Ty RI\u7cfb\u7d71\u3068\u96c4\u306eAXB19\/Pgn RI\u7cfb\u7d71\u3068\u306eF1\u4e16\u4ee3<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

     <\/p><\/blockquote>\n

    4.2.\u3000\u30df\u30c3\u30af\u30b9\u7cfb\u7d71\uff08Mixed Inbred Strains\uff09<\/strong>
    \n2\u3064\u306e\u89aa\u7cfb\u7d71\uff08\u3046\u30611\u3064\u306f\u907a\u4f1d\u5b50\u304c\u7d44\u307f\u63db\u3048\u3089\u308c\u305fES\u7d30\u80de\u682a\uff09\u304b\u3089\u4f5c\u51fa\u3055\u308c\u305f\u8fd1\u4ea4\u7cfb\uff0c\u3042\u308b\u3044\u306f\u8fd1\u4ea4\u7cfb\u306b\u306a\u308b\u524d\u306e\u7cfb\u7d71\u306f\uff0c2\u3064\u306e\u7cfb\u7d71\u306e\u5927\u6587\u5b57\u7565\u53f7\u3092\u30bb\u30df\u30b3\u30ed\u30f3\u201c\uff1b\u201d\u3067\u5206\u3051\u3066\u8868\u8a18\u3059\u308b\uff0e\u30e9\u30dc\u30b3\u30fc\u30c9\u3068\u901a\u3057\u756a\u53f7\u306f\uff0c\u7570\u306a\u308b\u7814\u7a76\u6240\u3067\u4f5c\u3089\u308c\u305f\u7cfb\u7d71\u3084\uff0c\u3042\u308b\u3044\u306f\u540c\u3058\u7814\u7a76\u6240\u306e\u8907\u6570\u306e\u7cfb\u7d71\u3092\u533a\u5225\u3059\u308b\u305f\u3081\u306b\u7528\u3044\u308b\uff0e\u3053\u308c\u3089\u306e\u540d\u79f0\u306f\uff0c\u5b8c\u5168\u306a\u8fd1\u4ea4\u7cfb\u306b\u306a\u308b\u524d\u306e\u30df\u30c3\u30af\u30b9\u7cfb\u7d71\uff08\u30b9\u30c8\u30c3\u30af\uff09\u306b\u304a\u3044\u3066\u4f7f\u308f\u308c\u308b\u5834\u5408\u3082\u3042\u308a\uff0c\u5341\u5206\u306a\u8fd1\u4ea4\u4e16\u4ee3\u6570\uff08\u4f8b\uff1a\uff1e20\u4e16\u4ee3\uff09\u306b\u306a\u3063\u3066\u304b\u3089\uff0c\u8fd1\u4ea4\u7cfb\u306b\u3059\u3079\u304d\u3067\u3042\u308b\uff0e<\/p>\n

    \u4f8b\uff1a<\/strong><\/p>\n\n\n\n
    B6;129P2-Gfaptm1Ito<\/sup><\/em><\/td>\nGfap<\/em> \u907a\u4f1d\u5b50\u3092\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u3057\u305f129P2\/OlaHsd\u7d30\u80de\u682a\u3068C57BL\/6J\u7cfb\u7d71\u304b\u3089\u4f5c\u51fa\u3055\u308c\u305f\u30df\u30c3\u30af\u30b9\u7cfb\u7d71\uff0e129P2\u7cfb\u7d71\uff08ES\u7d30\u80de\u7531\u6765\uff09\u3068B6\u7cfb\u7d71\u3068\u304c\u6df7\u3056\u3063\u305f\u80cc\u666f\u3067\u3042\u308b\uff0e<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/blockquote>\n

    2\u3064\u4ee5\u4e0a\u306e\u89aa\u7cfb\u7d71\u3092\u7531\u6765\u3059\u308b\u7cfb\u7d71\uff0c\u8fd1\u4ea4\u5316\u521d\u671f\u6bb5\u968e\u306e\u7cfb\u7d71\uff0c\u3042\u308b\u3044\u306f\u672a\u77e5\u306e\u7531\u6765\u304b\u3089\u907a\u4f1d\u7684\u5f71\u97ff\u3092\u53d7\u3051\u3066\u3044\u308b\u30df\u30e5\u30fc\u30bf\u30f3\u30c8\u7cfb\u7d71\u306f\uff0c\u201c\u30df\u30c3\u30af\u30b9\u8fd1\u4ea4\u7cfb\u201d\u3068\u3057\uff0c\u201cSTOCK\u201d\u3068\u3044\u3046\u8868\u8a18\u306e\u5f8c\u306b\u30b9\u30da\u30fc\u30b9\uff08\u30cf\u30a4\u30d5\u30f3\u7121\u3057\uff09\u3068\uff0c\u751f\u3058\u305f\u907a\u4f1d\u7684\u5909\u7570\u3042\u308b\u3044\u306f\u67d3\u8272\u4f53\u7570\u5e38\u3092\u7d9a\u3051\u3066\u8868\u8a18\u3059\u308b\uff0e<\/p>\n

    \u4f8b\uff1a<\/strong><\/p>\n\n\n\n
    STOCK Rb(X.2)2Ad<\/td>\n\u30ed\u30d0\u30fc\u30c8\u30bd\u30f3\u578b\u8ee2\u5ea7(X.2)2Ad\u3092\u6709\u3059\u308b\uff0c\u672a\u77e5\u3042\u308b\u3044\u306f\u8907\u96d1\u306a\u907a\u4f1d\u7684\u80cc\u666f\u306e\u8fd1\u4ea4\u7cfb\uff0e<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/blockquote>\n

    \u3053\u306e\u3088\u3046\u306a\u30df\u30e5\u30fc\u30bf\u30f3\u30c8\u7cfb\u7d71\u304c\u8fd1\u4ea4\u5316\u3055\u308c\u305f\u5f8c\u306f\uff0c\u9069\u5f53\u306a\u7cfb\u7d71\u540d\u3092\u3064\u3051\u308b\uff0e\u30df\u30e5\u30fc\u30bf\u30f3\u30c8\u306b\u95a2\u3059\u308b\u8868\u8a18\u304c\u77ed\u3051\u308c\u3070\uff0c\u305d\u306e\u8868\u8a18\u3092\u5168\u3066\u5927\u6587\u5b57\u3067\uff0c\u305d\u306e\u307e\u307e\u7528\u3044\u3066\u3082\u3088\u3044\uff0e\u7cfb\u7d71\u540d\u306e\u5909\u66f4\u306f\u7814\u7a76\u8005\u306b\u4efb\u3055\u308c\u3066\u3044\u308b\u306e\u3067\uff0c\u5909\u66f4\u3092\u5f37\u304f\u52e7\u3081\u3066\u306f\u3044\u308b\u304c\uff0c\u201cSTOCK\u201d\u3068\u8868\u8a18\u3055\u308c\u305f\u7cfb\u7d71\u540d\u304c\uff0c\u305d\u306e\u307e\u307e\u8fd1\u4ea4\u7cfb\u306b\u4f7f\u308f\u308c\u3066\u3044\u308b\u5834\u5408\u304c\u3042\u308b\uff0e<\/p>\n

    \u4f8b\uff1a<\/strong><\/p>\n\n\n\n
    JIGR\/Dn<\/td>\ngr<\/em>\uff08grizzled\uff09\u3068ji<\/em>\uff08jittery\uff09\u306e\u907a\u4f1d\u7684\u5909\u7570\u3092\u3082\u3061\uff0c\u30df\u30c3\u30af\u30b9\u3057\u305f\u907a\u4f1d\u7684\u80cc\u666f\u306e\u30b3\u30ed\u30cb\u30fc\u304b\u3089\u958b\u767a\u3055\u308c\u305f\u8fd1\u4ea4\u7cfb<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/blockquote>\n

    \u5909\u7570\u5bfe\u7acb\u907a\u4f1d\u5b50\uff08mutant allele\uff09\u3084\u67d3\u8272\u4f53\u5909\u7570\u3092\u3082\u3064\u52d5\u7269\u3092\uff0c\u6bce\u4e16\u4ee3\uff0c\u3042\u308b\u3044\u306f\u9694\u4e16\u4ee3\u3054\u3068\u306bF1\u4ea4\u96d1\u4ed4\u3068\u4ea4\u914d\u3057\u306a\u304c\u3089\u7dad\u6301\u3057\u3066\u3044\u308b\u5834\u5408\uff0c\u305d\u306e\u7cfb\u7d71\u540d\u306f\uff0cF1\u4ea4\u96d1\u4ed4\u3092\u8868\u3059\u8868\u8a18\u306e\u63a5\u5c3e\u8f9e\u201cF1\u201d\u3092\u4ed8\u3051\u305a\uff0c\u305d\u306e\u5f8c\u306b\u9069\u5207\u306a\u5bfe\u7acb\u907a\u4f1d\u5b50\u540d\uff0c\u3042\u308b\u3044\u306f\u67d3\u8272\u4f53\u7570\u5e38\u3092\u8868\u3059\u8868\u8a18\u3092\u7d9a\u3051\u308b\uff0e<\/p>\n

    \u4f8b\uff1a<\/strong><\/p>\n\n\n\n
    B6CBA-Tg(HDexon1)62Gpb<\/td>\nTg(HDexon1)62Gpb\u5c0e\u5165\u907a\u4f1d\u5b50\u306f\uff0cB6CBAF1\u306b\u6bce\u4e16\u4ee3\u4ea4\u914d\u3057\u306a\u304c\u3089\u7dad\u6301\u3055\u308c\u3066\u3044\u308b\u304c\uff0c\u7cfb\u7d71\u305d\u308c\u81ea\u4f53\u306fF1\u3067\u306f\u306a\u3044\uff0e<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/blockquote>\n

    4.3.\u3000\u30ea\u30b3\u30f3\u30d3\u30ca\u30f3\u30c8\u30b3\u30f3\u30b8\u30a7\u30cb\u30c3\u30af\u7cfb\u7d71\uff08Recombinant Congenic Strains\uff09<\/strong>
    \n\u30ea\u30b3\u30f3\u30d3\u30ca\u30f3\u30c8\u30b3\u30f3\u30b8\u30a7\u30cb\u30c3\u30af\uff08RC\uff09\u7cfb\u7d71\u306e\u4f5c\u51fa\u306f\uff0c2\u3064\u306e\u8fd1\u4ea4\u7cfb\u3092\u4ea4\u914d\u3057\uff0c\u305d\u306e\u4ed4\u3092\u4e00\u65b9\u306e\u89aa\u7cfb\u7d71\uff08\u30ec\u30b7\u30d4\u30a8\u30f3\u30c8\u7cfb\u7d71\uff09\u306b\u6570\u56de\uff08\u901a\u5e38\u306f2\u56de\uff09\u623b\u3057\u4ea4\u914d\u3057\uff0c\u305d\u306e\u5f8c\u306f\uff0c\u30de\u30fc\u30ab\u30fc\u306e\u9078\u5225\u3092\u305b\u305a\u306b\u8fd1\u89aa\u4ea4\u914d\u3060\u3051\u3067\u7dad\u6301\u3059\u308b\uff08Demant and Hart, 1986\uff09\uff0e\u3053\u306e\u3088\u3046\u306a\u8fd1\u4ea4\u7cfb\u306f\uff0c\u30ec\u30b7\u30d4\u30a8\u30f3\u30c8\u7cfb\u7d71\u306e\u907a\u4f1d\u7684\u80cc\u666f\u3092\u3082\u3061\uff0c\u30c9\u30ca\u30fc\u7cfb\u7d71\u306e\u30db\u30e2\u9818\u57df\u304c\u67d3\u8272\u4f53\u4e0a\u306b\u6563\u5728\u3059\u308b\uff0e\u30ea\u30b3\u30f3\u30d3\u30ca\u30f3\u30c8\u30b3\u30f3\u30b8\u30a7\u30cb\u30c3\u30af\u7cfb\u7d71\u306b\u304a\u3051\u308b\u30c9\u30ca\u30fc\u7cfb\u7d71\u306e\u67d3\u8272\u4f53\u9818\u57df\u306e\u5272\u5408\u306f\uff0c\u623b\u3057\u4ea4\u914d\u306e\u6570\u306b\u3088\u3063\u3066\u6c7a\u307e\u308b\uff0e2\u56de\u306e\u623b\u3057\u4ea4\u914d\u3067\uff0c\u5e73\u574712.5%\u306e\u30c9\u30ca\u30fc\u7cfb\u7d71\u306e\u67d3\u8272\u4f53\u9818\u57df\u304c\u6b8b\u3063\u3066\u3044\u308b\uff0e<\/p>\n

    \u30ea\u30b3\u30f3\u30d3\u30ca\u30f3\u30c8\u30b3\u30f3\u30b8\u30a7\u30cb\u30c3\u30af\u7cfb\u7d71\u306f\uff0c\u7406\u8ad6\u4e0a\u306e\u8fd1\u4ea4\u4fc2\u6570\u304c\uff0c\u901a\u5e38\u306e\u8fd1\u4ea4\u7cfb\u306e\u4fc2\u6570\u3068\u540c\u3058\u5024\u306b\u306a\u3063\u305f\u3068\u304d\uff0c\u5b8c\u5168\u306a\u8fd1\u4ea4\u7cfb\u3068\u898b\u306a\u3059\uff0e\u3053\u306e\u5834\u5408\uff0c\u623b\u3057\u4ea4\u914d\u306e\u201c1\u4e16\u4ee3\u201d\u306f\u5144\u59b9\u4ea4\u914d\u306e\u201c2\u4e16\u4ee3\u201d\u5206\u306b\u3042\u305f\u308b\u3068\u8003\u3048\u3066\u3088\u3044\uff0e\u3059\u306a\u308f\u3061\uff0c2\u5ea6\u306e\u623b\u3057\u4ea4\u914d\uff08N3\u306fF6\u306b\u7b49\u3057\u3044\uff09\u3092\u3057\u305f\u5f8c\uff0c14\u4e16\u4ee3\u306e\u5144\u59b9\u4ea4\u914d\uff08F14\uff09\u3092\u3057\u305f\u5834\u5408\uff0c\u5b8c\u5168\u306a\u8fd1\u4ea4\u7cfb\u3068\u306a\u308b\uff0e
    \n\u30ea\u30b3\u30f3\u30d3\u30ca\u30f3\u30c8\u30b3\u30f3\u30b8\u30a7\u30cb\u30c3\u30af\u7cfb\u7d71\u306f\uff0c2\u3064\u306e\u89aa\u7cfb\u7d71\u306e\u5927\u6587\u5b57\u7565\u53f7\u3092\u7528\u3044\u3066\u8868\u8a18\u3059\u308b\uff0e\u30ec\u30b7\u30d4\u30a8\u30f3\u30c8\u7cfb\u7d71\u3092\u6700\u521d\u306b\u304a\u304d\uff0c\u5c0f\u6587\u5b57\u306e\u201cc\u201d\u3067\u5206\u3051\u308b\uff0e<\/p>\n

    \u4f8b\uff1a<\/strong><\/p>\n\n\n\n
    CcS<\/td>\nBALB\/c\u30ec\u30b7\u30d4\u30a8\u30f3\u30c8\u7cfb\u7d71\uff0cSTS\u30c9\u30ca\u30fc\u7cfb\u7d71\u306e\u30ea\u30b3\u30f3\u30d3\u30ca\u30f3\u30c8\u30b3\u30f3\u30b8\u30a7\u30cb\u30c3\u30af\u7cfb\u7d71<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/blockquote>\n

    \u8907\u6570\u306e\u30ea\u30b3\u30f3\u30d3\u30ca\u30f3\u30c8\u30b3\u30f3\u30b8\u30a7\u30cb\u30c3\u30af\u7cfb\u7d71\u306b\u306f\u901a\u3057\u756a\u53f7\u3092\u3075\u308b\uff0e<\/p>\n

    \u4f8b\uff1a<\/strong>
    \nCcS1\uff0cCcS2\uff0cCcS3\u306a\u3069\uff0e<\/blockquote>\n

    2\u756a\u76ee\uff08\u30c9\u30ca\u30fc\uff09\u7cfb\u7d71\u306e\u7565\u53f7\u304c\u6570\u5b57\u3067\u7d42\u308f\u308b\u5834\u5408\uff0c\u901a\u3057\u756a\u53f7\u3068\u533a\u5225\u3059\u308b\u305f\u3081\u306b\u30cf\u30a4\u30d5\u30f3\u201c\uff0d\u201d\u3092\u7528\u3044\u308b\uff0e<\/p>\n

    \u4f8b\uff1a<\/strong>
    \nNcX1-1\uff0cNcX1-2
    \n\uff1aNC\/Jic\u30ec\u30b7\u30d4\u30a8\u30f3\u30c8\u7cfb\u7d71\uff0c129X1\/SvJ\u30c9\u30ca\u30fc\u7cfb\u7d71\u306eRC\u7cfb\u7d71\u30bb\u30c3\u30c8\u306e\u30e1\u30f3\u30d0\u30fc\uff0e<\/blockquote>\n

    4.4.\u3000Advanced Intercross Lines\uff08AIL\u7cfb\u7d71\uff09<\/strong>
    \nAdvanced intercross line\uff08AIL\uff09\u306f\uff0c2\u3064\u306e\u8fd1\u4ea4\u7cfb\u9593\u3067F2\u4e16\u4ee3\u3092\u4f5c\u51fa\u3057\uff0c\u305d\u306e\u5f8c\uff0c\u5144\u59b9\u4ea4\u914d\u3092\u907f\u3051\u306a\u304c\u3089\uff0c\u304a\u4e92\u3044\u306b\u4ea4\u914d\u3059\u308b\u3053\u3068\u3067\u4f5c\u51fa\u3059\u308b\uff08Darvasi and Soller, 1995\uff09\uff0e\u3053\u306e\u65b9\u6cd5\u306f\uff0c\u975e\u5e38\u306b\u8fd1\u63a5\u3057\u305f\u907a\u4f1d\u5b50\u5ea7\u9593\u306e\u7d44\u307f\u63db\u3048\u304c\u751f\u3058\u308b\u53ef\u80fd\u6027\u3092\u9ad8\u3081\u308b\u305f\u3081\u306b\u7528\u3044\u3089\u308c\u308b\uff0e<\/p>\n

    \u8868\u8a18\u306f\uff0c\u306f\u3058\u3081\u306b\u305d\u306e\u30e9\u30a4\u30f3\u3092\u4f5c\u51fa\u3057\u305f\u7814\u7a76\u6240\u306e\u30e9\u30dc\u30b3\u30fc\u30c9\u306b\u30b3\u30ed\u30f3\u201c\uff1a\u201d\u3092\u3064\u3051\uff0c\u30ab\u30f3\u30de\u201c\uff0c\u201d\u306b\u3088\u3063\u3066\u533a\u5207\u3089\u308c\u305f2\u3064\u306e\u8fd1\u4ea4\u7cfb\u306e\u7565\u8a9e\u3092\u8a18\u3057\uff0c\u6700\u5f8c\u306b\u30cf\u30a4\u30d5\u30f3\u201c\uff0d\u201d\u3092\u3064\u3051\u4e16\u4ee3\u6570\u3092\u3064\u3051\u308b\uff0e\u4e16\u4ee3\u6570\u306f\uff0cF2\u4e16\u4ee3\u306e\u5f8c\u306e\u4ea4\u914d\u304b\u3089\u306e\u6570\u3092G3\uff0cG4\u306e\u3088\u3046\u306b\u8868\u8a18\u3059\u308b\uff0e<\/p>\n

    \u4f8b\uff1a<\/strong><\/p>\n\n\n\n
    Pri:B6,D2-G#<\/td>\nPrinceton\u306e\u7814\u7a76\u5ba4\u306b\u304a\u3044\u3066\uff0cC57BL\/6\u3068DBA\/2\u7cfb\u7d71\u304b\u3089\u4f5c\u6210\u3055\u308c\u305fAIL\u7cfb\u7d71\uff0e\u201cG\u201d\u306e\u5f8c\u306b\u3064\u3051\u3089\u308c\u308b\u6570\u5b57\u306f\u4e16\u4ee3\u3068\u3068\u3082\u306b\u5897\u52a0\u3059\u308b\uff0e<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/blockquote>\n

    5\uff0e\u30b3\u30a2\u30a4\u30bd\u30b8\u30a7\u30cb\u30c3\u30af\uff0c\u30b3\u30f3\u30b8\u30a7\u30cb\u30c3\u30af\uff0c\u30bb\u30b0\u30ea\u30b2\u30a4\u30c6\u30a3\u30f3\u30b0\u7cfb\u7d71<\/strong>
    \n\u67d3\u8272\u4f53\u4e0a\u306e\u307b\u3093\u306e\u50c5\u304b\u306a\u9818\u57df\u3060\u3051\u304c\u7570\u306a\u308b\u8fd1\u4ea4\u7cfb\u3092\u8868\u8a18\u3059\u308b\u306b\u306f\uff0c\u3044\u304f\u3064\u304b\u306e\u65b9\u6cd5\u304c\u3042\u308b\uff0e<\/p>\n

    5.1.\u3000\u30b3\u30a2\u30a4\u30bd\u30b8\u30a7\u30cb\u30c3\u30af\u7cfb\u7d71\uff08Coisogenic Strains\uff09<\/strong>
    \n\u30b3\u30a2\u30a4\u30bd\u30b8\u30a7\u30cb\u30c3\u30af\u7cfb\u7d71\u3068\u306f\uff0c\u907a\u4f1d\u7684\u5909\u7570\u306b\u3088\u3063\u3066\u4e00\u3064\u306e\u907a\u4f1d\u5b50\u5ea7\u3060\u3051\u304c\u7570\u306a\u3063\u305f\u8fd1\u4ea4\u7cfb\u3067\u3042\u308b\uff0eES\u7d30\u80de\u304b\u3089\u4f5c\u6210\u3055\u308c\u305f\u7cfb\u7d71\u306f\uff0cES\u7d30\u80de\u304c\u7531\u6765\u3059\u308b\u8fd1\u4ea4\u7cfb\u306b\u4ea4\u914d\u3055\u308c\uff0c\u7dad\u6301\u3055\u308c\u3066\u3044\u308b\u5834\u5408\u306b\u306f\uff0c\u30b3\u30a2\u30a4\u30bd\u30b8\u30a7\u30cb\u30c3\u30af\u7cfb\u7d71\u3068\u307f\u306a\u3059\u3053\u3068\u304c\u3067\u304d\u308b\uff0e\u3057\u304b\u3057\u306a\u304c\u3089\uff0c\u305d\u308c\u4ee5\u5916\u306e\u67d3\u8272\u4f53\u4e0a\u306b\u907a\u4f1d\u7684\u5909\u7570\u304c\u5b58\u5728\u3059\u308b\u53ef\u80fd\u6027\u3082\u8003\u616e\u306b\u5165\u308c\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044\uff0e\u540c\u69d8\u306b\uff0c\u5316\u5b66\u7269\u8cea\uff0c\u3042\u308b\u3044\u306f\u653e\u5c04\u7dda\u306a\u3069\u306b\u3088\u308a\u8a98\u767a\u3055\u308c\u305f\u30df\u30e5\u30fc\u30bf\u30f3\u30c8\u52d5\u7269\u306f\u30b3\u30a2\u30a4\u30bd\u30b8\u30a7\u30cb\u30c3\u30af\u7cfb\u7d71\u3068\u307f\u306a\u3059\u3053\u3068\u304c\u3067\u304d\u308b\u304c\uff0c\u30b2\u30ce\u30e0\u4e0a\u306b\u306f\u305d\u306e\u4ed6\u306e\u907a\u4f1d\u7684\u5909\u7570\u304c\u5b58\u5728\u3059\u308b\u304b\u3082\u3057\u308c\u306a\u3044\uff0e\u3057\u305f\u304c\u3063\u3066\uff0c\u30b3\u30a2\u30a4\u30bd\u30b8\u30a7\u30cb\u30c3\u30af\u7cfb\u7d71\u306f\uff0c\u5b9a\u671f\u7684\u306b\u89aa\u7cfb\u7d71\u306b\u623b\u3057\u4ea4\u914d\u3092\u3057\u306a\u3051\u308c\u3070\uff0c\u907a\u4f1d\u7684\u6d6e\u52d5\u306b\u3088\u308a\uff0c\u6642\u9593\u3068\u3068\u3082\u306b\u89aa\u7cfb\u7d71\u3068\u306f\u907a\u4f1d\u7684\u5dee\u7570\u304c\u751f\u3058\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\uff0e<\/p>\n

    \u30b3\u30a2\u30a4\u30bd\u30b8\u30a7\u30cb\u30c3\u30af\u7cfb\u7d71\u306f\uff0c\u7cfb\u7d71\u540d\uff08\u4e9c\u7cfb\u7d71\u540d\uff08\u30e9\u30dc\u30b3\u30fc\u30c9\uff09\u306f\u3053\u3053\u306b\u3064\u3051\u308b\uff09\u3068\u30cf\u30a4\u30d5\u30f3\u201c\uff0d\u201d\u306e\u5f8c\u306b\uff0c\u7570\u306a\u308b\u907a\u4f1d\u5b50\u5ea7\u540d\u3092\u30a4\u30bf\u30ea\u30c3\u30af\u4f53\u3067\u7d9a\u3051\u3066\u8868\u8a18\u3059\u308b\uff0e<\/p>\n

    \u4f8b\uff1a<\/strong><\/p>\n\n\n\n\n
    129S7\/SvEvBrd-Fyntm1Sor<\/sup><\/em><\/td>\n129S7\/SvEvBrd\u7cfb\u7d71\u304b\u3089\u7531\u6765\u3059\u308bAB1 ES\u7d30\u80de\u682a\u3092\u7528\u3044\u3066\uff0cFyn<\/em>\u907a\u4f1d\u5b50\u5909\u7570\u304c\u4f5c\u6210\u3055\u308c\u305f\uff0e\u30ad\u30e1\u30e9\u52d5\u7269\u306f129S7\/SvEvBrd\u7cfb\u7d71\u306b\u4ea4\u914d\u3057\u3066\u4f5c\u3089\u308c\uff0c\u907a\u4f1d\u5b50\u5ea7\u306f\u3053\u306e\u30b3\u30a2\u30a4\u30bd\u30b8\u30a7\u30cb\u30c3\u30af\u7cfb\u7d71\u3067\u7dad\u6301\u3055\u308c\u3066\u3044\u308b\uff0e<\/td>\n<\/tr>\n
    C3H\/HeJNem-ruf<\/em><\/td>\nC3H\/HeJNem\u7cfb\u7d71\u306b\u304a\u3051\u308brough fur\u30df\u30e5\u30fc\u30bf\u30f3\u30c8\u30de\u30a6\u30b9<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/blockquote>\n

    \u3053\u306e\u3088\u3046\u306a\u907a\u4f1d\u7684\u5909\u7570\u306f\uff0c\u30d8\u30c6\u30ed\u63a5\u5408\u4f53\u306e\u72b6\u614b\u3067\u7dad\u6301\u3055\u308c\u3066\u3044\u308b\u5834\u5408\u304c\u3042\u308b\uff0e\u3057\u305f\u304c\u3063\u3066\uff0c\u7cfb\u7d71\u306e\u540d\u79f0\u304c\uff0c\u304b\u306a\u3089\u305a\u3057\u3082\u7e41\u6b96\u65b9\u6cd5\u3084\u4f5c\u51fa\u3055\u308c\u305f\u52d5\u7269\u306e\u907a\u4f1d\u5b50\u578b\u3092\u8868\u3057\u3066\u3044\u308b\u8a33\u3067\u306f\u306a\u3044\u3053\u3068\u306b\u6ce8\u610f\u3059\u3079\u304d\u3067\u3042\u308b\uff0e<\/p>\n

    \u4f8b\uff1a<\/strong><\/p>\n\n\n\n
    C57BL\/6J-cph<\/em><\/td>\nC57BL\/6J\u7cfb\u7d71\u306b\uff0c\u5148\u5929\u6027\u9032\u884c\u6027\u6c34\u814e\u75c7\u306e\u7a81\u7136\u5909\u7570\u304c\u751f\u3058\u305f\u30b3\u30a2\u30a4\u30bd\u30b8\u30a7\u30cb\u30c3\u30af\u7cfb\u7d71\u3060\u304c\uff0c\u30db\u30e2\u500b\u4f53\u306f\u901a\u5e38\uff0c\u5e7c\u9f62\u3067\u81f4\u6b7b\u306e\u305f\u3081\uff0c\u3053\u306e\u7cfb\u7d71\u306f+\/cph<\/em>\u00d7+\/cph<\/em>\u306e\u30d8\u30c6\u30ed\u540c\u58eb\u306e\u4ea4\u914d\u306b\u3088\u3063\u3066\u7dad\u6301\u3055\u308c\u308b\uff0e<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/blockquote>\n

    \u30b3\u30a2\u30a4\u30bd\u30b8\u30a7\u30cb\u30c3\u30af\u7cfb\u7d71\u306b\u304a\u3044\u3066\uff0c\u7a81\u7136\u5909\u7570\u304c\u751f\u3058\u3066\u304b\u3089\u306e\u4e16\u4ee3\u6570\u3092\u8868\u8a18\u3059\u308b\u5834\u5408\u306b\u306f\uff0c\u7a81\u7136\u5909\u7570\u4ee5\u964d\u306e\u4e16\u4ee3\u6570\u3092\u3053\u308c\u307e\u3067\u306e\u8fd1\u4ea4\u4e16\u4ee3\u6570\u306e\u3042\u3068\u306b\u52a0\u3048\u308b\uff0e<\/p>\n

    \u4f8b\uff1a<\/strong><\/p>\n\n\n\n
    F110+F23<\/td>\n\u8fd1\u4ea4\u7cfb110\u4e16\u4ee3\u3067\u7a81\u7136\u5909\u7570\u304c\u751f\u3058\u305f\u5f8c\uff0c23\u4e16\u4ee3\u306e\u5144\u59b9\u4ea4\u914d\u3092\u3057\u305f\u3053\u3068\u3092\u793a\u3059\uff0e<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/blockquote>\n

    5.2.\u3000\u30b3\u30f3\u30b8\u30a7\u30cb\u30c3\u30af\u7cfb\u7d71\uff08Congenic Strains\uff09<\/strong>
    \n\u30b3\u30f3\u30b8\u30a7\u30cb\u30c3\u30af\u7cfb\u7d71\u306f\uff0c\u30c9\u30ca\u30fc\u7cfb\u7d71\u3092\u7279\u5b9a\u306e\u30de\u30fc\u30ab\u30fc\u3067\u9078\u5225\u3057\u306a\u304c\u3089\uff0c\u8fd1\u4ea4\u7cfb\uff08\u30d0\u30c3\u30af\u30b0\u30e9\u30a6\u30f3\u30c9\u7cfb\u7d71\uff09\u3078\u623b\u3057\u4ea4\u914d\u3092\u7e70\u308a\u8fd4\u3059\u3053\u3068\u306b\u3088\u308a\u4f5c\u51fa\u3059\u308b\uff08Snell, 1278; Flaherty, 1981\uff09\uff0e\u7d44\u7e54\u9069\u5408\u6027\uff08MHC\uff09\u306e\u907a\u4f1d\u5b50\u5ea7\u304c\u7570\u306a\u3063\u3066\u3044\u3066\uff0c\u304a\u4e92\u3044\u306b\u79fb\u690d\u306b\u62b5\u6297\u6027\u304c\u3042\u308b\u30b3\u30f3\u30b8\u30a7\u30cb\u30c3\u30af\u7cfb\u7d71\u3092Congenic Resistant\uff08CR\uff09\u7cfb\u7d71\u3068\u547c\u3076\uff0e<\/p>\n

    \u3053\u306e\u65b9\u6cd5\u306b\u3088\u308a\u4f5c\u51fa\u3055\u308c\u305f\u7cfb\u7d71\u306f\uff0c\u6700\u521d\u306e\u4ea4\u914d\u3042\u308b\u3044\u306fF1\u4e16\u4ee3\u3092\u7b2c1\u4e16\u4ee3\u3068\u3057\uff0c\u6700\u4f4e10\u4e16\u4ee3\u30d0\u30c3\u30af\u30b0\u30e9\u30a6\u30f3\u30c9\u7cfb\u7d71\u3078\u623b\u3057\u4ea4\u914d\u3059\u308c\u3070\uff0c\u30b3\u30f3\u30b8\u30a7\u30cb\u30c3\u30af\u3068\u307f\u306a\u3057\u3066\u3044\u308b\uff0e\u3053\u306e\u6642\u70b9\u3067\uff0c\u6b8b\u3063\u3066\u3044\u308b\u30c9\u30ca\u30fc\u7cfb\u7d71\u306e\u30b2\u30ce\u30e0\u9818\u57df\u306f0.01\u4ee5\u4e0b\u306b\u306a\u308b\uff0e\u305f\u3060\u3057\u76ee\u7684\u3068\u3059\u308b\u907a\u4f1d\u5b50\u3084\u30de\u30fc\u30ab\u30fc\u8fd1\u508d\u306e\u67d3\u8272\u4f53\u9818\u57df\u306f\uff0c\u3082\u3063\u3068\u3086\u3063\u304f\u308a\u3068\u3057\u305f\u901f\u5ea6\u3067\u6e1b\u5c11\u3057\uff0c\u305d\u306e\u9577\u3055\uff08cM\uff09\u306f\u304a\u3088\u305d200\/N\u306b\u76f8\u5f53\u3059\u308b\uff08\u3053\u3053\u3067\u306eN\u3068\u306f\uff0cN\uff1e5\u306e\u623b\u3057\u4ea4\u914d\u4e16\u4ee3\u6570\uff09\uff08Flaherty, 1981; Silver, 1995\uff09\uff0e<\/p>\n

    \u30de\u30fc\u30ab\u30fc\u3067\u9078\u629c\u3057\u3066\u4ea4\u914d\u3059\u308b\u201c\u30b9\u30d4\u30fc\u30c9\u30b3\u30f3\u30b8\u30a8\u30cb\u30c3\u30af\u6cd5\u201d\u3068\u547c\u3070\u308c\u308b\u65b9\u6cd5\u3067\u306f\uff0c5\u4e16\u4ee3\u4ee5\u5185\u306e\u623b\u3057\u4ea4\u914d\u3060\u3051\u306710\u4e16\u4ee3\u5206\u306e\u623b\u3057\u4ea4\u914d\u306b\u76f8\u5f53\u3059\u308b\u30b3\u30f3\u30b8\u30a7\u30cb\u30c3\u30af\u7cfb\u7d71\u3092\u4f5c\u6210\u3059\u308b\u4e8b\u304c\u3067\u304d\u308b\uff08Markel et al., 1997; Wakeland et al., 1997\uff09\uff0e\u9069\u5207\u306a\u30de\u30fc\u30ab\u30fc\u3067\u9078\u5225\u3055\u308c\u305f\u5834\u5408\uff0c\u30c9\u30ca\u30fc\u7cfb\u7d71\u306e\u67d3\u8272\u4f53\u9818\u57df\u304c0.01\u4ee5\u4e0b\u306b\u306a\u3063\u305f\u306a\u3089\u3070\uff0c\u30b3\u30f3\u30b8\u30a7\u30cb\u30c3\u30af\u7cfb\u7d71\u3068\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\uff0e\u30b9\u30d4\u30fc\u30c9\u30b3\u30f3\u30b8\u30a7\u30cb\u30c3\u30af\u7cfb\u7d71\u3092\u51fa\u7248\u7269\u3067\u6700\u521d\u306b\u8a18\u8f09\u3059\u308b\u5834\u5408\u306f\uff0c\u3069\u308c\u304f\u3089\u3044\u305d\u306e\u7cfb\u7d71\u304c\u201c\u30b3\u30f3\u30b8\u30a7\u30cb\u30c3\u30af\u5316\u201d\u3055\u308c\u305f\u304b\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u305f\u3081\u306b\uff0c\u4f7f\u308f\u308c\u305f\u30de\u30fc\u30ab\u30fc\u306e\u6570\u3068\u67d3\u8272\u4f53\u4e0a\u306e\u9593\u9694\u3092\u660e\u8a18\u3059\u308b\u3079\u304d\u3067\u3042\u308b\uff0e\u30b9\u30d4\u30fc\u30c9\u30b3\u30f3\u30b8\u30a7\u30cb\u30c3\u30af\u6cd5\u306f\uff0c\u67d3\u8272\u4f53\u4e0a\u306e\u30de\u30fc\u30ab\u30fc\u89e3\u6790\u306e\u7cbe\u5ea6\uff0c\u5b9f\u9a13\u30d7\u30ed\u30c8\u30b3\u30fc\u30eb\u306b\u3088\u3063\u3066\u5909\u5316\u3059\u308b\u305f\u3081\uff0c\u30b3\u30f3\u30b8\u30a7\u30cb\u30c3\u30af\u7cfb\u7d71\u306e\u8fd1\u4ea4\u5316\u72b6\u614b\u306b\u306f\u6ce8\u610f\u3092\u6255\u308f\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044\uff0e<\/p>\n

    \u30b3\u30f3\u30b8\u30a7\u30cb\u30c3\u30af\u7cfb\u7d71\u306f\uff0c3\u3064\u306e\u90e8\u5206\u304b\u3089\u306a\u308b\u8868\u8a18\u306b\u3088\u308a\u540d\u524d\u304c\u3064\u3051\u3089\u308c\u308b\uff0e\u30ec\u30b7\u30d4\u30a8\u30f3\u30c8\u7cfb\u7d71\u306e\u5b8c\u5168\u3082\u3057\u304f\u306f\u7701\u7565\u3057\u305f\u8868\u8a18\u3068\uff0c\u30c9\u30ca\u30fc\u7cfb\u7d71\u306e\u8868\u8a18\u3068\u3092\u30d4\u30ea\u30aa\u30c9\u3067\u5206\u3051\u308b\uff0e\u3053\u306e\u5834\u5408\u306e\u30c9\u30ca\u30fc\u7cfb\u7d71\u3068\u306f\uff0c\u30b3\u30f3\u30b8\u30a7\u30cb\u30c3\u30af\u7cfb\u7d71\u3092\u4f5c\u51fa\u3059\u308b\u306b\u3042\u305f\u3063\u3066\uff0c\u3082\u3068\u3068\u306a\u308b\u304b\u3069\u3046\u304b\u306f\u5225\u3068\u3057\u3066\uff0c\u305d\u306e\u5bfe\u7acb\u907a\u4f1d\u5b50\u3084\u907a\u4f1d\u7684\u5909\u7570\u3092\u6709\u3059\u308b\u7cfb\u7d71\u306e\u3053\u3068\u3067\u3042\u308b\uff08\u30c9\u30ca\u30fc\u7cfb\u7d71\u304c\u8fd1\u4ea4\u7cfb\u3067\u306f\u7121\u3044\u5834\u5408\u3084\uff0c\u8907\u96d1\u306a\u7cfb\u7d71\u3067\u3042\u308b\u5834\u5408\uff0c\u30b3\u30f3\u30b8\u30a7\u30cb\u30c3\u30af\u3092\u3042\u3089\u308f\u3059\u305f\u3081\u306b\u201cCg\u201d\u3068\u3044\u3046\u7565\u53f7\u3092\u7528\u3044\u308b\uff0e\u30c9\u30ca\u30fc\u7cfb\u7d71\u306e\u8868\u8a18\u3084\uff0cCg\u306e\u8a18\u53f7\u3092\u7528\u3044\u308b\u3053\u3068\u3067\uff0c\u30b3\u30f3\u30b8\u30a7\u30cb\u30c3\u30af\u7cfb\u7d71\u3092\u30b3\u30a2\u30a4\u30bd\u30b8\u30a7\u30cb\u30c3\u30af\u7cfb\u7d71\u3068\u533a\u5225\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\uff09\uff0e\u7cfb\u7d71\u540d\u306e\u3042\u3068\u306b\u30cf\u30a4\u30d5\u30f3\u201c\uff0d\u201d\u3092\u7528\u3044\u3066\uff0c\u30c9\u30ca\u30fc\u7cfb\u7d71\u304b\u3089\u5c0e\u5165\u3055\u308c\u305f\u7279\u5b9a\u306e\u5bfe\u7acb\u907a\u4f1d\u5b50\u3092\u30a4\u30bf\u30ea\u30c3\u30af\u4f53\u3067\u8868\u8a18\u3059\u308b\uff0e<\/p>\n

    \u4f8b\uff1a<\/strong><\/p>\n\n\n\n
    B6.AK-H2k<\/sup><\/em><\/td>\nC57BL\/6\u7cfb\u7d71\u306e\u907a\u4f1d\u7684\u80cc\u666f\u3092\u3082\u3061\uff0cAKR\/J\u7cfb\u7d71\u7531\u6765\u306e\u5bfe\u7acb\u907a\u4f1d\u5b50\uff08H2k<\/sup>\uff09\u306e\u5c0e\u5165\u306b\u3088\u308a\uff0c\u305d\u3053\u3060\u3051\u304c\u7570\u306a\u308b\u30de\u30a6\u30b9\u7cfb\u7d71\uff0e<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/blockquote>\n

    \u540c\u3058\u907a\u4f1d\u7684\u80cc\u666f\u3067\uff0c\u540c\u3058\u30c9\u30ca\u30fc\u7cfb\u7d71\u306b\u7531\u6765\u3057\uff0c\u304b\u3064\u540c\u3058\u5c0e\u5165\u5bfe\u7acb\u907a\u4f1d\u5b50\u3092\u6301\u3064\uff0c\u3044\u304f\u3064\u304b\u306e\u30b3\u30f3\u30b8\u30a7\u30cb\u30c3\u30af\u7cfb\u7d71\u304c\u5229\u7528\u53ef\u80fd\u306a\u3089\uff0c\u305d\u308c\u305e\u308c\u306e\u7cfb\u7d71\u306f\uff0c\u30b9\u30e9\u30c3\u30b7\u30e5\u201c\uff0f\u201d\u306e\u3042\u3068\u306b\u901a\u3057\u756a\u53f7\u3068\u30e9\u30dc\u30b3\u30fc\u30c9\u3092\u4ed8\u3051\u308b\u3053\u3068\u3067\u533a\u5225\u3059\u308b\uff0e
    \n\u5bfe\u7acb\u907a\u4f1d\u5b50\u304c\u7b2c3\u306e\u7cfb\u7d71\u3092\u7d4c\u3066\u5c0e\u5165\u3055\u308c\u305f\u5834\u5408\uff0c\u7b2c3\u756a\u76ee\u306e\u7cfb\u7d71\u306f\u62ec\u5f27\uff08\uff09\u306e\u4e2d\u306b\u8a18\u8ff0\u3059\u308b\uff0e<\/p>\n

    \u4f8b\uff1a<\/strong>
    \nJ.129S2(B6)-Cd8atm1Mak<\/sup><\/em>\/2Dcr
    \nJ.129S2(B6)-Cd8atm1Mak<\/sup><\/em>\/3Dcr
    \n\uff1a2\u3064\u306e\u7570\u306a\u308b\u30b3\u30f3\u30b8\u30a7\u30cb\u30c3\u30af\u7cfb\u7d71\u3067\uff0c\u3069\u3061\u3089\u3082\u540c\u3058\u30c9\u30ca\u30fc\u7cfb\u7d71\uff0c\u30ec\u30b7\u30d4\u30a8\u30f3\u30c8\u7cfb\u7d71\u304b\u3089\u958b\u767a\u3055\u308c\uff0c\u540c\u3058\u5c0e\u5165\u907a\u4f1d\u5b50\u5ea7\u3092\u3082\u3064\uff0e<\/p>\n

    C.129S7(B6)-Rag1tm1Mom<\/sup><\/em>
    \n\uff1a\u3053\u306e\u4f8b\u3068\u4e0a\u306e\u4f8b\u306f\uff0c\u5c0e\u5165\u907a\u4f1d\u5b50\u5ea7\u306f\u7b2c3\u7cfb\u7d71\u304b\u3089\u79fb\u3055\u308c\u3066\u304a\u308a\uff0c\u7cfb\u7d71\u540d\u306e\u4e2d\u306b\u201c(B6)\u201d\u3067\u8868\u8a18\u3057\u3066\u3042\u308b\uff0e\u6a19\u7684\u3055\u308c\u305f\u907a\u4f1d\u5b50\u3067\u3042\u308bRag1tm1Mom<\/em><\/sup>\u304cB6;129S7\u304b\u3089\u7b2c\u4e09\u306e\u8fd1\u4ea4\u7cfb\uff08BALB\/c\uff09\u3078\u79fb\u3055\u308c\u3066\u3044\u308b\uff0e\u6a19\u7684\u306b\u306a\u3063\u305f\u907a\u4f1d\u5b50\u304cES\u7d30\u80de\u7531\u6765\u3067\u3042\u308b\u3053\u3068\u304b\u3089\u6a19\u7684\u907a\u4f1d\u5b50\u3092\u631f\u3080\u30b2\u30ce\u30e0\u9818\u57df\uff08\u67d3\u8272\u4f53\u65ad\u7247\uff09\u306f129S7\u7531\u6765\u3067\u3042\u308b\u304c\uff0c\u4e00\u65e6\uff0cB6\u7cfb\u7d71\u3068\u4ea4\u914d\u3057\u3066\u3044\u308b\u3053\u3068\u304b\u3089\uff0c\u631f\u307e\u308c\u3066\u3044\u308b129S7\u306e\u30b2\u30ce\u30e0\u306e\u5927\u304d\u3055\u304c\u3069\u306e\u7a0b\u5ea6\u3042\u308b\u306e\u304b\u306f\u4e0d\u660e\u3067\u3042\u308b\uff0e<\/blockquote>\n

    \u79fb\u884c\u3055\u308c\u305f\u67d3\u8272\u4f53\u9818\u57df\u304c\uff0c\u8907\u6570\u306e\u907a\u4f1d\u5b50\u3042\u308b\u3044\u306fDNA\u907a\u4f1d\u5b50\u5ea7\u3067\u6c7a\u3081\u3089\u308c\u3066\u3044\u308b\u5834\u5408\uff0c\u305d\u306e\u9818\u57df\u306e\u306a\u304b\u3067\uff0c\u6700\u3082\u8fd1\u4f4d\u3068\u9060\u4f4d\u306b\u3042\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u308b\u30de\u30fc\u30ab\u30fc\u3092\u30cf\u30a4\u30d5\u30f3\u201c\uff0d\u201d\u3067\u7d50\u3073\uff0c\u62ec\u5f27\uff08\uff09\u306e\u4e2d\u306b\u8868\u8a18\u3059\u308b\uff0e<\/p>\n

    \u4f8b\uff1a<\/strong><\/p>\n\n\n\n\n
    B6.Cg-(D4Mit25-D4Mit80<\/em>)\/Lt<\/td>\noutbred\u3042\u308b\u3044\u306fmixed\u7cfb\u7d71\uff08Cg\uff09\u304b\u3089\uff0c2\u3064\u306e\u7279\u5b9a\u306e\u30de\u30fc\u30ab\u30fc\u9593\u306b\u308f\u305f\u308b\u7b2c4\u67d3\u8272\u4f53\u4e0a\u9818\u57df\u3092C57BL\/6J\u306b\u5c0e\u5165\u3057\u3066\u4f5c\u6210\u3055\u308c\u305f\u30b3\u30f3\u30b8\u30a7\u30cb\u30c3\u30af\u7cfb\u7d71<\/td>\n<\/tr>\n
    NC.129X1-(D9Mit273-D9Mit78<\/em>)<\/td>\n\u30c9\u30ca\u30fc\u306e\u67d3\u8272\u4f53\u9818\u57df\u304c129X1\/SvJ\u7cfb\u7d71\u306b\u7531\u6765\u3059\u308b\u30b3\u30f3\u30b8\u30a7\u30cb\u30c3\u30af\u7cfb\u7d71\uff0e<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/blockquote>\n

    \u67d3\u8272\u4f53\u9818\u57df\u3092\u6c7a\u5b9a\u3059\u308b\u30de\u30fc\u30ab\u30fc\u306f\uff0c\u6700\u3082\u8fd1\u4f4d\u3068\u6700\u3082\u9060\u4f4d\u306b\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u308b\u30de\u30fc\u30ab\u30fc\u3067\u3042\u308a\uff0c\u3055\u3089\u306b\u8fd1\u4f4d\u306b\uff0c\u3042\u308b\u3044\u306f\u3055\u3089\u306b\u9060\u4f4d\u306b\u672a\u77e5\u306e\u30de\u30fc\u30ab\u30fc\u304c\u307e\u3063\u305f\u304f\u5b58\u5728\u3057\u306a\u3044\u3068\u3044\u3046\u3053\u3068\u3067\u306f\u306a\u3044\uff0e\u540c\u3058\u67d3\u8272\u4f53\u9818\u57df\u304c\u5c0e\u5165\u3055\u308c\u3066\u3044\u308b\u305f\u3081\u306b\u533a\u5225\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u306a\u3044\u7cfb\u7d71\u306f\uff0c\u30b9\u30e9\u30c3\u30b7\u30e5\u306e\u3042\u3068\u306b\uff0c\u901a\u3057\u756a\u53f7\u3068\u30e9\u30dc\u30b3\u30fc\u30c9\u3067\u533a\u5225\u3059\u308b\uff0e<\/p>\n

    \u5fc5\u8981\u306a\u3089\u3070\uff0c\u623b\u3057\u4ea4\u914d\u6570\u3092\u62ec\u5f27\uff08\uff09\u5185\u306b\u201cN\u201d\u3068\u6570\u5b57\u3067\u8868\u8a18\u3059\u308b\uff0e\u8907\u96d1\u306a\u4ea4\u914d\u30b7\u30b9\u30c6\u30e0\u3092\u7528\u3044\u305f\u5834\u5408\uff0c\u4e16\u4ee3\u6570\u306fN\u76f8\u5f53\u6570\uff08NE\uff09\u3068\u3057\u3066\u8868\u8a18\u3057\uff0c\u6700\u4f4eNE10\u4e16\u4ee3\u3067\u30b3\u30f3\u30b8\u30a7\u30cb\u30c3\u30af\u7cfb\u7d71\u3068\u307f\u306a\u3059\uff0c\u4f8b\u3048\u3070\uff0c\u52a3\u6027\u907a\u4f1d\u5b50\u3092\u8fd1\u4ea4\u7cfb\u306b\u623b\u3057\u4ea4\u914d\u3059\u308b\u5834\u5408\uff0c\u6b21\u306e\u623b\u3057\u4ea4\u914d\u306e\u305f\u3081\u306e\u30db\u30e2\u500b\u4f53\u3092\u5f97\u308b\u305f\u3081\uff0c\u623b\u3057\u4ea4\u914d\u3068\u30d8\u30c6\u30ed\u540c\u58eb\u306e\u4ea4\u914d\u3092\u4ea4\u4e92\u306b10\u56de\u7e70\u308a\u8fd4\u3059\u3053\u3068\u306b\u306a\u308b\u304c\uff08\u5408\u8a0820\u4e16\u4ee3\uff09\uff0c\u3053\u306e\u7cfb\u7d71\u306fNE10\u4ee3\u3068\u306a\u308b\uff0e\u30b3\u30f3\u30b8\u30a7\u30cb\u30c3\u30af\u7cfb\u7d71\u3092\u623b\u3057\u4ea4\u914d\u306e\u5f8c\uff0c\u5144\u59b9\u4ea4\u914d\u3067\u7dad\u6301\u3059\u308b\u5834\u5408\uff0c\u5144\u59b9\u4ea4\u914d\u4e16\u4ee3\u6570\u306f\u623b\u3057\u4ea4\u914d\u4e16\u4ee3\u6570\u306e\u5f8c\u306b\u8868\u8a18\u3059\u308b\uff0e\u4f8b\u3048\u3070\uff0cN10F6\u306f\u623b\u3057\u4ea4\u914d10\u4e16\u4ee3\u306e\u5f8c\u306b6\u4e16\u4ee3\u306e\u5144\u59b9\u4ea4\u914d\u3092\u3057\u305f\u3053\u3068\u3092\u610f\u5473\u3059\u308b\uff0eNE12F17\u306f\uff0c\u623b\u3057\u4ea4\u914d\u3068\u30d8\u30c6\u30ed\u540c\u58eb\u4ea4\u914d\u3092\u4ea4\u4e92\u306b12\u56de\u7e70\u308a\u8fd4\u3057\u305f\u5f8c\uff08\u907a\u4f1d\u5b66\u4e0a12\u4e16\u4ee3\u306e\u623b\u3057\u4ea4\u914d\u306b\u76f8\u5f53\u3059\u308b\uff09\uff0c17\u4e16\u4ee3\u306e\u5144\u59b9\u4ea4\u914d\u3092\u3057\u3066\u3044\u308b\uff0e<\/p>\n

    \u30b9\u30d4\u30fc\u30c9\u30b3\u30f3\u30b8\u30a7\u30cb\u30c3\u30af\u6cd5\u3067\u884c\u308f\u308c\u305f\u4e16\u4ee3\u6570N\u306f\uff0c10\u672a\u6e80\u306b\u306a\u308b\u3051\u308c\u3069\u3082\uff0c\u5b9f\u969b\u306e\u6570\u5b57\u3092\u305d\u306e\u307e\u307e\u4f7f\u7528\u3057\uff08\u4f8b\uff1aN6\uff09\uff0c\u4f7f\u7528\u3057\u305f\u30de\u30fc\u30ab\u30fc\u3084\u7e41\u6b96\u30b7\u30b9\u30c6\u30e0\u306e\u8a73\u7d30\u3092\u51fa\u7248\u7269\u3084\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u306a\u3069\u306b\u8a18\u8ff0\u3059\u308b\uff0e<\/p>\n

    5.3.\u3000\u30b3\u30f3\u30bd\u30df\u30c3\u30af\u7cfb\u7d71\uff08Consomic Strains\uff09<\/strong>
    \n\u30b3\u30f3\u30bd\u30df\u30c3\u30af\uff08chromosome substitution strain\u3068\u3082\u547c\u3070\u308c\u308b\uff0eNadeau et al., 2000\uff09\u306f\uff0c\u3042\u308b\u4e00\u3064\u306e\u67d3\u8272\u4f53\u5168\u4f53\u3092\u8fd1\u4ea4\u7cfb\u306b\u5c0e\u5165\u3059\u308b\u305f\u3081\uff0e\u623b\u3057\u4ea4\u914d\u3092\u7e70\u308a\u8fd4\u3059\u3053\u3068\u306b\u3088\u308a\u4f5c\u6210\u3059\u308b\uff0e\u30b3\u30f3\u30b8\u30a7\u30cb\u30c3\u30af\u7cfb\u7d71\u306e\u3088\u3046\u306b\uff0cF1\u4e16\u4ee3\u3092\u4e16\u4ee31\u3068\u3057\u3066\uff0c\u6700\u4f4e10\u4e16\u4ee3\u306e\u623b\u3057\u4ea4\u914d\u304c\u5fc5\u8981\u3067\u3042\u308b\uff0e\u5e38\u67d3\u8272\u4f53\u306e\u5834\u5408\u306f\uff0c\u9078\u3093\u3060\u30c9\u30ca\u30fc\u67d3\u8272\u4f53\u304c\uff0c\u76f8\u5f53\u3059\u308b\u30ec\u30b7\u30d4\u30a8\u30f3\u30c8\u67d3\u8272\u4f53\u3068\u7d44\u307f\u63db\u3048\u304c\u751f\u3058\u3066\u3044\u306a\u3044\u3053\u3068\u3092\u78ba\u8a8d\u3059\u308b\u305f\u3081\uff0c\u5404\u4e16\u4ee3\u3054\u3068\u306b\u7523\u307e\u308c\u3066\u304d\u305f\u4ed4\u306e\u907a\u4f1d\u5b50\u578b\u3092\u6c7a\u5b9a\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\uff0e\u30b3\u30f3\u30bd\u30df\u30c3\u30af\u7cfb\u7d71\u306e\u4e00\u822c\u7684\u306a\u8868\u8a18\u306f\uff0c\u201cHOST STRAIN-CHROMOSOMEDONOR STRAIN<\/sup>\u201d\u3067\u3042\u308b\uff0e<\/p>\n

    \u4f8b\uff1a<\/strong><\/p>\n\n\n\n
    BALB\/cA-19MSM<\/sup><\/td>\nMSM\/Ms\u306e\u7b2c19\u67d3\u8272\u4f53\u304cBALB\/cA\u306b\u623b\u3057\u4ea4\u914d\u3067\u79fb\u3055\u308c\u3066\u3044\u308b\uff0e<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/blockquote>\n

    \u30b3\u30f3\u30bd\u30df\u30c3\u30af\u7cfb\u7d71\u306f\uff0c\u6982\u5ff5\u4e0a\u3068\u4f5c\u6210\u6cd5\u306b\u304a\u3044\u3066\u30b3\u30f3\u30b8\u30a7\u30cb\u30c3\u30af\u7cfb\u7d71\u3068\u4f3c\u3066\u3044\u308b\u304c\uff0c\u30b3\u30f3\u30bd\u30df\u30c3\u30af\u7cfb\u7d71\u306e\u5b66\u8853\u547d\u540d\u6cd5\u306b\u304a\u3044\u3066\uff0c\u53d7\u3051\u624b\uff08host\uff09\u5074\u306e\u7cfb\u7d71\u306e\u540d\u524d\u306f\u7565\u3055\u308c\u305a\uff0c\u30d4\u30ea\u30aa\u30c9\u3082\uff0c\u305d\u306e\u5f8c\u306b\uff0c\u30c9\u30ca\u30fc\u7cfb\u7d71\u306e\u540d\u524d\u3082\u3064\u3051\u306a\u3044\uff0e\u30c9\u30ca\u30fc\u7cfb\u7d71\u306e\u540d\u524d\u306f\u80a9\u4ed8\u304d\u3067\u8868\u8a18\u3059\u308b\uff0e\u5bfe\u7acb\u907a\u4f1d\u5b50\u540d\u3068\u533a\u5225\u3059\u308b\u305f\u3081\uff0c\u80a9\u4ed8\u304d\u6587\u5b57\u306f\u5168\u3066\u5927\u6587\u5b57\u3092\u7528\u3044\uff0c\u67d3\u8272\u4f53\u3092\u8868\u3059\u6587\u5b57\uff0f\u6570\u5b57\u3084\u80a9\u4ed8\u304d\u6587\u5b57\u306f\u30a4\u30bf\u30ea\u30c3\u30af\u4f53\u3092\u7528\u3044\u306a\u3044\uff0e<\/p>\n

    5.4.\u3000\u907a\u4f1d\u5b50\u578b\u5206\u96e2\u8fd1\u4ea4\u7cfb\uff08Segregating Inbred Strains\uff09<\/strong>
    \n\u30bb\u30b0\u30ec\u30b2\u30a4\u30c6\u30a3\u30f3\u30b0\u7cfb\u7d71\u306f\uff0c\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u5ea7\uff0c\u3042\u308b\u3044\u306f\u907a\u4f1d\u7684\u5909\u7570\u3092\u30d8\u30c6\u30ed\u63a5\u5408\u4f53\u306e\u72b6\u614b\u3067\u7dad\u6301\u3057\u3066\u3044\u308b\u8fd1\u4ea4\u7cfb\u3067\u3042\u308b\uff0e\u8fd1\u89aa\u4ea4\u914d\uff08\u901a\u5e38\u306f\u5144\u59b9\u4ea4\u914d\uff09\u3067\u7dad\u6301\u3055\u308c\u308b\u304c\uff0c\u5404\u4e16\u4ee3\u306b\u304a\u3044\u3066\u30d8\u30c6\u30ed\u63a5\u5408\u4f53\u306e\u500b\u4f53\u3092\u9078\u629c\u3059\u308b\uff0e\u30bb\u30b0\u30ec\u30b2\u30a4\u30c6\u30a3\u30f3\u30b0\uff08\u30d8\u30c6\u30ed\uff09\u907a\u4f1d\u5b50\u5ea7\u306f\uff0c\u305d\u306e\u7cfb\u7d71\u306e\u6a19\u6e96\u7684\u306a\u907a\u4f1d\u5b50\u578b\u306e\u4e00\u90e8\u3092\u793a\u3057\u3066\u3044\u308b\u306e\u3067\uff0c\u4ed6\u306e\u8fd1\u4ea4\u7cfb\u306e\u5834\u5408\u3068\u540c\u3058\u3088\u3046\u306b\u8868\u8a18\u3059\u308b\uff08\u30bb\u30af\u30b7\u30e7\u30f35.1\u30b3\u30f3\u30bd\u30df\u30c3\u30af\u7cfb\u7d71\u3092\u53c2\u7167\uff09\uff0e\u5206\u96e2\u3057\u3066\u3044\u308b\u907a\u4f1d\u5b50\u5ea7\u304c\u6bdb\u8272\u306b\u95a2\u3059\u308b\u3082\u306e\u3067\u3042\u308a\uff0c\u3055\u3089\u306b\uff0c\u305d\u306e\u8fd1\u4ea4\u7cfb\u306e\u6b63\u5e38\u306a\u8868\u73fe\u578b\u3067\u3042\u308b\u5834\u5408\u306f\uff0c\u305d\u308c\u3089\u3092\u7cfb\u7d71\u540d\u5185\u306b\u8868\u8a18\u3059\u308b\u5fc5\u8981\u306f\u306a\u3044\uff08\u4e0b\u8a18\u306e\u4f8b\u3092\u53c2\u7167\uff09\uff0e\u307e\u305f\uff0c\u7cfb\u7d71\u306e\u907a\u4f1d\u5b50\u578b\u306b\u3064\u3044\u3066\u306f\uff0c\u51fa\u7248\u7269\u3084\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u306a\u3069\u3067\u5229\u7528\u53ef\u80fd\u306b\u3057\u3066\u304a\u304f\uff0e<\/p>\n

    \u4f8b\uff1a<\/strong><\/p>\n\n\n\n\n
    129P3\/J<\/td>\ntyrosinase\u907a\u4f1d\u5b50\u5ea7\u306b\u304a\u3044\u3066\uff0c\u30a2\u30eb\u30d3\u30ce\uff08Tyrc<\/sup><\/em>\uff09\u3068\u30c1\u30f3\u30c1\u30e9\uff08Tyrc-ch<\/sup><\/em>\uff09\u3092\u30d8\u30c6\u30ed\u3067\u6709\u3059\u308b\uff0e<\/td>\n<\/tr>\n
    WB<\/td>\nkit oncogene\u907a\u4f1d\u5b50\u5ea7\u306b\u304a\u3044\u3066\uff0c\u30d8\u30c6\u30ed\u3067\u512a\u6027\u767d\u6591\u5bfe\u7acb\u907a\u4f1d\u5b50\uff08KitW<\/sup><\/em>\uff09\u3092\u6709\u3059\u308b\uff0e<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/blockquote>\n

    \u9023\u9396\u3059\u308b2\u3064\u306e\u5bfe\u7acb\u907a\u4f1d\u5b50\u3092\u3082\u3064\u7cfb\u7d71\u306f\uff0c\u305d\u306e\u8868\u8a18\u306e\u4e2d\u3067\u5bfe\u7acb\u907a\u4f1d\u5b50\u304c\u9023\u9396\u3057\u3066\u3044\u308b\u3053\u3068\uff0c\u305d\u308c\u3089\u5bfe\u7acb\u907a\u4f1d\u5b50\u306e\u72b6\u614b\uff08\u3069\u3061\u3089\u306e\u89aa\u7531\u6765\u306e\u67d3\u8272\u4f53\u4e0a\u306b\u3042\u308b\u304b\uff09\u3092\u660e\u8a18\u3059\u308b\uff0e<\/p>\n

    \u4f8b\uff1a<\/strong><\/p>\n\n\n\n\n
    B6.Cg-m Leprdb<\/sup><\/em>\/+ +<\/td>\n\u3053\u306e\u7cfb\u7d71\u3067\u306f\uff0cm\u5bfe\u7acb\u907a\u4f1d\u5b50\u3068Leprdb<\/sup>\u5bfe\u7acb\u907a\u4f1d\u5b50\u306f\uff0c\u540c\u3058\u89aa\u7531\u6765\u306e\u67d3\u8272\u4f53\u4e0a\u306b\u3042\u308b\u305f\u3081\uff0c\u4e00\u7dd2\u306b\u52d5\u304f\uff0e\u305d\u308c\u305e\u308c\u306e\u91ce\u751f\u578b\u5bfe\u7acb\u907a\u4f1d\u5b50\u306f\uff0c\u3082\u3046\u4e00\u65b9\u306e\u89aa\u7531\u6765\u306e\u67d3\u8272\u4f53\u4e0a\u306b\u3042\u308b\uff0e<\/td>\n<\/tr>\n
    C57BL\/6-Hm+\/+Relnrl<\/sup><\/em><\/td>\n\u3053\u306e\u7cfb\u7d71\u3067\u306f\uff0cHm<\/em>\u5bfe\u7acb\u907a\u4f1d\u5b50\u3068Relnrl<\/sup><\/em>\u5bfe\u7acb\u907a\u4f1d\u5b50\u306f\u305d\u308c\u305e\u308c\u306e\u76f8\u540c\u67d3\u8272\u4f53\u4e0a\u306b\u3042\u308b\uff08\u5225\u3005\u306e\u89aa\u306b\u7531\u6765\u3057\u3066\u3044\u308b\u305f\u3081\uff0c\u53cd\u767a\u3057\u3066\u52d5\u304f\uff09\uff0e\u3053\u306e\u7cfb\u7d71\u3092\u30d0\u30e9\u30f3\u30b9\u7cfb\u7d71\u3068\u3082\u547c\u3076\uff0e<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/blockquote>\n

     <\/p>\n

    5.5.\u3000\u30b3\u30f3\u30d7\u30e9\u30b9\u30c6\u30a3\u30c3\u30af\u7cfb\u7d71\uff08Conplastic Strains\uff09<\/strong>
    \n\u30b3\u30f3\u30d7\u30e9\u30b9\u30c6\u30a3\u30c3\u30af\u7cfb\u7d71\u3068\u306f\uff0c\u3042\u308b\u7cfb\u7d71\u306e\u6838\u30b2\u30ce\u30e0\u3092\u5225\u306e\u7cfb\u7d71\u3078\u306e\u7d30\u80de\u8cea\u3078\u5c0e\u5165\u3057\u305f\u7cfb\u7d71\u306e\u3053\u3068\u3067\u3042\u308b\uff0e\u8a00\u3044\u63db\u3048\u308c\u3070\uff0c\u623b\u3057\u4ea4\u914d\u4e2d\uff0c\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u30c9\u30ca\u30fc\u7cfb\u7d71\u306f\u5e38\u306b\u6bcd\u89aa\u3067\u3042\u308b\uff0e\u8868\u8a18\u306f\uff0cNUCLEAR GENOME-mitCYTOPLASMIC GENOME<\/sup>\u3067\u3042\u308b\uff0e<\/p>\n

    \u4f8b\uff1a<\/strong><\/p>\n\n\n\n
    C57BL\/10SnJ-mitMSM<\/sup><\/td>\nC57BL\/10SnJ\u7cfb\u7d71\u306e\u6838\u30b2\u30ce\u30e0\u3068MSM\/Ms\u7cfb\u7d71\u306e\u7d30\u80de\u8cea\uff08\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\uff09\u30b2\u30ce\u30e0\u3092\u6301\u3064\u7cfb\u7d71<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/blockquote>\n

    \u3053\u306e\u3088\u3046\u306a\u7cfb\u7d71\u306f\uff0c\u96c4\u306eC57BL\/10SnJ\u30de\u30a6\u30b9\u3068\u96cc\u306eMSM\/Ms\u30de\u30a6\u30b9\u3068\u306e\u4ea4\u914d\u306b\u3088\u308a\u4f5c\u6210\u3055\u308c\uff0c\u96cc\u306e\u4ed4\u306b\u96c4C57BL\/10SnJ\u306e\u623b\u3057\u4ea4\u914d\u3092\u7e70\u308a\u8fd4\u3059\uff0e\u30b3\u30f3\u30b8\u30a7\u30cb\u30c3\u30af\u7cfb\u7d71\u306e\u3088\u3046\u306b\uff0cF1\u4e16\u4ee3\u3092\u7b2c1\u4e16\u4ee3\u3068\u3057\u3066\uff0c\u6700\u4f4e10\u4e16\u4ee3\u306e\u623b\u3057\u4ea4\u914d\u304c\u5fc5\u8981\u3067\u3042\u308b\uff0e<\/p>\n

    6\uff0e\u53c2\u8003\u6587\u732e<\/strong><\/p>\n

    Bailey, D.W. 1971. Recombinant inbred strains, an aid to finding identity, linkage, and function of histocompatibility and other genes. Transplantation 11:325-327<\/p>\n

    Committee on Rat Nomenclature. 1992. Definition, nomenclature, and conservation of rat strains. ILAR News 34: S1-S26<\/p>\n

    Committee on Standardized Genetic Nomenclature for Mice. 1952. Standardized nomenclature for inbred strains of mice. Cancer Res. 12:602-613.<\/p>\n

    Committee on Standardized Genetic Nomenclature for Mice. 1960. Standardized nomenclature for inbred strains of mice, second listing. Cancer Res. 20:145-169.<\/p>\n

    Committee on Standardized Genetic Nomenclature for Mice. 1976. Nomenclature for inbred strains of mice preserved by freezing. Mouse News Lett 54:2-3.<\/p>\n

    Committee on Standardized Genetic Nomenclature for Mice, Chair: Lyon, M.F. Rules for nomenclature of inbred strains, pp. 368-372. In: Genetic Variants and Strains of the Laboratory Mouse, Green, M.C. (ed.), First Edition, Gustav Fischer Verlag, Stuttgart, 1981.<\/p>\n

    Committee on Standardized Genetic Nomenclature for Mice, Chair: Lyon, M.F. Rules for nomenclature of inbred strains, pp. 632-635. In: Genetic Variants and Strains of the Laboratory Mouse, Lyon, M.F., A.G. Searle (eds.), Second Edition, Oxford University Press, Oxford, 1989.<\/p>\n

    Committee on Standardized Genetic Nomenclature for Mice, Chair: Davisson, M.T. Rules for nomenclature of inbred strains, pp. 1532-1536. In: Genetic Variants and Strains of the Laboratory Mouse, Lyon MF, Rastan S, Brown SDM (eds.), Third Edition, Oxford University Press, Oxford, 1996<\/p>\n

    Darvasi A, Soller M. 1995. Advanced intercross lines, an experimental population for fine genetic mapping. Genetics 141: 1199-1207<\/p>\n

    Demant, P. and Hart, A.A.M. 1986. Recombinant congenic strains- a new tool for analyzing genetic traits determined by more than one gene. Immunogenetics 24:416-422.<\/p>\n

    Festing, M.F.W. 1979. Inbred strains in biomedical research, Macmillan Press, London: Oxford University Press, New York.<\/p>\n

    Festing, M.F.W. 1993. Origins and characteristics of inbred strains of mice, 11th listing. Mouse Genome 91:393-550.<\/p>\n

    Flaherty L. 1981. Congenic strains. In The Mouse in Biomedical Research, Vol. 1, Foster HL, Small JD, Fox JG (eds.), Academic Press, New York, pp. 215-222.<\/p>\n

    Green EL. 1981. Genetics and Probability in Animal Breeding Experiments. Oxford University Press, New York<\/p>\n

    Maltais LJ, Blake JA, Eppig JT, Davisson MT 1997. Rules and guidelines for mouse gene nomenclature: a condensed version. International Committee on Standardized Genetic Nomenclature for Mice. Genomics 45: 471-476<\/p>\n

    Markel P, Shu P, Ebeling C, Carlson GA, Nagle DL, Smutko JS, Moore KJ. 1997. Theoretical and empirical issues for marker-assisted breeding of congenic mouse strains. Nat Genet.17:280-284.<\/p>\n

    Nadeau JH, Singer JB, Matin A, Lander ES. 2000. Analyzing complex genetic traits with chromosome substitution strains. Nat Genet. 24: 221-225.<\/p>\n

    Silver LM. 1995. Mouse Genetics: Concepts and Applications. Oxford University Press, Oxford.<\/p>\n

    Snell GD. 1941. Biology of the Laboratory Mouse, 1st Edition, McGraw-Hill, New York<\/p>\n

    Snell GD. 1978. Congenic resistant strains of mice. In Origins of Inbred Mice, Morse HC (ed.), Academic Press, New York, pp. 1-31.<\/p>\n

    Staats J. 1985. Standardized Nomenclature for Inbred Strains of Mice: eighth listing. Cancer Res. 45: 945-977<\/p>\n

    Taylor B.A. 1978. Recombinant inbred strains: use in gene mapping. In Origins of Inbred Mice, Morse, HC. (eds.), Academic Press, New York, pp. 423-438.<\/p>\n

    Wakeland E, Morel L, Achey K, Yui M, Longmate J. 1997. Speed congenics:a classic technique in the fast lane (relatively speaking). Immunol Today 18: 472-477.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

    Rules for Nomenclature of Mouse Strains \uff08\u30de\u30a6\u30b9\u7cfb\u7d71\u306e\u5b66\u8853\u547d\u540d\u898f\u7d04\uff09 \u3000\u30ca\u30b7\u30e7\u30ca\u30eb\u30d0\u30a4\u30aa\u30ea\u30bd\u30fc\u30b9\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u300c\u30e9\u30c3\u30c8\u300d\u30fb\u771f\u4e0b\u77e5\u58eb\u535a\u58eb\u306b\u3088\u308a\u548c\u8a33\u3055\u308c\u305f\u300cRules for Nomenclature of Mouse and Rat Strains\u300d\u304b\u3089\u30de\u30a6\u30b9\u90e8\u5206\u3092\u629c\u7c8b\u3057\uff0c\u82e5\u5e72\u306e\u7de8\u96c6\u3092\u52a0\u3048\u305f\u3082\u306e\u3067\u3042\u308b\uff0e 2004\u5e743\u670810\u65e5 1.\u3000\u5e8f\u8ad6 \u5b9f\u9a13\u306b\u7528\u3044\u308b\u30de\u30a6\u30b9\u306e\u7531\u6765 […]<\/p>\n","protected":false},"author":8,"featured_media":0,"parent":4081,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_seopress_robots_follow":"","_seopress_robots_imageindex":"","_seopress_robots_snippet":"","_seopress_robots_primary_cat":"","_seopress_robots_breadcrumbs":"","_seopress_robots_freeze_modified_date":"","_seopress_robots_custom_modified_date":"","_seopress_robots_canonical":"","_seopress_social_fb_title":"","_seopress_social_fb_desc":"","_seopress_social_fb_img":"","_seopress_social_fb_img_attachment_id":0,"_seopress_social_fb_img_width":0,"_seopress_social_fb_img_height":0,"_seopress_social_twitter_title":"","_seopress_social_twitter_desc":"","_seopress_social_twitter_img":"","_seopress_social_twitter_img_attachment_id":0,"_seopress_social_twitter_img_width":0,"_seopress_social_twitter_img_height":0,"_seopress_redirections_value":"","_seopress_redirections_enabled":"","_seopress_redirections_enabled_regex":"","_seopress_redirections_logged_status":"both","_seopress_redirections_param":"","_seopress_redirections_type":301,"_seopress_analysis_target_kw":"","footnotes":"","_wp_rev_ctl_limit":""},"class_list":["post-3607","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/3607","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/comments?post=3607"}],"version-history":[{"count":17,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/3607\/revisions"}],"predecessor-version":[{"id":19793,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/3607\/revisions\/19793"}],"up":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/4081"}],"wp:attachment":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/media?parent=3607"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}