{"id":5254,"date":"2013-06-27T11:11:43","date_gmt":"2013-06-27T02:11:43","guid":{"rendered":"http:\/\/mus.brc.riken.jp:7301\/?page_id=5254"},"modified":"2015-07-29T10:39:32","modified_gmt":"2015-07-29T01:39:32","slug":"jan_2012_mm","status":"publish","type":"page","link":"http:\/\/mus.brc.riken.jp\/ja\/mouse_of_month\/jan_2012_mm","title":{"rendered":"Jan 2012 A gene for central respiratory regulation<\/em>"},"content":{"rendered":"

\"mouse_of_month_201201\"<\/a><\/p>\n\n\n\n
\n

A gene for central respiratory regulation<\/em><\/h2>\n
B6.129P2-Dscamtm1.1Kzy<\/sup><\/em>\/A151KzyRbrc RBRC05290<\/h5>\n

\"mn1201_0101\"
\nDscam-\/- P0 mice (C57BL\/6 background) show jerky or dyspnea-like movements<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\n

Down syndrome cell adhesion molecule (DSCAM) is expressed in neuronal tissues and reportedly has diverse roles in neural development. To elucidate its physiological function\u00a0in vivo,<\/em>\u00a0a targeted disruption of\u00a0Dscam<\/em>\u00a0in mice was generated. Homozygous null mutants (Dscam(-\/-)) were found to be lethal within 24 h of birth. Dscam(-\/-) mice also had an irregular respiratory rhythm with frequent apneas. Detailed measurement of respiration\u00a0in vivo<\/em>\u00a0and\u00a0in vitro<\/em>\u00a0was performed to determine whether there was irregular respiration and a lower ventilatory response to hypercapnia in the null mutants. Heterozygous Dscam(+\/-) mice, which survive to adulthood without significant abnormalities, also showed irregular respiration, but it was milder than that observed in the homozygous deficient mice. These mice are useful to study the physiological role of DSCAM\u00a0in vivo<\/em>\u00a0and to understand the molecular mechanism of central respiratory regulation.<\/p>\n

 <\/p>\n

 <\/p>\n\n\n\n\n
Depositor<\/td>\n:<\/td>\nDr. Kazuhiro Yamakawa, RIKEN Brain Science Institute<\/a><\/td>\n<\/tr>\n
Reference<\/td>\n:<\/td>\nAmano K, Fujii M, Arata S, Tojima T, Ogawa M, Morita N, Shimohata A,Furuichi T, Itohara S, Kamiguchi H, Korenberg JR, Arata A, Yamakawa K.
\nDSCAM deficiency causes loss of pre-inspiratory neuron synchroneity and perinatal death.
\nJ Neurosci.;<\/em><\/strong>\u00a029(9):2984-96, 2009.<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

A gene for central respiratory regulation B6.129P2-Dscamtm1.1Kzy\/A151KzyRbrc RBRC05290 Dscam-\/- P0 mice (C57BL\/6 background) show jerky or dyspnea-like movements Down syndrome cell adhesion molecule ( […]<\/p>\n","protected":false},"author":8,"featured_media":0,"parent":198,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_seopress_robots_follow":"","_seopress_robots_imageindex":"","_seopress_robots_snippet":"","_seopress_robots_primary_cat":"","_seopress_robots_breadcrumbs":"","_seopress_robots_freeze_modified_date":"","_seopress_robots_custom_modified_date":"","_seopress_robots_canonical":"","_seopress_social_fb_title":"","_seopress_social_fb_desc":"","_seopress_social_fb_img":"","_seopress_social_fb_img_attachment_id":0,"_seopress_social_fb_img_width":0,"_seopress_social_fb_img_height":0,"_seopress_social_twitter_title":"","_seopress_social_twitter_desc":"","_seopress_social_twitter_img":"","_seopress_social_twitter_img_attachment_id":0,"_seopress_social_twitter_img_width":0,"_seopress_social_twitter_img_height":0,"_seopress_redirections_value":"","_seopress_redirections_enabled":"","_seopress_redirections_enabled_regex":"","_seopress_redirections_logged_status":"","_seopress_redirections_param":"","_seopress_redirections_type":0,"_seopress_analysis_target_kw":"","footnotes":"","_wp_rev_ctl_limit":""},"class_list":["post-5254","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/5254","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/comments?post=5254"}],"version-history":[{"count":4,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/5254\/revisions"}],"predecessor-version":[{"id":12995,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/5254\/revisions\/12995"}],"up":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/198"}],"wp:attachment":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/media?parent=5254"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}