{"id":5258,"date":"2013-06-27T11:15:24","date_gmt":"2013-06-27T02:15:24","guid":{"rendered":"http:\/\/mus.brc.riken.jp:7301\/?page_id=5258"},"modified":"2021-04-07T14:16:49","modified_gmt":"2021-04-07T05:16:49","slug":"nov_2011_mm","status":"publish","type":"page","link":"http:\/\/mus.brc.riken.jp\/ja\/mouse_of_month\/nov_2011_mm","title":{"rendered":"Nov 2011 Hairless Congenics for Dermatology Studies<\/em>"},"content":{"rendered":"

\"mouse_of_month_201111\"<\/a><\/p>\n\n\n\n
\n

Hairless Congenics for Dermatology Studies<\/em><\/strong><\/h2>\n
B6.HR1-Hrhr<\/sup><\/em>\/Rbrc (RBRC01223)<\/a>
\nC.HR1-Hrhr<\/sup><\/em>\/Rbrc (RBRC01417)<\/a>
\nC3.HR1-Hrhr<\/sup><\/em>\/Rbrc (RBRC01418)<\/a>
\nMSM.HR1-Hrhr<\/sup><\/em>\/Rbrc (RBRC01222)<\/a><\/h5>\n

\"mn1111_0101\"
\nA: Donor Hos:HR-1 mice. Homozygous hairless mother and shedding littermates at 18 days old. B: B6.HR1-Hrhr<\/sup><\/em>\/Rbrc at 22 days. C: MSM.HR1-Hrhr<\/sup><\/em>\/Rbrc at 24 weeks. D: C.HR1-Hrhr<\/sup><\/em>\/Rbrc at 26 weeks. E: C3.HR1-Hrhr<\/sup><\/em>\/Rbrc at 10 weeks.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

The homozygous\u00a0Hrhr<\/sup><\/em>\/Hrhr<\/sup><\/em>\u00a0mutant mouse is widely used in dermatological studies as various skin tests can be conducted without shaving [1, 2]. To utilize the hairless characteristics in various genetic backgrounds, four congenic strains of the\u00a0Hrhr<\/sup><\/em>\u00a0gene have been generated by using the Hos:HR-1 mouse as the donor strain and performing successive backcrossing to C57BL\/6JJcl (RBRC01223), BALB\/cAnNMs (RBRC01417), C3H\/HeNCrlj (RBRC01418) and MSM\/MsRbrc (RBRC01222) strains as the recipients. The Hos:HR-1 donor strain has been established at HOSHINO LABORATORY ANIMALS, CORP. (Masayuki Hoshino, President) from Skh:HR-1 mice imported in 1987 from Temple University Skin and Cancer Hospital, Philadelphia, United States. The homozygous\u00a0Hrhr<\/sup><\/em>\/Hrhr<\/sup><\/em>\u00a0mutant exhibits hair loss after growth of the first hair coat and does not grow a second coat. Shedding of hairs starts around the nose at 14 days of age and spreads posteriorly to the base of the tail. ALOPECIA UNIVERSALIS CONGENITA (OMIM ID:\u00a0203655<\/a>) is caused by a mutation in the human homolog of the mouse “hairless” (HR) gene. These hairless congenic mice are therefore useful for various dermatological studies.\n<\/div>\n

 <\/p>\n\n\n\n\n\n
Depositor<\/td>\n:<\/td>\nDr. Atsushi Yoshiki, Experimental Animal Division, RIKEN BioResource Center<\/td>\n<\/tr>\n
References<\/td>\n:<\/td>\n[1]<\/td>\nBrooke HC, Hairless mice, J Hered 17:173-174, 1926.<\/td>\n<\/tr>\n
[2]<\/td>\nSundberg JP (ed.),\u00a0Handbook of Mouse Mutations with Skin and Hair Abnormalities: Animal Models and Biomedical Tools<\/em>,<\/strong>\u00a01994.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"

Hairless Congenics for Dermatology Studies B6.HR1-Hrhr\/Rbrc (RBRC01223) C.HR1-Hrhr\/Rbrc (RBRC01417) C3.HR1-Hrhr\/Rbrc (RBRC01418) MSM.HR1-Hrhr\/Rbrc (RBRC01222) A: Donor Hos:HR-1 mice. Homozygous hairle […]<\/p>\n","protected":false},"author":8,"featured_media":0,"parent":198,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_seopress_robots_follow":"","_seopress_robots_imageindex":"","_seopress_robots_snippet":"","_seopress_robots_primary_cat":"","_seopress_robots_breadcrumbs":"","_seopress_robots_freeze_modified_date":"","_seopress_robots_custom_modified_date":"","_seopress_robots_canonical":"","_seopress_social_fb_title":"","_seopress_social_fb_desc":"","_seopress_social_fb_img":"","_seopress_social_fb_img_attachment_id":0,"_seopress_social_fb_img_width":0,"_seopress_social_fb_img_height":0,"_seopress_social_twitter_title":"","_seopress_social_twitter_desc":"","_seopress_social_twitter_img":"","_seopress_social_twitter_img_attachment_id":0,"_seopress_social_twitter_img_width":0,"_seopress_social_twitter_img_height":0,"_seopress_redirections_value":"","_seopress_redirections_enabled":"","_seopress_redirections_enabled_regex":"","_seopress_redirections_logged_status":"","_seopress_redirections_param":"","_seopress_redirections_type":301,"_seopress_analysis_target_kw":"","footnotes":"","_wp_rev_ctl_limit":""},"class_list":["post-5258","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/5258","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/comments?post=5258"}],"version-history":[{"count":6,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/5258\/revisions"}],"predecessor-version":[{"id":18164,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/5258\/revisions\/18164"}],"up":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/198"}],"wp:attachment":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/media?parent=5258"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}