{"id":5279,"date":"2013-06-27T11:33:35","date_gmt":"2013-06-27T02:33:35","guid":{"rendered":"http:\/\/mus.brc.riken.jp:7301\/?page_id=5279"},"modified":"2021-04-07T13:57:18","modified_gmt":"2021-04-07T04:57:18","slug":"jun_2010_mm","status":"publish","type":"page","link":"http:\/\/mus.brc.riken.jp\/ja\/mouse_of_month\/jun_2010_mm","title":{"rendered":"Jun 2010 A model for psychiatric disorder<\/em>"},"content":{"rendered":"

\"mouse_of_month_201006\"<\/a><\/p>\n\n\n\n\n\n
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A model for psychiatric disorder<\/h2>\n

M100174 RBRC GSC 0036<\/a><\/h5>\n
Mutated gene:Grin1<\/em>, Chr 2
\n Allele symbol:Grin1Rgsc174<\/sup><\/em><\/h5>\n<\/td>\n<\/tr>\n
\n \n \"mn1006_0102\"<\/td>\n<\/tr>\n
The heterozygote was hyperactive and exhibited inattention to another mouse.
\n The frequency of interaction with another subject of the same genotype as the heterozygote was initially similar to that of the wild type (left), but thereafter the heterozygote spent a shorter time interacting with the other subject (right).<\/td>\n		\u00a0Effect of MPH on the locomotor activity of +\/+ mice and\u00a0Grin1Rgsc174<\/sup><\/em>\/+
\n The distance traveled by wild-type (left) andGrin1Rgsc174<\/sup><\/em>\/+ (right) mice in the open field for 20 min following saline or MPH injection. Error bars represent SEM of male mice (n = 10; 11 weeks old) of each genotype.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

\u00a0\u00a0\u00a0The founder mouse, M100174, exhibited a significant increase in spontaneous locomotor activity in an open-field test. A C to T missense mutation was identified in exon 18 of the Grin1 gene and resulted in an arginine to cysteine substitution in the C0 domain of the protein. Detailed analyses revealed that the\u00a0Grin1Rgsc174<\/sup><\/em>\u00a0heterozygote exhibited increased novelty-seeking behavior and slight social isolation compared with the wild type. Additionally, the hyperlocomotor activity of the heterozygote was decreased by methylphenidate (MPH) administration. MPH is one of the main therapeutic agents used to treat attention-deficit hyperactivity disorder (ADHD) and narcolepsy. Phenotypes ofGrin1Rgsc174<\/sup><\/em>\u00a0indicate that this mutant displays some of the signs and symptoms of psychiatric disorders including ADHD.<\/strong>\n<\/div>\n

 <\/p>\n\n\n\n\n
Depositor<\/td>\n:<\/td>\nMouse Functional Genomics Research Group, RIKEN Genomic Sciences Center<\/td>\n<\/tr>\n
Reference<\/td>\n:<\/td>\n\nFuruse T\u00a0et al.<\/em>\u00a0Phenotypic characterization of a new Grin1 mutant mouse generated by ENU mutagenesis.\u00a0European Journal of Neuroscience 31(7):1281-1291, 2010.<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"

A model for psychiatric disorder M100174 RBRC GSC 0036 Mutated gene:Grin1, Chr 2 Allele symbol:Grin1Rgsc174 \u52d5\u753b\u3092\u518d\u751f\u3059\u308b\u306b\u306f\u3001video\u30bf\u30b0\u3092\u30b5\u30dd\u30fc\u30c8\u3057\u305f\u30d6\u30e9\u30a6\u30b6\u304c\u5fc5\u8981\u3067\u3059\u3002 Wild type \u52d5\u753b\u3092\u518d\u751f\u3059\u308b\u306b\u306f\u3001video\u30bf\u30b0\u3092\u30b5\u30dd\u30fc\u30c8\u3057\u305f\u30d6\u30e9\u30a6\u30b6\u304c\u5fc5\u8981\u3067\u3059\u3002 Heterozygote […]<\/p>\n","protected":false},"author":8,"featured_media":0,"parent":198,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_seopress_robots_follow":"","_seopress_robots_imageindex":"","_seopress_robots_snippet":"","_seopress_robots_primary_cat":"","_seopress_robots_breadcrumbs":"","_seopress_robots_freeze_modified_date":"","_seopress_robots_custom_modified_date":"","_seopress_robots_canonical":"","_seopress_social_fb_title":"","_seopress_social_fb_desc":"","_seopress_social_fb_img":"","_seopress_social_fb_img_attachment_id":0,"_seopress_social_fb_img_width":0,"_seopress_social_fb_img_height":0,"_seopress_social_twitter_title":"","_seopress_social_twitter_desc":"","_seopress_social_twitter_img":"","_seopress_social_twitter_img_attachment_id":0,"_seopress_social_twitter_img_width":0,"_seopress_social_twitter_img_height":0,"_seopress_redirections_value":"","_seopress_redirections_enabled":"","_seopress_redirections_enabled_regex":"","_seopress_redirections_logged_status":"","_seopress_redirections_param":"","_seopress_redirections_type":301,"_seopress_analysis_target_kw":"","footnotes":"","_wp_rev_ctl_limit":""},"class_list":["post-5279","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/5279","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/comments?post=5279"}],"version-history":[{"count":17,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/5279\/revisions"}],"predecessor-version":[{"id":18128,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/5279\/revisions\/18128"}],"up":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/198"}],"wp:attachment":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/media?parent=5279"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}