{"id":6453,"date":"2008-08-31T10:11:28","date_gmt":"2008-08-31T01:11:28","guid":{"rendered":"http:\/\/mus.brc.riken.jp:7301\/?page_id=6453"},"modified":"2021-04-07T13:16:03","modified_gmt":"2021-04-07T04:16:03","slug":"aug_2008_mm","status":"publish","type":"page","link":"http:\/\/mus.brc.riken.jp\/ja\/mouse_of_month\/aug_2008_mm","title":{"rendered":"Aug 2008   <em> Delphilin KO Mouse<\/em>"},"content":{"rendered":"<p><a title=\"\u4eca\u6708\u306e\u30de\u30a6\u30b9\u30fb\u30d0\u30c3\u30af\u30ca\u30f3\u30d0\u30fc\" href=\"\/ja\/mouse_of_month\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6457\" alt=\"mouse_of_month_200808\" src=\"\/ja\/wp-content\/uploads\/2008\/08\/mouse_of_month_200808.png\" width=\"501\" height=\"84\" srcset=\"http:\/\/mus.brc.riken.jp\/ja\/wp-content\/uploads\/2008\/08\/mouse_of_month_200808.png 501w, http:\/\/mus.brc.riken.jp\/ja\/wp-content\/uploads\/2008\/08\/mouse_of_month_200808-150x25.png 150w, http:\/\/mus.brc.riken.jp\/ja\/wp-content\/uploads\/2008\/08\/mouse_of_month_200808-400x67.png 400w\" sizes=\"auto, (max-width: 501px) 100vw, 501px\" \/><\/a><\/p>\n<table width=\"700\">\n<tbody>\n<tr>\n<td style=\"background-color: #ffffff; border: 0px;\">\n<h2 style=\"text-align: center;\"><em>Delphilin KO Mouse<\/em><br \/>\nA model with facilitated LTD and enhanced motor learning<\/h2>\n<h5 style=\"text-align: center;\"><a href=\"https:\/\/brc.riken.jp\/mus\/RBRC02695\" target=\"_blank\" rel=\"noopener noreferrer\">BRC No. RBRC02695 B6.Cg-Grid2ip<\/a><\/h5>\n<h5 style=\"text-align: center;\">Research Application : Neurobiology Research<\/h5>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6456\" alt=\"mn0808_0101\" src=\"\/ja\/wp-content\/uploads\/2008\/08\/mn0808_0101.png\" width=\"700\" height=\"488\" srcset=\"http:\/\/mus.brc.riken.jp\/ja\/wp-content\/uploads\/2008\/08\/mn0808_0101.png 700w, http:\/\/mus.brc.riken.jp\/ja\/wp-content\/uploads\/2008\/08\/mn0808_0101-150x104.png 150w, http:\/\/mus.brc.riken.jp\/ja\/wp-content\/uploads\/2008\/08\/mn0808_0101-400x278.png 400w\" sizes=\"auto, (max-width: 700px) 100vw, 700px\" \/><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<div style=\"width: 700px; text-align: left;\">\u00a0Delphilin selectively expresses on Purkinje cells (PCs) and exclusively localizes at parallel fiber (PF) synapses in cerebellum, and associates with glutamate receptor (GluR) \u03b42, an essential molecule for long-term depression (LTD), motor learning and cerebellar wiring. Delphilin homozygous mutant mice showed facilitation of LTD induction and enhancement of the eye movement that follows the movements of large visual fields, and its adaptation (optokinetic response (OKR) adaptation). These homozygous mutant mice with C57BL\/6 background are useful for studying the cerebellar synapses plasticity mechanisms in motor learning.\n<\/div>\n<p>&nbsp;<\/p>\n<table width=\"700\">\n<tbody>\n<tr>\n<td style=\"border: 0px; background-color: #ffffff; text-align: left; white-space: nowrap;\" valign=\"top\">Depositor<\/td>\n<td style=\"border: 0px; background-color: #ffffff; text-align: left; white-space: nowrap;\" valign=\"top\">:<\/td>\n<td style=\"border: 0px; background-color: #ffffff; text-align: left;\" valign=\"top\">Dr. Masayoshi Mishina (University of Tokyo)\u00a0<span style=\"color: #999999;\">(Japanese page)<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"border: 0px; background-color: #ffffff; text-align: left; white-space: nowrap;\" valign=\"top\">Reference<\/td>\n<td style=\"border: 0px; background-color: #ffffff; text-align: left; white-space: nowrap;\" valign=\"top\">:<\/td>\n<td style=\"border: 0px; background-color: #ffffff; text-align: left;\" valign=\"top\"><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?cmd=Retrieve&amp;db=pubmed&amp;dopt=Abstract&amp;list_uids=18509461\" target=\"_blank\" rel=\"noopener noreferrer\"><em>PLoS One.<\/em>\u00a02008 May 28;3(5):e2297.<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"<p>Delphilin KO Mouse A model with facilitated LTD and enhanced motor learning BRC No. RBRC02695 B6.Cg-Grid2ip Research Application : Neurobiology Research &nbsp; \u00a0Delphilin selectively expresses on Purk [&hellip;]<\/p>\n","protected":false},"author":8,"featured_media":0,"parent":198,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_seopress_robots_follow":"","_seopress_robots_imageindex":"","_seopress_robots_snippet":"","_seopress_robots_primary_cat":"","_seopress_robots_breadcrumbs":"","_seopress_robots_freeze_modified_date":"","_seopress_robots_custom_modified_date":"","_seopress_robots_canonical":"","_seopress_social_fb_title":"","_seopress_social_fb_desc":"","_seopress_social_fb_img":"","_seopress_social_fb_img_attachment_id":0,"_seopress_social_fb_img_width":0,"_seopress_social_fb_img_height":0,"_seopress_social_twitter_title":"","_seopress_social_twitter_desc":"","_seopress_social_twitter_img":"","_seopress_social_twitter_img_attachment_id":0,"_seopress_social_twitter_img_width":0,"_seopress_social_twitter_img_height":0,"_seopress_redirections_value":"","_seopress_redirections_enabled":"","_seopress_redirections_enabled_regex":"","_seopress_redirections_logged_status":"","_seopress_redirections_param":"","_seopress_redirections_type":301,"_seopress_analysis_target_kw":"","footnotes":"","_wp_rev_ctl_limit":""},"class_list":["post-6453","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/6453","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/comments?post=6453"}],"version-history":[{"count":8,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/6453\/revisions"}],"predecessor-version":[{"id":18069,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/6453\/revisions\/18069"}],"up":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/198"}],"wp:attachment":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/media?parent=6453"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}