{"id":6464,"date":"2008-06-25T10:37:05","date_gmt":"2008-06-25T01:37:05","guid":{"rendered":"http:\/\/mus.brc.riken.jp:7301\/?page_id=6464"},"modified":"2021-04-07T13:56:05","modified_gmt":"2021-04-07T04:56:05","slug":"jun_2008_mm","status":"publish","type":"page","link":"http:\/\/mus.brc.riken.jp\/ja\/mouse_of_month\/jun_2008_mm","title":{"rendered":"Jun 2008 Drs KO Mouse<\/em>"},"content":{"rendered":"

\"mouse_of_month_200806\"<\/a><\/p>\n\n\n\n\n\n
\n

Drs KO Mouse<\/em><\/strong>
\nA Key Molecule for Tumor Suppression<\/h2>\n
BRC No. RBRC02435 B6.Cg-Srpx<tm1Hzi><\/a><\/strong><\/h5>\n<\/td>\n<\/tr>\n

Research Application<\/td>\n:<\/td>\nApoptosis Research
\nCancer Research<\/td>\n<\/tr>\n
\"mn0806_0101\"
\nRBRC02435 B6.Cg-Srpx<tm1Hzi><\/strong><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

\u00a0\u3000The Drs (downregulated by v-src) gene is originally found as a novel suppressor of v-src transformation. The Drs gene expresses in most normal tissues, however the expression is completely downregulated in a variety of cancer cell lines and tissues. It has been shown that malignant tumors such as lymphomas, lung adenocarcinomas and hepatomas were generated in about 30% of the Drs KO mice between 7 and 12 months. The Drs KO embryonic fibroblasts also showed enhanced sensitivity to transformation by viral oncogenes. Reintroduction of Drs gene into a tumor cell line derived from the tumor of the Drs KO mouse suppresses tumorigenesis and enhances caspase-mediated apoptosis.\n<\/div>\n

 <\/p>\n\n\n\n\n
Depositor<\/td>\n:<\/td>\n\u00a0Dr. Hirokazu Inoue (Shiga University of Medical Science)<\/a>\u00a0(Japanese page)<\/span><\/td>\n<\/tr>\n
Reference<\/td>\n:<\/td>\n\u00a0Carcinogenesis.<\/em>\u00a02007 28(4):777-84.<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"

Drs KO Mouse A Key Molecule for Tumor Suppression BRC No. RBRC02435 B6.Cg-Srpx<tm1Hzi> Research Application : Apoptosis Research Cancer Research RBRC02435 B6.Cg-Srpx<tm1Hzi>   \u00a0\u3000The D […]<\/p>\n","protected":false},"author":8,"featured_media":0,"parent":198,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_seopress_robots_follow":"","_seopress_robots_imageindex":"","_seopress_robots_snippet":"","_seopress_robots_primary_cat":"","_seopress_robots_breadcrumbs":"","_seopress_robots_freeze_modified_date":"","_seopress_robots_custom_modified_date":"","_seopress_robots_canonical":"","_seopress_social_fb_title":"","_seopress_social_fb_desc":"","_seopress_social_fb_img":"","_seopress_social_fb_img_attachment_id":0,"_seopress_social_fb_img_width":0,"_seopress_social_fb_img_height":0,"_seopress_social_twitter_title":"","_seopress_social_twitter_desc":"","_seopress_social_twitter_img":"","_seopress_social_twitter_img_attachment_id":0,"_seopress_social_twitter_img_width":0,"_seopress_social_twitter_img_height":0,"_seopress_redirections_value":"","_seopress_redirections_enabled":"","_seopress_redirections_enabled_regex":"","_seopress_redirections_logged_status":"","_seopress_redirections_param":"","_seopress_redirections_type":301,"_seopress_analysis_target_kw":"","footnotes":"","_wp_rev_ctl_limit":""},"class_list":["post-6464","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/6464","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/comments?post=6464"}],"version-history":[{"count":11,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/6464\/revisions"}],"predecessor-version":[{"id":18126,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/6464\/revisions\/18126"}],"up":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/198"}],"wp:attachment":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/media?parent=6464"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}