{"id":6477,"date":"2008-05-31T11:20:03","date_gmt":"2008-05-31T02:20:03","guid":{"rendered":"http:\/\/mus.brc.riken.jp:7301\/?page_id=6477"},"modified":"2021-04-07T14:12:38","modified_gmt":"2021-04-07T05:12:38","slug":"may_2008_mm","status":"publish","type":"page","link":"http:\/\/mus.brc.riken.jp\/ja\/mouse_of_month\/may_2008_mm","title":{"rendered":"May 2008 TH-GFP Transgenic Mouse<\/em>"},"content":{"rendered":"

\"mouse_of_month_200805\"<\/a><\/p>\n\n\n\n\n
\n

TH-GFP Transgenic Mouse<\/i>
\nA Model for Visualizing Dopamine Neurons<\/h2>\n
BRC No. RBRC02095_B6.Cg-Tg(TH-GFP)21-31<\/a><\/h5>\n
Research Application:Neurobiology Research<\/h5>\n<\/td>\n<\/tr>\n

\"\"
\nRBRC02095 B6.Cg-Tg(TH-GFP)21-31<\/td>\n		\"\"
\nGFP fluorescence in dopamine neurons of 12 weeks-old TH-GFP mice. (Coronal section of the ventral midbrain. Scale bar, 200 \u03bcm.)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

Dopamine is a neurotransmitter which mediates motor control, cognition, emotion, reward, and neuroendocrine functions. Dysfunction of dopamine-producing neurons in the midbrain is involved in some neurological and neuropsychiatric diseases such as Parkinson\u0081fs disease and schizophrenia. These dopamine neurons express tyrosine hydroxylase (TH), a key enzyme of catecholamine biosynthesis. The TH-GFP transgenic mouse was generated to express GFP in the majority of midbrain dopamine neurons under the control of the rat TH gene promoter. This transgenic mouse is useful for visualizing dopamine neurons to study the physiology and pathogenesis of dopamine neurons.\n<\/div>\n

 <\/p>\n\n\n\n\n
Depositor<\/td>\n:<\/td>\nDr. Kazuto Kobayashi<\/td>\n<\/tr>\n
Reference<\/td>\n:<\/td>\nJ. Neurochem.<\/i>\u00a082: 295-304 (2002).<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"

TH-GFP Transgenic Mouse A Model for Visualizing Dopamine Neurons BRC No. RBRC02095_B6.Cg-Tg(TH-GFP)21-31 Research Application:Neurobiology Research RBRC02095 B6.Cg-Tg(TH-GFP)21-31 GFP fluorescence in […]<\/p>\n","protected":false},"author":8,"featured_media":0,"parent":198,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_seopress_robots_follow":"","_seopress_robots_imageindex":"","_seopress_robots_snippet":"","_seopress_robots_primary_cat":"","_seopress_robots_breadcrumbs":"","_seopress_robots_freeze_modified_date":"","_seopress_robots_custom_modified_date":"","_seopress_robots_canonical":"","_seopress_social_fb_title":"","_seopress_social_fb_desc":"","_seopress_social_fb_img":"","_seopress_social_fb_img_attachment_id":0,"_seopress_social_fb_img_width":0,"_seopress_social_fb_img_height":0,"_seopress_social_twitter_title":"","_seopress_social_twitter_desc":"","_seopress_social_twitter_img":"","_seopress_social_twitter_img_attachment_id":0,"_seopress_social_twitter_img_width":0,"_seopress_social_twitter_img_height":0,"_seopress_redirections_value":"","_seopress_redirections_enabled":"","_seopress_redirections_enabled_regex":"","_seopress_redirections_logged_status":"","_seopress_redirections_param":"","_seopress_redirections_type":301,"_seopress_analysis_target_kw":"","footnotes":"","_wp_rev_ctl_limit":""},"class_list":["post-6477","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/6477","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/comments?post=6477"}],"version-history":[{"count":7,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/6477\/revisions"}],"predecessor-version":[{"id":18154,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/6477\/revisions\/18154"}],"up":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/198"}],"wp:attachment":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/media?parent=6477"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}