{"id":6507,"date":"2008-01-25T13:46:42","date_gmt":"2008-01-25T04:46:42","guid":{"rendered":"http:\/\/mus.brc.riken.jp:7301\/?page_id=6507"},"modified":"2021-04-07T13:47:53","modified_gmt":"2021-04-07T04:47:53","slug":"jan_2008_mm","status":"publish","type":"page","link":"http:\/\/mus.brc.riken.jp\/ja\/mouse_of_month\/jan_2008_mm","title":{"rendered":"Jan 2008 mDomino KO Mouse<\/em>"},"content":{"rendered":"

\"mouse_of_month_200801\"<\/a><\/p>\n\n\n\n\n\n
\n

mDomino KO Mouse<\/em>
\nAn essential molecule for embryonic hematopoiesis<\/h2>\n
BRC No. RBRC01774_mDomino knockout mouse<\/a><\/h5>\n
Research Application : Developmental Biology<\/h5>\n<\/td>\n<\/tr>\n

Wild-type<\/strong>
\n\"mn0801_0101\"<\/td>\n		mutant<\/strong>
\n\"mn0801_0102\"<\/td>\n<\/tr>\n
Defect in primitive hematopoiesis in mDom-mutated embryos (E9.5)
\n(o-dianisidine staining for hemoglobin)<\/strong><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

The SWI2\/SNF2 family protein, p400\/mDomino (mammalian Domino), is an Swr1-class DNA-dependent ATPase that is a core subunit of a large chromatin-remodeling complex, and is suggested to play a unique function in histone variant exchange. The mDomino-mutated mice are embryonic lethal by day 11.5 (E11.5), and show a defect in embryonic hematopoiesis. The gene expression profile revealed that erythroid-specific genes were reduced in mDomino-mutated embryo (E8.5). The mDomino mutation also enhanced the expression of Hox genes, including Hoxa7, Hoxa9 and Hoxb9, in the yolk sac.\n<\/div>\n

 <\/p>\n\n\n\n\n
Depositor<\/td>\n:<\/td>\nDr. Rikiro Fukunaga (Kyoto University)<\/td>\n<\/tr>\n
Reference<\/td>\n:<\/td>\nGenes Cells.<\/i>\u00a0(2007) May;12(5):581-92.<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"

mDomino KO Mouse An essential molecule for embryonic hematopoiesis BRC No. RBRC01774_mDomino knockout mouse Research Application : Developmental Biology Wild-type mutant Defect in primitive hematopoie […]<\/p>\n","protected":false},"author":8,"featured_media":0,"parent":198,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_seopress_robots_follow":"","_seopress_robots_imageindex":"","_seopress_robots_snippet":"","_seopress_robots_primary_cat":"","_seopress_robots_breadcrumbs":"","_seopress_robots_freeze_modified_date":"","_seopress_robots_custom_modified_date":"","_seopress_robots_canonical":"","_seopress_social_fb_title":"","_seopress_social_fb_desc":"","_seopress_social_fb_img":"","_seopress_social_fb_img_attachment_id":0,"_seopress_social_fb_img_width":0,"_seopress_social_fb_img_height":0,"_seopress_social_twitter_title":"","_seopress_social_twitter_desc":"","_seopress_social_twitter_img":"","_seopress_social_twitter_img_attachment_id":0,"_seopress_social_twitter_img_width":0,"_seopress_social_twitter_img_height":0,"_seopress_redirections_value":"","_seopress_redirections_enabled":"","_seopress_redirections_enabled_regex":"","_seopress_redirections_logged_status":"","_seopress_redirections_param":"","_seopress_redirections_type":301,"_seopress_analysis_target_kw":"","footnotes":"","_wp_rev_ctl_limit":""},"class_list":["post-6507","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/6507","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/comments?post=6507"}],"version-history":[{"count":7,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/6507\/revisions"}],"predecessor-version":[{"id":18104,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/6507\/revisions\/18104"}],"up":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/198"}],"wp:attachment":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/media?parent=6507"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}