{"id":6551,"date":"2007-09-11T16:03:25","date_gmt":"2007-09-11T07:03:25","guid":{"rendered":"http:\/\/mus.brc.riken.jp:7301\/?page_id=6551"},"modified":"2024-02-01T10:22:26","modified_gmt":"2024-02-01T01:22:26","slug":"sep_2007_mm","status":"publish","type":"page","link":"http:\/\/mus.brc.riken.jp\/ja\/mouse_of_month\/sep_2007_mm","title":{"rendered":"Gdf5Rgsc451<\/sup>\u00a0Mouse"},"content":{"rendered":"\n\n\n
\"RIKEN<\/td>\nSeptember 2007<\/span>
\nMouse of the Month<\/span><\/a>\n <\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n\n\n\n\n\n\n
\n

Gdf5Rgsc451<\/sup>\u00a0Mouse<\/em>
\nA model for osteoarthritis<\/h2>\n
BRC No. RBRC-GSC0080_Strain Name : M100451<\/a><\/h5>\n<\/td>\n<\/tr>\n

Mutated gene<\/td>\n:<\/td>\n\u00a0Gdf5<\/i>, Chr 2<\/td>\n<\/tr>\n
Allele Symbol<\/td>\n:<\/td>\n\u00a0Gdf5Rgsc451<\/sup><\/i><\/td>\n<\/tr>\n
Research Application<\/td>\n:<\/td>\n\u00a0Mouse models for human disease<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n\n
\"mn0709_0101\"<\/td>\n\"mn0709_0102\"<\/td>\n<\/tr>\n
Homozygote of\u00a0Gdf5Rgsc451<\/sup><\/i><\/b><\/td>\nOA phenotype in the elbow joints of homozygotes with clacking of cartliage (arrow heads) and abnormal cell size (arrows). ra, radius ; hu, humerus.<\/b><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

\u00a0\u00a0Osteoarthritis (OA) is the most common form of joint disorder, and is characterized by the degeneration of articular cartilage. A new\u00a0Gdf5<\/i>\u00a0allele derived from a large scale ENU mutagenesis screen,\u00a0Gdf5Rgsc451<\/i>, carries an amino acid substitution (W408R) which is a dominant negative form of GDF5 protein. The mutation is semidominant, showing brachypodism and ankylosis in heterozygotes, and much more severe brachypodism, ankylosis of the knee joint, and malformation with early-onset (8 weeks of age) OA of the elbow joint in homozygotes.\n<\/div>\n

 <\/p>\n\n\n\n\n
Depositor<\/td>\n:<\/td>\nMouse Functional Genomics Research Group, RIKEN Genomic Sciences Center<\/td>\n<\/tr>\n
Reference<\/td>\n:<\/td>\nHum Mol Genet<\/i>\u00a0(2007) 16(19):2366-75.<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"

September 2007 Mouse of the Month   Gdf5Rgsc451\u00a0Mouse A model for osteoarthritis BRC No. RBRC-GSC0080_Strain Name : M100451 Mutated gene : \u00a0Gdf5, Chr 2 Allele Symbol : \u00a0Gdf5Rgsc451 Research Appli […]<\/p>\n","protected":false},"author":8,"featured_media":0,"parent":198,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_seopress_robots_follow":"","_seopress_robots_imageindex":"","_seopress_robots_snippet":"","_seopress_robots_primary_cat":"","_seopress_robots_breadcrumbs":"","_seopress_robots_freeze_modified_date":"","_seopress_robots_custom_modified_date":"","_seopress_robots_canonical":"","_seopress_social_fb_title":"","_seopress_social_fb_desc":"","_seopress_social_fb_img":"","_seopress_social_fb_img_attachment_id":0,"_seopress_social_fb_img_width":0,"_seopress_social_fb_img_height":0,"_seopress_social_twitter_title":"","_seopress_social_twitter_desc":"","_seopress_social_twitter_img":"","_seopress_social_twitter_img_attachment_id":0,"_seopress_social_twitter_img_width":0,"_seopress_social_twitter_img_height":0,"_seopress_redirections_value":"","_seopress_redirections_enabled":"","_seopress_redirections_enabled_regex":"","_seopress_redirections_logged_status":"both","_seopress_redirections_param":"","_seopress_redirections_type":301,"_seopress_analysis_target_kw":"","footnotes":"","_wp_rev_ctl_limit":""},"class_list":["post-6551","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/6551","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/comments?post=6551"}],"version-history":[{"count":9,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/6551\/revisions"}],"predecessor-version":[{"id":20039,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/6551\/revisions\/20039"}],"up":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/198"}],"wp:attachment":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/media?parent=6551"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}