{"id":6587,"date":"2007-03-01T10:25:59","date_gmt":"2007-03-01T01:25:59","guid":{"rendered":"http:\/\/mus.brc.riken.jp:7301\/?page_id=6587"},"modified":"2022-07-08T14:17:00","modified_gmt":"2022-07-08T05:17:00","slug":"mar_2007_mm","status":"publish","type":"page","link":"http:\/\/mus.brc.riken.jp\/ja\/mouse_of_month\/mar_2007_mm","title":{"rendered":"ERAI transgenic mouse"},"content":{"rendered":"\n\n\n
\"RIKEN<\/td>\nMarch 2007<\/span>
\nMouse of the Month<\/span><\/a>\n <\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n\n
\n ERAI transgenic mouse
\nA model for monitoring endoplasmic reticulum stress<\/spam><\/p>\n
BRC No. 01099_ERAI mice<\/a>
\nResearch Application : Cell Biology Research<\/h5>\n<\/td>\n<\/tr>\n
\"Mouse
\nBRC No.01099 ERAI mice<\/td>\n		\"mn0703_0102\"
\nFluorescence activity in internal organs of ERAI transgenic mice injected with PBS (left) or tunicamycin (right)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

Endoplasmic reticulum (ER) stress is caused by the accumulation of unfolded proteins in the ER lumen, and is associated with vascular and neurodegenerative diseases. ERAI (ER stress-activated indicator) transgenic mice carry human XBP1 and venus (a variant of green fluorescent protein) fusion gene under control of a CAG promoter. The transcripts from ERAI constructs are spliced under ER stress, the spliced mRNA is translated into an XBP1-venus fusion protein, which can be detected by fluorescence of the venus. This strain is useful to monitor physiological and pathological ER stress in vivo.\n<\/div>\n

 <\/p>\n\n\n\n\n
Depositor<\/td>\n:<\/td>\n\u00a0Dr. Masayuki Miura
\n(University of Tokyo)<\/a><\/td>\n<\/tr>\n
Reference<\/td>\n:<\/td>\n\u00a0Iwawaki T, Akai R, Kohno K, Miura M
\nA transgenic mouse model for monitoring endoplasmic reticulum stress.
\nNature Medicine.<\/i>\u00a010(1):98-102. (2004)<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"

March 2007 Mouse of the Month ERAI transgenic mouse A model for monitoring endoplasmic reticulum stress BRC No. 01099_ERAI mice Research Application : Cell Biology Research BRC No.01099 ERAI mice Fluo […]<\/p>\n","protected":false},"author":8,"featured_media":0,"parent":198,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_seopress_robots_follow":"","_seopress_robots_imageindex":"","_seopress_robots_snippet":"","_seopress_robots_primary_cat":"","_seopress_robots_breadcrumbs":"","_seopress_robots_freeze_modified_date":"","_seopress_robots_custom_modified_date":"","_seopress_robots_canonical":"","_seopress_social_fb_title":"","_seopress_social_fb_desc":"","_seopress_social_fb_img":"","_seopress_social_fb_img_attachment_id":0,"_seopress_social_fb_img_width":0,"_seopress_social_fb_img_height":0,"_seopress_social_twitter_title":"","_seopress_social_twitter_desc":"","_seopress_social_twitter_img":"","_seopress_social_twitter_img_attachment_id":0,"_seopress_social_twitter_img_width":0,"_seopress_social_twitter_img_height":0,"_seopress_redirections_value":"","_seopress_redirections_enabled":"","_seopress_redirections_enabled_regex":"","_seopress_redirections_logged_status":"both","_seopress_redirections_param":"","_seopress_redirections_type":301,"_seopress_analysis_target_kw":"","footnotes":"","_wp_rev_ctl_limit":""},"class_list":["post-6587","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/6587","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/comments?post=6587"}],"version-history":[{"count":11,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/6587\/revisions"}],"predecessor-version":[{"id":19123,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/6587\/revisions\/19123"}],"up":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/198"}],"wp:attachment":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/media?parent=6587"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}