{"id":6676,"date":"2006-05-01T16:22:29","date_gmt":"2006-05-01T07:22:29","guid":{"rendered":"http:\/\/mus.brc.riken.jp:7301\/?page_id=6676"},"modified":"2022-07-08T13:27:34","modified_gmt":"2022-07-08T04:27:34","slug":"may_2006_mm","status":"publish","type":"page","link":"http:\/\/mus.brc.riken.jp\/ja\/mouse_of_month\/may_2006_mm","title":{"rendered":"A model for bipolar disorder"},"content":{"rendered":"\n\n\n
\"RIKEN<\/td>\nMay 2006<\/span>
\nMouse of the Month<\/span><\/a>\n <\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n
\n \u8e81\u3046\u3064\u75c5\u30e2\u30c7\u30eb\u30de\u30a6\u30b9
\nA model for bipolar disorder<\/span><\/p>\n
\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2DNA\u5408\u6210\u9175\u7d20 (POLG) \u5909\u7570\u4f53\u30c8\u30e9\u30f3\u30b9\u30b8\u30a7\u30cb\u30c3\u30af\u30de\u30a6\u30b9
\nMitochondorial DNA polymerase (POLG) mutant transgenic mouse<\/h5>\n
BRC No. 01498 C57BL\/6-Tg(Camk2-mutPolg)1Bsi<\/a><\/h5>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n\n\n\n\n\n\n\n
\"\"<\/td>\n<\/td>\n\uff08\u5de6\u56f3\uff09\u8e81\u3046\u3064\u75c5\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\u3067\u3042\u308b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2DNA\u5408\u6210\u9175\u7d20(POLG)\u5909\u7570\u4f53\u30c8\u30e9\u30f3\u30b9\u30b8\u30a7\u30cb\u30c3\u30af\u30de\u30a6\u30b9<\/td>\n\"\"<\/td>\n<\/tr>\n
\uff08\u53f3\u56f3\uff09\u8e81\u3046\u3064\u75c5\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\u306e\u884c\u52d5\u30d1\u30bf\u30fc\u30f3\u6a2a\u8ef8\u306f\u6642\u9593(\uff12\uff14\u6642\u9593)\u3001\u7e26\u8ef8\u304c\u8f2a\u56de\u3057\u884c\u52d5\u91cf\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002 \u5468\u671f\u7684\u306b\u884c\u52d5\u91cf\u304c\u5909\u5316\u3057\u3066\u3044\u308b\u69d8\u5b50\u304c\u308f\u304b\u308a\u307e\u3059\u3002 \u3053\u306e\u30de\u30a6\u30b9\u306b\u8e81\u3046\u3064\u75c5\u6cbb\u7642\u85ac\u306e\u4e00\u3064\u3067\u3042\u308b\u30ea\u30c1\u30a6\u30e0\u3092\u6295\u4e0e\u3057\u305f\u3068\u3053\u308d\u3001\u5468\u671f\u7684\u306a\u884c\u52d5\u91cf\u306e\u5909\u5316\u306f\u53ce\u307e\u308a\u307e\u3057\u305f\u3002<\/td>\n<\/tr>\n
\u00a0\u00a0\u8e81\u3046\u3064\u75c5\u306f\u3001\u4e8c\u5927\u7cbe\u795e\u75be\u60a3\u306e\u4e00\u3064\u3067\u3001\u8e81\u72b6\u614b\u3068\u3046\u3064\u72b6\u614b\u3092\u7e70\u308a\u8fd4\u3059\u75c5\u6c17\u3067\u3059\u3002 \u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u304b\u3089\u3001\u8e81\u3046\u3064\u75c5\u306e\u60a3\u8005\u3067\u306f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd\u969c\u5bb3\u304c\u898b\u3089\u308c\u308b\u3053\u3068\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u75c5\u306b\u306f\u8e81\u3046\u3064\u75c5\u3084\u3046\u3064\u75c5\u3092\u4f34\u3046\u5834\u5408\u304c\u3042\u308b\u3053\u3068\u306a\u3069\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002 \u305d\u3053\u3067\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2DNA\u5408\u6210\u9175\u7d20 (POLG) \u306e\u6821\u6b63\u6d3b\u6027\u3092\u5931\u308f\u305b\u305f\u5909\u7570\u4f53 (D181A) \u306e\u907a\u4f1d\u5b50\u3068\u524d\u8133\u7279\u7570\u7684\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\uff08CaMKIIa\u001a\u0081j\u3092\u7d50\u5408\u3057\u305f\u30c8\u30e9\u30f3\u30b9\u30b8\u30fc\u30f3\u3092\u5c0e\u5165\u3057\u305f\u30de\u30a6\u30b9\u3092\u4f5c\u88fd\u3057\u3001\u8133\u306b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd\u969c\u5bb3\u3092\u8a98\u5c0e\u3057\u305f\u3068\u3053\u308d\u3001\u8e81\u3046\u3064\u75c5\u306b\u985e\u4f3c\u3057\u305f\u884c\u52d5\u7279\u6027\u3092\u793a\u3059\u30de\u30a6\u30b9\u304c\u5f97\u3089\u308c\u307e\u3057\u305f\u3002 \u3053\u306e\u30de\u30a6\u30b9\u306f\u8e81\u3046\u3064\u75c5\u306e\u30e2\u30c7\u30eb\u52d5\u7269\u3068\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u8e81\u3046\u3064\u75c5\u306e\u539f\u56e0\u7a76\u660e\u306b\u3064\u306a\u304c\u308b\u3070\u304b\u308a\u3067\u306f\u306a\u304f\u3001\u672c\u75be\u60a3\u306b\u6709\u52b9\u306a\u65b0\u85ac\u306e\u958b\u767a\u306b\u3082\u5bc4\u4e0e\u3059\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/td>\n<\/tr>\n
<\/td>\n<\/tr>\n
\n\n\n\n\n\n\n
\u5bc4\u8a17\u8005<\/td>\n\uff1a<\/td>\n\u52a0\u85e4 \u5fe0\u53f2\u30c1\u30fc\u30e0\u30ea\u30fc\u30c0\u30fc\uff08\u7406\u7814\u8133\u79d1\u5b66\u7dcf\u5408\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\uff09<\/a><\/td>\n<\/tr>\n
<\/td>\n<\/tr>\n
\u53c2\u8003\u6587\u732e<\/td>\n\uff1a<\/td>\nT. Kasahara, M. Kubota, T. Miyauchi, Y. Noda, A. Mouri, T. Nabeshima and T. Kato
\nMice with neuron-specific accumulation of mitochondrial DNA mutations show mood disorder-like phenotypes.
\nMolecular Psychiatry<\/i>\u00a0advance online publication 18 April 2006
\nhttp:\/\/www.nature.com\/mp\/journal\/vaop\/ncurrent\/full\/4001824a.html<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/td>\n<\/tr>\n
\u95a2\u9023\u60c5\u5831\u306f\u4e0b\u8a18URL\u3078
\nhttp:\/\/www.riken.jp\/~\/media\/riken\/pr\/press\/2006\/20060418_1\/20060418_1.pdf<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"

May 2006 Mouse of the Month \u8e81\u3046\u3064\u75c5\u30e2\u30c7\u30eb\u30de\u30a6\u30b9 A model for bipolar disorder \u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2DNA\u5408\u6210\u9175\u7d20 (POLG) \u5909\u7570\u4f53\u30c8\u30e9\u30f3\u30b9\u30b8\u30a7\u30cb\u30c3\u30af\u30de\u30a6\u30b9 Mitochondorial DNA polymerase (POLG) mutant transgenic mouse BRC No. 01498 C57BL\/6-Tg(Camk2-mu […]<\/p>\n","protected":false},"author":8,"featured_media":0,"parent":198,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_seopress_robots_follow":"","_seopress_robots_imageindex":"","_seopress_robots_snippet":"","_seopress_robots_primary_cat":"","_seopress_robots_breadcrumbs":"","_seopress_robots_freeze_modified_date":"","_seopress_robots_custom_modified_date":"","_seopress_robots_canonical":"","_seopress_social_fb_title":"","_seopress_social_fb_desc":"","_seopress_social_fb_img":"","_seopress_social_fb_img_attachment_id":0,"_seopress_social_fb_img_width":0,"_seopress_social_fb_img_height":0,"_seopress_social_twitter_title":"","_seopress_social_twitter_desc":"","_seopress_social_twitter_img":"","_seopress_social_twitter_img_attachment_id":0,"_seopress_social_twitter_img_width":0,"_seopress_social_twitter_img_height":0,"_seopress_redirections_value":"","_seopress_redirections_enabled":"","_seopress_redirections_enabled_regex":"","_seopress_redirections_logged_status":"both","_seopress_redirections_param":"","_seopress_redirections_type":301,"_seopress_analysis_target_kw":"","footnotes":"","_wp_rev_ctl_limit":""},"class_list":["post-6676","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/6676","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/comments?post=6676"}],"version-history":[{"count":11,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/6676\/revisions"}],"predecessor-version":[{"id":19102,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/6676\/revisions\/19102"}],"up":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/198"}],"wp:attachment":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/media?parent=6676"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}