{"id":6692,"date":"2006-03-02T11:22:34","date_gmt":"2006-03-02T02:22:34","guid":{"rendered":"http:\/\/mus.brc.riken.jp:7301\/?page_id=6692"},"modified":"2022-07-08T13:26:33","modified_gmt":"2022-07-08T04:26:33","slug":"mar_2006_mm","status":"publish","type":"page","link":"http:\/\/mus.brc.riken.jp\/ja\/mouse_of_month\/mar_2006_mm","title":{"rendered":"t(7;11)AML\u539f\u56e0\u907a\u4f1d\u5b50NUP98-HOXA9"},"content":{"rendered":"\n\n\n
\"RIKEN<\/td>\nMarch 2006<\/span>
\nMouse of the Month<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n\n
\n

t(7;11)AML\u539f\u56e0\u907a\u4f1d\u5b50NUP98-HOXA9<\/a>
\n\u9aa8\u9ac4\u6027\u767d\u8840\u75c5\u306e\u30e2\u30c7\u30eb<\/h2>\n
Transgene\uff1aNUP98-HOXA9, Nucleoporin, 96-KD & HOMEOBOX A9
\nGene Symbol\uff1aNUP98\/HOXA9 FUSION GENE (OMIM601021<\/a>&142956<\/a>)
\nStrain name\uff1aB6.Cg-Tg(NUP98-HOXA9)<\/a>\u00a0(BRC No. 01188<\/a>)
\nResearch Application\uff1aLeukemia, Cancer Research, Hematological Research, Genetical Research<\/h5>\n<\/td>\n<\/tr>\n

\"mn0603_0101\"<\/td>\n\"mn0603_0102\"<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

\u00a0 \u30ad\u30e1\u30e9\u907a\u4f1d\u5b50NUP98-HOXA9\u306f\u67d3\u8272\u4f53\u8ee2\u5ea7t(7;11)(p15;p15)\u3092\u6709\u3059\u308b\u30d2\u30c8\u6025\u6027\u304a\u3088\u3073\u6162\u6027\u9aa8\u9ac4\u6027\u767d\u8840\u75c5\u3068\u9aa8\u9ac4\u7570\u5f62\u6210\u75c7\u5019\u7fa4\u3067\u898b\u3089\u308c\u307e\u3059\u3002 \u3053\u306e\u30c8\u30e9\u30f3\u30b9\u30b8\u30a7\u30cb\u30c3\u30af\u30de\u30a6\u30b9\u306f(C57BL\/6J x DBA\/2J) F2\u306e\u53d7\u7cbe\u5375\u306bNUP98-HOXA9\u30ad\u30e1\u30e9\u907a\u4f1d\u5b50\u3092\u5c0e\u5165\u3057\u305f\u3082\u306e\u3067\u3001\u767a\u73fe\u5236\u5fa1\u306fhuman Cathepsin G\u907a\u4f1d\u5b50\u306e\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u306b\u3088\u308a\u307e\u3059\u3002 \u30c8\u30e9\u30f3\u30b9\u30b8\u30a7\u30cb\u30c3\u30af\u30de\u30a6\u30b9\u306e\u7d0420%\u304c\u9aa8\u9ac4\u5897\u6b96\u75c7\u53ca\u3073\u6025\u6027\u9aa8\u9ac4\u6027\u767d\u8840\u75c5\u3092\u767a\u75c7\u3057\u307e\u3059\u3002
\nNUP98-HOXA9\u30ad\u30e1\u30e9\u907a\u4f1d\u5b50\u306e\u9aa8\u9ac4\u6027\u767d\u8840\u75c5\u306b\u304a\u3051\u308b\u5f79\u5272\u306e\u89e3\u6790\u3001\u767a\u30ac\u30f3\u306b\u95a2\u308f\u308b\u5354\u8abf\u907a\u4f1d\u5b50\u306e\u540c\u5b9a\u3084\u767d\u8840\u75c5\u767a\u75c7\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u6790\u306b\u6709\u7528\u306a\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\u3067\u3059\u3002
\nC57BL\/6J\u306b10\u4e16\u4ee3\u4ee5\u4e0a\u623b\u3057\u4ea4\u914d\u3055\u308c\u3066\u3044\u307e\u3059\u3002\n<\/div>\n

 <\/p>\n\n\n\n\n
\u5bc4\u8a17\u8005<\/td>\n:<\/td>\n\u00a0\u4e2d\u6751\u5353\u90ce\u535a\u58eb\uff08\u764c\u7814\u7a76\u4f1a \u764c\u7814\u7a76\u6240\uff09<\/td>\n<\/tr>\n
\u53c2\u8003\u6587\u732e<\/td>\n:<\/td>\n\u00a0\u00a0 Iwasaki M, Kuwata T, Yamazaki Y, Jenkins NA, Copeland NG, Osato M, Ito Y, Kroon E, Sauvageau G, Nakamura T. \u00a0\u00a0Identification of cooperative genes for NUP98-HOXA9 in myeloid leukemogenesis using a mouse model. \u00a0\u00a0Blood<\/i>\u00a0105, 784-793, 2005.<\/a>
\n\u00a0\u00a0Nakamura T, Largaespada DA, Lee MP, Johnson LA, Ohyashiki K, Toyama K, Chen SJ, Willman CL, Chen IM, Feinberg AP, Jenkins NA, Copeland NG, Shaughnessy JD Jr. \u00a0\u00a0Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia. \u00a0\u00a0Nat Genet<\/i>\u00a012, 154-158, 1996.<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u95a2\u9023\u60c5\u5831\u306f\u4e0b\u8a18URL\u3078
\nhttp:\/\/www.jfcr.or.jp\/laboratory\/tci\/carcinogenesis\/index.html<\/p>\n","protected":false},"excerpt":{"rendered":"

March 2006 Mouse of the Month t(7;11)AML\u539f\u56e0\u907a\u4f1d\u5b50NUP98-HOXA9 \u9aa8\u9ac4\u6027\u767d\u8840\u75c5\u306e\u30e2\u30c7\u30eb Transgene\uff1aNUP98-HOXA9, Nucleoporin, 96-KD & HOMEOBOX A9 Gene Symbol\uff1aNUP98\/HOXA9 FUSION GENE (OMIM601021&142956) Strain name\uff1a […]<\/p>\n","protected":false},"author":8,"featured_media":0,"parent":198,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_seopress_robots_follow":"","_seopress_robots_imageindex":"","_seopress_robots_snippet":"","_seopress_robots_primary_cat":"","_seopress_robots_breadcrumbs":"","_seopress_robots_freeze_modified_date":"","_seopress_robots_custom_modified_date":"","_seopress_robots_canonical":"","_seopress_social_fb_title":"","_seopress_social_fb_desc":"","_seopress_social_fb_img":"","_seopress_social_fb_img_attachment_id":0,"_seopress_social_fb_img_width":0,"_seopress_social_fb_img_height":0,"_seopress_social_twitter_title":"","_seopress_social_twitter_desc":"","_seopress_social_twitter_img":"","_seopress_social_twitter_img_attachment_id":0,"_seopress_social_twitter_img_width":0,"_seopress_social_twitter_img_height":0,"_seopress_redirections_value":"","_seopress_redirections_enabled":"","_seopress_redirections_enabled_regex":"","_seopress_redirections_logged_status":"both","_seopress_redirections_param":"","_seopress_redirections_type":301,"_seopress_analysis_target_kw":"","footnotes":"","_wp_rev_ctl_limit":""},"class_list":["post-6692","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/6692","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/comments?post=6692"}],"version-history":[{"count":10,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/6692\/revisions"}],"predecessor-version":[{"id":19100,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/6692\/revisions\/19100"}],"up":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/198"}],"wp:attachment":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/media?parent=6692"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}