{"id":6720,"date":"2005-12-02T14:35:52","date_gmt":"2005-12-02T05:35:52","guid":{"rendered":"http:\/\/mus.brc.riken.jp:7301\/?page_id=6720"},"modified":"2022-07-08T13:24:27","modified_gmt":"2022-07-08T04:24:27","slug":"dec_2005_mm","status":"publish","type":"page","link":"http:\/\/mus.brc.riken.jp\/ja\/mouse_of_month\/dec_2005_mm","title":{"rendered":"A Model for Type 2 Hyper-IgM Syndrome"},"content":{"rendered":"\n\n\n
\"RIKEN<\/td>\nDecember 2005<\/span>
\nMouse of the Month<\/span><\/a>\n <\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n\n
\n

A Model for Type 2 Hyper-IgM Syndrome<\/h2>\n

Activation-induced cytidine Deaminase (AID)-deficient mouse<\/h4>\n<\/td>\n<\/tr>\n

\n\n\n\n\n\n\n\n\n
Targeted mutation<\/b><\/td>\n\uff1a<\/b><\/td>\nAicdatm1Hon<\/sup>, Chr 6<\/b><\/td>\n<\/tr>\n
Gene Symbol<\/b><\/td>\n\uff1a<\/b><\/td>\nAicda (activation-induced cytidine deaminase)<\/i><\/b><\/td>\n<\/tr>\n
Human homolog<\/b><\/td>\n\uff1a<\/b><\/td>\nAID\u00a0(OMIM605257)<\/a><\/b><\/td>\n<\/tr>\n
BRC No. 00897 AID-KO (C57BL\/6 backcross N10)<\/a><\/b><\/td>\n<\/tr>\n
Research Application<\/b><\/td>\n\uff1a<\/b><\/td>\nImmunology and Inflammation Research, Cancer Research<\/b><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/td>\n<\/tr>\n
\"mn051228_0101\"<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

AID (Activation-Induced cytidine Deaminase)\u306f\u6297\u539f\u523a\u6fc0\u5f8c\u306eB\u30ea\u30f3\u30d1\u7403\u306b\u7279\u7570\u7684\u306b\u767a\u73fe\u3059\u308b\u5206\u5b50\u3068\u3057\u3066\u767a\u898b\u3055\u308c\u307e\u3057\u305f\u3002 AID \u6b20\u640d\u30de\u30a6\u30b9\u3067\u306f\u3001B\u30ea\u30f3\u30d1\u7403\u306b\u304a\u3051\u308b\u30af\u30e9\u30b9\u30b9\u30a4\u30c3\u30c1\u7d44\u63db\u3048(class switch recombination: CSR)\u304c\u8d77\u3053\u3089\u305a\u3001IgM\u4ee5\u5916\u306e\u3059\u3079\u3066\u306e\u30af\u30e9\u30b9\u306e\u6297\u4f53(IgG,IgA,IgE)\u304c\u7523\u751f\u3055\u308c\u307e\u305b\u3093\u3002\u8178\u7ba1\u7c98\u819c\u56fa\u6709\u5c64\u306b\u306fIgM\u967d\u6027B\u7d30\u80de\u306e\u84c4\u7a4d\u304c\u9855\u8457\u3067\u3059\u3002 \u3055\u3089\u306b\u3001\u30d2\u30c8\u3067\u3082\u907a\u4f1d\u6027\u514d\u75ab\u4e0d\u5168\u75c7\u30012\u578b\u9ad8 IgM \u75c7\u5019\u7fa4 (type-2 hyper-IgM syndrome; HIGM2) \u306e\u539f\u56e0\u304cAID \u907a\u4f1d\u5b50\u306e\u5909\u7570\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002 AID \u6b20\u640d\u30de\u30a6\u30b9\u3067\u306f\u3001CSR\u306b\u52a0\u3048\u3066\u3001\u6297\u4f53\u53ef\u5909\u9818\u57df\u907a\u4f1d\u5b50\u306e\u4f53\u7d30\u80de\u7a81\u7136\u5909\u7570\u304a\u3088\u3073\u907a\u4f1d\u5b50\u5909\u63db\u3082\u5168\u304f\u8d77\u3053\u3089\u306a\u304f\u306a\u308b\u4e8b\u304c\u660e\u3089\u304b\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002 AID \u907a\u4f1d\u5b50\u306fB\u7d30\u80de\u306e\u6297\u4f53\u907a\u4f1d\u5b50\u591a\u69d8\u6027\u7372\u5f97\u6a5f\u69cb\u306b\u304a\u3044\u3066\u4e2d\u5fc3\u7684\u5f79\u5272\u3092\u679c\u305f\u3059\u5206\u5b50\u3068\u8a00\u3048\u307e\u3059\u3002\n<\/div>\n
\n<\/div>\n
\n<\/div>\n\n\n\n\n\n
\u5bc4\u8a17\u8005<\/td>\n:<\/td>\n\u672c\u5eb6 \u4f51 \u6559\u6388 \u4eac\u90fd\u5927\u5b66\u5927\u5b66\u9662\u533b\u5b66\u7814\u7a76\u79d1\u3000\u514d\u75ab\u30b2\u30ce\u30e0\u533b\u5b66\u8b1b\u5ea7<\/td>\n<\/tr>\n
\u53c2\u8003\u6587\u732e<\/td>\n:<\/td>\nHonjo T et al.\u00a0(2005) Nat Immunol 6: 655-661.<\/a>
\nBegum NA et al.\u00a0(2004) Science 305: 1160-1163.<\/a>
\nYoshikawa K\u00a0(2002) Science 296: 2033-2036.<\/a>
\nOkazaki I et al.\u00a0(2002) Nature 416: 340-345.<\/a>
\nMuramatsu M et al.\u00a0(2000) Cell 102: 553-563.<\/a>
\nRevy P et al.\u00a0(2000) Cell 102: 565-575.<\/a><\/td>\n<\/tr>\n
URL<\/td>\n:<\/td>\nhttp:\/\/www2.mfour.med.kyoto-u.ac.jp\/<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"

December 2005 Mouse of the Month A Model for Type 2 Hyper-IgM Syndrome Activation-induced cytidine Deaminase (AID)-deficient mouse Targeted mutation \uff1a Aicdatm1Hon, Chr 6 Gene Symbol \uff1a Aicda (activatio […]<\/p>\n","protected":false},"author":8,"featured_media":0,"parent":198,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_seopress_robots_follow":"","_seopress_robots_imageindex":"","_seopress_robots_snippet":"","_seopress_robots_primary_cat":"","_seopress_robots_breadcrumbs":"","_seopress_robots_freeze_modified_date":"","_seopress_robots_custom_modified_date":"","_seopress_robots_canonical":"","_seopress_social_fb_title":"","_seopress_social_fb_desc":"","_seopress_social_fb_img":"","_seopress_social_fb_img_attachment_id":0,"_seopress_social_fb_img_width":0,"_seopress_social_fb_img_height":0,"_seopress_social_twitter_title":"","_seopress_social_twitter_desc":"","_seopress_social_twitter_img":"","_seopress_social_twitter_img_attachment_id":0,"_seopress_social_twitter_img_width":0,"_seopress_social_twitter_img_height":0,"_seopress_redirections_value":"","_seopress_redirections_enabled":"","_seopress_redirections_enabled_regex":"","_seopress_redirections_logged_status":"both","_seopress_redirections_param":"","_seopress_redirections_type":301,"_seopress_analysis_target_kw":"","footnotes":"","_wp_rev_ctl_limit":""},"class_list":["post-6720","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/6720","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/comments?post=6720"}],"version-history":[{"count":10,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/6720\/revisions"}],"predecessor-version":[{"id":19097,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/6720\/revisions\/19097"}],"up":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/198"}],"wp:attachment":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/media?parent=6720"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}