{"id":6768,"date":"2005-06-02T17:08:13","date_gmt":"2005-06-02T08:08:13","guid":{"rendered":"http:\/\/mus.brc.riken.jp:7301\/?page_id=6768"},"modified":"2022-07-08T13:21:43","modified_gmt":"2022-07-08T04:21:43","slug":"jun_2005_mm","status":"publish","type":"page","link":"http:\/\/mus.brc.riken.jp\/ja\/mouse_of_month\/jun_2005_mm","title":{"rendered":"A Model for Tumor Biology: p53 KO mouse"},"content":{"rendered":"\n\n\n
\"RIKEN<\/td>\nJune 2005<\/span>
\nMouse of the Month<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n\n
\nA Model for Tumor Biology: p53 KO mouse<\/span><\/p>\n
Trp53 regulates cell cycle and apoptosis
\n Targeted mutation,\u00a0Trp53tm1Sia<\/sup><\/i>, Chr 11
\n Gene Symbol:Trp53 (transformation related protein 53)<\/i>
\n Human homolog:TP53 (OMIM191170)<\/a>
\n BRC No. 01361
\n Strain name:C57BL-p53<\/i>+\/-, B6.Cg-Trp53tm1Sia<\/sup><\/i><\/b><\/h5>\n<\/td>\n<\/tr>\n
\"mn050629_0101\"<\/td>\n\"mn050629_0102\"<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

Research Application: Apoptosis; Cell Cycle; Cancer; Immunology and Inflammation; Aging; DNA repair Mechanism; Toxicology
\nThe\u00a0Trp53tm1Sia<\/sup><\/i>\u00a0mutant allele was created by Dr. Shinichi Aizawa in the Molecular Oncology Laboratory of the RIKEN, Tsukuba. The TT2 ES cells originated from an F1 embryo between C57BL\/6 and CBA mice were used to disrupt the\u00a0Trp53<\/i>\u00a0gene by homologous recombination. A neomycin selection cassette was inserted into the second exon of the\u00a0Trp53<\/i>\u00a0gene. Homozygous deficient mice can grow after birth, but often suffered from development of tumors in various region of the body. In C57BL\/6 background most of the female homozygotes die in utero. A series of congenic p53 KO mice have been deposited to the\u00a0RIKEN BRC<\/a>.\n<\/div>\n

 <\/p>\n\n\n\n\n\n
BRC No.00107<\/a>,<\/b><\/td>\nC3H\/HeN-\u00a0p53<\/i>\u00a0KO \/ C3.Cg-Trp53tm1Sia<\/sup><\/i>\u00a0(available)<\/b><\/td>\n<\/tr>\n
BRC No.01348<\/a>,<\/b><\/td>\nICR-p53<\/i>+\/- \/ ICR.Cg-Trp53tm1Sia<\/sup><\/i>\u00a0(available)<\/b><\/td>\n<\/tr>\n
BRC No.00815<\/a>,<\/b><\/td>\nMSM-\u00a0p53<\/i>\u00a0KO \/ MSM.Cg-Trp53tm1Sia<\/sup><\/i>\u00a0(available, depositor: Dr. Ryo Kominami)<\/b><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n\n
DEPOSITOR:<\/td>\nDr. Ohtsura Niwa<\/td>\n<\/tr>\n
Reference:<\/td>\nTsukada T, Tomooka Y, Takai S, Ueda Y, Nishikawa S, Yagi T, Tokunaga T, Takeda N, Suda Y, Abe S, et al. Enhanced proliferative potential in culture of cells from p53-deficient mice.\u00a0Oncogene 8, 3313-3322 (1993)<\/a>.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"

June 2005 Mouse of the Month A Model for Tumor Biology: p53 KO mouse Trp53 regulates cell cycle and apoptosis Targeted mutation,\u00a0Trp53tm1Sia, Chr 11 Gene Symbol:Trp53 (transformation related protein 5 […]<\/p>\n","protected":false},"author":8,"featured_media":0,"parent":198,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_seopress_robots_follow":"","_seopress_robots_imageindex":"","_seopress_robots_snippet":"","_seopress_robots_primary_cat":"","_seopress_robots_breadcrumbs":"","_seopress_robots_freeze_modified_date":"","_seopress_robots_custom_modified_date":"","_seopress_robots_canonical":"","_seopress_social_fb_title":"","_seopress_social_fb_desc":"","_seopress_social_fb_img":"","_seopress_social_fb_img_attachment_id":0,"_seopress_social_fb_img_width":0,"_seopress_social_fb_img_height":0,"_seopress_social_twitter_title":"","_seopress_social_twitter_desc":"","_seopress_social_twitter_img":"","_seopress_social_twitter_img_attachment_id":0,"_seopress_social_twitter_img_width":0,"_seopress_social_twitter_img_height":0,"_seopress_redirections_value":"","_seopress_redirections_enabled":"","_seopress_redirections_enabled_regex":"","_seopress_redirections_logged_status":"both","_seopress_redirections_param":"","_seopress_redirections_type":301,"_seopress_analysis_target_kw":"","footnotes":"","_wp_rev_ctl_limit":""},"class_list":["post-6768","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/6768","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/comments?post=6768"}],"version-history":[{"count":10,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/6768\/revisions"}],"predecessor-version":[{"id":19091,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/6768\/revisions\/19091"}],"up":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/198"}],"wp:attachment":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/media?parent=6768"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}