{"id":6792,"date":"2005-03-07T10:51:31","date_gmt":"2005-03-07T01:51:31","guid":{"rendered":"http:\/\/mus.brc.riken.jp:7301\/?page_id=6792"},"modified":"2022-07-08T13:18:03","modified_gmt":"2022-07-08T04:18:03","slug":"mar_2005_mm","status":"publish","type":"page","link":"http:\/\/mus.brc.riken.jp\/ja\/mouse_of_month\/mar_2005_mm","title":{"rendered":"\u81ea\u5df1\u514d\u75ab\u6027\u62e1\u5f35\u578b\u5fc3\u7b4b\u75c7\u30e2\u30c7\u30eb"},"content":{"rendered":"<table width=\"700\" border=\"0\">\n<tbody>\n<tr>\n<td style=\"background-color: #ffffff; border: 0px; text-align: left;\" width=\"40\"><a title=\"\u4eca\u6708\u306e\u30de\u30a6\u30b9\u30fb\u30d0\u30c3\u30af\u30ca\u30f3\u30d0\u30fc\" href=\"\/ja\/mouse_of_month\"><img loading=\"lazy\" decoding=\"async\" alt=\"\" src=\"\/ja\/wp-content\/uploads\/2013\/05\/brc_logo2.png\" width=\"36\" height=\"74\" \/><\/a><\/td>\n<td style=\"background-color: #ffffff; border: 0px; text-align: center;\" colspan=\"2\">\n<h1><b><span style=\"color: #0000ff;\">2005\u5e743\u6708<\/span><br \/>\n<span>\u00a0\u4eca\u6708\u306e\u30ea\u30bd\u30fc\u30b9<\/span><\/b><\/h1>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<table width=\"700\" border=\"0\">\n<tbody>\n<tr>\n<td style=\"background-color: #ffffff; border: 0px; text-align: center;\">\n<h5>\u81ea\u5df1\u514d\u75ab\u6027\u62e1\u5f35\u578b\u5fc3\u7b4b\u75c7\u30e2\u30c7\u30eb<\/h5>\n<p><img loading=\"lazy\" decoding=\"async\" alt=\"mn050308_0301\" src=\"\/ja\/wp-content\/uploads\/2005\/03\/mn050308_0301.png\" width=\"225\" height=\"169\" \/><\/td>\n<td style=\"background-color: #ffffff; border: 0px; text-align: left;\" valign=\"middle\">\n<h2><b>Targeted mutation<br \/>\n\u907a\u4f1d\u5b50\uff1a<i>Pdcd1<\/i><br \/>\nprogrammed cell death 1<br \/>\nChromosome 1<\/b><\/h2>\n<\/td>\n<\/tr>\n<tr>\n<td style=\"background-color: #ffffff; border: 0px; text-align: left;\" colspan=\"2\">BRC No. 00903, 00904<br \/>\n\u7cfb\u7d71\u540d\uff1aPD-1-KO-N10 (BALB\/c), PD-1-KO-N12 (BALB\/c)\u3000(C;129S2-<i>Pdcd1<sup>tm1Hon<\/sup><\/i>)<br \/>\n\u7814\u7a76\u5206\u91ce\uff1aCardiovascular;Immunology and Inflammation; apoptosis; Cancer<br \/>\n\u75be\u60a3\u7b49\uff1aImmunology and Inflammation Research; dilated cardiomyopathy<br \/>\nPD-1\u907a\u4f1d\u5b50\u306fCD28\u30d5\u30a1\u30df\u30ea\u30fc\u306b\u5c5e\u3059\u308b\u514d\u75ab\u6291\u5236\u53d7\u5bb9\u4f53\u3067\u3042\u308a\uff0c\u6d3b\u6027\u5316\u3057\u305f\u30ea\u30f3\u30d1\u7403\u306b\u767a\u73fe\u3057\u3001\u30ea\u30f3\u30d1\u7403\u306e\u6a5f\u80fd\u3092\u6291\u5236\u3059\u308b\uff0ePD-1\uff08Pdcd1\uff09\u907a\u4f1d\u5b50\u3092\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u3057\u305f\u30de\u30a6\u30b9\u3067\u306f\u30c9\u30ca\u30fc\u306b\u7528\u3044\u305f\u30de\u30a6\u30b9\u306e\u907a\u4f1d\u7684\u80cc\u666f\u306b\u3088\u3063\u3066\u3055\u307e\u3056\u307e\u306a\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u3092\u767a\u75c7\u3059\u308b\uff0eBALB\/c\u80cc\u666f\u306ePD-1\u907a\u4f1d\u5b50\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u30de\u30a6\u30b9\u306f\u81ea\u5df1\u514d\u75ab\u6027\u306e\u62e1\u5f35\u578b\u5fc3\u7b4b\u75c7\u3092\u767a\u75c7\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u308b\uff0e\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u5236\u5fa1\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\uff0c\u305d\u306e\u907a\u4f1d\u7684\u8981\u56e0\u306e\u95a2\u4e0e\u306e\u89e3\u660e\u306b\u6709\u7528. N12\u306e\u30e9\u30a4\u30f3\u306f\u3042\u307e\u308a\u767a\u75c7\u304c\u3072\u3069\u304f\u306a\u304f\u3001\u30db\u30e2\u6b20\u640d\u578b\u3067\u7dad\u6301\u53ef\u80fd\u3002N10\u306e\u30e9\u30a4\u30f3\u306f\u767a\u75c7\u3057\u3084\u3059\u304f\u7a0b\u5ea6\u3082\u3072\u3069\u3044\u3002\u30db\u30e2\u6b20\u640d\u30de\u30a6\u30b9\u306f\u4e00\u90e8\u304c\u751f\u5f8c5\u9031\u9f62\u3088\u308a\uff0c\u81ea\u5df1\u514d\u75ab\u6027\u306e\u62e1\u5f35\u578b\u5fc3\u7b4b\u75c7\u3092\u767a\u75c7\uff0e\u7e41\u6b96\u52b9\u7387\u306f\u91ce\u751f\u578b\u3068\u5909\u308f\u3089\u306a\u3044\uff0e<\/td>\n<\/tr>\n<tr>\n<td style=\"background-color: #ffffff; border: 0px; text-align: center;\" colspan=\"2\" height=\"20\"><\/td>\n<\/tr>\n<tr>\n<td style=\"background-color: #ffffff; border: 0px; text-align: left;\" colspan=\"2\">\u53c2\u8003\u6587\u732e\uff1a<br \/>\nNishimura H; Minato N; Nakano T; Honjo T<br \/>\nImmunological studies on PD-1 deficient mice: implication of PD-1 as a negative regulator for B cell responses. Int Immunol 10, 1563-1572 (1998).<br \/>\nNishimura, H., et al.<br \/>\nAutoimmune dilated cardiomyopathy in PD-1 receptor deficient mice.<br \/>\nScience 291, 319-322(2001).<br \/>\n\u5bc4\u8a17\u8005\uff1a\u672c\u5eb6\u3000\u4f51\uff08\u4eac\u90fd\u5927\u5b66\uff09<\/td>\n<\/tr>\n<tr>\n<td style=\"background-color: #ffffff; border: 0px; text-align: center;\" colspan=\"2\"><b>\u3082\u3063\u3068\u8a73\u3057\u304f\u77e5\u308a\u305f\u3044\u65b9\u306f\u4e0b\u8a18\u30b5\u30a4\u30c8\u3078<\/b><br \/>\n<b><a href=\"http:\/\/www2.mfour.med.kyoto-u.ac.jp\/\">http:\/\/www2.mfour.med.kyoto-u.ac.jp\/<\/a><\/b><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"<p>2005\u5e743\u6708 \u00a0\u4eca\u6708\u306e\u30ea\u30bd\u30fc\u30b9 \u81ea\u5df1\u514d\u75ab\u6027\u62e1\u5f35\u578b\u5fc3\u7b4b\u75c7\u30e2\u30c7\u30eb Targeted mutation \u907a\u4f1d\u5b50\uff1aPdcd1 programmed cell death 1 Chromosome 1 BRC No. 00903, 00904 \u7cfb\u7d71\u540d\uff1aPD-1-KO-N10 (BALB\/c), PD-1-KO-N12 (BALB\/c)\u3000(C;129S2-Pdcd1tm1Hon) \u7814\u7a76\u5206\u91ce\uff1aCardiova [&hellip;]<\/p>\n","protected":false},"author":8,"featured_media":0,"parent":198,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_seopress_robots_follow":"","_seopress_robots_imageindex":"","_seopress_robots_snippet":"","_seopress_robots_primary_cat":"","_seopress_robots_breadcrumbs":"","_seopress_robots_freeze_modified_date":"","_seopress_robots_custom_modified_date":"","_seopress_robots_canonical":"","_seopress_social_fb_title":"","_seopress_social_fb_desc":"","_seopress_social_fb_img":"","_seopress_social_fb_img_attachment_id":0,"_seopress_social_fb_img_width":0,"_seopress_social_fb_img_height":0,"_seopress_social_twitter_title":"","_seopress_social_twitter_desc":"","_seopress_social_twitter_img":"","_seopress_social_twitter_img_attachment_id":0,"_seopress_social_twitter_img_width":0,"_seopress_social_twitter_img_height":0,"_seopress_redirections_value":"","_seopress_redirections_enabled":"","_seopress_redirections_enabled_regex":"","_seopress_redirections_logged_status":"both","_seopress_redirections_param":"","_seopress_redirections_type":301,"_seopress_analysis_target_kw":"","footnotes":"","_wp_rev_ctl_limit":""},"class_list":["post-6792","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/6792","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/comments?post=6792"}],"version-history":[{"count":6,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/6792\/revisions"}],"predecessor-version":[{"id":19085,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/6792\/revisions\/19085"}],"up":[{"embeddable":true,"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/pages\/198"}],"wp:attachment":[{"href":"http:\/\/mus.brc.riken.jp\/ja\/wp-json\/wp\/v2\/media?parent=6792"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}