Strain Information | |
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Image | |
BRC No. | RBRC05119 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | C;B6CB-Tnf<tm1Sek> |
Former Common name | |
H-2 Haplotype | |
ES Cell line | TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1] |
Background strain | |
Appearance | |
Strain development | Developed by Kenji Sekikawa, STAFF-Institute in 1997. The mice were backcrossed to BALB/c for at least 12 times by Yoichiro Iwakura, The Institute of Medical Science, The University of Tokyo. |
Strain description | TNF alpha knockout mice. Homozygous mutant mice show increased susceptibility to infection. |
Colony maintenance | |
References | Failure of germinal center formation and impairment of response to endotoxin in tumor necrosis factor alpha-deficient mice. Taniguchi T, Takata M, Ikeda A, Momotani E, Sekikawa K Lab. Invest., 77, 647-658 (1997). 9426403 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
Tnf | tumor necrosis factor | 17 | Tnf | targeted mutation 1, Kenji Sekikawa | |||
neo | neomycin resistance gene (E. coli) | 17 | mouse phosphoglycerate kinase promoter (PGK promoter) |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | more 18 phenotypes |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | mouse tnf genomic DNA, Neomycin resistance gene (E. coli), Phosphoglycerate kinase (PGK) promoter (mouse) |
Research application | Immunology and Inflammation Research covid19_onset |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Lab. Invest., 77, 647-658 (1997). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature designated by the DEPOSITOR is requested. |
Depositor | Yoichiro Iwakura (The University of Tokyo) |
Strain Status | Frozen sperm |
Strain Availability | Recovered litters from cryopreserved sperm (2 to 4 months) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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No Data |