Strain Information | |
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Image | |
BRC No. | RBRC11052 |
Type | CRISPR/Cas9![]() |
Species | Mus musculus |
Strain name | B6D2-Prss55<em1Osb> |
Former Common name | Prss55<del/wt> |
H-2 Haplotype | |
ES Cell line | |
Background strain | |
Appearance | |
Strain development | Deposited by Masahito Ikawa, Research Institute for Microbial Diseases, Osaka University in 2020. Fertilized eggs derived from BDF1 × BDF1 were used to generate this line. Mixed genetic background. |
Strain description | Prss55 knockout mouse generated by the CRISPR/Cas9. 6527 bp deletion in the Prss55 gene. Homozygous male mutants tend to exhibit infertility. |
Colony maintenance | |
References | Prss55 but not Prss51 is required for male fertility in micedagger. Kobayashi K, Endo T, Matsumura T, Lu Y, Yu Z, Matzuk M M, Ikawa M Biol. Reprod., 103(2):223-234 (2020). doi: 10.1093/biolre/ioaa041. 32301961 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
Prss55 MGI:1918287 | serine protease 55 | 14 | Prss55<em1Osb> | endonuclease-mediated mutation 1, Research Institute for Microbial Diseases, Osaka University |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | Streptococcus pyogenes crRNA, tracrRNA, Mouse a part of Prss55 gene |
Research application | |
Specific Term and Conditions | The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Biol. Reprod., 103(2):223-234 (2020).The RECIPIENT which wants to use the BIOLOGICAL RESOURCE for the purpose other than education or not-for-profit research is requested to enter into a Material Transfer Agreement with Osaka University. The RECIPIENT which wants to use the BIOLOGICAL RESOURCE even after five years must obtain a written consent from the DEPOSITOR again. |
Depositor | Masahito Ikawa (Osaka University) |
Strain Status | ![]() |
Strain Availability | ![]() |
Additional Info. | Necessary documents for ordering:
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BRC mice in Publications |
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No Data |