The 2016 Nobel Prize in Physiology or Medicine was awarded to Dr. Yoshinori Ohsumi “for his discoveries of mechanisms for autophagy” [1]. Collaborative studies with Dr. Ohsumi led Dr. Noboru Mizushima and Dr. Masaaki Komatsu to establish popular strains to investigate the role of autophagy in the mouse [2-4]. Their mouse strains have been deposited to RIKEN BRC and distributed to over 240 institutions worldwide.
Popular strains
| BRC No. | Strain Name | Depositor | References |
|---|---|---|---|
| RBRC00806 | GFP-LC3#53 | Dr. Noboru Mizushima | 2, 3 |
| RBRC02231 | B6;129-Atg5<tm1Nmz> | Dr. Noboru Mizushima | 3 |
| RBRC02759 | B6.Cg-Atg7<tm1Tchi> | Dr. Masaaki Komatsu | 4 |
| RBRC02760 | B6.Cg-Atg7<tm1.1Tchi> | Dr. Masaaki Komatsu | 4 |
References
[1] The 2016 Nobel Prize in Physiology or Medicine
http://www.nobelprize.org/nobel_prizes/medicine/laureates/2016/
[2] Mizushima N, Yamamoto A, Matsui M, Yoshimori T, Ohsumi Y. In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol Biol Cell 15(3):1101-1111, 2004.
[3] Kuma, A., Hatano, M., Matsui, M., Yamamoto, A., Nakaya, H., Yoshimori, T., Ohsumi, Y., Tokuhisa, T., and Mizushima, N. The role of autophagy during the early neonatal starvation period. Nature 432, 1032–1036, 2004.
[4] Komatsu M, Waguri S, Ueno T, Iwata J, Murata S, Tanida I, Ezaki J, Mizushima N, Ohsumi Y, Uchiyama Y, Kominami E, Tanaka K, Chiba T. Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol 169(3):425-434, 2005.
Mouse strains related to autophagy gene and autophagic machinery
| BRC No. | Strain Name | Depositor | References |
|---|---|---|---|
| RBRC02761 | B6.Cg-Atg3<tm1> | Dr. Masaaki Komatsu | Mol. Biol. Cell 19:4762-4775 (2008). |
| RBRC02975 | B6.129S-Atg5<tm1Myok> | Dr. Noboru Mizushima | Nature 441, 885-889 (2006). |
| RBRC03914 | C57BL/6-Tg(Myh6-mCherry/LC3)1Acvm | Dr. Kiyoshi Nobori | Circ. J. 74, 203-206 (2010). |
| RBRC05545 | C.129S4-Tecpr1<tm1> | Dr. Chihiro Sasakawa, Dr. Michinaga Ogawa | Cell Host Microbe, 9, 376-389 (2011). Mol. Cell, 45, 629-641 (2012). |
| RBRC09404 | B6.CBA-Park2<tm1Tchi> | Dr. Tomoki Chiba | J. Neurosci. Res., 84:1350-1357 (2006). |
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