| Date | Title | BRC No. | Description | References |
|---|---|---|---|---|
| 24.12.04 | ARMC12-targeted BioID Tg mice | RBRC11045 | This strain expresses ARMC12 and biotin ligase BioID2 fusion protein under the control of the Clgn promoter.1) | 1) Proc Natl Acad Sci U S A. 2021 Feb 9;118(6):e2018355118. |
| 24.12.04 | TESMIN-targeted BioID Tg mice | RBRC11222 | This strain expresses TESMIN and biotin ligase TurboID fusion protein under the control of the Clgn promoter.1) | 1) Sci Rep. 2022 Dec 23;12(1):22198. |
| 24.12.04 | TESMIN-targeted BioID Tg mice | RBRC11665 | This strain expresses TESMIN and biotin ligase BioID2 fusion protein under the control of the Clgn promoter, and also has deletion of Tesmin gene.1) | 1) Sci Rep. 2022 Dec 23;12(1):22198. |
| 24.04.01 | Cma1(Mcpt5)-DTR KI mice | RBRC11317 | This strain is capable of inducing mast cell depletion by administration of DT (diphtherial toxin). 1) | 1) Biochem Biophys Res Commun. 2021 Apr 30:551:127-132. |
| 24.04.01 | Msr1(Cd204)-DTR KI mice | RBRC06357 | This strain is capable of inducing CD204-positive macrophages depletion by administration of DT (diphtherial toxin). 1) | 1) Biochem Biophys Rep. 2020 Aug 7:23:100791. |
| 24.04.01 | Ly75(Cd205)-DTR KI mice | RBRC05659 | This strain is capable of inducing mast CD205-positive cDCs (conventional dendritic cells) depletion by administration of DT (diphtherial toxin). 1) | 1) Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11288-93. |
| 24.04.01 | Lyz2(Lysm)-DTR KI mice | RBRC04394 | This strain is capable of inducing alveolar epithelial type II (AE2) cells and macrophages depletion by administration of DT (diphtherial toxin). 1)2)3) | 1) iScience. 2023 Jan 5;26(2):105934. 2) Nat Immunol. 2014 Nov;15(11):1064-9. 3) J Immunol. 2007 Apr 15;178(8):5001-9. |
| 23.12.01 | p16<INK4a>(CDKN2A) luminescent reporter mice | RBRC05271 (ICR) RBRC09236 (B6) | These Tg strains carry the entire human p16<INK4a>(CDKN2A) gene locus tagged with luciferase.1) | 1) J Cell Biol. 2009 Aug 10;186(3):393-407. |
| 23.12.01 | p21(CDKN1A) luminescent reporter mice | RBRC09237 | This Tg strain expresses luciferase under the human p21(CDKN1A) promoter.1) | 1) Proc Natl Acad Sci U S A. 2007 Sep 18;104(38):15034-9. |
| 23.12.01 | Arc luminescent reporter mice | RBRC06053 | This BAC Tg strain expresses luciferase under the exogenous Arc promoter.1) | 1) Brain Struct Funct. 2011 Jun;216(2):91-104. |
| 23.12.01 | Bdnf luminescent reporter mice | RBRC11093 | This BAC Tg strain expresses luciferase under the exogenous Bdnf promoter. 1)2) | 1) Sci Rep. 2017 Jul 10;7(1):4949. 2) J Neurosci. 2015 Apr 8;35(14):5606-24. |
| 23.10.02 | The clock gene Bmal1(Arntl) floxed mice | RBRC11399 | Analysis of crosses with various Cre driver mice has been reported.1)2)3)4)5) | 1) Mol Metab. 2021 Jul;49:101202. 2) Cell Rep. 2021 Jul 6;36(1):109336. 3) JCI Insight. 2019 Mar 7;4(5):e121798. 4) Sci Rep. 2018 Jan 31;8(1):1996. 5) PLoS One. 2011;6(9):e25231. |
| 23.10.02 | The clock gene Bmal1(Arntl) luminescent reporter mice | RBRC09717 | This Tg strain expresses luciferase after Cre-mediated recombination under the exogenous Bmal1(Arnt).1) | 1) Biochemistry. 2010 Sep 21;49(37):8053-61. |
| 23.10.02 | The clock gene Per1 luminescent reporter mice | RBRC09608 | This Tg strain expresses luciferase under the exogenous Per1 promoter. 1)2) | 1) Sci Rep. 2015 Jul 21;5:12310. 2) Proc Natl Acad Sci U S A. 2007 May 1;104(18):7664-9. |
| 23.10.02 | The clock genes Bmal1(Arntl) and Per1 luminescent reporter mice | RBRC02670 | This Tg strain expresses different luciferases under the exogenous Bmal1(Arntl) and Per1 promoter, respectively.1) | 1) Genes Cells. 2006 Oct;11(10):1173-82. |
| 23.08.03 | Zeb2 (SIP1, Zfhx1b) gene fluorescent reporter mice | RBRC09239 (ICR) RBRC09240 (ICR and B6 mixed) | These KI strains express a EGFP under the control of endogenous Zeb2 promoter.1)2)3)4)5) | 1) Cell Rep. 2023 Mar 20;112276. 2) Cardiovasc Res. 2022 Mar 25;118(5):1262-1275. 3) Immunity. 2021 Jul 13;54(7):1417-1432.e7. 4) Elife. 2019 Aug 8;8:e47605. 5) Genesis. 2014 Jan;52(1):56-67. |
| 23.08.03 | Sox9 gene fluorescent reporter mice | RBRC05651 | This KI strain expresses a EGFP under the control of endogenous Sox9 promoter.1)2)3)4)5) | 1) Front Cell Dev Biol. 2020 Oct 22;8:585640. 2) Endocrinology. 2019 Feb 1;160(2):387-398. 3) Nat Commun. 2018 Aug 22;9(1):3356. 4) PLoS One. 2017 Nov 30;12(11):e0188705. 5) Dev Dyn. 2009 May;238(5):1100-10. |
| 23.08.03 | Tg mice for conditional overexpression of SOX9 | RBRC05654 | This Tg strain overexpresses SOX9 after Cre-mediated recombination.1)2)3)4)5) | 1) Proc Natl Acad Sci U S A. 2019 Jan 29;116(5):1704-1713. 2) Elife. 2018 Apr 3;7:e32358. 3) J Clin Invest. 2018 Aug 1;128(8):3475-3489. 4) Gastroenterology. 2018 Jul;155(1):194-209.e2. 5) J Bone Miner Metab. 2011 Jan;29(1):123-9. |
| 23.08.03 | Tg mice for misexpression of SOX9 in limb bud mesenchyme | RBRC05525 | This Tg strain misexpresses SOX9 under the control of Prrx1 promoter.1)2) | 1) Development. 2009 Apr;136(8):1263-72. 2) Matrix Biol. 2007 May;26(4):224-33. |
| 23.06.01 | Neuronal cells Cre-driver mice | RBRC11130 | This KI strain expresses a Cre under the control of endogenous Tubb3 promoter.1) | 1) Cell Rep. 2021 Jul 27;36(4):109427. |
| 23.06.01 | Spleen TLX1 expressing cells Cre-driver mice | RBRC11118 | This KI strain expresses CreERT2 and Venus under the control of endogenous Tlx1 promoter.1)2)3) | 1) Sci Rep. 2019 Dec 31;9(1):20408. 2) Sci Rep. 2018 May 29;8(1):8308. 3) Genesis. 2014 Nov;52(11):916-23. |
| 23.06.01 | Glucagon-producing α-cells Cre-driver mice | RBRC10958 | This KI strain expresses Cre under the control of Gcg promoter.1) | 1) Exp Anim. 2020 Apr 24;69(2):178-188. |
| 23.06.01 | KRT19 expressing cells Cre-driver mice | RBRC10923 | This BAC Tg strain expresses iCre under the control of Krt19 promoter.1) | 1) PLoS One. 2019 Aug 8;14(8):e0220818. |
| 23.04.03 | Orexin neurons FLP driver mice | RBRC11555 | This KI strain expresses FLP and GFP under the control of endogenous Hcrt promoter.1) | 1) Elife. 2019 Jun 4;8:e44927. |
| 23.04.03 | FLPe driver mice | RBRC10708 RBRC10707 RBRC01834 | These Tg strains express FLPe under the control of CAG promoter in C57BL/6J background.1) | 1) Exp Anim. 2006 Apr;55(2):137-41. |
| 23.04.03 | FLPo driver mice | RBRC09982 RBRC06479 RBRC06470 | These Tg strains express FLPo under the control of CAG promoter.1) | 1) J Cell Sci. 2016 May 1;129(9):1940-9. |
| 23.02.03 | Notch signaling fluorescent reporter mice | RBRC06137 | This Tg strain expresses Venus depend on activation of Notch signaling via RBP-jk-binding sequence.1)2)3)4) | 1) Stem Cells. 2016 Aug;34(8):2169-82. 2) Nat Commun. 2015 Jul 23;6:7739. 3) Development. 2011 Jan;138(1):55-64. 4) Dev Biol. 2005 Oct 1;286(1):311-25. |
| 23.02.03 | A transcriptional co-activator in the Notch signaling Maml1 KO mice | RBRC10002 | This strain has been used for analysis of the Notch signaling pathway.1)2)3)4) | 1) PLoS Genet. 2016 Dec 27;12(12):e1006514. 2) PLoS Genet. 2013;9(1):e1003132. 3) Development. 2011 Dec;138(23):5235-46. 4) Proc Natl Acad Sci U S A. 2007 Jun 5;104(23):9764-9. |
| 23.02.03 | Notch2 floxed mice | RBRC09647 | This strain has been used for analysis of the Notch signaling pathway.1)2)3)4) | 1) Nat Commun. 2019 Jan 14;10(1):190. 2) PLoS Biol. 2019 May 9;17(5):e3000262. 3) Nat Med. 2015 Jan;21(1):55-61. 4) Immunity. 2003 May;18(5):675-85. |
| 22.12.06 | RAG2 expressing cells fluorescent reporter mice | RBRC09497 | This KI strain expresses a EGFP under the control of endogenous Rag2 promoter.1) | 1) Int Immunol. 2003 Mar;15(3):393-402. |
| 22.12.06 | GATA1 expressing cells fluorescent reporter mice | RBRC09400 | This BAC Tg strain expresses GFP under the control of Gata1 promoter.1) | 1) Mol Cell Biol. 2009 Mar;29(5):1163-75. |
| 22.12.06 | Inhibitory neurons fluorescent reporter mice | RBRC09645 | This BAC Tg strain expresses YFP under the control of VGAT(Slc32a1) promoter.1) | 1) Neuroscience. 2009 Dec 15;164(3):1031-43. |
| 22.12.06 | Inhibitory neurons fluorescent reporter mice | RBRC10799 RBRC10800 | These BAC Tg strains express tdTomato under the control of VGAT(Slc32a1) promoter.1) | 1) J Comp Neurol. 2018 Feb 15;526(3):373-396. |
| 22.10.03 | PDGFRα expressing cells Cre-driver mice | RBRC09616 | This KI strain expresses a GFP-CreERT2 fucion protein under the control of endogenous Pdgfra promoter.1)2)3)4)5) | 1) Sci Rep. 2021 Apr 21;11(1):8683. 2) Nat Commun. 2020 May 8;11(1):2303. 3) Development. 2018 Jan 29;145(2):dev155879. 4) Genesis. 2015 May;53(5):329-36. 5) Mouse of the Month September 2016. |
| 22.10.03 | Astrocytes Cre-driver mice | RBRC10705 | This Tg strain expresses Cre under the control of S100b promoter.1)2)3) | 1) J Neurosci. 2017 Oct 18;37(42):10052-10062. 2) Front Neurosci. 2008 Dec 15;2(2):225-33. 3) Front Behav Neurosci. 2008 Apr 23;2:1. |
| 22.10.03 | Specific excitatory neurons Cre-driver mice | RBRC10626 | This Tg strain expresses CreERT2 under the control of Atoh1 promoter.1) | 1) Science. 2015 Nov 20;350(6263):957-61. |
| 22.10.03 | Testicular germ cells Cre-driver mice | RBRC06480 | This Tg strain expresses Cre under the control of Stra8 promoter.1) | 1) Sci Rep. 2015 Sep 21;5:14254. |
| 22.08.01 | Lateral nucleus of the amygdala Cre-driver mice | RBRC10694 | This KI strain expresses iCre under the control of endogenous Grp( Gastrin-releasing peptide) promoter.1) | 1) Elife. 2018 Jun 26;7:e34135. |
| 22.08.01 | Vesicular GABA transporters Cre-driver mice | RBRC10606 | This BAC Tg strain expresses Cre under the control of Slc32a1 promoter.1)2)3)4)5) | 1) Hum Mol Genet. 2021 May 28;30(9):758-770. 2) Nat Commun. 2020 Oct 9;11(1):5113. 3) Nat Commun. 2019 Apr 23;10(1):1917. 4) Mol Autism. 2019 Mar 28;10:15. 5) Hum Mol Genet. 2013 Dec 1;22(23):4784-804. |
| 22.08.01 | Osteoblasts Cre-driver mice | RBRC05603 | This Tg strain expresses Cre under the control of Col1a1 promoter.1)2)3)4)5) | 1) Bone. 2021 Sep;150:116010. 2) JBMR Plus. 2021 May 17;5(6):e10496. 3) Cell. 2020 Aug 6;182(3):609-624.e21. 4) Genes Cells. 2018 May;23(5):345-356. 5) Dev Dyn. 2002 Jun;224(2):245-51. |
| 22.08.01 | Osteoblasts Cre-driver mice | RBRC05524 | This Tg strain expresses Cre under the control of Col1a1 promoter.1)2)3)4)5) | 1) JCI Insight. 2020 May 7;5(9):e135355. 2) Stem Cells. 2016 Aug;34(8):2145-56. 3) J Bone Miner Res. 2015 Apr;30(4):715-22. 4) EMBO J. 2015 Jun 12;34(12):1648-60. 5) J Bone Miner Res. 2008 Feb;23(2):271-7. |
| 22.06.01 | Rspo2-Cre BAC Tg mice | RBRC10754 | Cre expression is detected in basolateral amygdala (BLA)1). (BAC clone ID：RP23-39M21) | 1) Nat Neurosci. 2016 Dec;19(12):1636-1646. |
| 22.06.01 | Gpr151-Cre BAC Tg mice | RBRC10728 | Cre expression is detected in cholinergic neurons of medial habenula (mHb)1)2). (BAC clone ID：MSMg01-81G4) | 1) J Comp Neurol. 2017 Oct 15;525(15):3227-3250. 2) Front Behav Neurosci. 2013 Mar 12;7:17. |
| 22.06.01 | Prkcd-Cre BAC Tg mice | RBRC10725 | Cre expression is detected in almost the entire dorsal thalamus1). (BAC clone ID：RP23-220I83) | 1) Sci Rep. 2016 Jun 27;6:28750. |
| 22.06.01 | VGAT(Slc32a1)-Cre BAC Tg mice | RBRC10723 | Cre expression is detected in inhibitory neurons1)2). (BAC clone ID：RP23-392P11) | 1) Sci Rep. 2016 Jun 27;6:28750. 2) Hum Mol Genet. 2013 Dec 1;22(23):4784-804. |
| 22.03.30 | Otx2-tdTomato KI mice1) | RBRC10897 | This strain expresses tdTomato under the control of ectoderm marker Otx2. | 1) Exp Anim. 2019 Nov 6;68(4):499-509 |
| 22.03.30 | Sox17-EGFP KI mice1) | RBRC10898 | This strain expresses EGFP under the control of endoderm marker Sox17. | 1) Exp Anim. 2019 Nov 6;68(4):499-509 |
| 22.03.30 | Tppp3-EGFP KI mice1) | RBRC10145 | This strain expresses EGFP under the control of Tppp3. | 1) Nat Commun. 2019 Sep 5;10(1):3999 |
| 22.03.30 | Tppp3-CreERT2 KI mice1) | RBRC10144 | This strain expresses CreERT2 under the control of Tppp3. | 1) Nat Commun. 2019 Sep 5;10(1):3999 |
| 22.03.30 | Sox10-CreERT2 KI mice1) | RBRC10143 | This strain expresses CreERT2 under the control of Sox10. | 1) Nat Commun. 2019 Sep 5;10(1):3999 |
| 22.01.31 | Actin-tTS Tg mice1)2) | RBRC05447 | This strain express tTS in whole body 3)4)5). | 1) Genomics. 2003 Apr;81(4):356-60 2) Biol Psychiatry. 2010 Apr 15;67(8):770-3 3) Sci Rep. 2019 Mar 4;9(1):3422 4) Sci Rep. 2017 Oct 19;7(1):13605 5) Neuron. 2015 May 6;86(3):813-26 |
| 22.01.31 | Gad1-tTA KI mice1) | RBRC11365 | tTA expression is detected in GABAergic neurons. | 1) Mol Brain. 2021 Jan 7;14(1):5 |
| 22.01.31 | Gad1-Stop-tetO KI mice1) | RBRC11364 | This strain is used for Gad1 gene expression control by Tet on/off system. | 1) Mol Brain. 2021 Jan 7;14(1):5 |
| 22.01.31 | Nkcc1-tetO KI mice1) | RBRC11202 | This strain is used for Nkcc1 (Slc12a2) gene expression control by Tet on/off system. | 1) Sci Rep. 2017 Oct 19;7(1):13605 |
| 22.01.31 | CatC-tetO KI mice1) | RBRC10854 | This strain is used for Cathepsin C gene expression control by Tet on/off system. | 1) Glia. 2017 Jun;65(6):917-930 |
| 21.12.01 | Sox9-CreERT2 KI mice1) | RBRC05522 | This strain is useful for research of embryonic development and cell differentiation2)3)4)5). | 1) Genesis. 2010 Nov;48(11):635-44. 2) Development. 2021 Jul 1;148(13):dev199543. 3) Nat Commun. 2021 May 4;12(1):2509. 4) Proc Natl Acad Sci U S A. 2021 Feb 16;118(7):e2017115118. 5) Proc Natl Acad Sci U S A. 2020 Jun 2;117(22):12182-12191. |
| 21.12.01 | Sox9-Cre KI mice1) | RBRC05523 | This strain is useful for research of embryonic development and cell differentiation2)3)4)5). | 1) Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14665-70. 2) Elife. 2020 May 12;9:e53688. 3) Development. 2019 Oct 4;146(20):dev182782. 4) J Neurosci. 2018 Jun 6;38(23):5429-5440. 5) Development. 2018 Dec 18;145(24):dev165381. |
| 21.12.01 | Sox1-Cre KI mice1) | RBRC05065 | This strain is useful for research of embryonic development and cell differentiation2)3)4)5). | 1) Cell. 2007 Jun 29;129(7):1377-88. 2) Genes Cells. 2021 Feb;26(2):45-55. 3) PLoS Genet. 2020 Feb 24;16(2):e1008300. 4) Dev Biol. 2020 Dec 1;468(1-2):101-109. 5) Nat Commun. 2020 Nov 11;11(1):5709. |
| 21.12.01 | Dkk3-Cre BAC Tg mice1) | RBRC10900 (C57BL/6) RBRC05427 (129) | Theses strains are useful for eye development research2)3)4)5). | 1) Genesis. 2007 Aug;45(8):502-7. 2) Genes Cells. 2020 Jun;25(6):402-412. 3) Elife. 2020 Feb 25;9:e51275. 4) Invest Ophthalmol Vis Sci. 2020 Sep 1;61(11):43. 5) Invest Ophthalmol Vis Sci. 2017 Apr 1;58(4):1916-1929. |
| 21.10.01 | Plp1-tTA Tg mice | RBRC05446 | tTA expression is detected in oligodendrocytes1). It was contributed to some results2)3)4)5). | 1) Genesis. 2012 May;50(5):424-8. 2) J Neurosci. 2019 May 22;39(21):4036-4050. 3) J Neurochem. 2019 Jul;150(2):158-172. 4) Nat Neurosci. 2018 Apr;21(4):625-637. 5) Cell Rep. 2018 Aug 21;24(8):2196-2210.e9. |
| 21.10.01 | Htr5b-tTA KI mice | RBRC05445 | tTA expression is detected in 5-hydroxytryptamine (serotonin) receptor 5B positive cells1). It was contributed to some results2)3)4). | 1) Cell Rep. 2012 Aug 30;2(2):397-406. 2) Nat Neurosci. 2019 May;22(5):770-777. 3) Cell Rep. 2018 Aug 21;24(8):2196-2210.e9. 4) Cell Rep. 2017 Nov 21;21(8):2066-2073. |
| 21.10.01 | Pmch-tTA BAC Tg mice | RBRC05844 | tTA expression is detected in MCH (melanin-concentrating hormone) neurons1). It was contributed to some results2)3). | 1) J Neurosci. 2014 May 14;34(20):6896-909. 2) Science. 2019 Sep 20;365(6459):1308-1313. 3) Elife. 2020 Apr 21;9:e54275. |
| 21.10.01 | Tph2-tTA BAC Tg mice | RBRC05846 | tTA expression is detected in serotonergic neurons1). It was contributed to some results2)3)4). | 1) Int J Neuropsychopharmacol. 2014 Nov;17(11):1777-83. 2) Nat Neurosci. 2019 May;22(5):770-777. 3) Neuropharmacology. 2020 May 1;167:107703. 4) Nat Commun. 2018 Jun 1;9(1):2048. |
| 21.08.02 | Cre-driver mice for inner ear | RBRC09434 | Pax2-Cre Tg strain is utilized as Cre-driver mice for inner ear1)2)3). | 1) Elife. 2020 Jan 8;9:e52160. 2) PLoS Genet. 2017 Oct 23;13(10):e1007048. 3) Genesis. 2004 Apr;38(4):195-9. |
| 21.08.02 | Cre-driver mice for olfactory sensory neurons | RBRC06339 | Olfr1507(MOR28)-Cre Tg strain is utilized as Cre-driver mice for a part of olfactory sensory neurons1)2)3). | 1) Science. 2019 Jul 5;365(6448):eaaw5030. 2) Mouse of the Month October 2015. 3) Cell. 2010 Jun 11;141(6):1056-67. |
| 21.08.02 | Cre-driver mice for olfactory sensory neurons | RBRC06346 | Ascm4(OMACS)-Cre KI strain is utilized as Cre-driver mice for dorsal zone olfactory sensory neurons1)2)3). | 1) Commun Biol. 2019 Jan 8;2:14. 2) Sci Rep. 2015 Sep 11;5:14073. 3) Nature. 2007 Nov 22;450(7169):503-8. |
| 21.08.02 | Cre-driver mice for retinal photoreceptor cells and progenitor cells | RBRC05426 | Crx-Cre Tg strain is utilized as Cre-driver mice for retinal photoreceptor cells and progenitor cells1)2)3). | 1) Sci Rep. 2018 Jun 4;8(1):8543. 2) Hum Mol Genet. 2018 Sep 15;27(18):3137-3153. 3) Nat Neurosci. 2003 Dec;6(12):1255-63. |
| 21.08.02 | CreERT2-driver mice for retinal photoreceptor cells and progenitor cells | RBRC05559 | Crx-CreERT2 Tg strain is utilized as tamoxifen-inducible Cre-driver mice for retinal photoreceptor cells and progenitor cells1)2)3). | 1) Exp Eye Res. 2018 Aug;173:32-43. 2) Cell Rep. 2015 Nov 3;13(5):990-1002. 3) J Neurosci. 2011 Nov 16;31(46):16792-807. |
| 21.03.31 | G-CaMP7 Tg mice controlled by Thy1 promoter | RBRC06579 | Using this strain, longitudina imaging of large-scale functional hippocampal cellular maps was performed1)2). | 1) Cell Rep. 2020 Jul 7;32(1):107864. 2) PLoS One. 2012;7(12):e51286. |
| 21.03.31 | G-CaMP7 Tg mice controlled by Slc1a2 (GLT1) promoter | RBRC09650 | This strain expresses G-CaMP7 in astrocytes and a subpopulation of cortical neurons1)2)3)4). It contributed to elucidation of the recovery mechanism after acute ischemic stroke5). | 1) Nat Commun. 2016 Mar 22;7:11100. 2) Mouse of the Month August 2017. 3) J Neurosci. 2007 Jun 20;27(25):6607-19. 4) PLoS One. 2012;7(12):e51286. 5) Proc Natl Acad Sci U S A. 2019 May 28;116(22):11010-11019. |
| 21.03.31 | G-CaMP6 Tg mice controlled by Thy1 promoter | RBRC10611 | This strain expresses G-CaMP6 in brain1)2). | 1) Neurosci Res. 2020 Feb;151:53-60. 2) PLoS One. 2012;7(12):e51286. |
| 21.03.31 | G-CaMP7 expression conditionally controllable Tg mice | RBRC06510 | This strain is reported to show a growth retardation with hypothyroidism1)2)3). | 1) PLoS One. 2015 May 6;10(5):e0125354. 2) Mouse of the Month June 2015. 3) PLoS One. 2012;7(12):e51286. |
| 21.02.01 | A member of formin protein family mDia1 floxed mice | RBRC02595 | This strain contributed to elucidation of actin cytokine-mediated T cell activation mechanism1)2)3). | 1) Sci Adv6 (1) 2020 eaay2432 2) Cell Rep 2016 17 (9) 2405-2417 3) J Exp Med 2007 204 (9) 2031-8 |
| 21.02.01 | Oncostatin M (a member of IL-6 family of cytokines) receptor KO mice1)2) | RBRC02711 | This strain is widely used for variety research fields including immunology3)4)5). | 1) Blood 2003 102 (9) 3154-62 2) Hepatology 2004 39 (3) 635-44 3) Proc Natl Acad Sci U S A 2020 117 (9) 5028-5038 4) Nat Commun 2017 8 13946 5) J Lipid Res 2017 58 (5) 895-906 |
| 21.02.01 | Cytokine TNFα KO mice1)2) | RBRC05118 (C57BL/6) RBRC05119 (BALB/c) | These strains are widely used for elucidation of immune mechanism3)4). | 1) J Immunol 1997 159 (3) 1418-28 2) Lab Invest 1997 77 (6) 647-58 3) J Immunol 2019 203 (4) 783-788 4) Front Immunol 2018 9 2619 |
| 20.12.01 | Endogenous membrane protein Mavs (IPS-1) KO mice1) | RBRC04546 | Mavs (IPS-1) is related to the cytokine production as adaptor to recognize cytoplasmic RNA virus. This strain contributed to elucidate some findings 2)3)4)5). | 1) J Immunol. 2011 Nov 15;187(10):5320-7. 2) Cancer Sci. 2018 Apr;109(4):956-965. 3) Cell Rep. 2017 May 30;19(9):1874-1887. 4) Cell Rep. 2015 May 26;11(8):1193-207. 5) Immunity. 2015 Dec 15;43(6):1148-59. |
| 20.12.01 | Ubiquitin ligase Efp (Trim25) KO mice1) | RBRC02844 | Analysis of this strain revealed that Efp (Trim25) is related to the breast tumor growth2), neuroinflammation pathogenesis3) and inhibition of virus infection4)5). | 1) Proc Natl Acad Sci U S A. 1999 Oct 12;96(21):12027-32. 2) Nature. 2002 Jun 20;417(6891):871-5. 3) Nat Immunol. 2017 Jan;18(1):54-63. 4) Nat Immunol. 2010 Jan;11(1):63-9. 5) Nature. 2007 Apr 19;446(7138):916-920. |
| 20.12.01 | Itgal (LFA-1, Cd11a) KO mice1) | RBRC00850 | Analysis of this strain revealed several type I interferon secretion mechanism by plasmacytoid dendritic cells2). | 1) J Exp Med. 1996 Apr 1;183(4):1415-26. 2) Nat Commun. 2017 Nov 17;8(1):1592. |
| 20.12.01 | Agt (angiotensinogen) KO mice1) | RBRC01120 | This strain is widely used for functional analysis of renin-angiotensin system2)3). | 1) J Biol Chem. 1994 Dec 16;269(50):31334-7. 2) PLoS One. 2015 Jun 24;10(6):e0129484. 3) Circ Res. 2014 Jul 7;115(2):263-72. |
| 20.10.01 | Pro-inflammatory cytokine IL-6 KO mice1) | RBRC04918 (C57BL/6) RBRC04919 (BALB/c) RBRC05131 (DBA/1) | IL-6 (interleukin-6) is a cytokine that has multifunction, including inflammatory response, in many kinds of cells. These strains were utilized for IL-6 functional analysis2)3)4). | 1) Nature. 1994 Mar 24;368(6469):339-42. 2) Sci Rep. 2019 Jul 25;9(1):10842. 3) Sci Adv. 2018 Jul 11;4(7):eaas9944. 4) Sci Rep. 2018 Oct 25;8(1):15783. |
| 20.10.01 | IL-6-related inflammatory status in vivo imaging mice | RBRC09487 | This BAC-based human IL-6-luciferase Tg strain is useful for evaluation of inflammatory status in vivo by luciferase luminescence1)2)3)4)5). | 1) Sci Rep. 2018 May 23;8(1):8037. 2) Eur J Pharmacol. 2017 May 5;802:76-84. 3) Nat Commun. 2016 May 23;7:11624. 4) Mouse of the Month May 2016 5) Mol Cell Biol. 2015 Oct;35(20):3590-601. |
| 20.10.01 | Human IL-6 expression conditionally controllable mice | RBRC09734 RBRC09735 | This strain expresses human IL-6 according to Cre recombinase1). | 1) Exp Anim. 2016 Nov 1;65(4):455-463. |
| 20.04.01 | Cre reporter mice showing green-to-red fluorescent conversion1)2)3) | RBRC04874 | This ROSA26-KI strain express EGFP signal before and tdsRed signal after Cre-mediated recombination. It was contributed to some results4)5)6). | 1) Exp Anim. 2013;62(4):295-304. 2) Mouse of the Month October 2018 3) Mouse of the Month March 2014 4) iScience. 2019 Oct 25;20:337-347. 5) Dev Cell. 2019 Jul 22;50(2):139-154.e5. 6) PLoS One. 2018 Jan 11;13(1):e0190800. |
| 20.04.01 | Cre reporter mice expressing EGFP signal1) | RBRC09806 | This Tg strain express EGFP signal after Cre-mediated recombination. It was contributed to some results2)3)4). | 1) FEBS Lett. 2000 Mar 31;470(3):263-8. 2) Dev Cell. 2019 Jan 28;48(2):151-166.e7. 3) Cell Stem Cell. 2018 Mar 1;22(3):384-397.e6. 4) Nat Commun. 2018 Apr 24;9(1):1623. |
| 20.04.01 | Cre reporter mice expressing LacZ signal1)2) | RBRC02657 | This ROSA26-KI strain express LacZ signal after Cre-mediated recombination. It was contributed to some results3)4)5). | 1) Front Behav Neurosci. 2013 Mar 12;7:17. 2) Mouse of the Month March 2013 3) Transgenic Res. 2018 Apr;27(2):193-201. 4) J Neurosci. 2017 Aug 9;37(32):7682-7699. 5) Genesis. 2016 Nov;54(11):568-572. |
| 20.02.03 | Siglec-H gene DTR-EGFP KI mice | RBRC05658 (C57BL/6) RBRC09688 (BALB/c) | In this strain, plasmacytoid dendritic cells (pDCs) can be depleted by injection of diphtheria toxin 1)2)3). User reported that pDCs are related with acute liver injury4). | 1) Glia. 2017 Dec;65(12):1927-1943. 2) Sci Rep. 2016 Apr 14;6:24477. 3) Immunity. 2011 Dec 23;35(6):958-71. 4) J Clin Invest. 2019 Jul 2;129(8):3201-3213. |
| 20.02.03 | Xcr1 gene KikGR KI mice | RBRC09928 | This is a photoconvertible KikGR reporter mice for Xcr1 gene, which express chemokine receptor at one subset of dendritic cells1). | 1) Proc Natl Acad Sci U S A. 2016 Jan 26;113(4):1044-9. |
| 20.02.03 | Xcr1 gene DTR-Venus KI mice | RBRC09485 (C57BL/6) RBRC10391 (BALB/c) | In this strain, XCR1-positive dendritic cells can be depleted by injection of diphtheria toxin 1) 2) 3). | 1) Nat Microbiol. 2018 May;3(5):611-621. 2) J Immunol. 2017 Dec 15;199(12):4165-4179. 3) Mouse of the Month January 2016 |
| 20.02.03 | Relb gene Venus KI mice | RBRC09496 | This is a Venus reporter strain for Nf-κB family gene Relb, which is related with immune cell maturation 1). | 1) J Biochem. 2015 Dec;158(6):485-95. |
| 19.12.02 | Cre-driver mice for CRF neuron | RBRC06520 | Crh (corticotropin-releasing hormone) Cre KI strain is useful for stress response research 1) 2). | 1) Sci Adv. 2016 Aug 17;2(8):e1501723. 2) Endocrinology. 2014 Oct;155(10):4054-60. |
| 19.12.02 | Crh gene reporter mice | RBRC09893 | Crh (corticotropin-releasing hormone) Venus KI strain allows the visualization of CRF neurons 1) 2) 3). | 1) Biol Sex Differ. 2019 Jan 28;10(1):6. 2) Brain Struct Funct. 2017 May;222(4):1705-1732. 3) Endocrinology. 2014 Oct;155(10):4054-60. |
| 19.12.02 | Cre-driver mice for Oligodendrocyte lineage and motoneuron | RBRC01507 | Olig2-tamoxifen inducible Cre KI strain is frequently used in neuroscience 1) 2) 3) 4) 5). | 1) Nat Neurosci. 2018 May;21(5):696-706. 2) Science. 2014 Sep 26;345(6204):1254927.v 3) Mouse of the Month July 2006 4) Dev Biol. 2006 May 15;293(2):358-69. 5) Curr Biol. 2002 Jul 9;12(13):1157-63. |
| 19.12.02 | Transcription factor Olig2 reporter mice | RBRC06017 RBRC06018 RBRC06022 | This strain express Venus, mCherry or luciferase-OLIG2 fusion protein 1). | 1) Science. 2013 Dec 6;342(6163):1203-8. |
| 19.12.02 | Cre-driver mice for dorsal telencephalon | RBRC01345 | Emx1 (empty spiracles homeobox 1) Cre KI strain is frequently used in neuroscience 1) 2) 3) 4) 5). | 1) Nat Commun. 2019 Aug 8;10(1):3581. 2) Nat Commun. 2017 May 23;8:15488. 3) Mouse of the Month July 2006 4) Genesis. 2004 Mar;38(3):130-8. 5) Nature. 2000 Aug 17;406(6797):726-31. |
| 19.12.02 | Cre-driver mice for developing cochleae | RBRC02272 | Emx2 (empty spiracles homeobox 2) Cre KI strain 1) is useful for inner ear development research 2) 3) 4). | 1) J Neurosci. 2005 May 25;25(21):5097-108. 2) J Neurosci. 2019 Oct 9;39(41):8013-8023. 3) Dev Biol. 2018 May 1;437(1):17-26. 4) Development. 2018 Jun 14;145(12). |
| 19.10.01 | Cellualar oxidative stress imaging mice | RBRC057041) RBRC061612) | Nrf2 (oxidative stress-responsive transcription factor) reporter mice were utilized for the elucidation of oxidative stress sensing mechanism3). | 1) Sci Rep. 2012;2:229. 2) Free Radic Biol Med. 2014 Jul;72:124-33. 3) Cell Rep. 2019 Jul 16;28(3):746-758.e4. |
| 19.10.01 | ROS production conditionally regulatable mice1) | RBRC09859 | This strain expresses SDAD (ROS homeostasis-related enzyme) defective mutants according to Cre recombinase. | 1) Eur J Immunol. 2017 Feb;47(2):406-418. |
| 19.10.01 | Sperm-egg fusion imaging mice1) | RBRC05763 | Izumo1 (sperm acrosomal gene) reporter strain is useful for the elucidation of gamete fusion mechanism2) 3). | 1) J Cell Sci. 2012 Nov 1;125(Pt 21):4985-90. 2) Cell Cycle. 2018;17(11):1279-1285. 3) Nat Commun. 2015 Nov 16;6:8858. |
| 19.10.01 | Sperm acrosome−GFP： sperm mitochondria−DsRed dual reporter mice1) | RBRC03743 RBRC05861 | This strain is useful for the elucidation of fertilization or acrosome reaction mechanism2) 3) 4). | 1) Exp Anim. 2010;59(1):105-7. 2) J Cell Biol. 2018 Jun 4;217(6):2103-2119. 3) J Biol Chem. 2018 Jul 27;293(30):11796-11808. 4) Biol Reprod. 2016 Apr;94(4):80. |
| 19.08.01 | Cre-driver mice for orexin neurons | RBRC06806 | This strain expresses Cre recombinase and EGFP in orexin neurons1) 2). | 1) Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):E10740-E10747. 2) Neuropharmacology. 2014 Oct;85:451-60. |
| 19.08.01 | Full maturated OSN (olfactory sensory neuron) reporter mice1) | RBRC02092 | OMP (olfactory marker protein) gene-GFP KI mice are broadly utilized for olfactory analysis2) 3) 4). | 1) J Neurosci. 2001 Dec 15;21(24):9713-23. 2) J Neurosci. 2019 Jan 30;39(5):814-832. 3) Cell Stem Cell. 2017 Dec 7;21(6):761-774.e5. 4) Cell. 2016 Jun 16;165(7):1734-1748. |
| 19.08.01 | Selenocysteine-tRNA (Trsp) floxed mice1) | RBRC02681 | This strain was utilized for an oxidative stress model2) 3). | 1) J Biol Chem. 2008 Jan 25;283(4):2021-30. 2) Cell Rep. 2017 Feb 21;18(8):2030-2044. 3) Blood. 2011 Jan 20;117(3):986-96. |
| 19.08.01 | Neuronally enriched Rufy3 KO-first mice | RBRC05780 | Analysis of this strain revealed that RUFY3 is essential for caspase-mediated axon degeneration1). | 1) Neuron. 2019 Jun 7. pii: S0896-6273(19)30483-0. |
| 19.06.03 | Cre-driver mice for postnatal somatic motor neurons | RBRC01515 RBRC01516 | These strain express Cre recombinase in slow type motor neurons1) 2). | 1) Genesis. 2016 Nov;54(11):568-572. 2) Brain Res. 2014 Mar 6;1550:36-46. |
| 19.06.03 | Mitochondria-EGFP labeled mice1) 2) | RBRC02250 | This transgenic strain is utilized to identify and monitor the mitochondorial morphology3) 4). | 1) Exp Anim. 2010;59(1):99-103. 2) FEBS Lett. 2001 Jun 29;500(1-2):7-11. 3) Sci Transl Med. 2017 Oct 25;9(413). 4) PLoS One. 2012;7(6):e36850. |
| 19.06.03 | Zinc transporter Slc39a10 (Zip10) floxed mice | RBRC06221 | Analysis of this strain revealed novel functions of Slc39a10 in humoral immune system1) 2) and epidermal development3). | 1) Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):11786-91. 2) Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):11780-5. 3) Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):12243-12248. |
| 19.06.03 | Cell adhesion molecule Cadm1 (SynCAM1) KO mice | RBRC04062 | This strain was utilized for analysis of not only nervous system1) 2) 3) but also bone turnover4). | 1) J Neurosci. 2016 Jul 13;36(28):7464-75. 2) Neuron. 2010 Dec 9;68(5):894-906. 3) Biochem Biophys Res Commun. 2010 Jun 4;396(3):703-8. 4) PLoS One. 2017 Apr 17;12(4):e0175632. |
| 19.04.01 | Cre-driver mice for myelinating cells of the central nervous system1) | RBRC01461 | This strain is useful for the elucidation of gene function in oligodendrocyte myelination2). | 1) Genesis. 2000 Feb;26(2):127-9. 2) Nat Commun. 2016 Nov 23;7:13478. |
| 19.04.01 | Oct3/4 (Pou5f1) reporter mice | RBRC007711) RBRC060372) | These strains are useful for stem cell research because they express EGFP under the control of pluripotency marker Oct3/43) 4) 5). | 1) Dev Biol. 2003 Jun 1;258(1):209-25. 2) Development. 2008 Mar;135(5):909-18. 3) Cell Res. 2011 Jan;21(1):196-204. 4) Dev Biol. 2010 Oct 1;346(1):90-101. 5) Stem Cells. 2009 Feb;27(2):383-9. |
| 19.04.01 | Fgf5 spontaneous mutant mice | RBRC05894 RBRC05895 | This strain shows abnormal hair follicle cycle1). In addition, it contributed to the research about spermatogenic stem cells2). | 1) Exp Anim. 2011;60(2):161-7. 2) Cell Stem Cell. 2019 Jan 3;24(1):79-92. e6. |
| 19.04.01 | Fstl4 (Mahya) reporter mice | RBRC04952 | This strain is useful for revolutionary genetic research1)In addition, it was used to monitor specific subtypes of retinal ganglion cells2). | 1) Dev Genes Evol. 2005 Nov;215(11):564-74. 2) Curr Eye Res. 2016 Apr;41(4):558-68. |
| Date | Title | BRC No. | Description | References |
|---|---|---|---|---|
| 25.04.09 | Awat1 gene KO mice Awat2 gene KO mice | RBRC11537 RBRC11538 RBRC11539 | Awat1 gene KO mice, Awat2 gene KO mice, and Awat1 gene/Awat2 gene double KO mice have each been reported to have dry eye phenotypes. | 1) iScience. 2021 Sep 25;24(10):103160. |
| 25.04.09 | Cyp4f39 gene Tg mice Cyp4f39 gene KO mice | RBRC11422 RBRC11423 | Tg-Cyp4f39 KO mice, created by crossing Cyp4f39 gene Tg mice with Cyp4f39 gene KO mice, have been reported to have dry eye phenotypes. | 1) Elife. 2020 Apr 7:9:e53582. |
| 25.04.09 | Itpr2 gene KO mice Itpr3 gene KO mice | RBRC10289 RBRC10290 RBRC10291 | Double KO mice, created by crossing Itpr2 gene KO mice with Itpr3 gene KO mice, have been reported to have dry eye phenotypes. | 1) PLoS One. 2014 Jun 5;9(6):e99205. 2) Science. 2005 Sep 30;309(5744):2232-4. |
| 24.02.26 | Sensory neurons Cre-driver mice | RBRC10246 | This KI strain expresses Cre under the control of endogenous Advillin promoter.1) | 1) Proc Natl Acad Sci U S A. 2010 May 18;107(20):9424-9. |
| 24.02.26 | Homeobox gene Vsx2 Cre-driver mice | RBRC09714 | This KI strain expresses CreERT2 under the control of endogenous Vsx2(Chx10) promoter. | |
| 24.02.26 | Homeobox gene Vsx2 Cre-driver mice | RBRC06574 | This BAC Tg strain expresses CreERT2 under the control of Vsx2(Chx10) promoter.1)2) | 1) Development. 2020 Sep 28;147(18):dev188730. 2) Cell Death Dis. 2020 Aug 18;11(8):655. |
| 24.02.26 | Homeobox gene Vsx2 Cre-driver mice | RBRC05564 | This Tg strain expresses Cre under the control of Vsx2(Chx10) promoter.1)2)3)4) | 1) Dev Biol. 2020 Aug 15;464(2):137-144. 2) Development. 2017 Jul 1;144(13):2392-2401. 3) J Exp Med. 2016 Jun 27;213(7):1175-83. 4) J Neurosci. 2011 Nov 16;31(46):16792-807. |
| 23.12.28. | Kpna1(importin α5) gene KO mice | RBRC06031 (KO) RBRC06030 (floxed) | KPNA1 KO mice have been reported to have behavioral abnormalities and female functional incompetence in delivery.1)2) | 1) PLoS One. 2021 Nov 12;16(11):e0258364. 2) FEBS J. 2011 May;278(9):1561-72. |
| 23.12.28. | Kiss1 gene floxed mice | RBRC10389 | This strain has been reported to be infertile when crossed with Cre driver strains.1)2) | 1) J Reprod Dev. 2020 Aug 20;66(4):359-367. 2) J Reprod Dev. 2020 Aug 20;66(4):369-375. |
| 23.12.28. | Prl gene KO mice | RBRC06232 | Prolactin has been reported to be involved in a variety of physiological phenomena and diseases.1)2)3)4)5) | 1) Cell Rep. 2021 Jun 1;35(9):109204. 2) Cancer Res. 2019 Oct 15;79(20):5316-5327. 3) PLoS One. 2016 Nov 28;11(11):e0166416. 4) Biol Reprod. 2015 Sep;93(3):75. 5) EMBO J. 1997 Dec 1;16(23):6926-35. |
| 23.11.02 | Il17rb gene KO mice | RBRC10254 (C57BL/6 background) RBRC10255 (BALB/c background) | IL17RB is a receptor for IL17B and IL17E (IL25) and has been studied in relation to inflammatory diseases.1)2)3)4) | 1) J Exp Med. 2023 Aug 7;220(8):e20221773. 2) J Immunol. 2017 Jan 15;198(2):669-680. 3) Immunity. 2015 Apr 21;42(4):692-703. 4) PLoS Biol. 2012 Feb;10(2):e1001255. |
| 23.11.02 | Il22ra2gene KO mice | RBRC10360 | IL22RA2(IL22BP) has been studied in relation to inflammatory cutaneous diseases. 1) | 1) Front Immunol. 2018 Jun 21:9:1418. |
| 23.11.02 | Il33 gene KO mice | RBRC09341 | IL33 has been studied in relation to various diseases. 1)2)3)4)5) | 1) Dis Model Mech. 2023 Sep 1;16(9):dmm050174. 2) Immunity. 2022 Jan 11;55(1):159-173.e9. 3) Sci Immunol. 2022 Jun 24;7(72):eabl7209. 4) Immunity. 2021 Jan 12;54(1):151-163.e6. 5) Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18581-6. |
| 23.09.01 | A molecular chaperon Serpinh1(Hsp47) floxed mice | RBRC10972 | Serpinh1 is essential for collagen synthesis and various phenotypes have been reported using this strain.1)2)3)4) | 1) JCI Insight. 2019 Aug 8;4(15):e128722. 2) Mol Cell. 2018 Jan 18;69(2):238-252.e7. 3) J Biol Chem. 2015 Feb 6;290(6):3639-46. 4) J Cell Sci. 2012 Mar 1;125(Pt 5):1118-28. |
| 23.09.01 | A molecular chaperon Serpinh1(Hsp47) KO mice | RBRC10971 | Serpinh1 is essential for collagen synthesis and it has been reported that null mutant mice do not survive beyond 11.5 dpc.1)2)3) | 1) Mol Biol Cell. 2006 May;17(5):2346-55. 2) J Cell Sci. 2004 Nov 15;117(Pt 24):5913-22. 3) J Cell Biol. 2000 Sep 18;150(6):1499-506. |
| 23.09.01 | A TNF superfamily Tnfsf11 (RANKL) floxed mice | RBRC06142 | Using this strain, Tnfsf11 mutations have been reported to result in bone abnormalities.1)2) | 1) J Bone Miner Res. 2014 Apr;29(4):830-42. 2) J Clin Invest. 2013 Sep;123(9):3914-24. |
| 23.09.01 | A transmembrane protein Pmepa1 mutated mice | RBRC11387 | This strain has been reported to show bone abnormalities.1)2) | 1) FASEB J. 2021 Feb;35(2):e21281. 2) FASEB J. 2019 Mar;33(3):4365-4375. |
| 23.07.03 | Mad2l2 mutated mice | RBRC09685 | This Mad2l2 (Rev7) mutated strain established by ENU mutagenesis has been reported that both male and female homozygotes exhibit infertility and female homozygotes develop ovarian tumors at a high frequencyto1)2)3. | 1) Mol Cell Endocrinol. 2015 Sep 5;412:19-25. 2) J Biol Chem. 2014 Feb 7;289(6):3811-24. 3) J Reprod Dev. 2008 Jun;54(3):225-8. |
| 23.07.03 | Mad2l2 KO mice | RBRC05473 | This strain has been reported that both male and female homozygotes lack germ cells1). | 1) J Biol Chem. 2013 Apr 12;288(15):10459-71. |
| 23.07.03 | Tdrd12 mutated mice | RBRC09686 | This Tdrd12 mutated strain established by ENU mutagenesis has been reported that male homozygotes exhibit infertility1)2). | 1) Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16492-7. 2) Exp Anim. 2009 Oct;58(5):525-32. |
| 23.07.03 | Tdrd12(Ecat8) KO mice | RBRC02326 | This strain has been reported that male homozygotes exhibit infertility1)2). | 1) Cell Rep. 2018 Sep 25;24(13):3423-3432.e4. 2) Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16492-7. |
| 23.07.03 | Rnf212 mutated mice | RBRC09687 | This Rnf212 mutated strain established by ENU mutagenesis has been reported that male homozygotes exhibit infertility1). | 1) Reproduction. 2015 Jan;149(1):67-74. |
| 23.04.27 | Osteoarthritis (OMIM: 612400) model mice | RBRC-GSC0080 | This Gdf5 mutated strain established by ENU mutagenesis has been reported to show brachypodism and ankylosis1)2)3)4)5). | 1) Sci Rep. 2016 Mar 31;6:23670. 2) Diabetes. 2014 Jan;63(1):162-75. 3) Biochem Biophys Res Commun. 2014 Jul 18;450(1):255-60. 4) Hum Mol Genet. 2007 Oct 1;16(19):2366-75. 5) Mouse of the Month September 2007 |
| 23.04.27 | Spondyloepimetaphyseal dysplasia (OMIM: 183900) model mice | RBRC-GSC0164 | This Col2a1mutated strain established by ENU mutagenesis has been reported to show skeletal dysplasia-like phenotypes1). | 1) Mamm Genome. 2011 Jun;22(5-6):318-28. |
| 23.04.27 | Spontaneous steoarthritis model mice | RBRC06803 | This strain is an inbred line derived from STR/1N1)2). | 1) Osteoarthritis Cartilage. 2001 Feb;9(2):85-91. 2) Osteoarthritis Cartilage. 1994 Jun;2(2):103-9. |
| 23.04.27 | Menkes disease (OMIM: 309400) model mice | RBRC01261 | Menkes disease is an X-chromosome recessive genetic disorder caused by ATP7A gene mutations. This strain has a mutation in the Atp7a gene1). | 1) Genomics. 2006 Feb;87(2):191-9. |
| 23.04.27 | Menkes disease (OMIM: 309400) model mice | RBRC09617 | Menkes disease is an X-chromosome recessive genetic disorder caused by ATP7A gene mutations. This strain has a mutation in the Atp7a gene1)2)3). | 1) J Inherit Metab Dis. 1998 Jun;21(3):199-202. 2) Mamm Genome. 1997 Jun;8(6):407-10. 3) Nat Genet. 1994 Apr;6(4):369-73. |
| 23.03.02 | Nasu-Hakola disease (OMIM: 221770) responsible gene Tyrobp(DAP12) KO mice | RBRC11704 | This strain is reported to show the developmental arrest of osteoclasts and ligodendrocytes1)2)3)4)5). | 1) Cell Rep. 2021 Dec 14;37(11):110111. 2) EMBO J. 2020 Nov 16;39(22):e104464. 3) Sci Signal. 2019 Jan 15;12(564):eaar5514. 4) J Biol Chem. 2018 Mar 9;293(10):3793-3805. 5) J Clin Invest. 2003 Feb;111(3):323-32. |
| 23.03.02 | NGLY1 deficiency (OMIM: 615273) responsible gene Ngly1 KO mice | RBRC11332 | By crossing this strain JF1/Ms Ngly1-/+ mice with C57BL/6 Ngly1-/+ mice (RBRC06293), we can partially avoid embryonic lethality and obtain JF1/B6F1 Ngly1-/- mice1). | 1) Proc Jpn Acad Ser B Phys Biol Sci. 2021;97(2):89-102. |
| 23.03.02 | Fgf9 spontaneous mutant mice | RBRC09906 | This strain was reported to show elbow knee synostosis1)2)3)4). | 1) Histochem Cell Biol. 2020 Apr;153(4):215-223. 2) Hum Mol Genet. 2020 Aug 3;29(13):2148-2161. 3) Nat Genet. 2009 Mar;41(3):289-98. 4) Mamm Genome. 2002 Jul;13(7):341-4. |
| 23.03.02 | Vimentin phosphorylated Site amino acid substitution mice | RBRC11719 | This strain was reported to show some premature aging phenotypes1)2). | 1) Cells. 2019 Sep 1;8(9):1016. 2) J Biol Chem. 2013 Dec 13;288(50):35626-35. |
| 23.01.05 | A receptor of cytokine BAFFTnfrsf13c floxed mice | RBRC10245 | BAFF-R(Tnfrsf13c) gene encodes a receptor for the cytokine TNF family member BAFF. This strain has been used for analysis of B cell functions and autoimmun diseases1)2) | 1) Blood. 2011 Mar 17;117(11):3104-12. 2) J Immunol. 2004 Aug 15;173(4):2245-52. |
| 23.01.05 | A CDM family molecule DOCK2 KO mice | RBRC10168 | This strain is widely utilized in basic immunology and basic disease research1)2)3)4)5) | 1) Am J Pathol. 2022 Feb;192(2):226-238. 2) J Allergy Clin Immunol. 2019 Nov;144(5):1377-1390.e4. 3) J Immunol. 2018 Sep 1;201(5):1442-1451. 4) Nat Genet. 2017 Oct;49(10):1437-1449. 5) Nature. 2001 Aug 23;412(6849):826-31. |
| 23.01.05 | A cadherin superfamily CDH17 KO mice | RBRC09896 | This strain has been reported to show development of B cells and dysfunction of memory B cells1)2) | 1) PLoS One. 2015 Jan 22;10(1):e0117566. 2) Eur J Immunol. 2005 Mar;35(3):957-63. |
| 22.09.01 | Skin melanoma(OMIM:608035, 612263) model mice | RBRC00694 | This KRT14-Kitl Tg strain has been reported to show epidermal pigmentation1)2)3)4)5). | 1) J Invest Dermatol. 2017 May;137(5):1126-1134. 2) Cell Rep. 2017 Jun 13;19(11):2177-2184. 3) J Invest Dermatol. 2015 Jul;135(7):1829-1838. 4) Development. 1998 Aug;125(15):2915-23. 5) J Exp Med. 1998 May 18;187(10):1565-73. |
| 22.09.01 | Atopic dermatitis(OMIM:603165) model mice | RBRC06233 (Coisogenic strain) RBRC06234 (C57BL/6J background) RBRC06235 (BALB/c background) | These Trpv3 point mutation strains have been reported to show both non-hair and atopic dermatitis-like phenotypes1)2)3)4)5). | 1) J Invest Dermatol. 2009 Mar;129(3):714-22. 2) Immunology. 2007 May;121(1):51-61. 3) Biochem Biophys Res Commun. 2007 Nov 23;363(3):479-83. 4) Exp Anim. 2003 Oct;52(5):419-23. 5) Exp Anim. 1997 Jul;46(3):225-9. |
| 22.09.01 | IL4 KO mice | RBRC04920 (C57BL/6J background) RBRC04921 (BALB/c background) RBRC05130 (DBA/1 background) | This strain has been reported to show increased susceptibility to infection of parasites. In addition, this strain has been used for some immunology research1)2)3)4). | 1) Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):13057-13062. 2) Immunity. 2014 May 15;40(5):758-71. 3) Microbiol Immunol. 2000;44(12):971-9. 4) Nature. 1993 Mar 18;362(6417):245-8. |
| 22.07.01 | Cytokine signal inhibitor Socs1 floxed mice | RBRC04753 | This strain has been used for analysis of anti-inflammatory mechanism in some kind of cells (endothelial cells, hepatic cells, neurons, etc.)1)2)3)4)5). | 1) FASEB J. 2021 Apr;35(4):e21388. 2) J Immunol. 2018 Jan 1;200(1):177-185. 3) J Immunol. 2017 Jul 1;199(1):149-158. 4) Nat Immunol. 2017 Jan;18(1):54-63. 5) J Immunol. 2008 Mar 15;180(6):3746-56. |
| 22.07.01 | Cytokine signal inhibitor Socs3 floxed mice | RBRC04754 | This strain has been used for analysis of anti-inflammatory mechanism in some kind of cells (endothelial cells, hematopoietic cells, neurons, etc.) 1)2)3)4)5). | 1) J Biol Chem. Jan-Jun 2021;296:100239. 2) Neuron. 2021 Apr 21;109(8):1333-1349.e6. 3) EBioMedicine. 2021 Nov;73:103632. 4) JCI Insight. 2021 Jul 22;6(14):e147280. 5) Nat Immunol. 2003 Jun;4(6):551-6. |
| 22.07.01 | NF-κB negative regulator Tnfaip3(A20) floxed mice | RBRC05494 (Tnfaip3 floxed) RBRC05495 (Tnfaip3 KO) | These strains have been used for analysis of anti-inflammatory mechanism in some kind of cells (immune cells, hematopoietic cells, etc.)1)2)3). | 1) Int J Mol Sci. 2020 Apr 18;21(8):2830. 2) J Immunol. 2017 Jan 15;198(2):820-831. 3) PLoS One. 2014 Jan 31;9(1):e87425. |
| 22.05.06 | Angiogenic factor Angpt1 floxed mice | RBRC09330 | This strain has been used for some research such as various retinal diseases and diabetes mellitus1)2)3)4)5). | 1) Diabetes. 2019 Apr;68(4):774-786. 2) Sci Adv. 2019 Feb 13;5(2):eaau6732. 3) Nat Commun. 2018 Jun 22;9(1):2448. 4) Nat Commun. 2017 May 16;8:15296. 5) Sci Transl Med. 2013 Sep 18;5(203):203ra127. |
| 22.05.06 | Src point mutated (S75D) mice with progressive optic neuropathy-like phenotypes | RBRC10208 | The age-related retinal ganglion cell number reduction have been reported1)2). | 1) Sci Rep. 2017 Dec 1;7(1):16779. 2) J Biochem. 2003 May;133(5):563-9. |
| 22.05.06 | Mef2d KO mice with retinitis pigmentosa like phenotypes | RBRC09366 (Mef2d floxed) RBRC09367 (Mef2d KO) | Progressive retinal photoreceptor cell loss, abnormal retinal electroretinogram, shortening of the photoreceptor outer segment, and abnormal formation of photoreceptor ribbon synapses have been reported1)2). | 1) Cells. 2020 Apr 10;9(4):931. 2) Genes Cells. 2015 May;20(5):408-26. |
| 22.05.06 | Membrane scaffold protein Epb4.1l2 (4.1G) KO mice | RBRC09370 | Mislocalization of photoreceptor terminals in retinas and visual acuity impairments in an optokinetic response have been reported 1). | 1) Cell Rep. 2015 Feb 10;10(5):796-808. |
| 22.03.01 | Infantile-onset leukoencephalopathy model mice | RBRC10267 ( Mlc1-STOPtetO KI) RBRC10268 ( Mlc1-tetO KI) | These strains are capable of inducing KO or overexpression of Mlc1 gene. They reported to exhibit a phenotype similar to that of human pathology1). | 1) Glia. 2017 Jan;65(1):150-168. |
| 22.03.01 | Early infantile epileptic encephalopathy model mice | RBRC03654 | 7 repeats of the GCG triple is knocked into codon 330 of Arx gene1)2)3)4)5). | 1) Neurobiol Dis. 2021 Jun;153:105329. 2) Neuroscience. 2017 Aug 15;357:220-231. 3) Neurobiol Dis. 2017 Sep;105:245-256. 4) Hum Mol Genet. 2016 Dec 15;25(24):5433-5443. 5) Hum Mol Genet. 2009 Oct 1;18(19):3708-24. |
| 22.03.01 | Lissencephaly model mice | RBRC03438 RBRC03435 | Using these Arx KO strains, various results were reported1)2)3)4). | 1) Biol Open. 2017 Oct 15;6(10):1552-1568. 2) PLoS One. 2013 Jun 28;8(6):e68050. 3) Development. 2005 Feb;132(4):751-62. 4) Nat Genet. 2002 Nov;32(3):359-69. |
| 22.03.01 | Protrudin (Zfyve27) KO mice | RBRC10084 | Some behavioral abnormalities containig a depression-like phenotype were reported1). | 1) Mol Brain. 2020 Nov 10;13(1):146. |
| 22.01.05 | Cloned mice lines derived from antigen-specific CD4+ T cells | RBRC10902 RBRC10903 | These strains are useful for allergic-related research as animal model with allergic predisposition1). | 1) EMBO Rep. 2017 Jun;18(6):885-893. |
| 22.01.05 | Ca2+-dependent modulator Cys proteases Capn6 gene KO mice | RBRC06237 (C57BL/6) RBRC06238 (ICR) | Capn6 expression is observed in embryonic skeletal muscle and adult regenerated skeletal muscle. These strains are useful for research related with development and regeneration of skeletal muscle1)2). | 1) J Clin Invest. 2016 Sep 1;126(9):3417-32. 2) PLoS Genet. 2013;9(8):e1003668. |
| 22.01.05 | Axon guidance molecule Sema4d gene KO mice | RBRC10202 (C.B17/Icr-+/+Jcl) | This strain has been reported to have high reproducibility of focal cerebral infarction by middle cerebral artery occlusion1)2)3)4)5). | 1) Biochem Biophys Res Commun. 2020 Jan 22;521(4):827-832. 2) Neuroscience. 2019 May 15;406:420-431. 3) Glia. 2015 Dec;63(12):2249-59. 4) J Exp Stroke Transl Med. 2010 Mar;3(1):28-33. 5) J Neurosci Res. 2009 Oct;87(13):2833-41. |
| 22.01.05 | Sema4D receptor Plxnb1 gene KO mice | RBRC10201 (C.B17/Icr-+/+Jcl) | This strain has been reported to have high reproducibility of focal cerebral infarction by middle cerebral artery occlusion1)2)3). | 1) J Exp Stroke Transl Med. 2010 Mar;3(1):28-33. 2) Development. 2008 Oct;135(20):3333-43. 3) Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13188-93. |
| 21.11.01 | Major components of stratum corneum Flg (filaggrin) gene KO mice1) | RBRC05850 (C57BL/6J) RBRC05851 (BALB/c) | These strains were used for research of skin diseases2)3)4). | 1) J Allergy Clin Immunol. 2012 Jun;129(6):1538-46.e6. 2) J Dermatol Sci. 2019 Jun;94(3):346-349. 3) Immunity. 2015 Apr 21;42(4):756-66. 4) Sci Rep. 2013;3:1731. |
| 21.11.01 | GPI-anchored membrane protein Cd109 gene KO mice1) | RBRC09599 | CD109 is highly expressed in several types of human cancers. Analysis of this strains indicated the relationship between Cd109 and some diseases2)3)4)5). | 1) Am J Pathol. 2012 Oct;181(4):1180-9. 2) Cell Rep. 2019 Oct 8;29(2):391-405.e5. 3) Genes Cells. 2018 Jul;23(7):590-598. 4) J Pathol. 2017 Dec;243(4):468-480. |
| 21.11.01 | Foxp2[R552H] KI mice | RBRC04059 RBRC04060 | These strains carry a Foxp2[R552H] mutation related to human speech-language disorder1)2)3)4)5). | 1) Cereb Cortex. 2017 Jul 1;27(7):3648-3659. 2) Neurosci Lett. 2014 Apr 30;566:162-6. 3) J Neurochem. 2012 Jul;122(1):72-80. 4) Neurosci Lett. 2012 Jan 11;506(2):277-80. |
| 21.11.01 | GPI-anchored membrane protein Mdga1 KO mice | RBRC05286 RBRC10977 RBRC10978 | These strains were reported to show several cognitive learning disorder or schizophrenia-like phenotypes1)2)3)4). | 1) Neurosci Lett. 2020 Jan 18;716:134677. 2) Cell Rep. 2017 Dec 26;21(13):3637-3645. 3) Neuroscience. 2012 Jun 1;211:136-64. 4) Dev Dyn. 2011 Jan;240(1):96-107. |
| 21.09.01 | Usher syndrome type 2C (OMIM:605472) responsible gene Adgrv1(Vlgr1,Gpr98) KO mice | RBRC09313 (KO) RBRC09315 (KO) RBRC09314 (EYFP KI) | These strains were reported to show auditory abnormalities1)2)3)4)5). | 1) Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):7765-7774. 2) J Clin Endocrinol Metab. 2012 Apr;97(4):E565-74. 3) Neurosci Lett. 2009 Sep 18;461(2):190-5. 4) J Neurosci. 2007 Jun 13;27(24):6478-88. 5) J Neurochem. 2005 Jan;92(1):191-202. |
| 21.09.01 | Prader-Willi syndrome (OMIM:176270) responsible gene Necdin(Ndn) KO mice | RBRC09382 (B6) RBRC09363 (ICR) RBRC02316 (ICR and B6 mixed) | These strains were reported to show behavioral and neuromorphological abnormalities1)2)3)4)5). | 1) Nat Commun. 2016 Mar 14;7:10943. 2) PLoS One. 2014 Jan 2;9(1):e84460. 3) J Neurosci. 2013 Jun 19;33(25):10362-73. 4) J Neurosci. 2012 Apr 18;32(16):5562-72. 5) J Neurosci. 2005 Jul 27;25(30):7090-9. |
| 21.09.01 | Congenital stationary night blindness responsible gene Trpm1 KO mice | RBRC05509 (B6) RBRC05138 (129) | These strains were reported to show vision abnormalities1)2)3)4)5). | 1) Mol Brain. 2021 Mar 30;14(1):61. 2) J Neurosci. 2017 Oct 11;37(41):9889-9900. 3) PLoS One. 2013 Nov 25;8(11):e81507. 4) Eur J Neurosci. 2013 Sep;38(6):2823-31. 5) Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):332-7. |
| 21.09.01 | SNARE protein family Snap25 gene amino acid substitution mice | RBRC09306 | This strain was reported to show behavioral disorders1)2)3)4). | 1) Sci Rep. 2017 Aug 11;7(1):7996. 2) Epilepsy Res. 2015 Sep;115:30-44. 3) J Neurosci. 2012 Nov 28;32(48):17186-96. 4) PLoS One. 2011;6(9):e25158. |
| 21.07.01 | One subunit of NMDA receptor Grin2a gene KO mice1) | RBRC01195 (C57BL/6J) RBRC02256 (B6 and 129 mixed) | These strains were used for research of neural mechanism2)3) or NMDA receptor-related neural disorders4). | 1) J Neurosci. 1996 Dec 15;16(24):7859-67. 2) Proc Natl Acad Sci U S A. 2019 Oct 15;116(42):21207-21212. 3) Nat Neurosci. 2011 Mar;14(3):338-44. 4) Cell Rep. 2020 Jan 14;30(2):381-396.e4. |
| 21.07.01 | Synaptic protein Stxbp1 (Munc18-1) gene floxed mice | RBRC05604 | Analysis of this strain revealed a novel mechanism to trigger epilepsy1)2). | 1) Nat Commun. 2019 Apr 23;10(1):1917. 2) Hum Mol Genet. 2017 Dec 15;26(24):4961-4974. |
| 21.07.01 | Serine protease Klk8 (Neuropsin) gene KO mice1) | RBRC02740 | The relationship between some behavior disorders (social discrimination behavior2), cognitive disorders3), stress disorders4), etc.) and Neuropsin was indicated by analysis of this strain. | 1) Mol Cell Neurosci. 2001 Mar;17(3):600-10. 2) Neurobiol Learn Mem. 2019 Jul;162:47-58. 3) Transl Psychiatry. 2017 Mar 7;7(3):e1052. 4) PLoS Genet. 2016 Oct 4;12(10):e1006356. |
| 21.07.01 | Secreted glycoprotein Reln (Reelin) gene C-terminal deficient mice1) | RBRC03079 | This strain was reported to show several neuropsychiatric or behavior disorders2)3). | 1) J Neurosci. 2015 Mar 18;35(11):4776-87. 2) Neuroscience. 2016 Nov 12;336:20-29. 3) Sci Rep. 2016 Jun 27;6:28636. |
| 21.04.27 | Downstream factor of IL-17 signaling pathway Nfkbiz (IκB-ζ) floxed mice1) | RBRC06410 | This strain is useful for Nfkbiz functional analyisis in various kinds of cells2)3)4)5). Recently, the relationship between ulcerative colitis and NHKBIZ was indicated by using this strain6). | 1) Immunity. 2013 Mar 21;38(3):450-60. 2) J Immunol. 2020 Apr 15;204(8):2033-2042. 3) JCI Insight. 2019 Nov 14;4(22):e130835. 4) Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):10088-10093. 5) Mouse of the Month Apr 2017 6) Nature. 2020 Jan;577(7789):260-265. |
| 21.04.27 | Tyrosine kinase receptor family EphB6 KO mice1) | RBRC02280 | The relationship between metastatic process of colorectal cancer and EPHB6 was indicated by analysis of this strain2). | 1) Biochem Biophys Res Commun. 2002 Oct 18;298(1):87-94. 2) Sci Rep. 2017 Mar 6;7:43702. |
| 21.04.27 | ROS1-fusion positive lung cancer model mice | RBRC09696 (CD74-ROS1 Tg) RBRC09697 (SDC4-ROS1 Tg) | These strains are Tg mice expressing CD74-ROS1 or SDC4-ROS1 fusion proteins which have been reported in human lung cancer cases1). | 1) Carcinogenesis. 2016 May;37(5):452-60. |
| 21.04.27 | Glycolysis enzyme PKM (pyruvate kinase M) mutant mice | RBRC10481 (PKM1 KI) RBRC10482 (PKM2 KI) | These strains selectively expressing PKM splicing isoforms (PKM1 or PKM2) were developed to analyze glycolytic enzyme PKM function for cancer glucose metabolism (Warburg effect)1). | 1) Cancer Cell. 2018 Mar 12;33(3):355-367.e7. |
| 21.03.01 | Autism spectrum disorder model mice | RBRC05954 | This strain is a mouse model of human 15q11–13 duplication1)2)3)4). Using functional MRI, neural circuit dysfunction in this strain was reported5). | 1) Sci Rep. 2018 Sep 12;8(1):13675. 2) Sci Rep. 2017 Aug 29;7(1):9902. 3) Mouse of the Month April 2015. 4) Cell. 2009 Jun 26;137(7):1235-46. 5) Sci Adv. 2020 Feb 5;6(6):eaav4520. |
| 21.03.01 | Ednrb (endothelin receptor type B) KO mice1) | RBRC06163 | This strain was reported as a Hirschsprung's disease2), melanoma3) or Waardenburg syndrome4) model. | 1) Cell. 1994 Dec 30;79(7):1267-76. 2) Development. 1998 Mar;125(5):825-36. 3) Cancer Res. 2010 Jan 1;70(1):24-9. 4) J Biol Chem. 2011 Aug 26;286(34):29621-6. |
| 21.03.01 | Lymphoedema-distichiasis syndrome responsible gene Foxc2 floxed mice | RBRC10306 | The phenotype analysis results of Foxc2 conditionally deleted mice in kidneys were reported1). | 1) Mamm Genome. 2016 Feb;27(1-2):62-9. |
| 21.03.01 | TPST2 enzymatic activity deficient mice | RBRC05261 | This strain is reported to show a growth retardation with hypothyroidism1)2)3). | 1) Biomed Res. 2010 Jun;31(3):207-11. 2) J Vet Med Sci. 2008 Oct;70(10):1043-9. 3) Mol Endocrinol. 2007 Jul;21(7):1713-21. |
| 21.01.04 | Vitamin D receptor VDR KO mice1)2) | RBRC05885 | This strain shows osteoporosis and rickets-like phenotypes. Therefore, it is utilized to reveal the relationship between vitamin D and osteogenesis3)4)5). | 1) Endocrinology. 2000 Apr;141(4):1317-24. 2) Nat Genet. 1997 Aug;16(4):391-6. 3) Biochem Biophys Res Commun. 2017 Jan 29;483(1):359-365. 4) Endocrinology. 2017 Jun 1;158(6):1951-1963. 5) Sci Rep. 2017 Aug 10;7(1):7786. |
| 21.01.04 | A kind of GPCR GPRC5B KO mice1) | RBRC10166 | Analysis of this strain suggested that GPRC5B is related with obesity-associated inflammatory signaling and synapse formation in Purkinje cells2)3). | 1) Biochem Biophys Res Commun. 2011 Sep 2;412(3):460-5. 2) Sci Signal. 2012 Nov 20;5(251):ra85. 3) Neurosci Res. 2018 Nov;136:33-47. |
| 21.01.04 | ACAM(CLMP) Tg mice controlled by adipocyte P2 promoter | RBRC06443 RBRC06444 RBRC06445 | In response to high fat-high sucrose diet feeding, these strains show resistance to obesity and diabetes1)2)3). | 1) J Lipid Res. 2000 Oct;41(10):1615-22. 2) Biochem J. 2005 Apr 15;387(Pt 2):343-53. 3) Diabetes. 2016 May;65(5):1255-67. |
| 21.01.04 | Phosphatidylcholine biosynthetic enzyme Pemt KO mice | RBRC06436 | In response to high fat-high sucrose diet feeding, these strains show not only resistance to obesity and diabetes but also non-alcoholic steatohepatitis1)2). | 1) Sci Rep. 2016 Feb 17;6:21721. 2) PLoS One. 2014 Mar 25;9(3):e92647. |
| 20.10.23 | Human renin・human angiotensinogen double Tg mice | RBRC01122 (hRN Tg) RBRC01123 (hAG Tg) RBRC02432 (F1(hRN × hAG)) | These strains were contributed to some results as Tsukuba Hypertensive mice1)2)3). Additionally, these are known as pregnancy-induced hypertension models4)5). | 1) Eur J Histochem. 2018 Jul 24;62(3):2930. 2) Mouse of the Month May 2012 3) Biochem Biophys Res Commun. 1991 Oct 31;180(2):1103-9.v 4) Sleep. 2018 Mar 1;41(3). 5) Sci Signal. 2017 May 16;10(479):eaam5711. |
| 20.10.23 | Prolin isomerase Pin1-KO mice1)2) | RBRC10368 | Analysis of this strain suggested the relationship between PIN1 and various biological phenomenon and diseases3)4)5). | 1) Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1335-40. 2) Biochem Biophys Res Commun. 1999 Nov 30;265(3):658-63. 3) Hum Mol Genet. 2018 Nov 15;27(22):3827-3839. 4) Biochem Biophys Res Commun. 2018 Feb 26;497(1):388-393. 5) Biochem Biophys Res Commun. 2017 Nov 18;493(2):946-951. |
| 20.10.23 | p53-target gene Tigar-KO mice | RBRC10981 | Analysis of this strain suggested the relationship between TIGAR and cardiac metabolism1)2). | 1) Am J Physiol Heart Circ Physiol. 2019 Jun 1;316(6):H1366-H1377. 2) J Mol Cell Cardiol. 2012 Jan;52(1):175-84. |
| 20.10.23 | Endogenous membrane protein Aqp7-KO mice | RBRC06294 | Analysis of this strain suggested the relationship between AQP7 and various metabolism pathways1)2)3). | 1) Cardiovasc Res. 2009 Jul 1;83(1):34-41. 2) Proc Natl Acad Sci U S A. 2005 Aug 2;102(31):10993-8. 3) Proc Natl Acad Sci U S A. 2004 Dec 21;101(51):17801-6. |
| 20.03.02 | Endoplasmic reticulum (ER) transmembrane protein IRE1α(ERN1)-KO/cKO mice1)| RBRC05515 | (floxed) RBRC05516 (KO) These strains are utilized to reveal the relationship between ER stress and some diseases2)3)4). | 1) Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16657-62. |
2) Nat Commun. 2018 Dec 17;9(1):5340. 3) Nature. 2018 Oct;562(7727):423-428. 4) J Cell Biol. 2018 Apr 2;217(4):1287-1301. |
| 20.03.02 | Tumor necrosis factor (TNF) receptor-associated factor TRAF6-KO mice1) | RBRC04950 (C57BL/6) RBRC05386 (BALB/c) | These strains show various disorders like ectodermal dysplasia, osteopertrosis, autoimmunity and so on2)3)4)5). | 1) Genes Cells. 1999 Jun;4(6):353-62. 2) Commun Biol. 2019 Aug 6;2:292. 3) Proc Natl Acad Sci U S A. 2017 Aug 22;114(34):E7140-E7149. 4) J Biol Chem. 2017 Jun 16;292(24):10169-10179. 5) Mouse of the Month Sep 2012 |
| 20.03.02 | Tubulin glutamylation enzyme TTLL1-KO mice | RBRC03327 | This strain shows primary ciliary dyskinesia-like phenotype1)2)3). | 1) Sci Rep. 2018 Feb 13;8(1):2904. 2) PLoS One. 2015 Nov 18;10(11):e0141823. 3) Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10490-5. |
| 20.03.02 | Apoptosis-related transmembrane receptor FAS-KO mice | RBRC01474 (C57BL/6) RBRC01476 (MRL) | These strains show autoimmune lymphoproliferative syndrome (OMIM: 601859)-like phenotype1)2)3)4). | 1) Proc Natl Acad Sci U S A. 1996 Mar 5;93(5):2131-6. 2) Nat Genet. 1995 Nov;11(3):294-300. 3) Eur J Immunol. 2013 Jul;43(7):1789-98. 4) J Exp Med. 2013 Sep 23;210(10):2087-103. |
| 20.01.06 | Spinal and bulbar muscular atrophy (SBMA) model mice | RBRC00344 | This strain shows some phenotypes similar to human patients. It is utilized to explore molecular mechanisms and therapeutic agents1) 2) 3). | 1) Hum Mol Genet. 2018 Jul 15;27(14):2425-2442. 2) J Neurosci. 2016 May 4;36(18):5094-106. 3) Neuron. 2002 Aug 29;35(5):843-54. |
| 20.01.06 | Limb-girdle muscular dystrophy type 2A (LGMD2A) model mice | RBRC04787 | CAPN3 protease activity-deficient mice show muscular disease-like phenotypes1) 2) 3). | 1) Hum Mol Genet. 2018 May 1;27(9):1642-1653. 2) J Clin Invest. 2010 Aug;120(8):2672-83. 3) J Biol Chem. 2010 Jul 23;285(30):22986-98. |
| 20.01.06 | Sporadic amyotrophic lateral sclerosis (ALS) model mice | RBRC09428 | This strain shows some phenotypes similar to human patients. It is utilized to explore molecular mechanisms and therapeutic agents1) 2) 3) 4). | 1) Sci Rep. 2017 Jan 3;7:39994. 2) Sci Rep. 2016 Jun 28;6:28649. 3) J Neurosci. 2010 Sep 8;30(36):11917-25. 4) Mouse of the Month Nov 2015. |
| 20.01.06 | Familial amyotrophic lateral sclerosis (ALS) model mice | RBRC09642 RBRC09643 RBRC09644 | Tg mice harboring mutated human SOD1 show progressive motor neuron disease-like phenotypes1). | 1) Hum Mol Genet. 2015 Jun 15;24(12):3427-39. |
| 19.11.06 | Disc1 point mutated (L100P) mice with schizophrenia-like phenotypes | RBRC06364 | This strain is a schizophrenia model, which established by ENU mutagenesis 1) 2) 3) 4). | 1) Neuron. 2007 May 3;54(3):387-402. 2) Front Cell Neurosci. 2018 Aug 2;12:238. 3) Behav Brain Res. 2017 Mar 1;320:113-118. 4) Schizophr Bull. 2017 Jan;43(1):214-225. |
| 19.11.06 | Disc1 point mutated (Q13L) mice with depression-like phenotypes | RBRC06365 | This strain is a endogenous depression model, which established by ENU mutagenesis 1) 2) 3). | 1) Neuron. 2007 May 3;54(3):387-402. 2) Neuroscience. 2016 May 3;321:99-107. 3) PLoS One. 2014 Oct 1;9(10):e108088. |
| 19.11.06 | CaMKIIα point mutated (K42R) mice with learning and memory deficits | RBRC05821 RBRC05636 | CaMKIIα kinase activity-deficient mice shows hippocampus-dependent learning and memory deficits 1) 2) 3). | 1) eNeuro. 2018 Aug 21;5(4). pii: ENEURO.0133-18.2018. 2) Genes Dev. 2014 May 15;28(10):1101-10. 3) J Neurosci. 2009 Jun 10;29(23):7607-18. |
| 19.11.06 | Metabotropic glutamate receptor 2 (mGluR2)-KO mice 1) | RBRC01351 | Analysis of this strain suggested the relationship between mGluR2 and schizophrenia 2) 3) 4). | 1) Science. 1996 Aug 2;273(5275):645-7. 2) Sci Signal. 2016 Jan 12;9(410):ra5. 3) J Neurosci. 2016 Nov 9;36(45):11521-11531. 4) PLoS One. 2015 May 7;10(5):e0125523. |
| 19.09.03 | GPI-anchored protein CD109-KO mice1) 2) | RBRC05911 | This strain shows osteopenia3) and psoriasis-like epidermal hyperplasia4). In addition, CD109 is known to be a regulator of tumor progression5). | 1) Pathol Int. 2019 May;69(5):249-259. 2) Mouse of the Month Nov 2013. 3) Genes Cells. 2018 Jul;23(7):590-598. 4) Am J Pathol. 2012 Oct;181(4):1180-9. 5) J Pathol. 2017 Dec;243(4):468-480. |
| 19.09.03 | G protein-coupled receptor BLT2-KO mice | RBRC04741 RBRC04742 | This strain shows not only DSS-induced colitis exacerbation1) but also delayed skin or corneal wound healing 2) 3) 4). | 1) FASEB J. 2010 Dec;24(12):4678-90. 2) Sci Rep. 2017 Oct 16;7(1):13267. 3) FASEB J. 2016 Feb;30(2):933-47. 4) J Exp Med. 2014 Jun 2;211(6):1063-78. |
| 19.09.03 | Scott syndrome (OMIM: 262890) disease gene Ano6 (Tmem16F) floxed mice1) | RBRC09797 | Platelet-specific Ano6-null mice shows a mild bleeding disorder similar to the human condition2). | 1) J Biol Chem. 2013 May 10;288(19):13305-16. 2) Proc Natl Acad Sci U S A. 2015 Oct 13;112(41):12800-5. |
| 19.09.03 | Winchester syndrome (OMIM: 277950) disease gene Mmp14 (MT1-MMP) KO/LacZ KI mice | RBRC05977 | Mmp14-null mice shows severve osteolysis. In addition, this strain is useful for Mmp14 expression analysis1) 2) 3) 4) 5). | 1) Development. 2013 Jan 15;140(2):343-52. 2) Dev Cell. 2013 May 28;25(4):402-16. 3) Diabetes. 2010 Oct;59(10):2484-94. 4) Genes Cells. 2009 May;14(5):617-26. 5) J Cell Sci. 2007 May 1;120(Pt 9):1607-14. |
| 19.07.01 | ATR-X syndrome (OMIM: 301040) model mice | RBRC04937 | This is a Atrx (disease gene) knockout mouse strain, which shows some abnormal phenotypes similar to the human condition1) 2) and is utilized to explore therapeutic agents3). | 1) J Neurosci. 2011 Jan 5;31(1):346-58. 2) Hippocampus. 2011 Jun;21(6):678-87. 3) Nat Med. 2018 Jun;24(6):802-813. |
| 19.07.01 | Cardio-facio-cutaneous syndrome-1 (OMIM: 115150) model mice | RBRC09730 RBRC09731 RBRC09907 RBRC09908 | This is a Braf (disease gene) point mutation knockin mouse strain, which shows some abnormal phenotypes similar to the human condition1) 2) 3) 4). | 1) Hum Mol Genet. 2019 Jan 1;28(1):74-83. 2) Hum Mol Genet. 2017 Dec 1;26(23):4715-4727. 3) Hum Mol Genet. 2015 Dec 20;24(25):7349-60. 4) Hum Mol Genet. 2014 Dec 15;23(24):6553-66. |
| 19.07.01 | Chédiak-Higashi syndrome (OMIM: 214500) model mice | RBRC00134 | This is a Lyst (disease gene) spontaneous mutation mouse strain, which shows some abnormal phenotypes similar to the human condition1) and is utilized to analyze the mechanism2) 3). | 1) Nature. 1996 Jul 18;382(6588):262-5. 2) Mol Genet Metab. 2010 Apr;99(4):389-95. 3) J Biol Chem. 1997 Nov 21;272(47):29790-4. |
| 19.07.01 | Griscelli syndrome cutaneous and neurologic type (OMIM: 214450) model mice | RBRC02978 | This is a Myo5a (disease gene) spontaneous point mutation mouse strain, which shows abnormal pigmentation and neurological impairment similar to the human condition1) 2). | 1) J Neurosci. 2011 Apr 20;31(16):6067-78. 2) Genetics. 1998 Apr;148(4):1963-72. |
