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Today’s tool for functional analysis / Today’s model for human disease

▶ Today’s tool for functional analysis▶ Today’s model for human disease

Date	Title	BRC No.	Description	References
19.04.01	Cre-driver mice for myelinating cells of the central nervous system¹⁾	RBRC01461	This strain is useful for the elucidation of gene function in oligodendrocyte myelination²⁾.	1) Genesis. 2000 Feb;26(2):127-9. 2) Nat Commun. 2016 Nov 23;7:13478.
19.04.01	Oct3/4 (Pou5f1) reporter mice	RBRC00771¹⁾ RBRC06037²⁾	These strains are useful for stem cell research because they express EGFP under the control of pluripotency marker Oct3/4^{3) 4) 5)}.	1) Dev Biol. 2003 Jun 1;258(1):209-25. 2) Development. 2008 Mar;135(5):909-18. 3) Cell Res. 2011 Jan;21(1):196-204. 4) Dev Biol. 2010 Oct 1;346(1):90-101. 5) Stem Cells. 2009 Feb;27(2):383-9.
19.04.01	Fgf5 spontaneous mutant mice	RBRC05894 RBRC05895	This strain shows abnormal hair follicle cycle¹⁾. In addition, it contributed to the research about spermatogenic stem cells²⁾.	1) Exp Anim. 2011;60(2):161-7. 2) Cell Stem Cell. 2019 Jan 3;24(1):79-92. e6.
19.04.01	Fstl4 (Mahya) reporter mice	RBRC04952	This strain is useful for revolutionary genetic research¹⁾In addition, it was used to monitor specific subtypes of retinal ganglion cells²⁾.	1) Dev Genes Evol. 2005 Nov;215(11):564-74. 2) Curr Eye Res. 2016 Apr;41(4):558-68.

Date	Title	BRC No.	Description	References
19.05.08	Ehlers-Danlos syndorome spondylodysplastic type 3 (OMIM: 612350) model mice	RBRC06217	This is a Slc39a13 (disease gene) knockout mouse strain, which shows defect of connective tissue similar to the human condition^{1) 2)}.	1) PLoS Genet. 2017 Aug 30;13(8):e1006950. 2) PLoS One. 2008;3(11):e3642.
19.05.08	Myoclonic epilepsy of Lafora (OMIM: 254780) model mice	RBRC02715	This is a Epm2a (disease gene) knockout mouse strain, which shows progressive neurodegeneration similar to the human condition^{1) 2) 3)}.	1) Hum Mol Genet. 2017 Dec 15;26(24):4778-4785. 2) Brain. 2014 Mar;137(Pt 3):806-18. 3) Hum Mol Genet. 2002 May 15;11(11):1251-62.
19.05.08	Hirschsprung disease susceptibility to 1 (OMIM: 142623) model mice	RBRC06249	This is a Ret (disease gene) point mutation knockin mouse strain, which shows megacolon and deafness similar to the human condition^{1) 2) 3)}.	1) Dev Biol. 2011 Jan 15;349(2):160-8. 2) Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13051-6. 3) Mol Cell Biol. 2004 Sep;24(18):8026-36.
19.05.08	Mowat-Wilson syndrome (OMIM: 235730) model mice	RBRC01925	This is a Zeb2 (disease gene) knockout mouse strain, which shows some abnormal phenotypes similar to the human condition^{1) 2) 3)}.	1) Hum Mol Genet. 2007 Jun 15;16(12):1423-36. 2) Am J Hum Genet. 2003 Feb;72(2):465-70. 3) Genesis. 2002 Feb;32(2):82-4.