TOP > Today’s tool for functional analysis / Today’s model for human disease

Today’s tool for functional analysis / Today’s model for human disease




DateTitleBRC No.DescriptionReferences
21.08.02Cre-driver mice for inner earRBRC09434Pax2-Cre Tg strain is utilized as Cre-driver mice for inner ear1)2)3).1) Elife. 2020 Jan 8;9:e52160.
2) PLoS Genet. 2017 Oct 23;13(10):e1007048.
3) Genesis. 2004 Apr;38(4):195-9.
21.08.02Cre-driver mice for olfactory sensory neuronsRBRC06339Olfr1507(MOR28)-Cre Tg strain is utilized as Cre-driver mice for a part of olfactory sensory neurons1)2)3).1) Science. 2019 Jul 5;365(6448):eaaw5030.
2) Mouse of the Month October 2015.
3) Cell. 2010 Jun 11;141(6):1056-67.
21.08.02Cre-driver mice for olfactory sensory neuronsRBRC06346Ascm4(OMACS)-Cre KI strain is utilized as Cre-driver mice for dorsal zone olfactory sensory neurons1)2)3).1) Commun Biol. 2019 Jan 8;2:14.
2) Sci Rep. 2015 Sep 11;5:14073.
3) Nature. 2007 Nov 22;450(7169):503-8.
21.08.02Cre-driver mice for retinal photoreceptor cells and progenitor cells RBRC05426Crx-Cre Tg strain is utilized as Cre-driver mice for retinal photoreceptor cells and progenitor cells1)2)3).1) Sci Rep. 2018 Jun 4;8(1):8543.
2) Hum Mol Genet. 2018 Sep 15;27(18):3137-3153.
3) Nat Neurosci. 2003 Dec;6(12):1255-63.
21.08.02CreERT2-driver mice for retinal photoreceptor cells and progenitor cells RBRC05559Crx-CreERT2 Tg strain is utilized as tamoxifen-inducible Cre-driver mice for retinal photoreceptor cells and progenitor cells1)2)3).1) Exp Eye Res. 2018 Aug;173:32-43.
2) Cell Rep. 2015 Nov 3;13(5):990-1002.
3) J Neurosci. 2011 Nov 16;31(46):16792-807.
21.03.31G-CaMP7 Tg mice controlled by Thy1 promoterRBRC06579Using this strain, longitudina imaging of large-scale functional hippocampal cellular maps was performed1)2).1) Cell Rep. 2020 Jul 7;32(1):107864.
2) PLoS One. 2012;7(12):e51286.
21.03.31G-CaMP7 Tg mice controlled by Slc1a2 (GLT1) promoterRBRC09650This strain expresses G-CaMP7 in astrocytes and a subpopulation of cortical neurons1)2)3)4).　It contributed to elucidation of the recovery mechanism after acute ischemic stroke5).1) Nat Commun. 2016 Mar 22;7:11100.
2) Mouse of the Month August 2017.
3) J Neurosci. 2007 Jun 20;27(25):6607-19.
4) PLoS One. 2012;7(12):e51286.
5) Proc Natl Acad Sci U S A. 2019 May 28;116(22):11010-11019.
21.03.31G-CaMP6 Tg mice controlled by Thy1 promoterRBRC10611This strain expresses G-CaMP6 in brain1)2).1) Neurosci Res. 2020 Feb;151:53-60.
2) PLoS One. 2012;7(12):e51286.
21.03.31G-CaMP7 expression conditionally controllable Tg miceRBRC06510This strain is reported to show a growth retardation with hypothyroidism1)2)3).1) PLoS One. 2015 May 6;10(5):e0125354.
2) Mouse of the Month June 2015.
3) PLoS One. 2012;7(12):e51286.
21.02.01A member of formin protein family mDia1 floxed miceRBRC02595This strain contributed to elucidation of actin cytokine-mediated T cell activation mechanism1)2)3).1) Sci Adv6 (1) 2020 eaay2432
2) Cell Rep 2016 17 (9) 2405-2417
3) J Exp Med 2007 204 (9) 2031-8
21.02.01Oncostatin M (a member of IL-6 family of cytokines) receptor KO mice1)2)RBRC02711This strain is widely used for variety research fields including immunology3)4)5).1) Blood 2003 102 (9) 3154-62
2) Hepatology 2004 39 (3) 635-44
3) Proc Natl Acad Sci U S A 2020 117 (9) 5028-5038
4) Nat Commun 2017 8 13946
5) J Lipid Res 2017 58 (5) 895-906
21.02.01Cytokine TNFα KO mice1)2)RBRC05118
(C57BL/6)
RBRC05119
(BALB/c)		These strains are widely used for elucidation of immune mechanism3)4).1) J Immunol 1997 159 (3) 1418-28
2) Lab Invest 1997 77 (6) 647-58
3) J Immunol 2019 203 (4) 783-788
4) Front Immunol 2018 9 2619
20.12.01Endogenous membrane protein Mavs (IPS-1) KO mice1)RBRC04546Mavs (IPS-1) is related to the cytokine production as adaptor to recognize cytoplasmic RNA virus. This strain contributed to elucidate some findings 2)3)4)5). 1) J Immunol. 2011 Nov 15;187(10):5320-7.
2) Cancer Sci. 2018 Apr;109(4):956-965.
3) Cell Rep. 2017 May 30;19(9):1874-1887.
4) Cell Rep. 2015 May 26;11(8):1193-207.
5) Immunity. 2015 Dec 15;43(6):1148-59.
20.12.01Ubiquitin ligase Efp (Trim25) KO mice1)RBRC02844Analysis of this strain revealed that Efp (Trim25) is related to the breast tumor growth2), neuroinflammation pathogenesis3) and inhibition of virus infection4)5).1) Proc Natl Acad Sci U S A. 1999 Oct 12;96(21):12027-32.
2) Nature. 2002 Jun 20;417(6891):871-5.
3) Nat Immunol. 2017 Jan;18(1):54-63.
4) Nat Immunol. 2010 Jan;11(1):63-9.
5) Nature. 2007 Apr 19;446(7138):916-920.
20.12.01Itgal (LFA-1, Cd11a) KO mice1)RBRC00850Analysis of this strain revealed several type I interferon secretion
mechanism by plasmacytoid dendritic cells2).		1) J Exp Med. 1996 Apr 1;183(4):1415-26.
2) Nat Commun. 2017 Nov 17;8(1):1592.
20.12.01Agt (angiotensinogen) KO mice1)RBRC01120This strain is widely used for functional analysis of renin-angiotensin system2)3).1) J Biol Chem. 1994 Dec 16;269(50):31334-7.
2) PLoS One. 2015 Jun 24;10(6):e0129484.
3) Circ Res. 2014 Jul 7;115(2):263-72.
20.10.01Pro-inflammatory cytokine IL-6 KO mice1)RBRC04918
(C57BL/6)
RBRC04919
(BALB/c)
RBRC05131
(DBA/1)		IL-6 (interleukin-6) is a cytokine that has multifunction, including inflammatory response, in many kinds of cells. These strains were utilized for IL-6 functional analysis2)3)4).1) Nature. 1994 Mar 24;368(6469):339-42.
2) Sci Rep. 2019 Jul 25;9(1):10842.
3) Sci Adv. 2018 Jul 11;4(7):eaas9944. 
4) Sci Rep. 2018 Oct 25;8(1):15783.
20.10.01IL-6-related inflammatory status in vivo imaging miceRBRC09487This BAC-based human IL-6-luciferase Tg strain is useful for evaluation of inflammatory status in vivo by luciferase luminescence1)2)3)4)5).1) Sci Rep. 2018 May 23;8(1):8037. 
2) Eur J Pharmacol. 2017 May 5;802:76-84.
3) Nat Commun. 2016 May 23;7:11624.
4) Mouse of the Month May 2016
5) Mol Cell Biol. 2015 Oct;35(20):3590-601. 
20.10.01Human IL-6 expression conditionally controllable miceRBRC09734
RBRC09735		This strain expresses human IL-6 according to Cre recombinase1).1) Exp Anim. 2016 Nov 1;65(4):455-463.
20.04.01Cre reporter mice showing green-to-red fluorescent conversion1)2)3)RBRC04874This ROSA26-KI strain express EGFP signal before and tdsRed signal after Cre-mediated recombination. It was contributed to some results4)5)6).1) Exp Anim. 2013;62(4):295-304.
2) Mouse of the Month October 2018
3) Mouse of the Month March 2014
4) iScience. 2019 Oct 25;20:337-347.
5) Dev Cell. 2019 Jul 22;50(2):139-154.e5.
6) PLoS One. 2018 Jan 11;13(1):e0190800.
20.04.01Cre reporter mice expressing EGFP signal1)RBRC09806This Tg strain express EGFP signal after Cre-mediated recombination. It was contributed to some results2)3)4).1) FEBS Lett. 2000 Mar 31;470(3):263-8.
2) Dev Cell. 2019 Jan 28;48(2):151-166.e7.
3) Cell Stem Cell. 2018 Mar 1;22(3):384-397.e6.
4) Nat Commun. 2018 Apr 24;9(1):1623.
20.04.01Cre reporter mice expressing LacZ signal1)2)RBRC02657This ROSA26-KI strain express LacZ signal after Cre-mediated recombination. It was contributed to some results3)4)5).1) Front Behav Neurosci. 2013 Mar 12;7:17.
2) Mouse of the Month March 2013
3) Transgenic Res. 2018 Apr;27(2):193-201.
4) J Neurosci. 2017 Aug 9;37(32):7682-7699.
5) Genesis. 2016 Nov;54(11):568-572.
20.02.03Siglec-H gene
DTR-EGFP KI mice		RBRC05658
(C57BL/6)
RBRC09688
(BALB/c)		In this strain, plasmacytoid dendritic cells (pDCs) can be depleted by injection of diphtheria toxin 1)2)3). User reported that pDCs are related with acute liver injury4). 1) Glia. 2017 Dec;65(12):1927-1943.
2) Sci Rep. 2016 Apr 14;6:24477.
3) Immunity. 2011 Dec 23;35(6):958-71.
4) J Clin Invest. 2019 Jul 2;129(8):3201-3213.
20.02.03Xcr1 gene
KikGR KI mice		RBRC09928This is a photoconvertible KikGR reporter mice for Xcr1 gene, which express chemokine receptor at one subset of dendritic cells1).1) Proc Natl Acad Sci U S A. 2016 Jan 26;113(4):1044-9.
20.02.03Xcr1 gene
DTR-Venus KI mice		RBRC09485
(C57BL/6)
RBRC10391
(BALB/c)		In this strain, XCR1-positive dendritic cells can be depleted by injection of diphtheria toxin 1) 2) 3). 1) Nat Microbiol. 2018 May;3(5):611-621.
2) J Immunol. 2017 Dec 15;199(12):4165-4179.
3) Mouse of the Month January 2016
20.02.03Relb gene
Venus KI mice		RBRC09496This is a Venus reporter strain for Nf-κB family gene Relb, which is related with immune cell maturation 1).1) J Biochem. 2015 Dec;158(6):485-95.
19.12.02Cre-driver mice for CRF neuronRBRC06520Crh (corticotropin-releasing hormone) Cre KI strain is useful for stress response research 1) 2).1) Sci Adv. 2016 Aug 17;2(8):e1501723.
2) Endocrinology. 2014 Oct;155(10):4054-60.
19.12.02Crh gene reporter miceRBRC09893Crh (corticotropin-releasing hormone) Venus KI strain allows the visualization of CRF neurons 1) 2) 3).1) Biol Sex Differ. 2019 Jan 28;10(1):6.
2) Brain Struct Funct. 2017 May;222(4):1705-1732.
3) Endocrinology. 2014 Oct;155(10):4054-60.
19.12.02Cre-driver mice for Oligodendrocyte lineage and motoneuronRBRC01507Olig2-tamoxifen inducible Cre KI strain is frequently used in neuroscience 1) 2) 3) 4) 5).1) Nat Neurosci. 2018 May;21(5):696-706.
2) Science. 2014 Sep 26;345(6204):1254927.v
3) Mouse of the Month July 2006
4) Dev Biol. 2006 May 15;293(2):358-69.
5) Curr Biol. 2002 Jul 9;12(13):1157-63.
19.12.02Transcription factor Olig2 reporter miceRBRC06017
RBRC06018
RBRC06022		This strain express Venus, mCherry or luciferase-OLIG2 fusion protein 1).1) Science. 2013 Dec 6;342(6163):1203-8.
19.12.02Cre-driver mice for dorsal telencephalonRBRC01345Emx1 (empty spiracles homeobox 1) Cre KI strain is frequently used in neuroscience 1) 2) 3) 4) 5).1) Nat Commun. 2019 Aug 8;10(1):3581.
2) Nat Commun. 2017 May 23;8:15488.
3) Mouse of the Month July 2006
4) Genesis. 2004 Mar;38(3):130-8.
5) Nature. 2000 Aug 17;406(6797):726-31.
19.12.02Cre-driver mice for developing cochleaeRBRC02272Emx2 (empty spiracles homeobox 2) Cre KI strain 1) is useful for inner ear development research 2) 3) 4).1) J Neurosci. 2005 May 25;25(21):5097-108.
2) J Neurosci. 2019 Oct 9;39(41):8013-8023.
3) Dev Biol. 2018 May 1;437(1):17-26.
4) Development. 2018 Jun 14;145(12).
19.10.01Cellualar oxidative stress imaging miceRBRC057041)
RBRC061612)		Nrf2 (oxidative stress-responsive transcription factor) reporter mice were utilized for the elucidation of oxidative stress sensing mechanism3).1) Sci Rep. 2012;2:229.
2) Free Radic Biol Med. 2014 Jul;72:124-33.
3) Cell Rep. 2019 Jul 16;28(3):746-758.e4.
19.10.01ROS production conditionally regulatable mice1)RBRC09859This strain expresses SDAD (ROS homeostasis-related enzyme) defective mutants according to Cre recombinase.1) Eur J Immunol. 2017 Feb;47(2):406-418.
19.10.01Sperm-egg fusion imaging mice1)RBRC05763Izumo1 (sperm acrosomal gene) reporter strain is useful for the elucidation of gamete fusion mechanism2) 3).1) J Cell Sci. 2012 Nov 1;125(Pt 21):4985-90.
2) Cell Cycle. 2018;17(11):1279-1285.
3) Nat Commun. 2015 Nov 16;6:8858.
19.10.01Sperm acrosome−GFP：
sperm mitochondria−DsRed
dual reporter mice1)		RBRC03743
RBRC05861
This strain is useful for the elucidation of fertilization or acrosome reaction mechanism2) 3) 4).1) Exp Anim. 2010;59(1):105-7.
2) J Cell Biol. 2018 Jun 4;217(6):2103-2119.
3) J Biol Chem. 2018 Jul 27;293(30):11796-11808.
4) Biol Reprod. 2016 Apr;94(4):80.
19.08.01Cre-driver mice for orexin neuronsRBRC06806This strain expresses Cre recombinase and EGFP in orexin neurons1) 2).1) Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):E10740-E10747.
2) Neuropharmacology. 2014 Oct;85:451-60.
19.08.01Full maturated OSN (olfactory sensory neuron) reporter mice1)RBRC02092OMP (olfactory marker protein) gene-GFP KI mice are broadly utilized for olfactory analysis2) 3) 4).1) J Neurosci. 2001 Dec 15;21(24):9713-23.
2) J Neurosci. 2019 Jan 30;39(5):814-832.
3) Cell Stem Cell. 2017 Dec 7;21(6):761-774.e5.
4) Cell. 2016 Jun 16;165(7):1734-1748.
19.08.01Selenocysteine-tRNA (Trsp) floxed mice1)RBRC02681This strain was utilized for an oxidative stress model2) 3).1) J Biol Chem. 2008 Jan 25;283(4):2021-30.
2) Cell Rep. 2017 Feb 21;18(8):2030-2044.
3) Blood. 2011 Jan 20;117(3):986-96.
19.08.01Neuronally enriched Rufy3 KO-first miceRBRC05780Analysis of this strain revealed that RUFY3 is essential for caspase-mediated axon degeneration1).1) Neuron. 2019 Jun 7. pii: S0896-6273(19)30483-0. 
19.06.03Cre-driver mice for postnatal somatic motor neuronsRBRC01515
RBRC01516		These strain express Cre recombinase in slow type motor neurons1) 2).1) Genesis. 2016 Nov;54(11):568-572.
2) Brain Res. 2014 Mar 6;1550:36-46.
19.06.03Mitochondria-EGFP labeled mice1) 2)RBRC02250This transgenic strain is utilized to identify and monitor the mitochondorial morphology3) 4).1) Exp Anim. 2010;59(1):99-103.
2) FEBS Lett. 2001 Jun 29;500(1-2):7-11.
3) Sci Transl Med. 2017 Oct 25;9(413).
4) PLoS One. 2012;7(6):e36850.
19.06.03Zinc transporter Slc39a10 (Zip10) floxed miceRBRC06221Analysis of this strain revealed novel functions of Slc39a10 in humoral immune system1) 2) and epidermal development3).1) Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):11786-91.
2) Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):11780-5.
3) Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):12243-12248.
19.06.03Cell adhesion molecule Cadm1 (SynCAM1) KO miceRBRC04062This strain was utilized for analysis of not only nervous system1) 2) 3) but also bone turnover4).1) J Neurosci. 2016 Jul 13;36(28):7464-75.
2) Neuron. 2010 Dec 9;68(5):894-906.
3) Biochem Biophys Res Commun. 2010 Jun 4;396(3):703-8.
4) PLoS One. 2017 Apr 17;12(4):e0175632.
19.04.01Cre-driver mice for myelinating cells of the central nervous system1)RBRC01461This strain is useful for the elucidation of gene function in oligodendrocyte myelination2).1) Genesis. 2000 Feb;26(2):127-9.
2) Nat Commun. 2016 Nov 23;7:13478.
19.04.01Oct3/4 (Pou5f1) reporter miceRBRC007711)
RBRC060372)		These strains are useful for stem cell research because they express EGFP under the control of pluripotency marker Oct3/43) 4) 5).1) Dev Biol. 2003 Jun 1;258(1):209-25.
2) Development. 2008 Mar;135(5):909-18.
3) Cell Res. 2011 Jan;21(1):196-204.
4) Dev Biol. 2010 Oct 1;346(1):90-101.
5) Stem Cells. 2009 Feb;27(2):383-9.
19.04.01Fgf5 spontaneous mutant miceRBRC05894
RBRC05895		This strain shows abnormal hair follicle cycle1). In addition, it contributed to the research about spermatogenic stem cells2).1) Exp Anim. 2011;60(2):161-7.
2) Cell Stem Cell. 2019 Jan 3;24(1):79-92. e6.
19.04.01Fstl4 (Mahya) reporter miceRBRC04952This strain is useful for revolutionary genetic research1)In addition, it was used to monitor specific subtypes of retinal ganglion cells2).1) Dev Genes Evol. 2005 Nov;215(11):564-74.
2) Curr Eye Res. 2016 Apr;41(4):558-68.


DateTitleBRC No.DescriptionReferences
21.09.01Usher syndrome type 2C (OMIM:605472) responsible gene Adgrv1(Vlgr1,Gpr98) KO miceRBRC09313
(KO)
RBRC09315
(KO)
RBRC09314
(EYFP KI)		These strains were reported to show auditory abnormalities1)2)3)4)5).1) Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):7765-7774.
2) J Clin Endocrinol Metab. 2012 Apr;97(4):E565-74.
3) Neurosci Lett. 2009 Sep 18;461(2):190-5.
4) J Neurosci. 2007 Jun 13;27(24):6478-88.
5) J Neurochem. 2005 Jan;92(1):191-202.
21.09.01Prader-Willi syndrome (OMIM:176270) responsible gene Necdin(Ndn) KO miceRBRC09382
(B6)
RBRC09363
(ICR)
RBRC02316
(ICR and B6 mixed)		These strains were reported to show behavioral and neuromorphological abnormalities1)2)3)4)5).1) Nat Commun. 2016 Mar 14;7:10943.
2) PLoS One. 2014 Jan 2;9(1):e84460.
3) J Neurosci. 2013 Jun 19;33(25):10362-73.
4) J Neurosci. 2012 Apr 18;32(16):5562-72.
5) J Neurosci. 2005 Jul 27;25(30):7090-9.
21.09.01Congenital stationary night blindness responsible gene Trpm1 KO miceRBRC05509
(B6)
RBRC05138
(129)		These strains were reported to show vision abnormalities1)2)3)4)5).1) Mol Brain. 2021 Mar 30;14(1):61.
2) J Neurosci. 2017 Oct 11;37(41):9889-9900.
3) PLoS One. 2013 Nov 25;8(11):e81507.
4) Eur J Neurosci. 2013 Sep;38(6):2823-31.
5) Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):332-7.
21.09.01SNARE protein family Snap25 gene amino acid substitution miceRBRC09306
This strain was reported to show behavioral disorders1)2)3)4).1) Sci Rep. 2017 Aug 11;7(1):7996.
2) Epilepsy Res. 2015 Sep;115:30-44.
3) J Neurosci. 2012 Nov 28;32(48):17186-96.
4) PLoS One. 2011;6(9):e25158.
21.07.01One subunit of NMDA receptor
Grin2a gene KO mice1)		RBRC01195
(C57BL/6J)
RBRC02256
(B6 and 129 mixed)		These strains were used for research of neural mechanism2)3) or NMDA receptor-related neural disorders4).1) J Neurosci. 1996 Dec 15;16(24):7859-67.
2) Proc Natl Acad Sci U S A. 2019 Oct 15;116(42):21207-21212.
3) Nat Neurosci. 2011 Mar;14(3):338-44.
4) Cell Rep. 2020 Jan 14;30(2):381-396.e4.
21.07.01Synaptic protein
Stxbp1 (Munc18-1) gene
floxed mice		RBRC05604Analysis of this strain revealed a novel mechanism to trigger epilepsy1)2).1) Nat Commun. 2019 Apr 23;10(1):1917.
2) Hum Mol Genet. 2017 Dec 15;26(24):4961-4974.
21.07.01Serine protease
Klk8 (Neuropsin) gene
KO mice1)		RBRC02740The relationship between some behavior disorders (social discrimination behavior2), cognitive disorders3), stress disorders4), etc.) and Neuropsin was indicated by analysis of this strain.1) Mol Cell Neurosci. 2001 Mar;17(3):600-10.
2) Neurobiol Learn Mem. 2019 Jul;162:47-58.
3) Transl Psychiatry. 2017 Mar 7;7(3):e1052.
4) PLoS Genet. 2016 Oct 4;12(10):e1006356.
21.07.01Secreted glycoprotein
Reln (Reelin) gene
C-terminal deficient mice1)		RBRC03079This strain was reported to show several neuropsychiatric or behavior disorders2)3).1) J Neurosci. 2015 Mar 18;35(11):4776-87.
2) Neuroscience. 2016 Nov 12;336:20-29.
3) Sci Rep. 2016 Jun 27;6:28636.
21.04.27Downstream factor of IL-17 signaling pathway Nfkbiz (IκB-ζ) floxed mice1)RBRC06410This strain is useful for Nfkbiz functional analyisis in various kinds of cells2)3)4)5). Recently, the relationship between ulcerative colitis and NHKBIZ was indicated by using this strain6). 1) Immunity. 2013 Mar 21;38(3):450-60.
2) J Immunol. 2020 Apr 15;204(8):2033-2042.
3) JCI Insight. 2019 Nov 14;4(22):e130835.
4) Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):10088-10093.
5) Mouse of the Month Apr 2017
6) Nature. 2020 Jan;577(7789):260-265.
21.04.27Tyrosine kinase receptor family EphB6 KO mice1)RBRC02280The relationship between metastatic process of colorectal cancer and EPHB6 was indicated by analysis of this strain2).1) Biochem Biophys Res Commun. 2002 Oct 18;298(1):87-94.
2) Sci Rep. 2017 Mar 6;7:43702.
21.04.27ROS1-fusion positive lung cancer model miceRBRC09696
(CD74-ROS1 Tg)
RBRC09697
(SDC4-ROS1 Tg)		These strains are Tg mice expressing CD74-ROS1 or SDC4-ROS1 fusion proteins which have been reported in human lung cancer cases1).1) Carcinogenesis. 2016 May;37(5):452-60.
21.04.27Glycolysis enzyme PKM (pyruvate kinase M) mutant miceRBRC10481
(PKM1 KI)
RBRC10482
(PKM2 KI)		These strains selectively expressing PKM splicing isoforms (PKM1 or PKM2) were developed to analyze glycolytic enzyme PKM function for cancer glucose metabolism (Warburg effect)1).1) Cancer Cell. 2018 Mar 12;33(3):355-367.e7.
21.03.01Autism spectrum disorder model miceRBRC05954This strain is a mouse model of human 15q11–13 duplication1)2)3)4).
Using functional MRI, neural circuit dysfunction in this strain
was reported5).		1) Sci Rep. 2018 Sep 12;8(1):13675.
2) Sci Rep. 2017 Aug 29;7(1):9902.
3) Mouse of the Month April 2015.
4) Cell. 2009 Jun 26;137(7):1235-46.
5) Sci Adv. 2020 Feb 5;6(6):eaav4520.
21.03.01Ednrb (endothelin receptor type B) KO mice1)RBRC06163This strain was reported as a Hirschsprung's disease2), melanoma3) or Waardenburg syndrome4) model.1) Cell. 1994 Dec 30;79(7):1267-76.
2) Development. 1998 Mar;125(5):825-36.
3) Cancer Res. 2010 Jan 1;70(1):24-9.
4) J Biol Chem. 2011 Aug 26;286(34):29621-6.
21.03.01 Lymphoedema-distichiasis syndrome responsible gene Foxc2 floxed miceRBRC10306The phenotype analysis results of Foxc2 conditionally deleted mice in kidneys were reported1).1) Mamm Genome. 2016 Feb;27(1-2):62-9.
21.03.01TPST2 enzymatic activity deficient mice RBRC05261This strain is reported to show a growth retardation with hypothyroidism1)2)3).1) Biomed Res. 2010 Jun;31(3):207-11.
2) J Vet Med Sci. 2008 Oct;70(10):1043-9.
3) Mol Endocrinol. 2007 Jul;21(7):1713-21.
21.01.04Vitamin D receptor VDR KO mice1)2)RBRC05885This strain shows osteoporosis and rickets-like phenotypes. Therefore, it is utilized to reveal the relationship between vitamin D and osteogenesis3)4)5).1) Endocrinology. 2000 Apr;141(4):1317-24.
2) Nat Genet. 1997 Aug;16(4):391-6.
3) Biochem Biophys Res Commun. 2017 Jan 29;483(1):359-365.
4) Endocrinology. 2017 Jun 1;158(6):1951-1963.
5) Sci Rep. 2017 Aug 10;7(1):7786.
21.01.04A kind of GPCR GPRC5B KO mice1)RBRC10166Analysis of this strain suggested that GPRC5B is related with obesity-associated inflammatory signaling and synapse formation in Purkinje cells2)3).1) Biochem Biophys Res Commun. 2011 Sep 2;412(3):460-5.
2) Sci Signal. 2012 Nov 20;5(251):ra85.
3) Neurosci Res. 2018 Nov;136:33-47.
21.01.04ACAM(CLMP) Tg mice controlled by adipocyte P2 promoter RBRC06443
RBRC06444
RBRC06445		In response to high fat-high sucrose diet feeding, these strains show resistance to obesity and diabetes1)2)3).1) J Lipid Res. 2000 Oct;41(10):1615-22.
2) Biochem J. 2005 Apr 15;387(Pt 2):343-53.
3) Diabetes. 2016 May;65(5):1255-67.
21.01.04Phosphatidylcholine biosynthetic enzyme Pemt KO miceRBRC06436In response to high fat-high sucrose diet feeding, these strains show not only resistance to obesity and diabetes but also non-alcoholic steatohepatitis1)2).1) Sci Rep. 2016 Feb 17;6:21721.
2) PLoS One. 2014 Mar 25;9(3):e92647.
20.10.23Human renin・human angiotensinogen double Tg miceRBRC01122
(hRN Tg)
RBRC01123
(hAG Tg)
RBRC02432
(F1(hRN × hAG))		These strains were contributed to some results as Tsukuba Hypertensive mice1)2)3). Additionally, these are known as pregnancy-induced hypertension models4)5).1) Eur J Histochem. 2018 Jul 24;62(3):2930.
2) Mouse of the Month May 2012
3) Biochem Biophys Res Commun. 1991 Oct 31;180(2):1103-9.v
4) Sleep. 2018 Mar 1;41(3).
5) Sci Signal. 2017 May 16;10(479):eaam5711.
20.10.23Prolin isomerase Pin1-KO mice1)2)RBRC10368Analysis of this strain suggested the relationship between PIN1 and various biological phenomenon and diseases3)4)5).1) Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1335-40.
2) Biochem Biophys Res Commun. 1999 Nov 30;265(3):658-63.
3) Hum Mol Genet. 2018 Nov 15;27(22):3827-3839.
4) Biochem Biophys Res Commun. 2018 Feb 26;497(1):388-393.
5) Biochem Biophys Res Commun. 2017 Nov 18;493(2):946-951.
20.10.23p53-target gene Tigar-KO miceRBRC10981Analysis of this strain suggested the relationship between TIGAR and cardiac metabolism1)2).1) Am J Physiol Heart Circ Physiol. 2019 Jun 1;316(6):H1366-H1377.
2) J Mol Cell Cardiol. 2012 Jan;52(1):175-84.
20.10.23Endogenous membrane protein Aqp7-KO miceRBRC06294Analysis of this strain suggested the relationship between AQP7 and various metabolism pathways1)2)3).1) Cardiovasc Res. 2009 Jul 1;83(1):34-41.
2) Proc Natl Acad Sci U S A. 2005 Aug 2;102(31):10993-8.
3) Proc Natl Acad Sci U S A. 2004 Dec 21;101(51):17801-6.
20.03.02Endoplasmic reticulum (ER) transmembrane protein IRE1α(ERN1)-KO/cKO mice1)RBRC05515
(floxed)
RBRC05516
(KO)		These strains are utilized to reveal the relationship between ER stress and some diseases2)3)4).1) Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16657-62.
2) Nat Commun. 2018 Dec 17;9(1):5340.
3) Nature. 2018 Oct;562(7727):423-428.
4) J Cell Biol. 2018 Apr 2;217(4):1287-1301.
20.03.02Tumor necrosis factor (TNF) receptor-associated factor TRAF6-KO mice1)RBRC04950
(C57BL/6)
RBRC05386
(BALB/c)		These strains show various disorders like ectodermal dysplasia, osteopertrosis, autoimmunity and so on2)3)4)5).1) Genes Cells. 1999 Jun;4(6):353-62.
2) Commun Biol. 2019 Aug 6;2:292.
3) Proc Natl Acad Sci U S A. 2017 Aug 22;114(34):E7140-E7149.
4) J Biol Chem. 2017 Jun 16;292(24):10169-10179.
5) Mouse of the Month Sep 2012
20.03.02Tubulin glutamylation enzyme TTLL1-KO miceRBRC03327This strain shows primary ciliary dyskinesia-like phenotype1)2)3).1) Sci Rep. 2018 Feb 13;8(1):2904.
2) PLoS One. 2015 Nov 18;10(11):e0141823.
3) Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10490-5.
20.03.02Apoptosis-related transmembrane receptor FAS-KO miceRBRC01474
(C57BL/6)
RBRC01476
(MRL)		These strains show autoimmune
lymphoproliferative syndrome (OMIM: 601859)-like phenotype1)2)3)4).		1) Proc Natl Acad Sci U S A. 1996 Mar 5;93(5):2131-6.
2) Nat Genet. 1995 Nov;11(3):294-300.
3) Eur J Immunol. 2013 Jul;43(7):1789-98.
4) J Exp Med. 2013 Sep 23;210(10):2087-103.
20.01.06Spinal and bulbar muscular atrophy (SBMA) model miceRBRC00344This strain shows some phenotypes similar to human patients. It is utilized to explore molecular mechanisms and therapeutic agents1) 2) 3).1) Hum Mol Genet. 2018 Jul 15;27(14):2425-2442.
2) J Neurosci. 2016 May 4;36(18):5094-106.
3) Neuron. 2002 Aug 29;35(5):843-54.
20.01.06Limb-girdle muscular dystrophy type 2A (LGMD2A) model miceRBRC04787CAPN3 protease activity-deficient mice show muscular disease-like phenotypes1) 2) 3).1) Hum Mol Genet. 2018 May 1;27(9):1642-1653.
2) J Clin Invest. 2010 Aug;120(8):2672-83.
3) J Biol Chem. 2010 Jul 23;285(30):22986-98.
20.01.06Sporadic amyotrophic lateral sclerosis (ALS) model mice RBRC09428This strain shows some phenotypes similar to human patients. It is utilized to explore molecular mechanisms and therapeutic agents1) 2) 3) 4).1) Sci Rep. 2017 Jan 3;7:39994.
2) Sci Rep. 2016 Jun 28;6:28649.
3) J Neurosci. 2010 Sep 8;30(36):11917-25.
4) Mouse of the Month Nov 2015.
20.01.06Familial amyotrophic lateral sclerosis (ALS) model mice RBRC09642
RBRC09643
RBRC09644		Tg mice harboring mutated human SOD1 show progressive motor neuron disease-like phenotypes1).1) Hum Mol Genet. 2015 Jun 15;24(12):3427-39.
19.11.06Disc1 point mutated (L100P) mice with schizophrenia-like phenotypesRBRC06364This strain is a schizophrenia model, which established by ENU mutagenesis 1) 2) 3) 4).1) Neuron. 2007 May 3;54(3):387-402.
2) Front Cell Neurosci. 2018 Aug 2;12:238.
3) Behav Brain Res. 2017 Mar 1;320:113-118.
4) Schizophr Bull. 2017 Jan;43(1):214-225.
19.11.06Disc1 point mutated (Q13L) mice with depression-like phenotypesRBRC06365This strain is a endogenous depression model, which established by ENU mutagenesis 1) 2) 3).1) Neuron. 2007 May 3;54(3):387-402.
2) Neuroscience. 2016 May 3;321:99-107.
3) PLoS One. 2014 Oct 1;9(10):e108088.
19.11.06CaMKIIα point mutated (K42R) mice with learning and memory deficits RBRC05821
RBRC05636		CaMKIIα kinase activity-deficient mice shows hippocampus-dependent learning and memory deficits 1) 2) 3).1) eNeuro. 2018 Aug 21;5(4). pii: ENEURO.0133-18.2018.
2) Genes Dev. 2014 May 15;28(10):1101-10.
3) J Neurosci. 2009 Jun 10;29(23):7607-18.
19.11.06Metabotropic glutamate receptor 2 (mGluR2)-KO mice 1)RBRC01351Analysis of this strain suggested the relationship between mGluR2 and schizophrenia 2) 3) 4).1) Science. 1996 Aug 2;273(5275):645-7.
2) Sci Signal. 2016 Jan 12;9(410):ra5.
3) J Neurosci. 2016 Nov 9;36(45):11521-11531.
4) PLoS One. 2015 May 7;10(5):e0125523.
19.09.03GPI-anchored protein CD109-KO mice1) 2)RBRC05911This strain shows osteopenia3) and psoriasis-like epidermal hyperplasia4). In addition, CD109 is known to be a regulator of tumor progression5).1) Pathol Int. 2019 May;69(5):249-259.
2) Mouse of the Month Nov 2013.
3) Genes Cells. 2018 Jul;23(7):590-598.
4) Am J Pathol. 2012 Oct;181(4):1180-9.
5) J Pathol. 2017 Dec;243(4):468-480.
19.09.03G protein-coupled receptor BLT2-KO miceRBRC04741
RBRC04742		This strain shows not only DSS-induced colitis exacerbation1) but also delayed skin or corneal wound healing 2) 3) 4). 1) FASEB J. 2010 Dec;24(12):4678-90.
2) Sci Rep. 2017 Oct 16;7(1):13267.
3) FASEB J. 2016 Feb;30(2):933-47.
4) J Exp Med. 2014 Jun 2;211(6):1063-78.
19.09.03Scott syndrome
(OMIM: 262890)
disease gene Ano6 (Tmem16F) floxed mice1)		RBRC09797Platelet-specific Ano6-null mice shows a mild bleeding disorder similar to the human condition2).1) J Biol Chem. 2013 May 10;288(19):13305-16.
2) Proc Natl Acad Sci U S A. 2015 Oct 13;112(41):12800-5.
19.09.03Winchester syndrome
(OMIM: 277950)
disease gene Mmp14 (MT1-MMP) KO/LacZ KI mice		RBRC05977Mmp14-null mice shows severve osteolysis. In addition, this strain is useful for Mmp14 expression analysis1) 2) 3) 4) 5).1) Development. 2013 Jan 15;140(2):343-52.
2) Dev Cell. 2013 May 28;25(4):402-16.
3) Diabetes. 2010 Oct;59(10):2484-94.
4) Genes Cells. 2009 May;14(5):617-26.
5) J Cell Sci. 2007 May 1;120(Pt 9):1607-14.
19.07.01ATR-X syndrome
(OMIM: 301040)
model mice		RBRC04937This is a Atrx (disease gene) knockout mouse strain, which shows some abnormal phenotypes similar to the human condition1) 2) and is utilized to explore therapeutic agents3).1) J Neurosci. 2011 Jan 5;31(1):346-58.
2) Hippocampus. 2011 Jun;21(6):678-87.
3) Nat Med. 2018 Jun;24(6):802-813.
19.07.01Cardio-facio-cutaneous syndrome-1
(OMIM: 115150)
model mice		RBRC09730
RBRC09731
RBRC09907
RBRC09908		This is a Braf (disease gene) point mutation knockin mouse strain, which shows some abnormal phenotypes similar to the human condition1) 2) 3) 4).1) Hum Mol Genet. 2019 Jan 1;28(1):74-83.
2) Hum Mol Genet. 2017 Dec 1;26(23):4715-4727.
3) Hum Mol Genet. 2015 Dec 20;24(25):7349-60.
4) Hum Mol Genet. 2014 Dec 15;23(24):6553-66.
19.07.01Chédiak-Higashi syndrome
(OMIM: 214500)
model mice		RBRC00134This is a Lyst (disease gene) spontaneous mutation mouse strain, which shows some abnormal phenotypes similar to the human condition1) and is utilized to analyze the mechanism2) 3).1) Nature. 1996 Jul 18;382(6588):262-5.
2) Mol Genet Metab. 2010 Apr;99(4):389-95.
3) J Biol Chem. 1997 Nov 21;272(47):29790-4.
19.07.01Griscelli syndrome
cutaneous and neurologic type
(OMIM: 214450)
model mice		RBRC02978This is a Myo5a (disease gene) spontaneous point mutation mouse strain, which shows abnormal pigmentation and neurological impairment similar to the human condition1) 2).1) J Neurosci. 2011 Apr 20;31(16):6067-78.
2) Genetics. 1998 Apr;148(4):1963-72.



 

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