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Cryopreservation of Mouse Embryos by Ethylene Glycol-Based Vitrification
JoVE 3155 11/18/2011

Today’s tool for functional analysis / Today’s model for human disease





DateTitleBRC No.DescriptionReferences
19.08.01Cre-driver mice for orexin neuronsRBRC06806This strain expresses Cre recombinase and EGFP exclusively in orexin neurons1) 2).1) Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):E10740-E10747.
2) Neuropharmacology. 2014 Oct;85:451-60.
19.08.01Full maturated OSN (olfactory sensory neuron) reporter mice1)RBRC02092OMP (olfactory marker protein) gene-GFP KI mice are broadly utilized for olfactory analysis2) 3) 4).1) J Neurosci. 2001 Dec 15;21(24):9713-23.
2) J Neurosci. 2019 Jan 30;39(5):814-832.
3) Cell Stem Cell. 2017 Dec 7;21(6):761-774.e5.
4) Cell. 2016 Jun 16;165(7):1734-1748.
19.08.01Selenocysteine-tRNA (Trsp) floxed mice1)RBRC02681This strain was utilized for an oxidative stress model2) 3).1) J Biol Chem. 2008 Jan 25;283(4):2021-30.
2) Cell Rep. 2017 Feb 21;18(8):2030-2044.
3) Blood. 2011 Jan 20;117(3):986-96.
19.08.01Neuronally enriched Rufy3 KO-first miceRBRC05780Analysis of this strain revealed that RUFY3 is essential for caspase-mediated axon degeneration1).1) Neuron. 2019 Jun 7. pii: S0896-6273(19)30483-0. 
19.06.03Cre-driver mice for postnatal somatic motor neuronsRBRC01515
RBRC01516
These strain express Cre recombinase selectively in slow type motor neurons1) 2).1) Genesis. 2016 Nov;54(11):568-572.
2) Brain Res. 2014 Mar 6;1550:36-46.
19.06.03Mitochondria-EGFP labeled mice1) 2)RBRC02250This transgenic strain is utilized to identify and monitor the mitochondorial morphology3) 4).1) Exp Anim. 2010;59(1):99-103.
2) FEBS Lett. 2001 Jun 29;500(1-2):7-11.
3) Sci Transl Med. 2017 Oct 25;9(413).
4) PLoS One. 2012;7(6):e36850.
19.06.03Zinc transporter Slc39a10 (Zip10) floxed miceRBRC06221Analysis of this strain revealed novel functions of Slc39a10 in humoral immune system1) 2) and epidermal development3).1) Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):11786-91.
2) Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):11780-5.
3) Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):12243-12248.
19.06.03Cell adhesion molecule Cadm1 (SynCAM1) KO miceRBRC04062This strain was utilized for analysis of not only nervous system1) 2) 3) but also bone turnover4).1) J Neurosci. 2016 Jul 13;36(28):7464-75.
2) Neuron. 2010 Dec 9;68(5):894-906.
3) Biochem Biophys Res Commun. 2010 Jun 4;396(3):703-8.
4) PLoS One. 2017 Apr 17;12(4):e0175632.
19.04.01Cre-driver mice for myelinating cells of the central nervous system1)RBRC01461This strain is useful for the elucidation of gene function in oligodendrocyte myelination2).1) Genesis. 2000 Feb;26(2):127-9.
2) Nat Commun. 2016 Nov 23;7:13478.
19.04.01Oct3/4 (Pou5f1) reporter miceRBRC007711)
RBRC060372)
These strains are useful for stem cell research because they express EGFP under the control of pluripotency marker Oct3/43) 4) 5).1) Dev Biol. 2003 Jun 1;258(1):209-25.
2) Development. 2008 Mar;135(5):909-18.
3) Cell Res. 2011 Jan;21(1):196-204.
4) Dev Biol. 2010 Oct 1;346(1):90-101.
5) Stem Cells. 2009 Feb;27(2):383-9.
19.04.01Fgf5 spontaneous mutant miceRBRC05894
RBRC05895
This strain shows abnormal hair follicle cycle1). In addition, it contributed to the research about spermatogenic stem cells2).1) Exp Anim. 2011;60(2):161-7.
2) Cell Stem Cell. 2019 Jan 3;24(1):79-92. e6.
19.04.01Fstl4 (Mahya) reporter miceRBRC04952This strain is useful for revolutionary genetic research1)In addition, it was used to monitor specific subtypes of retinal ganglion cells2).1) Dev Genes Evol. 2005 Nov;215(11):564-74.
2) Curr Eye Res. 2016 Apr;41(4):558-68.


DateTitleBRC No.DescriptionReferences
19.07.01ATR-X syndrome
(OMIM: 301040)
model mice
RBRC04937This is a Atrx (disease gene) knockout mouse strain, which shows some abnormal phenotypes similar to the human condition1) 2) and is utilized to explore therapeutic agents3).1) J Neurosci. 2011 Jan 5;31(1):346-58.
2) Hippocampus. 2011 Jun;21(6):678-87.
3) Nat Med. 2018 Jun;24(6):802-813.
19.07.01Cardio-facio-cutaneous syndrome-1
(OMIM: 115150)
model mice
RBRC09730
RBRC09731
RBRC09907
RBRC09908
This is a Braf (disease gene) point mutation knockin mouse strain, which shows some abnormal phenotypes similar to the human condition1) 2) 3) 4).1) Hum Mol Genet. 2019 Jan 1;28(1):74-83.
2) Hum Mol Genet. 2017 Dec 1;26(23):4715-4727.
3) Hum Mol Genet. 2015 Dec 20;24(25):7349-60.
4) Hum Mol Genet. 2014 Dec 15;23(24):6553-66.
19.07.01Chédiak-Higashi syndrome
(OMIM: 214500)
model mice
RBRC00134This is a Lyst (disease gene) spontaneous mutation mouse strain, which shows some abnormal phenotypes similar to the human condition1) and is utilized to analyze the mechanism2) 3).1) Nature. 1996 Jul 18;382(6588):262-5.
2) Mol Genet Metab. 2010 Apr;99(4):389-95.
3) J Biol Chem. 1997 Nov 21;272(47):29790-4.
19.07.01Griscelli syndrome
cutaneous and neurologic type
(OMIM: 214450)
model mice
RBRC02978This is a Myo5a (disease gene) spontaneous point mutation mouse strain, which shows abnormal pigmentation and neurological impairment similar to the human condition1) 2).1) J Neurosci. 2011 Apr 20;31(16):6067-78.
2) Genetics. 1998 Apr;148(4):1963-72.
19.05.08Ehlers-Danlos syndorome spondylodysplastic type 3
(OMIM: 612350)
model mice
RBRC06217This is a Slc39a13 (disease gene) knockout mouse strain, which shows defect of connective tissue similar to the human condition1) 2).1) PLoS Genet. 2017 Aug 30;13(8):e1006950.
2) PLoS One. 2008;3(11):e3642.
19.05.08Myoclonic epilepsy of Lafora
(OMIM: 254780)
model mice
RBRC02715This is a Epm2a (disease gene) knockout mouse strain, which shows progressive eurodegeneration similar to the human condition1) 2) 3).1) Hum Mol Genet. 2017 Dec 15;26(24):4778-4785.
2) Brain. 2014 Mar;137(Pt 3):806-18.
3) Hum Mol Genet. 2002 May 15;11(11):1251-62.
19.05.08Hirschsprung disease susceptibility to 1
(OMIM: 142623)
model mice
RBRC06249This is a Ret (disease gene) point mutation knockin mouse strain, which shows megacolon and deafness similar to the human condition1) 2) 3).1) Dev Biol. 2011 Jan 15;349(2):160-8.
2) Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13051-6.
3) Mol Cell Biol. 2004 Sep;24(18):8026-36.
19.05.08Mowat-Wilson syndrome
(OMIM: 235730)
model mice
RBRC01925This is a Zeb2 (disease gene) knockout mouse strain, which shows some abnormal phenotypes similar to the human condition1) 2) 3).1) Hum Mol Genet. 2007 Jun 15;16(12):1423-36.
2) Am J Hum Genet. 2003 Feb;72(2):465-70.
3) Genesis. 2002 Feb;32(2):82-4.