| Date | Title | BRC No. | Description | References |
|---|---|---|---|---|
| 20.02.03 | Siglec-H gene DTR-EGFP KI mice | RBRC05658 (C57BL/6) RBRC09688 (BALB/c) | In this strain, plasmacytoid dendritic cells (pDCs) can be depleted by injection of diphtheria toxin 1) 2) 3). User reported that pDCs are related with acute liver injury 4). | 1) Glia. 2017 Dec;65(12):1927-1943. 2) Sci Rep. 2016 Apr 14;6:24477. 3) Immunity. 2011 Dec 23;35(6):958-71. 4) J Clin Invest. 2019 Jul 2;129(8):3201-3213. |
| 20.02.03 | Xcr1 gene KikGR KI mice | RBRC09928 | This is a photoconvertible KikGR reporter mice for Xcr1 gene, which express chemokine receptor at one subset of dendritic cells 1). | 1) Proc Natl Acad Sci U S A. 2016 Jan 26;113(4):1044-9. |
| 20.02.03 | Xcr1 gene DTR-Venus KI mice | RBRC09485 (C57BL/6) RBRC10391 (BALB/c) | In this strain, XCR1-positive dendritic cells can be depleted by injection of diphtheria toxin 1) 2) 3). | 1) Nat Microbiol. 2018 May;3(5):611-621. 2) J Immunol. 2017 Dec 15;199(12):4165-4179. 3) Mouse of the Month January 2016 |
| 20.02.03 | Relb gene Venus KI mice | RBRC09496 | This is a Venus reporter strain for Nf-κB family gene Relb, which is related with immune cell maturation 1). | 1) J Biochem. 2015 Dec;158(6):485-95. |
| 19.12.02 | Cre-driver mice for CRF neuron | RBRC06520 | Crh (corticotropin-releasing hormone) Cre KI strain is useful for stress response research 1) 2). | 1) Sci Adv. 2016 Aug 17;2(8):e1501723. 2) Endocrinology. 2014 Oct;155(10):4054-60. |
| 19.12.02 | Crh gene reporter mice | RBRC09893 | Crh (corticotropin-releasing hormone) Venus KI strain allows the visualization of CRF neurons 1) 2) 3). | 1) Biol Sex Differ. 2019 Jan 28;10(1):6. 2) Brain Struct Funct. 2017 May;222(4):1705-1732. 3) Endocrinology. 2014 Oct;155(10):4054-60. |
| 19.12.02 | Cre-driver mice for Oligodendrocyte lineage and motoneuron | RBRC01507 | Olig2-tamoxifen inducible Cre KI strain is frequently used in neuroscience 1) 2) 3) 4) 5). | 1) Nat Neurosci. 2018 May;21(5):696-706. 2) Science. 2014 Sep 26;345(6204):1254927.v 3) Mouse of the Month July 2006 4) Dev Biol. 2006 May 15;293(2):358-69. 5) Curr Biol. 2002 Jul 9;12(13):1157-63. |
| 19.12.02 | Transcription factor Olig2 reporter mice | RBRC06017 RBRC06018 RBRC06022 | This strain express Venus, mCherry or luciferase-OLIG2 fusion protein 1). | 1) Science. 2013 Dec 6;342(6163):1203-8. |
| 19.12.02 | Cre-driver mice for dorsal telencephalon | RBRC01345 | Emx1 (empty spiracles homeobox 1) Cre KI strain is frequently used in neuroscience 1) 2) 3) 4) 5). | 1) Nat Commun. 2019 Aug 8;10(1):3581. 2) Nat Commun. 2017 May 23;8:15488. 3) Mouse of the Month July 2006 4) Genesis. 2004 Mar;38(3):130-8. 5) Nature. 2000 Aug 17;406(6797):726-31. |
| 19.12.02 | Cre-driver mice for developing cochleae | RBRC02272 | Emx2 (empty spiracles homeobox 2) Cre KI strain 1) is useful for inner ear development research 2) 3) 4). | 1) J Neurosci. 2005 May 25;25(21):5097-108. 2) J Neurosci. 2019 Oct 9;39(41):8013-8023. 3) Dev Biol. 2018 May 1;437(1):17-26. 4) Development. 2018 Jun 14;145(12). |
| 19.10.01 | Cellualar oxidative stress imaging mice | RBRC057041) RBRC061612) | Nrf2 (oxidative stress-responsive transcription factor) reporter mice were utilized for the elucidation of oxidative stress sensing mechanism3). | 1) Sci Rep. 2012;2:229. 2) Free Radic Biol Med. 2014 Jul;72:124-33. 3) Cell Rep. 2019 Jul 16;28(3):746-758.e4. |
| 19.10.01 | ROS production conditionally regulatable mice1) | RBRC09859 | This strain expresses SDAD (ROS homeostasis-related enzyme) defective mutants according to Cre recombinase. | 1) Eur J Immunol. 2017 Feb;47(2):406-418. |
| 19.10.01 | Sperm-egg fusion imaging mice1) | RBRC05763 | Izumo1 (sperm acrosomal gene) reporter strain is useful for the elucidation of gamete fusion mechanism2) 3). | 1) J Cell Sci. 2012 Nov 1;125(Pt 21):4985-90. 2) Cell Cycle. 2018;17(11):1279-1285. 3) Nat Commun. 2015 Nov 16;6:8858. |
| 19.10.01 | Sperm acrosome−GFP： sperm mitochondria−DsRed dual reporter mice1) | RBRC03743 RBRC05861 | This strain is useful for the elucidation of fertilization or acrosome reaction mechanism2) 3) 4). | 1) Exp Anim. 2010;59(1):105-7. 2) J Cell Biol. 2018 Jun 4;217(6):2103-2119. 3) J Biol Chem. 2018 Jul 27;293(30):11796-11808. 4) Biol Reprod. 2016 Apr;94(4):80. |
| 19.08.01 | Cre-driver mice for orexin neurons | RBRC06806 | This strain expresses Cre recombinase and EGFP in orexin neurons1) 2). | 1) Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):E10740-E10747. 2) Neuropharmacology. 2014 Oct;85:451-60. |
| 19.08.01 | Full maturated OSN (olfactory sensory neuron) reporter mice1) | RBRC02092 | OMP (olfactory marker protein) gene-GFP KI mice are broadly utilized for olfactory analysis2) 3) 4). | 1) J Neurosci. 2001 Dec 15;21(24):9713-23. 2) J Neurosci. 2019 Jan 30;39(5):814-832. 3) Cell Stem Cell. 2017 Dec 7;21(6):761-774.e5. 4) Cell. 2016 Jun 16;165(7):1734-1748. |
| 19.08.01 | Selenocysteine-tRNA (Trsp) floxed mice1) | RBRC02681 | This strain was utilized for an oxidative stress model2) 3). | 1) J Biol Chem. 2008 Jan 25;283(4):2021-30. 2) Cell Rep. 2017 Feb 21;18(8):2030-2044. 3) Blood. 2011 Jan 20;117(3):986-96. |
| 19.08.01 | Neuronally enriched Rufy3 KO-first mice | RBRC05780 | Analysis of this strain revealed that RUFY3 is essential for caspase-mediated axon degeneration1). | 1) Neuron. 2019 Jun 7. pii: S0896-6273(19)30483-0. |
| 19.06.03 | Cre-driver mice for postnatal somatic motor neurons | RBRC01515 RBRC01516 | These strain express Cre recombinase in slow type motor neurons1) 2). | 1) Genesis. 2016 Nov;54(11):568-572. 2) Brain Res. 2014 Mar 6;1550:36-46. |
| 19.06.03 | Mitochondria-EGFP labeled mice1) 2) | RBRC02250 | This transgenic strain is utilized to identify and monitor the mitochondorial morphology3) 4). | 1) Exp Anim. 2010;59(1):99-103. 2) FEBS Lett. 2001 Jun 29;500(1-2):7-11. 3) Sci Transl Med. 2017 Oct 25;9(413). 4) PLoS One. 2012;7(6):e36850. |
| 19.06.03 | Zinc transporter Slc39a10 (Zip10) floxed mice | RBRC06221 | Analysis of this strain revealed novel functions of Slc39a10 in humoral immune system1) 2) and epidermal development3). | 1) Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):11786-91. 2) Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):11780-5. 3) Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):12243-12248. |
| 19.06.03 | Cell adhesion molecule Cadm1 (SynCAM1) KO mice | RBRC04062 | This strain was utilized for analysis of not only nervous system1) 2) 3) but also bone turnover4). | 1) J Neurosci. 2016 Jul 13;36(28):7464-75. 2) Neuron. 2010 Dec 9;68(5):894-906. 3) Biochem Biophys Res Commun. 2010 Jun 4;396(3):703-8. 4) PLoS One. 2017 Apr 17;12(4):e0175632. |
| 19.04.01 | Cre-driver mice for myelinating cells of the central nervous system1) | RBRC01461 | This strain is useful for the elucidation of gene function in oligodendrocyte myelination2). | 1) Genesis. 2000 Feb;26(2):127-9. 2) Nat Commun. 2016 Nov 23;7:13478. |
| 19.04.01 | Oct3/4 (Pou5f1) reporter mice | RBRC007711) RBRC060372) | These strains are useful for stem cell research because they express EGFP under the control of pluripotency marker Oct3/43) 4) 5). | 1) Dev Biol. 2003 Jun 1;258(1):209-25. 2) Development. 2008 Mar;135(5):909-18. 3) Cell Res. 2011 Jan;21(1):196-204. 4) Dev Biol. 2010 Oct 1;346(1):90-101. 5) Stem Cells. 2009 Feb;27(2):383-9. |
| 19.04.01 | Fgf5 spontaneous mutant mice | RBRC05894 RBRC05895 | This strain shows abnormal hair follicle cycle1). In addition, it contributed to the research about spermatogenic stem cells2). | 1) Exp Anim. 2011;60(2):161-7. 2) Cell Stem Cell. 2019 Jan 3;24(1):79-92. e6. |
| 19.04.01 | Fstl4 (Mahya) reporter mice | RBRC04952 | This strain is useful for revolutionary genetic research1)In addition, it was used to monitor specific subtypes of retinal ganglion cells2). | 1) Dev Genes Evol. 2005 Nov;215(11):564-74. 2) Curr Eye Res. 2016 Apr;41(4):558-68. |
| Date | Title | BRC No. | Description | References |
|---|---|---|---|---|
| 20.03.02 | Endoplasmic reticulum (ER) transmembrane protein IRE1α(ERN1)-KO/cKO mice1)| RBRC05515 | (floxed) RBRC05516 (KO) These strains are utilized to reveal the relationship between ER stress and some diseases.2) 3) 4). | 1) Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16657-62. |
2) Nat Commun. 2018 Dec 17;9(1):5340. 3) Nature. 2018 Oct;562(7727):423-428. 4) J Cell Biol. 2018 Apr 2;217(4):1287-1301. |
| 20.03.02 | Tumor necrosis factor (TNF) receptor-associated factor TRAF6-KO mice1) | RBRC04950 (C57BL/6) RBRC05386 (BALB/c) | These strains show various disorders like ectodermal dysplasia, osteopertrosis, autoimmunity and so on2) 3) 4) 5). | 1) Genes Cells. 1999 Jun;4(6):353-62. 2) Commun Biol. 2019 Aug 6;2:292. 3) Proc Natl Acad Sci U S A. 2017 Aug 22;114(34):E7140-E7149. 4) J Biol Chem. 2017 Jun 16;292(24):10169-10179. 5) Mouse of the Month Sep 2012 |
| 20.03.02 | Tubulin glutamylation enzyme TTLL1-KO mice | RBRC03327 | This strain shows primary ciliary dyskinesia-like phenotype1) 2) 3). | 1) Sci Rep. 2018 Feb 13;8(1):2904. 2) PLoS One. 2015 Nov 18;10(11):e0141823. 3) Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10490-5. |
| 20.03.02 | Apoptosis-related transmembrane receptor FAS-KO mice | RBRC01474 (C57BL/6) RBRC01476 (MRL) | These strains show autoimmune lymphoproliferative syndrome (OMIM: 601859)-like phenotype1) 2) 3) 4). | 1) Proc Natl Acad Sci U S A. 1996 Mar 5;93(5):2131-6. 2) Nat Genet. 1995 Nov;11(3):294-300. 3) Eur J Immunol. 2013 Jul;43(7):1789-98. 4) J Exp Med. 2013 Sep 23;210(10):2087-103. |
| 20.01.06 | Spinal and bulbar muscular atrophy (SBMA) model mice | RBRC00344 | This strain shows some phenotypes similar to human patients. It is utilized to explore molecular mechanisms and therapeutic agents1) 2) 3). | 1) Hum Mol Genet. 2018 Jul 15;27(14):2425-2442. 2) J Neurosci. 2016 May 4;36(18):5094-106. 3) Neuron. 2002 Aug 29;35(5):843-54. |
| 20.01.06 | Limb-girdle muscular dystrophy type 2A (LGMD2A) model mice | RBRC04787 | CAPN3 protease activity-deficient mice show muscular disease-like phenotypes1) 2) 3). | 1) Hum Mol Genet. 2018 May 1;27(9):1642-1653. 2) J Clin Invest. 2010 Aug;120(8):2672-83. 3) J Biol Chem. 2010 Jul 23;285(30):22986-98. |
| 20.01.06 | Sporadic amyotrophic lateral sclerosis (ALS) model mice | RBRC09428 | This strain shows some phenotypes similar to human patients. It is utilized to explore molecular mechanisms and therapeutic agents1) 2) 3) 4). | 1) Sci Rep. 2017 Jan 3;7:39994. 2) Sci Rep. 2016 Jun 28;6:28649. 3) J Neurosci. 2010 Sep 8;30(36):11917-25. 4) Mouse of the Month Nov 2015. |
| 20.01.06 | Familial amyotrophic lateral sclerosis (ALS) model mice | RBRC09642 RBRC09643 RBRC09644 | Tg mice harboring mutated human SOD1 show progressive motor neuron disease-like phenotypes1). | 1) Hum Mol Genet. 2015 Jun 15;24(12):3427-39. |
| 19.11.06 | Disc1 point mutated (L100P) mice with schizophrenia-like phenotypes | RBRC06364 | This strain is a schizophrenia model, which established by ENU mutagenesis 1) 2) 3) 4). | 1) Neuron. 2007 May 3;54(3):387-402. 2) Front Cell Neurosci. 2018 Aug 2;12:238. 3) Behav Brain Res. 2017 Mar 1;320:113-118. 4) Schizophr Bull. 2017 Jan;43(1):214-225. |
| 19.11.06 | Disc1 point mutated (Q13L) mice with depression-like phenotypes | RBRC06365 | This strain is a endogenous depression model, which established by ENU mutagenesis 1) 2) 3). | 1) Neuron. 2007 May 3;54(3):387-402. 2) Neuroscience. 2016 May 3;321:99-107. 3) PLoS One. 2014 Oct 1;9(10):e108088. |
| 19.11.06 | CaMKIIα point mutated (K42R) mice with learning and memory deficits | RBRC05821 RBRC05636 | CaMKIIα kinase activity-deficient mice shows hippocampus-dependent learning and memory deficits 1) 2) 3). | 1) eNeuro. 2018 Aug 21;5(4). pii: ENEURO.0133-18.2018. 2) Genes Dev. 2014 May 15;28(10):1101-10. 3) J Neurosci. 2009 Jun 10;29(23):7607-18. |
| 19.11.06 | Metabotropic glutamate receptor 2 (mGluR2)-KO mice 1) | RBRC01351 | Analysis of this strain suggested the relationship between mGluR2 and schizophrenia 2) 3) 4). | 1) Science. 1996 Aug 2;273(5275):645-7. 2) Sci Signal. 2016 Jan 12;9(410):ra5. 3) J Neurosci. 2016 Nov 9;36(45):11521-11531. 4) PLoS One. 2015 May 7;10(5):e0125523. |
| 19.09.03 | GPI-anchored protein CD109-KO mice1) 2) | RBRC05911 | This strain shows osteopenia3) and psoriasis-like epidermal hyperplasia4). In addition, CD109 is known to be a regulator of tumor progression5). | 1) Pathol Int. 2019 May;69(5):249-259. 2) Mouse of the Month Nov 2013. 3) Genes Cells. 2018 Jul;23(7):590-598. 4) Am J Pathol. 2012 Oct;181(4):1180-9. 5) J Pathol. 2017 Dec;243(4):468-480. |
| 19.09.03 | G protein-coupled receptor BLT2-KO mice | RBRC04741 RBRC04742 | This strain shows not only DSS-induced colitis exacerbation1) but also delayed skin or corneal wound healing 2) 3) 4). | 1) FASEB J. 2010 Dec;24(12):4678-90. 2) Sci Rep. 2017 Oct 16;7(1):13267. 3) FASEB J. 2016 Feb;30(2):933-47. 4) J Exp Med. 2014 Jun 2;211(6):1063-78. |
| 19.09.03 | Scott syndrome (OMIM: 262890) disease gene Ano6 (Tmem16F) floxed mice1) | RBRC09797 | Platelet-specific Ano6-null mice shows a mild bleeding disorder similar to the human condition2). | 1) J Biol Chem. 2013 May 10;288(19):13305-16. 2) Proc Natl Acad Sci U S A. 2015 Oct 13;112(41):12800-5. |
| 19.09.03 | Winchester syndrome (OMIM: 277950) disease gene Mmp14 (MT1-MMP) KO/LacZ KI mice | RBRC05977 | Mmp14-null mice shows severve osteolysis. In addition, this strain is useful for Mmp14 expression analysis1) 2) 3) 4) 5). | 1) Development. 2013 Jan 15;140(2):343-52. 2) Dev Cell. 2013 May 28;25(4):402-16. 3) Diabetes. 2010 Oct;59(10):2484-94. 4) Genes Cells. 2009 May;14(5):617-26. 5) J Cell Sci. 2007 May 1;120(Pt 9):1607-14. |
| 19.07.01 | ATR-X syndrome (OMIM: 301040) model mice | RBRC04937 | This is a Atrx (disease gene) knockout mouse strain, which shows some abnormal phenotypes similar to the human condition1) 2) and is utilized to explore therapeutic agents3). | 1) J Neurosci. 2011 Jan 5;31(1):346-58. 2) Hippocampus. 2011 Jun;21(6):678-87. 3) Nat Med. 2018 Jun;24(6):802-813. |
| 19.07.01 | Cardio-facio-cutaneous syndrome-1 (OMIM: 115150) model mice | RBRC09730 RBRC09731 RBRC09907 RBRC09908 | This is a Braf (disease gene) point mutation knockin mouse strain, which shows some abnormal phenotypes similar to the human condition1) 2) 3) 4). | 1) Hum Mol Genet. 2019 Jan 1;28(1):74-83. 2) Hum Mol Genet. 2017 Dec 1;26(23):4715-4727. 3) Hum Mol Genet. 2015 Dec 20;24(25):7349-60. 4) Hum Mol Genet. 2014 Dec 15;23(24):6553-66. |
| 19.07.01 | Chédiak-Higashi syndrome (OMIM: 214500) model mice | RBRC00134 | This is a Lyst (disease gene) spontaneous mutation mouse strain, which shows some abnormal phenotypes similar to the human condition1) and is utilized to analyze the mechanism2) 3). | 1) Nature. 1996 Jul 18;382(6588):262-5. 2) Mol Genet Metab. 2010 Apr;99(4):389-95. 3) J Biol Chem. 1997 Nov 21;272(47):29790-4. |
| 19.07.01 | Griscelli syndrome cutaneous and neurologic type (OMIM: 214450) model mice | RBRC02978 | This is a Myo5a (disease gene) spontaneous point mutation mouse strain, which shows abnormal pigmentation and neurological impairment similar to the human condition1) 2). | 1) J Neurosci. 2011 Apr 20;31(16):6067-78. 2) Genetics. 1998 Apr;148(4):1963-72. |
| 19.05.08 | Ehlers-Danlos syndorome spondylodysplastic type 3 (OMIM: 612350) model mice | RBRC06217 | This is a Slc39a13 (disease gene) knockout mouse strain, which shows defect of connective tissue similar to the human condition1) 2). | 1) PLoS Genet. 2017 Aug 30;13(8):e1006950. 2) PLoS One. 2008;3(11):e3642. |
| 19.05.08 | Myoclonic epilepsy of Lafora (OMIM: 254780) model mice | RBRC02715 | This is a Epm2a (disease gene) knockout mouse strain, which shows progressive eurodegeneration similar to the human condition1) 2) 3). | 1) Hum Mol Genet. 2017 Dec 15;26(24):4778-4785. 2) Brain. 2014 Mar;137(Pt 3):806-18. 3) Hum Mol Genet. 2002 May 15;11(11):1251-62. |
| 19.05.08 | Hirschsprung disease susceptibility to 1 (OMIM: 142623) model mice | RBRC06249 | This is a Ret (disease gene) point mutation knockin mouse strain, which shows megacolon and deafness similar to the human condition1) 2) 3). | 1) Dev Biol. 2011 Jan 15;349(2):160-8. 2) Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13051-6. 3) Mol Cell Biol. 2004 Sep;24(18):8026-36. |
| 19.05.08 | Mowat-Wilson syndrome (OMIM: 235730) model mice | RBRC01925 | This is a Zeb2 (disease gene) knockout mouse strain, which shows some abnormal phenotypes similar to the human condition1) 2) 3). | 1) Hum Mol Genet. 2007 Jun 15;16(12):1423-36. 2) Am J Hum Genet. 2003 Feb;72(2):465-70. 3) Genesis. 2002 Feb;32(2):82-4. |