| Date | Title | BRC No. | Description | References |
|---|---|---|---|---|
| 26.10.13 | Fluorescent reporter mice useful for analyzing the embryonic node | RBRC11822 | This Tg strain labels the immotile cilia of the embryonic node with green fluorescent protein mNeonGreen and the node crown cells with red fluorescent protein tdKatushka2. 1)2) | 1) Science. 2023 Jan 6;379(6627):66-71. 2) Sci Adv. 2020 Jul 22;6(30):eaba1195. |
| 26.10.13 | Fluorescent reporter mice useful for analyzing the embryonic node | RBRC11821 | This Tg strain enables fluorescent imaging of calcium dynamics in the cilia of the node. 1)2) | 1) Science. 2023 Jan 6;379(6627):66-71. 2) Sci Adv. 2020 Jul 22;6(30):eaba1195. |
| 26.10.13 | Fluorescent reporter mice useful for analyzing the embryonic node | RBRC11823 | This Tg strain enables fluorescent imaging of the calcium dynamics in the crown cells of the node. 1)2) | 1) Science. 2023 Jan 6;379(6627):66-71. 2) Sci Adv. 2020 Jul 22;6(30):eaba1195. |
| 26.10.13 | Fluorescent reporter mice useful for analyzing the embryonic node | RBRC11824 | This Tg strain expresses the green calcium sensor GCaMP6 and the red fluorescent protein mKeima in the node's crown cells. This enables ratiometric measurement of the cilia's calcium concentration using single-wavelength excitation. 1) | 1) Science. 2023 Jan 6;379(6627):66-71. |
| 26.08.05 | alphaCGRP KO mice | RBRC04109 | This KO strain lacks exon 5 of the Calca gene. They are widely used to elucidate the role of α-CGRP in various physiological phenomena and diseases 1)2)3)4)5) | 1) Sci Rep. 2024 Aug 8;14(1):18377. 2) Nature. 2024 Nov;635(8038):444-452. 3) Front Physiol. 2020 Jul 31:11:733. 4) Immunity. 2019 Oct 15;51(4):709-723.e6. 5) Circ Res. 2001 Nov 23;89(11):983-90. |
| 26.08.05 | Ramp1 gene KO mice | RBRC02825 | Ramp1 is a receptor subunit for CGRP. This Ramp1 KO strain is useful for analyzing CGRP function 1)2) | 1) Sci Rep. 2024 Jan 16;14(1):1344. 2) Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16702-7. |
| 26.08.05 | Ramp1 gene floxed mice | RBRC11206 | Ramp1 is a receptor subunit for CGRP. This Ramp1 floxed strain is useful for analyzing CGRP function 1)2) | 1) Nature. 2024 Apr;628(8008):604-611. 2) Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16702-7. |
| 26.04.23 | ATP-sensitive potassium channel (K-ATP)-encoding gene Abcc9 Cre-driver mice | RBRC11634 RBRC11635 | These KI strains express Cre under the control of endogenous Abcc9 promoter.1) | 1) Dev Cell. 2022 Jun 6;57(11):1383-1399.e7. |
| 26.04.23 | Islet amyloid polypeptide-encoding gene Cre-driver mice | RBRC11709 | This Tg strain expresses Cre under the control of Iapp(Amylin) promoter.1) | 1) Nat Commun. 2022 Feb 8;13(1):709. |
| 26.04.23 | Galnt18 gene Cre-driver mice | RBRC10796 | This BAC Tg strain expresses CreERT2 under the control of Galnt18 promoter.1) | 1) J Comp Neurol. 2018 Feb 15;526(3):373-396. |
| 24.12.04 | ARMC12-targeted BioID Tg mice | RBRC11045 | This strain expresses ARMC12 and biotin ligase BioID2 fusion protein under the control of the Clgn promoter.1) | 1) Proc Natl Acad Sci U S A. 2021 Feb 9;118(6):e2018355118. |
| 24.12.04 | TESMIN-targeted BioID Tg mice | RBRC11222 | This strain expresses TESMIN and biotin ligase TurboID fusion protein under the control of the Clgn promoter.1) | 1) Sci Rep. 2022 Dec 23;12(1):22198. |
| 24.12.04 | TESMIN-targeted BioID Tg mice | RBRC11665 | This strain expresses TESMIN and biotin ligase BioID2 fusion protein under the control of the Clgn promoter, and also has deletion of Tesmin gene.1) | 1) Sci Rep. 2022 Dec 23;12(1):22198. |
| 24.04.01 | Cma1(Mcpt5)-DTR KI mice | RBRC11317 | This strain is capable of inducing mast cell depletion by administration of DT (diphtherial toxin). 1) | 1) Biochem Biophys Res Commun. 2021 Apr 30:551:127-132. |
| 24.04.01 | Msr1(Cd204)-DTR KI mice | RBRC06357 | This strain is capable of inducing CD204-positive macrophages depletion by administration of DT (diphtherial toxin). 1) | 1) Biochem Biophys Rep. 2020 Aug 7:23:100791. |
| 24.04.01 | Ly75(Cd205)-DTR KI mice | RBRC05659 | This strain is capable of inducing mast CD205-positive cDCs (conventional dendritic cells) depletion by administration of DT (diphtherial toxin). 1) | 1) Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11288-93. |
| 24.04.01 | Lyz2(Lysm)-DTR KI mice | RBRC04394 | This strain is capable of inducing alveolar epithelial type II (AE2) cells and macrophages depletion by administration of DT (diphtherial toxin). 1)2)3) | 1) iScience. 2023 Jan 5;26(2):105934. 2) Nat Immunol. 2014 Nov;15(11):1064-9. 3) J Immunol. 2007 Apr 15;178(8):5001-9. |
| 23.12.01 | p16<INK4a>(CDKN2A) luminescent reporter mice | RBRC05271 (ICR) RBRC09236 (B6) | These Tg strains carry the entire human p16<INK4a>(CDKN2A) gene locus tagged with luciferase.1) | 1) J Cell Biol. 2009 Aug 10;186(3):393-407. |
| 23.12.01 | p21(CDKN1A) luminescent reporter mice | RBRC09237 | This Tg strain expresses luciferase under the human p21(CDKN1A) promoter.1) | 1) Proc Natl Acad Sci U S A. 2007 Sep 18;104(38):15034-9. |
| 23.12.01 | Arc luminescent reporter mice | RBRC06053 | This BAC Tg strain expresses luciferase under the exogenous Arc promoter.1) | 1) Brain Struct Funct. 2011 Jun;216(2):91-104. |
| 23.12.01 | Bdnf luminescent reporter mice | RBRC11093 | This BAC Tg strain expresses luciferase under the exogenous Bdnf promoter. 1)2) | 1) Sci Rep. 2017 Jul 10;7(1):4949. 2) J Neurosci. 2015 Apr 8;35(14):5606-24. |
| 23.10.02 | The clock gene Bmal1(Arntl) floxed mice | RBRC11399 | Analysis of crosses with various Cre driver mice has been reported.1)2)3)4)5) | 1) Mol Metab. 2021 Jul;49:101202. 2) Cell Rep. 2021 Jul 6;36(1):109336. 3) JCI Insight. 2019 Mar 7;4(5):e121798. 4) Sci Rep. 2018 Jan 31;8(1):1996. 5) PLoS One. 2011;6(9):e25231. |
| 23.10.02 | The clock gene Bmal1(Arntl) luminescent reporter mice | RBRC09717 | This Tg strain expresses luciferase after Cre-mediated recombination under the exogenous Bmal1(Arnt).1) | 1) Biochemistry. 2010 Sep 21;49(37):8053-61. |
| 23.10.02 | The clock gene Per1 luminescent reporter mice | RBRC09608 | This Tg strain expresses luciferase under the exogenous Per1 promoter. 1)2) | 1) Sci Rep. 2015 Jul 21;5:12310. 2) Proc Natl Acad Sci U S A. 2007 May 1;104(18):7664-9. |
| 23.10.02 | The clock genes Bmal1(Arntl) and Per1 luminescent reporter mice | RBRC02670 | This Tg strain expresses different luciferases under the exogenous Bmal1(Arntl) and Per1 promoter, respectively.1) | 1) Genes Cells. 2006 Oct;11(10):1173-82. |
| 23.08.03 | Zeb2 (SIP1, Zfhx1b) gene fluorescent reporter mice | RBRC09239 (ICR) RBRC09240 (ICR and B6 mixed) | These KI strains express a EGFP under the control of endogenous Zeb2 promoter.1)2)3)4)5) | 1) Cell Rep. 2023 Mar 20;112276. 2) Cardiovasc Res. 2022 Mar 25;118(5):1262-1275. 3) Immunity. 2021 Jul 13;54(7):1417-1432.e7. 4) Elife. 2019 Aug 8;8:e47605. 5) Genesis. 2014 Jan;52(1):56-67. |
| 23.08.03 | Sox9 gene fluorescent reporter mice | RBRC05651 | This KI strain expresses a EGFP under the control of endogenous Sox9 promoter.1)2)3)4)5) | 1) Front Cell Dev Biol. 2020 Oct 22;8:585640. 2) Endocrinology. 2019 Feb 1;160(2):387-398. 3) Nat Commun. 2018 Aug 22;9(1):3356. 4) PLoS One. 2017 Nov 30;12(11):e0188705. 5) Dev Dyn. 2009 May;238(5):1100-10. |
| 23.08.03 | Tg mice for conditional overexpression of SOX9 | RBRC05654 | This Tg strain overexpresses SOX9 after Cre-mediated recombination.1)2)3)4)5) | 1) Proc Natl Acad Sci U S A. 2019 Jan 29;116(5):1704-1713. 2) Elife. 2018 Apr 3;7:e32358. 3) J Clin Invest. 2018 Aug 1;128(8):3475-3489. 4) Gastroenterology. 2018 Jul;155(1):194-209.e2. 5) J Bone Miner Metab. 2011 Jan;29(1):123-9. |
| 23.08.03 | Tg mice for misexpression of SOX9 in limb bud mesenchyme | RBRC05525 | This Tg strain misexpresses SOX9 under the control of Prrx1 promoter.1)2) | 1) Development. 2009 Apr;136(8):1263-72. 2) Matrix Biol. 2007 May;26(4):224-33. |
| 23.06.01 | Neuronal cells Cre-driver mice | RBRC11130 | This KI strain expresses a Cre under the control of endogenous Tubb3 promoter.1) | 1) Cell Rep. 2021 Jul 27;36(4):109427. |
| 23.06.01 | Spleen TLX1 expressing cells Cre-driver mice | RBRC11118 | This KI strain expresses CreERT2 and Venus under the control of endogenous Tlx1 promoter.1)2)3) | 1) Sci Rep. 2019 Dec 31;9(1):20408. 2) Sci Rep. 2018 May 29;8(1):8308. 3) Genesis. 2014 Nov;52(11):916-23. |
| 23.06.01 | Glucagon-producing α-cells Cre-driver mice | RBRC10958 | This KI strain expresses Cre under the control of Gcg promoter.1) | 1) Exp Anim. 2020 Apr 24;69(2):178-188. |
| 23.06.01 | KRT19 expressing cells Cre-driver mice | RBRC10923 | This BAC Tg strain expresses iCre under the control of Krt19 promoter.1) | 1) PLoS One. 2019 Aug 8;14(8):e0220818. |
| 23.04.03 | Orexin neurons FLP driver mice | RBRC11555 | This KI strain expresses FLP and GFP under the control of endogenous Hcrt promoter.1) | 1) Elife. 2019 Jun 4;8:e44927. |
| 23.04.03 | FLPe driver mice | RBRC10708 RBRC10707 RBRC01834 | These Tg strains express FLPe under the control of CAG promoter in C57BL/6J background.1) | 1) Exp Anim. 2006 Apr;55(2):137-41. |
| 23.04.03 | FLPo driver mice | RBRC09982 RBRC06479 RBRC06470 | These Tg strains express FLPo under the control of CAG promoter.1) | 1) J Cell Sci. 2016 May 1;129(9):1940-9. |
| 23.02.03 | Notch signaling fluorescent reporter mice | RBRC06137 | This Tg strain expresses Venus depend on activation of Notch signaling via RBP-jk-binding sequence.1)2)3)4) | 1) Stem Cells. 2016 Aug;34(8):2169-82. 2) Nat Commun. 2015 Jul 23;6:7739. 3) Development. 2011 Jan;138(1):55-64. 4) Dev Biol. 2005 Oct 1;286(1):311-25. |
| 23.02.03 | A transcriptional co-activator in the Notch signaling Maml1 KO mice | RBRC10002 | This strain has been used for analysis of the Notch signaling pathway.1)2)3)4) | 1) PLoS Genet. 2016 Dec 27;12(12):e1006514. 2) PLoS Genet. 2013;9(1):e1003132. 3) Development. 2011 Dec;138(23):5235-46. 4) Proc Natl Acad Sci U S A. 2007 Jun 5;104(23):9764-9. |
| 23.02.03 | Notch2 floxed mice | RBRC09647 | This strain has been used for analysis of the Notch signaling pathway.1)2)3)4) | 1) Nat Commun. 2019 Jan 14;10(1):190. 2) PLoS Biol. 2019 May 9;17(5):e3000262. 3) Nat Med. 2015 Jan;21(1):55-61. 4) Immunity. 2003 May;18(5):675-85. |
| 22.12.06 | RAG2 expressing cells fluorescent reporter mice | RBRC09497 | This KI strain expresses a EGFP under the control of endogenous Rag2 promoter.1) | 1) Int Immunol. 2003 Mar;15(3):393-402. |
| 22.12.06 | GATA1 expressing cells fluorescent reporter mice | RBRC09400 | This BAC Tg strain expresses GFP under the control of Gata1 promoter.1) | 1) Mol Cell Biol. 2009 Mar;29(5):1163-75. |
| 22.12.06 | Inhibitory neurons fluorescent reporter mice | RBRC09645 | This BAC Tg strain expresses YFP under the control of VGAT(Slc32a1) promoter.1) | 1) Neuroscience. 2009 Dec 15;164(3):1031-43. |
| 22.12.06 | Inhibitory neurons fluorescent reporter mice | RBRC10799 RBRC10800 | These BAC Tg strains express tdTomato under the control of VGAT(Slc32a1) promoter.1) | 1) J Comp Neurol. 2018 Feb 15;526(3):373-396. |
| 22.10.03 | PDGFRα expressing cells Cre-driver mice | RBRC09616 | This KI strain expresses a GFP-CreERT2 fucion protein under the control of endogenous Pdgfra promoter.1)2)3)4)5) | 1) Sci Rep. 2021 Apr 21;11(1):8683. 2) Nat Commun. 2020 May 8;11(1):2303. 3) Development. 2018 Jan 29;145(2):dev155879. 4) Genesis. 2015 May;53(5):329-36. 5) Mouse of the Month September 2016. |
| 22.10.03 | Astrocytes Cre-driver mice | RBRC10705 | This Tg strain expresses Cre under the control of S100b promoter.1)2)3) | 1) J Neurosci. 2017 Oct 18;37(42):10052-10062. 2) Front Neurosci. 2008 Dec 15;2(2):225-33. 3) Front Behav Neurosci. 2008 Apr 23;2:1. |
| 22.10.03 | Specific excitatory neurons Cre-driver mice | RBRC10626 | This Tg strain expresses CreERT2 under the control of Atoh1 promoter.1) | 1) Science. 2015 Nov 20;350(6263):957-61. |
| 22.10.03 | Testicular germ cells Cre-driver mice | RBRC06480 | This Tg strain expresses Cre under the control of Stra8 promoter.1) | 1) Sci Rep. 2015 Sep 21;5:14254. |
| 22.08.01 | Lateral nucleus of the amygdala Cre-driver mice | RBRC10694 | This KI strain expresses iCre under the control of endogenous Grp( Gastrin-releasing peptide) promoter.1) | 1) Elife. 2018 Jun 26;7:e34135. |
| 22.08.01 | Vesicular GABA transporters Cre-driver mice | RBRC10606 | This BAC Tg strain expresses Cre under the control of Slc32a1 promoter.1)2)3)4)5) | 1) Hum Mol Genet. 2021 May 28;30(9):758-770. 2) Nat Commun. 2020 Oct 9;11(1):5113. 3) Nat Commun. 2019 Apr 23;10(1):1917. 4) Mol Autism. 2019 Mar 28;10:15. 5) Hum Mol Genet. 2013 Dec 1;22(23):4784-804. |
| 22.08.01 | Osteoblasts Cre-driver mice | RBRC05603 | This Tg strain expresses Cre under the control of Col1a1 promoter.1)2)3)4)5) | 1) Bone. 2021 Sep;150:116010. 2) JBMR Plus. 2021 May 17;5(6):e10496. 3) Cell. 2020 Aug 6;182(3):609-624.e21. 4) Genes Cells. 2018 May;23(5):345-356. 5) Dev Dyn. 2002 Jun;224(2):245-51. |
| 22.08.01 | Osteoblasts Cre-driver mice | RBRC05524 | This Tg strain expresses Cre under the control of Col1a1 promoter.1)2)3)4)5) | 1) JCI Insight. 2020 May 7;5(9):e135355. 2) Stem Cells. 2016 Aug;34(8):2145-56. 3) J Bone Miner Res. 2015 Apr;30(4):715-22. 4) EMBO J. 2015 Jun 12;34(12):1648-60. 5) J Bone Miner Res. 2008 Feb;23(2):271-7. |
| 22.06.01 | Rspo2-Cre BAC Tg mice | RBRC10754 | Cre expression is detected in basolateral amygdala (BLA)1). (BAC clone ID：RP23-39M21) | 1) Nat Neurosci. 2016 Dec;19(12):1636-1646. |
| 22.06.01 | Gpr151-Cre BAC Tg mice | RBRC10728 | Cre expression is detected in cholinergic neurons of medial habenula (mHb)1)2). (BAC clone ID：MSMg01-81G4) | 1) J Comp Neurol. 2017 Oct 15;525(15):3227-3250. 2) Front Behav Neurosci. 2013 Mar 12;7:17. |
| 22.06.01 | Prkcd-Cre BAC Tg mice | RBRC10725 | Cre expression is detected in almost the entire dorsal thalamus1). (BAC clone ID：RP23-220I83) | 1) Sci Rep. 2016 Jun 27;6:28750. |
| 22.06.01 | VGAT(Slc32a1)-Cre BAC Tg mice | RBRC10723 | Cre expression is detected in inhibitory neurons1)2). (BAC clone ID：RP23-392P11) | 1) Sci Rep. 2016 Jun 27;6:28750. 2) Hum Mol Genet. 2013 Dec 1;22(23):4784-804. |
| 22.03.30 | Otx2-tdTomato KI mice1) | RBRC10897 | This strain expresses tdTomato under the control of ectoderm marker Otx2. | 1) Exp Anim. 2019 Nov 6;68(4):499-509 |
| 22.03.30 | Sox17-EGFP KI mice1) | RBRC10898 | This strain expresses EGFP under the control of endoderm marker Sox17. | 1) Exp Anim. 2019 Nov 6;68(4):499-509 |
| 22.03.30 | Tppp3-EGFP KI mice1) | RBRC10145 | This strain expresses EGFP under the control of Tppp3. | 1) Nat Commun. 2019 Sep 5;10(1):3999 |
| 22.03.30 | Tppp3-CreERT2 KI mice1) | RBRC10144 | This strain expresses CreERT2 under the control of Tppp3. | 1) Nat Commun. 2019 Sep 5;10(1):3999 |
| 22.03.30 | Sox10-CreERT2 KI mice1) | RBRC10143 | This strain expresses CreERT2 under the control of Sox10. | 1) Nat Commun. 2019 Sep 5;10(1):3999 |
| 22.01.31 | Actin-tTS Tg mice1)2) | RBRC05447 | This strain express tTS in whole body 3)4)5). | 1) Genomics. 2003 Apr;81(4):356-60 2) Biol Psychiatry. 2010 Apr 15;67(8):770-3 3) Sci Rep. 2019 Mar 4;9(1):3422 4) Sci Rep. 2017 Oct 19;7(1):13605 5) Neuron. 2015 May 6;86(3):813-26 |
| 22.01.31 | Gad1-tTA KI mice1) | RBRC11365 | tTA expression is detected in GABAergic neurons. | 1) Mol Brain. 2021 Jan 7;14(1):5 |
| 22.01.31 | Gad1-Stop-tetO KI mice1) | RBRC11364 | This strain is used for Gad1 gene expression control by Tet on/off system. | 1) Mol Brain. 2021 Jan 7;14(1):5 |
| 22.01.31 | Nkcc1-tetO KI mice1) | RBRC11202 | This strain is used for Nkcc1 (Slc12a2) gene expression control by Tet on/off system. | 1) Sci Rep. 2017 Oct 19;7(1):13605 |
| 22.01.31 | CatC-tetO KI mice1) | RBRC10854 | This strain is used for Cathepsin C gene expression control by Tet on/off system. | 1) Glia. 2017 Jun;65(6):917-930 |
| 21.12.01 | Sox9-CreERT2 KI mice1) | RBRC05522 | This strain is useful for research of embryonic development and cell differentiation2)3)4)5). | 1) Genesis. 2010 Nov;48(11):635-44. 2) Development. 2021 Jul 1;148(13):dev199543. 3) Nat Commun. 2021 May 4;12(1):2509. 4) Proc Natl Acad Sci U S A. 2021 Feb 16;118(7):e2017115118. 5) Proc Natl Acad Sci U S A. 2020 Jun 2;117(22):12182-12191. |
| 21.12.01 | Sox9-Cre KI mice1) | RBRC05523 | This strain is useful for research of embryonic development and cell differentiation2)3)4)5). | 1) Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14665-70. 2) Elife. 2020 May 12;9:e53688. 3) Development. 2019 Oct 4;146(20):dev182782. 4) J Neurosci. 2018 Jun 6;38(23):5429-5440. 5) Development. 2018 Dec 18;145(24):dev165381. |
| 21.12.01 | Sox1-Cre KI mice1) | RBRC05065 | This strain is useful for research of embryonic development and cell differentiation2)3)4)5). | 1) Cell. 2007 Jun 29;129(7):1377-88. 2) Genes Cells. 2021 Feb;26(2):45-55. 3) PLoS Genet. 2020 Feb 24;16(2):e1008300. 4) Dev Biol. 2020 Dec 1;468(1-2):101-109. 5) Nat Commun. 2020 Nov 11;11(1):5709. |
| 21.12.01 | Dkk3-Cre BAC Tg mice1) | RBRC10900 (C57BL/6) RBRC05427 (129) | Theses strains are useful for eye development research2)3)4)5). | 1) Genesis. 2007 Aug;45(8):502-7. 2) Genes Cells. 2020 Jun;25(6):402-412. 3) Elife. 2020 Feb 25;9:e51275. 4) Invest Ophthalmol Vis Sci. 2020 Sep 1;61(11):43. 5) Invest Ophthalmol Vis Sci. 2017 Apr 1;58(4):1916-1929. |
| 21.10.01 | Plp1-tTA Tg mice | RBRC05446 | tTA expression is detected in oligodendrocytes1). It was contributed to some results2)3)4)5). | 1) Genesis. 2012 May;50(5):424-8. 2) J Neurosci. 2019 May 22;39(21):4036-4050. 3) J Neurochem. 2019 Jul;150(2):158-172. 4) Nat Neurosci. 2018 Apr;21(4):625-637. 5) Cell Rep. 2018 Aug 21;24(8):2196-2210.e9. |
| 21.10.01 | Htr5b-tTA KI mice | RBRC05445 | tTA expression is detected in 5-hydroxytryptamine (serotonin) receptor 5B positive cells1). It was contributed to some results2)3)4). | 1) Cell Rep. 2012 Aug 30;2(2):397-406. 2) Nat Neurosci. 2019 May;22(5):770-777. 3) Cell Rep. 2018 Aug 21;24(8):2196-2210.e9. 4) Cell Rep. 2017 Nov 21;21(8):2066-2073. |
| 21.10.01 | Pmch-tTA BAC Tg mice | RBRC05844 | tTA expression is detected in MCH (melanin-concentrating hormone) neurons1). It was contributed to some results2)3). | 1) J Neurosci. 2014 May 14;34(20):6896-909. 2) Science. 2019 Sep 20;365(6459):1308-1313. 3) Elife. 2020 Apr 21;9:e54275. |
| 21.10.01 | Tph2-tTA BAC Tg mice | RBRC05846 | tTA expression is detected in serotonergic neurons1). It was contributed to some results2)3)4). | 1) Int J Neuropsychopharmacol. 2014 Nov;17(11):1777-83. 2) Nat Neurosci. 2019 May;22(5):770-777. 3) Neuropharmacology. 2020 May 1;167:107703. 4) Nat Commun. 2018 Jun 1;9(1):2048. |
| 21.08.02 | Cre-driver mice for inner ear | RBRC09434 | Pax2-Cre Tg strain is utilized as Cre-driver mice for inner ear1)2)3). | 1) Elife. 2020 Jan 8;9:e52160. 2) PLoS Genet. 2017 Oct 23;13(10):e1007048. 3) Genesis. 2004 Apr;38(4):195-9. |
| 21.08.02 | Cre-driver mice for olfactory sensory neurons | RBRC06339 | Olfr1507(MOR28)-Cre Tg strain is utilized as Cre-driver mice for a part of olfactory sensory neurons1)2)3). | 1) Science. 2019 Jul 5;365(6448):eaaw5030. 2) Mouse of the Month October 2015. 3) Cell. 2010 Jun 11;141(6):1056-67. |
| 21.08.02 | Cre-driver mice for olfactory sensory neurons | RBRC06346 | Ascm4(OMACS)-Cre KI strain is utilized as Cre-driver mice for dorsal zone olfactory sensory neurons1)2)3). | 1) Commun Biol. 2019 Jan 8;2:14. 2) Sci Rep. 2015 Sep 11;5:14073. 3) Nature. 2007 Nov 22;450(7169):503-8. |
| 21.08.02 | Cre-driver mice for retinal photoreceptor cells and progenitor cells | RBRC05426 | Crx-Cre Tg strain is utilized as Cre-driver mice for retinal photoreceptor cells and progenitor cells1)2)3). | 1) Sci Rep. 2018 Jun 4;8(1):8543. 2) Hum Mol Genet. 2018 Sep 15;27(18):3137-3153. 3) Nat Neurosci. 2003 Dec;6(12):1255-63. |
| 21.08.02 | CreERT2-driver mice for retinal photoreceptor cells and progenitor cells | RBRC05559 | Crx-CreERT2 Tg strain is utilized as tamoxifen-inducible Cre-driver mice for retinal photoreceptor cells and progenitor cells1)2)3). | 1) Exp Eye Res. 2018 Aug;173:32-43. 2) Cell Rep. 2015 Nov 3;13(5):990-1002. 3) J Neurosci. 2011 Nov 16;31(46):16792-807. |
| 21.03.31 | G-CaMP7 Tg mice controlled by Thy1 promoter | RBRC06579 | Using this strain, longitudina imaging of large-scale functional hippocampal cellular maps was performed1)2). | 1) Cell Rep. 2020 Jul 7;32(1):107864. 2) PLoS One. 2012;7(12):e51286. |
| 21.03.31 | G-CaMP7 Tg mice controlled by Slc1a2 (GLT1) promoter | RBRC09650 | This strain expresses G-CaMP7 in astrocytes and a subpopulation of cortical neurons1)2)3)4). It contributed to elucidation of the recovery mechanism after acute ischemic stroke5). | 1) Nat Commun. 2016 Mar 22;7:11100. 2) Mouse of the Month August 2017. 3) J Neurosci. 2007 Jun 20;27(25):6607-19. 4) PLoS One. 2012;7(12):e51286. 5) Proc Natl Acad Sci U S A. 2019 May 28;116(22):11010-11019. |
| 21.03.31 | G-CaMP6 Tg mice controlled by Thy1 promoter | RBRC10611 | This strain expresses G-CaMP6 in brain1)2). | 1) Neurosci Res. 2020 Feb;151:53-60. 2) PLoS One. 2012;7(12):e51286. |
| 21.03.31 | G-CaMP7 expression conditionally controllable Tg mice | RBRC06510 | This strain is reported to show a growth retardation with hypothyroidism1)2)3). | 1) PLoS One. 2015 May 6;10(5):e0125354. 2) Mouse of the Month June 2015. 3) PLoS One. 2012;7(12):e51286. |
| 21.02.01 | A member of formin protein family mDia1 floxed mice | RBRC02595 | This strain contributed to elucidation of actin cytokine-mediated T cell activation mechanism1)2)3). | 1) Sci Adv6 (1) 2020 eaay2432 2) Cell Rep 2016 17 (9) 2405-2417 3) J Exp Med 2007 204 (9) 2031-8 |
| 21.02.01 | Oncostatin M (a member of IL-6 family of cytokines) receptor KO mice1)2) | RBRC02711 | This strain is widely used for variety research fields including immunology3)4)5). | 1) Blood 2003 102 (9) 3154-62 2) Hepatology 2004 39 (3) 635-44 3) Proc Natl Acad Sci U S A 2020 117 (9) 5028-5038 4) Nat Commun 2017 8 13946 5) J Lipid Res 2017 58 (5) 895-906 |
| 21.02.01 | Cytokine TNFα KO mice1)2) | RBRC05118 (C57BL/6) RBRC05119 (BALB/c) | These strains are widely used for elucidation of immune mechanism3)4). | 1) J Immunol 1997 159 (3) 1418-28 2) Lab Invest 1997 77 (6) 647-58 3) J Immunol 2019 203 (4) 783-788 4) Front Immunol 2018 9 2619 |
| 20.12.01 | Endogenous membrane protein Mavs (IPS-1) KO mice1) | RBRC04546 | Mavs (IPS-1) is related to the cytokine production as adaptor to recognize cytoplasmic RNA virus. This strain contributed to elucidate some findings 2)3)4)5). | 1) J Immunol. 2011 Nov 15;187(10):5320-7. 2) Cancer Sci. 2018 Apr;109(4):956-965. 3) Cell Rep. 2017 May 30;19(9):1874-1887. 4) Cell Rep. 2015 May 26;11(8):1193-207. 5) Immunity. 2015 Dec 15;43(6):1148-59. |
| 20.12.01 | Ubiquitin ligase Efp (Trim25) KO mice1) | RBRC02844 | Analysis of this strain revealed that Efp (Trim25) is related to the breast tumor growth2), neuroinflammation pathogenesis3) and inhibition of virus infection4)5). | 1) Proc Natl Acad Sci U S A. 1999 Oct 12;96(21):12027-32. 2) Nature. 2002 Jun 20;417(6891):871-5. 3) Nat Immunol. 2017 Jan;18(1):54-63. 4) Nat Immunol. 2010 Jan;11(1):63-9. 5) Nature. 2007 Apr 19;446(7138):916-920. |
| 20.12.01 | Itgal (LFA-1, Cd11a) KO mice1) | RBRC00850 | Analysis of this strain revealed several type I interferon secretion mechanism by plasmacytoid dendritic cells2). | 1) J Exp Med. 1996 Apr 1;183(4):1415-26. 2) Nat Commun. 2017 Nov 17;8(1):1592. |
| 20.12.01 | Agt (angiotensinogen) KO mice1) | RBRC01120 | This strain is widely used for functional analysis of renin-angiotensin system2)3). | 1) J Biol Chem. 1994 Dec 16;269(50):31334-7. 2) PLoS One. 2015 Jun 24;10(6):e0129484. 3) Circ Res. 2014 Jul 7;115(2):263-72. |
| 20.10.01 | Pro-inflammatory cytokine IL-6 KO mice1) | RBRC04918 (C57BL/6) RBRC04919 (BALB/c) RBRC05131 (DBA/1) | IL-6 (interleukin-6) is a cytokine that has multifunction, including inflammatory response, in many kinds of cells. These strains were utilized for IL-6 functional analysis2)3)4). | 1) Nature. 1994 Mar 24;368(6469):339-42. 2) Sci Rep. 2019 Jul 25;9(1):10842. 3) Sci Adv. 2018 Jul 11;4(7):eaas9944. 4) Sci Rep. 2018 Oct 25;8(1):15783. |
| 20.10.01 | IL-6-related inflammatory status in vivo imaging mice | RBRC09487 | This BAC-based human IL-6-luciferase Tg strain is useful for evaluation of inflammatory status in vivo by luciferase luminescence1)2)3)4)5). | 1) Sci Rep. 2018 May 23;8(1):8037. 2) Eur J Pharmacol. 2017 May 5;802:76-84. 3) Nat Commun. 2016 May 23;7:11624. 4) Mouse of the Month May 2016 5) Mol Cell Biol. 2015 Oct;35(20):3590-601. |
| 20.10.01 | Human IL-6 expression conditionally controllable mice | RBRC09734 RBRC09735 | This strain expresses human IL-6 according to Cre recombinase1). | 1) Exp Anim. 2016 Nov 1;65(4):455-463. |
| 20.04.01 | Cre reporter mice showing green-to-red fluorescent conversion1)2)3) | RBRC04874 | This ROSA26-KI strain express EGFP signal before and tdsRed signal after Cre-mediated recombination. It was contributed to some results4)5)6). | 1) Exp Anim. 2013;62(4):295-304. 2) Mouse of the Month October 2018 3) Mouse of the Month March 2014 4) iScience. 2019 Oct 25;20:337-347. 5) Dev Cell. 2019 Jul 22;50(2):139-154.e5. 6) PLoS One. 2018 Jan 11;13(1):e0190800. |
| 20.04.01 | Cre reporter mice expressing EGFP signal1) | RBRC09806 | This Tg strain express EGFP signal after Cre-mediated recombination. It was contributed to some results2)3)4). | 1) FEBS Lett. 2000 Mar 31;470(3):263-8. 2) Dev Cell. 2019 Jan 28;48(2):151-166.e7. 3) Cell Stem Cell. 2018 Mar 1;22(3):384-397.e6. 4) Nat Commun. 2018 Apr 24;9(1):1623. |
| 20.04.01 | Cre reporter mice expressing LacZ signal1)2) | RBRC02657 | This ROSA26-KI strain express LacZ signal after Cre-mediated recombination. It was contributed to some results3)4)5). | 1) Front Behav Neurosci. 2013 Mar 12;7:17. 2) Mouse of the Month March 2013 3) Transgenic Res. 2018 Apr;27(2):193-201. 4) J Neurosci. 2017 Aug 9;37(32):7682-7699. 5) Genesis. 2016 Nov;54(11):568-572. |
| 20.02.03 | Siglec-H gene DTR-EGFP KI mice | RBRC05658 (C57BL/6) RBRC09688 (BALB/c) | In this strain, plasmacytoid dendritic cells (pDCs) can be depleted by injection of diphtheria toxin 1)2)3). User reported that pDCs are related with acute liver injury4). | 1) Glia. 2017 Dec;65(12):1927-1943. 2) Sci Rep. 2016 Apr 14;6:24477. 3) Immunity. 2011 Dec 23;35(6):958-71. 4) J Clin Invest. 2019 Jul 2;129(8):3201-3213. |
| 20.02.03 | Xcr1 gene KikGR KI mice | RBRC09928 | This is a photoconvertible KikGR reporter mice for Xcr1 gene, which express chemokine receptor at one subset of dendritic cells1). | 1) Proc Natl Acad Sci U S A. 2016 Jan 26;113(4):1044-9. |
| 20.02.03 | Xcr1 gene DTR-Venus KI mice | RBRC09485 (C57BL/6) RBRC10391 (BALB/c) | In this strain, XCR1-positive dendritic cells can be depleted by injection of diphtheria toxin 1) 2) 3). | 1) Nat Microbiol. 2018 May;3(5):611-621. 2) J Immunol. 2017 Dec 15;199(12):4165-4179. 3) Mouse of the Month January 2016 |
| 20.02.03 | Relb gene Venus KI mice | RBRC09496 | This is a Venus reporter strain for Nf-κB family gene Relb, which is related with immune cell maturation 1). | 1) J Biochem. 2015 Dec;158(6):485-95. |
| 19.12.02 | Cre-driver mice for CRF neuron | RBRC06520 | Crh (corticotropin-releasing hormone) Cre KI strain is useful for stress response research 1) 2). | 1) Sci Adv. 2016 Aug 17;2(8):e1501723. 2) Endocrinology. 2014 Oct;155(10):4054-60. |
| 19.12.02 | Crh gene reporter mice | RBRC09893 | Crh (corticotropin-releasing hormone) Venus KI strain allows the visualization of CRF neurons 1) 2) 3). | 1) Biol Sex Differ. 2019 Jan 28;10(1):6. 2) Brain Struct Funct. 2017 May;222(4):1705-1732. 3) Endocrinology. 2014 Oct;155(10):4054-60. |
| 19.12.02 | Cre-driver mice for Oligodendrocyte lineage and motoneuron | RBRC01507 | Olig2-tamoxifen inducible Cre KI strain is frequently used in neuroscience 1) 2) 3) 4) 5). | 1) Nat Neurosci. 2018 May;21(5):696-706. 2) Science. 2014 Sep 26;345(6204):1254927.v 3) Mouse of the Month July 2006 4) Dev Biol. 2006 May 15;293(2):358-69. 5) Curr Biol. 2002 Jul 9;12(13):1157-63. |
| 19.12.02 | Transcription factor Olig2 reporter mice | RBRC06017 RBRC06018 RBRC06022 | This strain express Venus, mCherry or luciferase-OLIG2 fusion protein 1). | 1) Science. 2013 Dec 6;342(6163):1203-8. |
| 19.12.02 | Cre-driver mice for dorsal telencephalon | RBRC01345 | Emx1 (empty spiracles homeobox 1) Cre KI strain is frequently used in neuroscience 1) 2) 3) 4) 5). | 1) Nat Commun. 2019 Aug 8;10(1):3581. 2) Nat Commun. 2017 May 23;8:15488. 3) Mouse of the Month July 2006 4) Genesis. 2004 Mar;38(3):130-8. 5) Nature. 2000 Aug 17;406(6797):726-31. |
| 19.12.02 | Cre-driver mice for developing cochleae | RBRC02272 | Emx2 (empty spiracles homeobox 2) Cre KI strain 1) is useful for inner ear development research 2) 3) 4). | 1) J Neurosci. 2005 May 25;25(21):5097-108. 2) J Neurosci. 2019 Oct 9;39(41):8013-8023. 3) Dev Biol. 2018 May 1;437(1):17-26. 4) Development. 2018 Jun 14;145(12). |
| 19.10.01 | Cellualar oxidative stress imaging mice | RBRC057041) RBRC061612) | Nrf2 (oxidative stress-responsive transcription factor) reporter mice were utilized for the elucidation of oxidative stress sensing mechanism3). | 1) Sci Rep. 2012;2:229. 2) Free Radic Biol Med. 2014 Jul;72:124-33. 3) Cell Rep. 2019 Jul 16;28(3):746-758.e4. |
| 19.10.01 | ROS production conditionally regulatable mice1) | RBRC09859 | This strain expresses SDAD (ROS homeostasis-related enzyme) defective mutants according to Cre recombinase. | 1) Eur J Immunol. 2017 Feb;47(2):406-418. |
| 19.10.01 | Sperm-egg fusion imaging mice1) | RBRC05763 | Izumo1 (sperm acrosomal gene) reporter strain is useful for the elucidation of gamete fusion mechanism2) 3). | 1) J Cell Sci. 2012 Nov 1;125(Pt 21):4985-90. 2) Cell Cycle. 2018;17(11):1279-1285. 3) Nat Commun. 2015 Nov 16;6:8858. |
| 19.10.01 | Sperm acrosome−GFP： sperm mitochondria−DsRed dual reporter mice1) | RBRC03743 RBRC05861 | This strain is useful for the elucidation of fertilization or acrosome reaction mechanism2) 3) 4). | 1) Exp Anim. 2010;59(1):105-7. 2) J Cell Biol. 2018 Jun 4;217(6):2103-2119. 3) J Biol Chem. 2018 Jul 27;293(30):11796-11808. 4) Biol Reprod. 2016 Apr;94(4):80. |
| 19.08.01 | Cre-driver mice for orexin neurons | RBRC06806 | This strain expresses Cre recombinase and EGFP in orexin neurons1) 2). | 1) Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):E10740-E10747. 2) Neuropharmacology. 2014 Oct;85:451-60. |
| 19.08.01 | Full maturated OSN (olfactory sensory neuron) reporter mice1) | RBRC02092 | OMP (olfactory marker protein) gene-GFP KI mice are broadly utilized for olfactory analysis2) 3) 4). | 1) J Neurosci. 2001 Dec 15;21(24):9713-23. 2) J Neurosci. 2019 Jan 30;39(5):814-832. 3) Cell Stem Cell. 2017 Dec 7;21(6):761-774.e5. 4) Cell. 2016 Jun 16;165(7):1734-1748. |
| 19.08.01 | Selenocysteine-tRNA (Trsp) floxed mice1) | RBRC02681 | This strain was utilized for an oxidative stress model2) 3). | 1) J Biol Chem. 2008 Jan 25;283(4):2021-30. 2) Cell Rep. 2017 Feb 21;18(8):2030-2044. 3) Blood. 2011 Jan 20;117(3):986-96. |
| 19.08.01 | Neuronally enriched Rufy3 KO-first mice | RBRC05780 | Analysis of this strain revealed that RUFY3 is essential for caspase-mediated axon degeneration1). | 1) Neuron. 2019 Jun 7. pii: S0896-6273(19)30483-0. |
| 19.06.03 | Cre-driver mice for postnatal somatic motor neurons | RBRC01515 RBRC01516 | These strain express Cre recombinase in slow type motor neurons1) 2). | 1) Genesis. 2016 Nov;54(11):568-572. 2) Brain Res. 2014 Mar 6;1550:36-46. |
| 19.06.03 | Mitochondria-EGFP labeled mice1) 2) | RBRC02250 | This transgenic strain is utilized to identify and monitor the mitochondorial morphology3) 4). | 1) Exp Anim. 2010;59(1):99-103. 2) FEBS Lett. 2001 Jun 29;500(1-2):7-11. 3) Sci Transl Med. 2017 Oct 25;9(413). 4) PLoS One. 2012;7(6):e36850. |
| 19.06.03 | Zinc transporter Slc39a10 (Zip10) floxed mice | RBRC06221 | Analysis of this strain revealed novel functions of Slc39a10 in humoral immune system1) 2) and epidermal development3). | 1) Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):11786-91. 2) Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):11780-5. 3) Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):12243-12248. |
| 19.06.03 | Cell adhesion molecule Cadm1 (SynCAM1) KO mice | RBRC04062 | This strain was utilized for analysis of not only nervous system1) 2) 3) but also bone turnover4). | 1) J Neurosci. 2016 Jul 13;36(28):7464-75. 2) Neuron. 2010 Dec 9;68(5):894-906. 3) Biochem Biophys Res Commun. 2010 Jun 4;396(3):703-8. 4) PLoS One. 2017 Apr 17;12(4):e0175632. |
| 19.04.01 | Cre-driver mice for myelinating cells of the central nervous system1) | RBRC01461 | This strain is useful for the elucidation of gene function in oligodendrocyte myelination2). | 1) Genesis. 2000 Feb;26(2):127-9. 2) Nat Commun. 2016 Nov 23;7:13478. |
| 19.04.01 | Oct3/4 (Pou5f1) reporter mice | RBRC007711) RBRC060372) | These strains are useful for stem cell research because they express EGFP under the control of pluripotency marker Oct3/43) 4) 5). | 1) Dev Biol. 2003 Jun 1;258(1):209-25. 2) Development. 2008 Mar;135(5):909-18. 3) Cell Res. 2011 Jan;21(1):196-204. 4) Dev Biol. 2010 Oct 1;346(1):90-101. 5) Stem Cells. 2009 Feb;27(2):383-9. |
| 19.04.01 | Fgf5 spontaneous mutant mice | RBRC05894 RBRC05895 | This strain shows abnormal hair follicle cycle1). In addition, it contributed to the research about spermatogenic stem cells2). | 1) Exp Anim. 2011;60(2):161-7. 2) Cell Stem Cell. 2019 Jan 3;24(1):79-92. e6. |
| 19.04.01 | Fstl4 (Mahya) reporter mice | RBRC04952 | This strain is useful for revolutionary genetic research1)In addition, it was used to monitor specific subtypes of retinal ganglion cells2). | 1) Dev Genes Evol. 2005 Nov;215(11):564-74. 2) Curr Eye Res. 2016 Apr;41(4):558-68. |
| Date | Title | BRC No. | Description | References |
|---|---|---|---|---|
| 26.09.03 | Aldh2 KO mice | RBRC05808 RBRC10321 | These mice are used to investigate the effects of reduced ALDH2 activity. 1)2)3)4)5) | 1) Am J Physiol Regul Integr Comp Physiol. 2022 Jun 1;322(6):R511-R525. 2) JCI Insight. 2021 Aug 9;6(15):e138183. 3) Am J Physiol Regul Integr Comp Physiol. 2020 Apr 1;318(4):R677-R690. 4) Biochem Biophys Res Commun. 2019 Apr 23;512(1):41-48. 5) FEBS Lett. 2000 Jul 7;476(3):306-11. |
| 26.09.03 | Tg mice overexpressing the E504K mutant form of Aldh2 | RBRC09897 | This strain has been reported to exhibit reduced ALDH2 activity through a dominant-negative effect and has been used as a model of cognitive impairment associated with increased oxidative stress in the brain. 1)2)3) | 1) Neurosci Lett. 2015 Feb 5:587:126-31. 2) Brain Res. 2015 Apr 24:1605:49-58. 3) J Neurosci. 2008 Jun 11;28(24):6239-49. |
| 26.09.03 | Tg mice overexpressing the E504K mutant form of Aldh2 | RBRC09898 | This strain has been reported to exhibit reduced ALDH2 activity through a dominant-negative effect and has been used to investigate the effects of reduced ALDH2 activity. 1)2)3)4)5) | 1) Bone. 2021 Jan:142:115739. 2) Biochem Biophys Res Commun. 2020 Jun 18;527(1):270-275. 3) BMC Complement Altern Med. 2014 Oct 11:14:390. 4) J Bone Miner Res. 2012 Sep;27(9):2015-23. 5) Circ Res. 2009 Nov 20;105(11):1118-27. |
| 26.06.30 | Piga gene floxed mice | RBRC06211 | The Piga gene is an X-linked gene that is essential for GPI anchor biosynthesis. It has also been reported to be associated with inherited GPI deficiency1)2)3). | 1) Hum Mol Genet. 2021 May 28;30(9):758-770. 2) Hum Mol Genet. 2020 May 8;29(7):1205-1217. 3) Proc Natl Acad Sci U S A. 1997 Jul 8;94(14):7400-5. |
| 26.06.30 | Abcd1 gene KO mice | RBRC03551 RBRC03552 | The Abcd1 gene is an X-linked gene. It has also been reported to be associated with adrenoleukodystrophy1)2). | 1) J Inherit Metab Dis. 2024 Mar;47(2):289-301. 2) Biochem Biophys Res Commun. 1997 Mar 27;232(3):631-6. |
| 26.06.30 | Nipal4 gene KO mice | RBRC11102 | The Nipal4 gene encodes a Mg2+ transporter It has also been reported to be associated with congenital ichthyosis1)2). | 1) J Lipid Res. 2024 Jun;65(6):100550. 2) J Invest Dermatol. 2018 Apr;138(4):741-749. |
| 25.04.09 | Awat1 gene KO mice Awat2 gene KO mice | RBRC11537 RBRC11538 RBRC11539 | Awat1 gene KO mice, Awat2 gene KO mice, and Awat1 gene/Awat2 gene double KO mice have each been reported to have dry eye phenotypes. | 1) iScience. 2021 Sep 25;24(10):103160. |
| 25.04.09 | Cyp4f39 gene Tg mice Cyp4f39 gene KO mice | RBRC11422 RBRC11423 | Tg-Cyp4f39 KO mice, created by crossing Cyp4f39 gene Tg mice with Cyp4f39 gene KO mice, have been reported to have dry eye phenotypes. | 1) Elife. 2020 Apr 7:9:e53582. |
| 25.04.09 | Itpr2 gene KO mice Itpr3 gene KO mice | RBRC10289 RBRC10290 RBRC10291 | Double KO mice, created by crossing Itpr2 gene KO mice with Itpr3 gene KO mice, have been reported to have dry eye phenotypes. | 1) PLoS One. 2014 Jun 5;9(6):e99205. 2) Science. 2005 Sep 30;309(5744):2232-4. |
| 24.02.26 | Sensory neurons Cre-driver mice | RBRC10246 | This KI strain expresses Cre under the control of endogenous Advillin promoter.1) | 1) Proc Natl Acad Sci U S A. 2010 May 18;107(20):9424-9. |
| 24.02.26 | Homeobox gene Vsx2 Cre-driver mice | RBRC09714 | This KI strain expresses CreERT2 under the control of endogenous Vsx2(Chx10) promoter. | |
| 24.02.26 | Homeobox gene Vsx2 Cre-driver mice | RBRC06574 | This BAC Tg strain expresses CreERT2 under the control of Vsx2(Chx10) promoter.1)2) | 1) Development. 2020 Sep 28;147(18):dev188730. 2) Cell Death Dis. 2020 Aug 18;11(8):655. |
| 24.02.26 | Homeobox gene Vsx2 Cre-driver mice | RBRC05564 | This Tg strain expresses Cre under the control of Vsx2(Chx10) promoter.1)2)3)4) | 1) Dev Biol. 2020 Aug 15;464(2):137-144. 2) Development. 2017 Jul 1;144(13):2392-2401. 3) J Exp Med. 2016 Jun 27;213(7):1175-83. 4) J Neurosci. 2011 Nov 16;31(46):16792-807. |
| 23.12.28. | Kpna1(importin α5) gene KO mice | RBRC06031 (KO) RBRC06030 (floxed) | KPNA1 KO mice have been reported to have behavioral abnormalities and female functional incompetence in delivery.1)2) | 1) PLoS One. 2021 Nov 12;16(11):e0258364. 2) FEBS J. 2011 May;278(9):1561-72. |
| 23.12.28. | Kiss1 gene floxed mice | RBRC10389 | This strain has been reported to be infertile when crossed with Cre driver strains.1)2) | 1) J Reprod Dev. 2020 Aug 20;66(4):359-367. 2) J Reprod Dev. 2020 Aug 20;66(4):369-375. |
| 23.12.28. | Prl gene KO mice | RBRC06232 | Prolactin has been reported to be involved in a variety of physiological phenomena and diseases.1)2)3)4)5) | 1) Cell Rep. 2021 Jun 1;35(9):109204. 2) Cancer Res. 2019 Oct 15;79(20):5316-5327. 3) PLoS One. 2016 Nov 28;11(11):e0166416. 4) Biol Reprod. 2015 Sep;93(3):75. 5) EMBO J. 1997 Dec 1;16(23):6926-35. |
| 23.11.02 | Il17rb gene KO mice | RBRC10254 (C57BL/6 background) RBRC10255 (BALB/c background) | IL17RB is a receptor for IL17B and IL17E (IL25) and has been studied in relation to inflammatory diseases.1)2)3)4) | 1) J Exp Med. 2023 Aug 7;220(8):e20221773. 2) J Immunol. 2017 Jan 15;198(2):669-680. 3) Immunity. 2015 Apr 21;42(4):692-703. 4) PLoS Biol. 2012 Feb;10(2):e1001255. |
| 23.11.02 | Il22ra2gene KO mice | RBRC10360 | IL22RA2(IL22BP) has been studied in relation to inflammatory cutaneous diseases. 1) | 1) Front Immunol. 2018 Jun 21:9:1418. |
| 23.11.02 | Il33 gene KO mice | RBRC09341 | IL33 has been studied in relation to various diseases. 1)2)3)4)5) | 1) Dis Model Mech. 2023 Sep 1;16(9):dmm050174. 2) Immunity. 2022 Jan 11;55(1):159-173.e9. 3) Sci Immunol. 2022 Jun 24;7(72):eabl7209. 4) Immunity. 2021 Jan 12;54(1):151-163.e6. 5) Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18581-6. |
| 23.09.01 | A molecular chaperon Serpinh1(Hsp47) floxed mice | RBRC10972 | Serpinh1 is essential for collagen synthesis and various phenotypes have been reported using this strain.1)2)3)4) | 1) JCI Insight. 2019 Aug 8;4(15):e128722. 2) Mol Cell. 2018 Jan 18;69(2):238-252.e7. 3) J Biol Chem. 2015 Feb 6;290(6):3639-46. 4) J Cell Sci. 2012 Mar 1;125(Pt 5):1118-28. |
| 23.09.01 | A molecular chaperon Serpinh1(Hsp47) KO mice | RBRC10971 | Serpinh1 is essential for collagen synthesis and it has been reported that null mutant mice do not survive beyond 11.5 dpc.1)2)3) | 1) Mol Biol Cell. 2006 May;17(5):2346-55. 2) J Cell Sci. 2004 Nov 15;117(Pt 24):5913-22. 3) J Cell Biol. 2000 Sep 18;150(6):1499-506. |
| 23.09.01 | A TNF superfamily Tnfsf11 (RANKL) floxed mice | RBRC06142 | Using this strain, Tnfsf11 mutations have been reported to result in bone abnormalities.1)2) | 1) J Bone Miner Res. 2014 Apr;29(4):830-42. 2) J Clin Invest. 2013 Sep;123(9):3914-24. |
| 23.09.01 | A transmembrane protein Pmepa1 mutated mice | RBRC11387 | This strain has been reported to show bone abnormalities.1)2) | 1) FASEB J. 2021 Feb;35(2):e21281. 2) FASEB J. 2019 Mar;33(3):4365-4375. |
| 23.07.03 | Mad2l2 mutated mice | RBRC09685 | This Mad2l2 (Rev7) mutated strain established by ENU mutagenesis has been reported that both male and female homozygotes exhibit infertility and female homozygotes develop ovarian tumors at a high frequencyto1)2)3. | 1) Mol Cell Endocrinol. 2015 Sep 5;412:19-25. 2) J Biol Chem. 2014 Feb 7;289(6):3811-24. 3) J Reprod Dev. 2008 Jun;54(3):225-8. |
| 23.07.03 | Mad2l2 KO mice | RBRC05473 | This strain has been reported that both male and female homozygotes lack germ cells1). | 1) J Biol Chem. 2013 Apr 12;288(15):10459-71. |
| 23.07.03 | Tdrd12 mutated mice | RBRC09686 | This Tdrd12 mutated strain established by ENU mutagenesis has been reported that male homozygotes exhibit infertility1)2). | 1) Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16492-7. 2) Exp Anim. 2009 Oct;58(5):525-32. |
| 23.07.03 | Tdrd12(Ecat8) KO mice | RBRC02326 | This strain has been reported that male homozygotes exhibit infertility1)2). | 1) Cell Rep. 2018 Sep 25;24(13):3423-3432.e4. 2) Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16492-7. |
| 23.07.03 | Rnf212 mutated mice | RBRC09687 | This Rnf212 mutated strain established by ENU mutagenesis has been reported that male homozygotes exhibit infertility1). | 1) Reproduction. 2015 Jan;149(1):67-74. |
| 23.04.27 | Osteoarthritis (OMIM: 612400) model mice | RBRC-GSC0080 | This Gdf5 mutated strain established by ENU mutagenesis has been reported to show brachypodism and ankylosis1)2)3)4)5). | 1) Sci Rep. 2016 Mar 31;6:23670. 2) Diabetes. 2014 Jan;63(1):162-75. 3) Biochem Biophys Res Commun. 2014 Jul 18;450(1):255-60. 4) Hum Mol Genet. 2007 Oct 1;16(19):2366-75. 5) Mouse of the Month September 2007 |
| 23.04.27 | Spondyloepimetaphyseal dysplasia (OMIM: 183900) model mice | RBRC-GSC0164 | This Col2a1mutated strain established by ENU mutagenesis has been reported to show skeletal dysplasia-like phenotypes1). | 1) Mamm Genome. 2011 Jun;22(5-6):318-28. |
| 23.04.27 | Spontaneous steoarthritis model mice | RBRC06803 | This strain is an inbred line derived from STR/1N1)2). | 1) Osteoarthritis Cartilage. 2001 Feb;9(2):85-91. 2) Osteoarthritis Cartilage. 1994 Jun;2(2):103-9. |
| 23.04.27 | Menkes disease (OMIM: 309400) model mice | RBRC01261 | Menkes disease is an X-chromosome recessive genetic disorder caused by ATP7A gene mutations. This strain has a mutation in the Atp7a gene1). | 1) Genomics. 2006 Feb;87(2):191-9. |
| 23.04.27 | Menkes disease (OMIM: 309400) model mice | RBRC09617 | Menkes disease is an X-chromosome recessive genetic disorder caused by ATP7A gene mutations. This strain has a mutation in the Atp7a gene1)2)3). | 1) J Inherit Metab Dis. 1998 Jun;21(3):199-202. 2) Mamm Genome. 1997 Jun;8(6):407-10. 3) Nat Genet. 1994 Apr;6(4):369-73. |
| 23.03.02 | Nasu-Hakola disease (OMIM: 221770) responsible gene Tyrobp(DAP12) KO mice | RBRC11704 | This strain is reported to show the developmental arrest of osteoclasts and ligodendrocytes1)2)3)4)5). | 1) Cell Rep. 2021 Dec 14;37(11):110111. 2) EMBO J. 2020 Nov 16;39(22):e104464. 3) Sci Signal. 2019 Jan 15;12(564):eaar5514. 4) J Biol Chem. 2018 Mar 9;293(10):3793-3805. 5) J Clin Invest. 2003 Feb;111(3):323-32. |
| 23.03.02 | NGLY1 deficiency (OMIM: 615273) responsible gene Ngly1 KO mice | RBRC11332 | By crossing this strain JF1/Ms Ngly1-/+ mice with C57BL/6 Ngly1-/+ mice (RBRC06293), we can partially avoid embryonic lethality and obtain JF1/B6F1 Ngly1-/- mice1). | 1) Proc Jpn Acad Ser B Phys Biol Sci. 2021;97(2):89-102. |
| 23.03.02 | Fgf9 spontaneous mutant mice | RBRC09906 | This strain was reported to show elbow knee synostosis1)2)3)4). | 1) Histochem Cell Biol. 2020 Apr;153(4):215-223. 2) Hum Mol Genet. 2020 Aug 3;29(13):2148-2161. 3) Nat Genet. 2009 Mar;41(3):289-98. 4) Mamm Genome. 2002 Jul;13(7):341-4. |
| 23.03.02 | Vimentin phosphorylated Site amino acid substitution mice | RBRC11719 | This strain was reported to show some premature aging phenotypes1)2). | 1) Cells. 2019 Sep 1;8(9):1016. 2) J Biol Chem. 2013 Dec 13;288(50):35626-35. |
| 23.01.05 | A receptor of cytokine BAFFTnfrsf13c floxed mice | RBRC10245 | BAFF-R(Tnfrsf13c) gene encodes a receptor for the cytokine TNF family member BAFF. This strain has been used for analysis of B cell functions and autoimmun diseases1)2) | 1) Blood. 2011 Mar 17;117(11):3104-12. 2) J Immunol. 2004 Aug 15;173(4):2245-52. |
| 23.01.05 | A CDM family molecule DOCK2 KO mice | RBRC10168 | This strain is widely utilized in basic immunology and basic disease research1)2)3)4)5) | 1) Am J Pathol. 2022 Feb;192(2):226-238. 2) J Allergy Clin Immunol. 2019 Nov;144(5):1377-1390.e4. 3) J Immunol. 2018 Sep 1;201(5):1442-1451. 4) Nat Genet. 2017 Oct;49(10):1437-1449. 5) Nature. 2001 Aug 23;412(6849):826-31. |
| 23.01.05 | A cadherin superfamily CDH17 KO mice | RBRC09896 | This strain has been reported to show development of B cells and dysfunction of memory B cells1)2) | 1) PLoS One. 2015 Jan 22;10(1):e0117566. 2) Eur J Immunol. 2005 Mar;35(3):957-63. |
| 22.09.01 | Skin melanoma(OMIM:608035, 612263) model mice | RBRC00694 | This KRT14-Kitl Tg strain has been reported to show epidermal pigmentation1)2)3)4)5). | 1) J Invest Dermatol. 2017 May;137(5):1126-1134. 2) Cell Rep. 2017 Jun 13;19(11):2177-2184. 3) J Invest Dermatol. 2015 Jul;135(7):1829-1838. 4) Development. 1998 Aug;125(15):2915-23. 5) J Exp Med. 1998 May 18;187(10):1565-73. |
| 22.09.01 | Atopic dermatitis(OMIM:603165) model mice | RBRC06233 (Coisogenic strain) RBRC06234 (C57BL/6J background) RBRC06235 (BALB/c background) | These Trpv3 point mutation strains have been reported to show both non-hair and atopic dermatitis-like phenotypes1)2)3)4)5). | 1) J Invest Dermatol. 2009 Mar;129(3):714-22. 2) Immunology. 2007 May;121(1):51-61. 3) Biochem Biophys Res Commun. 2007 Nov 23;363(3):479-83. 4) Exp Anim. 2003 Oct;52(5):419-23. 5) Exp Anim. 1997 Jul;46(3):225-9. |
| 22.09.01 | IL4 KO mice | RBRC04920 (C57BL/6J background) RBRC04921 (BALB/c background) RBRC05130 (DBA/1 background) | This strain has been reported to show increased susceptibility to infection of parasites. In addition, this strain has been used for some immunology research1)2)3)4). | 1) Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):13057-13062. 2) Immunity. 2014 May 15;40(5):758-71. 3) Microbiol Immunol. 2000;44(12):971-9. 4) Nature. 1993 Mar 18;362(6417):245-8. |
| 22.07.01 | Cytokine signal inhibitor Socs1 floxed mice | RBRC04753 | This strain has been used for analysis of anti-inflammatory mechanism in some kind of cells (endothelial cells, hepatic cells, neurons, etc.)1)2)3)4)5). | 1) FASEB J. 2021 Apr;35(4):e21388. 2) J Immunol. 2018 Jan 1;200(1):177-185. 3) J Immunol. 2017 Jul 1;199(1):149-158. 4) Nat Immunol. 2017 Jan;18(1):54-63. 5) J Immunol. 2008 Mar 15;180(6):3746-56. |
| 22.07.01 | Cytokine signal inhibitor Socs3 floxed mice | RBRC04754 | This strain has been used for analysis of anti-inflammatory mechanism in some kind of cells (endothelial cells, hematopoietic cells, neurons, etc.) 1)2)3)4)5). | 1) J Biol Chem. Jan-Jun 2021;296:100239. 2) Neuron. 2021 Apr 21;109(8):1333-1349.e6. 3) EBioMedicine. 2021 Nov;73:103632. 4) JCI Insight. 2021 Jul 22;6(14):e147280. 5) Nat Immunol. 2003 Jun;4(6):551-6. |
| 22.07.01 | NF-κB negative regulator Tnfaip3(A20) floxed mice | RBRC05494 (Tnfaip3 floxed) RBRC05495 (Tnfaip3 KO) | These strains have been used for analysis of anti-inflammatory mechanism in some kind of cells (immune cells, hematopoietic cells, etc.)1)2)3). | 1) Int J Mol Sci. 2020 Apr 18;21(8):2830. 2) J Immunol. 2017 Jan 15;198(2):820-831. 3) PLoS One. 2014 Jan 31;9(1):e87425. |
| 22.05.06 | Angiogenic factor Angpt1 floxed mice | RBRC09330 | This strain has been used for some research such as various retinal diseases and diabetes mellitus1)2)3)4)5). | 1) Diabetes. 2019 Apr;68(4):774-786. 2) Sci Adv. 2019 Feb 13;5(2):eaau6732. 3) Nat Commun. 2018 Jun 22;9(1):2448. 4) Nat Commun. 2017 May 16;8:15296. 5) Sci Transl Med. 2013 Sep 18;5(203):203ra127. |
| 22.05.06 | Src point mutated (S75D) mice with progressive optic neuropathy-like phenotypes | RBRC10208 | The age-related retinal ganglion cell number reduction have been reported1)2). | 1) Sci Rep. 2017 Dec 1;7(1):16779. 2) J Biochem. 2003 May;133(5):563-9. |
| 22.05.06 | Mef2d KO mice with retinitis pigmentosa like phenotypes | RBRC09366 (Mef2d floxed) RBRC09367 (Mef2d KO) | Progressive retinal photoreceptor cell loss, abnormal retinal electroretinogram, shortening of the photoreceptor outer segment, and abnormal formation of photoreceptor ribbon synapses have been reported1)2). | 1) Cells. 2020 Apr 10;9(4):931. 2) Genes Cells. 2015 May;20(5):408-26. |
| 22.05.06 | Membrane scaffold protein Epb4.1l2 (4.1G) KO mice | RBRC09370 | Mislocalization of photoreceptor terminals in retinas and visual acuity impairments in an optokinetic response have been reported 1). | 1) Cell Rep. 2015 Feb 10;10(5):796-808. |
| 22.03.01 | Infantile-onset leukoencephalopathy model mice | RBRC10267 ( Mlc1-STOPtetO KI) RBRC10268 ( Mlc1-tetO KI) | These strains are capable of inducing KO or overexpression of Mlc1 gene. They reported to exhibit a phenotype similar to that of human pathology1). | 1) Glia. 2017 Jan;65(1):150-168. |
| 22.03.01 | Early infantile epileptic encephalopathy model mice | RBRC03654 | 7 repeats of the GCG triple is knocked into codon 330 of Arx gene1)2)3)4)5). | 1) Neurobiol Dis. 2021 Jun;153:105329. 2) Neuroscience. 2017 Aug 15;357:220-231. 3) Neurobiol Dis. 2017 Sep;105:245-256. 4) Hum Mol Genet. 2016 Dec 15;25(24):5433-5443. 5) Hum Mol Genet. 2009 Oct 1;18(19):3708-24. |
| 22.03.01 | Lissencephaly model mice | RBRC03438 RBRC03435 | Using these Arx KO strains, various results were reported1)2)3)4). | 1) Biol Open. 2017 Oct 15;6(10):1552-1568. 2) PLoS One. 2013 Jun 28;8(6):e68050. 3) Development. 2005 Feb;132(4):751-62. 4) Nat Genet. 2002 Nov;32(3):359-69. |
| 22.03.01 | Protrudin (Zfyve27) KO mice | RBRC10084 | Some behavioral abnormalities containig a depression-like phenotype were reported1). | 1) Mol Brain. 2020 Nov 10;13(1):146. |
| 22.01.05 | Cloned mice lines derived from antigen-specific CD4+ T cells | RBRC10902 RBRC10903 | These strains are useful for allergic-related research as animal model with allergic predisposition1). | 1) EMBO Rep. 2017 Jun;18(6):885-893. |
| 22.01.05 | Ca2+-dependent modulator Cys proteases Capn6 gene KO mice | RBRC06237 (C57BL/6) RBRC06238 (ICR) | Capn6 expression is observed in embryonic skeletal muscle and adult regenerated skeletal muscle. These strains are useful for research related with development and regeneration of skeletal muscle1)2). | 1) J Clin Invest. 2016 Sep 1;126(9):3417-32. 2) PLoS Genet. 2013;9(8):e1003668. |
| 22.01.05 | Axon guidance molecule Sema4d gene KO mice | RBRC10202 (C.B17/Icr-+/+Jcl) | This strain has been reported to have high reproducibility of focal cerebral infarction by middle cerebral artery occlusion1)2)3)4)5). | 1) Biochem Biophys Res Commun. 2020 Jan 22;521(4):827-832. 2) Neuroscience. 2019 May 15;406:420-431. 3) Glia. 2015 Dec;63(12):2249-59. 4) J Exp Stroke Transl Med. 2010 Mar;3(1):28-33. 5) J Neurosci Res. 2009 Oct;87(13):2833-41. |
| 22.01.05 | Sema4D receptor Plxnb1 gene KO mice | RBRC10201 (C.B17/Icr-+/+Jcl) | This strain has been reported to have high reproducibility of focal cerebral infarction by middle cerebral artery occlusion1)2)3). | 1) J Exp Stroke Transl Med. 2010 Mar;3(1):28-33. 2) Development. 2008 Oct;135(20):3333-43. 3) Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13188-93. |
| 21.11.01 | Major components of stratum corneum Flg (filaggrin) gene KO mice1) | RBRC05850 (C57BL/6J) RBRC05851 (BALB/c) | These strains were used for research of skin diseases2)3)4). | 1) J Allergy Clin Immunol. 2012 Jun;129(6):1538-46.e6. 2) J Dermatol Sci. 2019 Jun;94(3):346-349. 3) Immunity. 2015 Apr 21;42(4):756-66. 4) Sci Rep. 2013;3:1731. |
| 21.11.01 | GPI-anchored membrane protein Cd109 gene KO mice1) | RBRC09599 | CD109 is highly expressed in several types of human cancers. Analysis of this strains indicated the relationship between Cd109 and some diseases2)3)4)5). | 1) Am J Pathol. 2012 Oct;181(4):1180-9. 2) Cell Rep. 2019 Oct 8;29(2):391-405.e5. 3) Genes Cells. 2018 Jul;23(7):590-598. 4) J Pathol. 2017 Dec;243(4):468-480. |
| 21.11.01 | Foxp2[R552H] KI mice | RBRC04059 RBRC04060 | These strains carry a Foxp2[R552H] mutation related to human speech-language disorder1)2)3)4)5). | 1) Cereb Cortex. 2017 Jul 1;27(7):3648-3659. 2) Neurosci Lett. 2014 Apr 30;566:162-6. 3) J Neurochem. 2012 Jul;122(1):72-80. 4) Neurosci Lett. 2012 Jan 11;506(2):277-80. |
| 21.11.01 | GPI-anchored membrane protein Mdga1 KO mice | RBRC05286 RBRC10977 RBRC10978 | These strains were reported to show several cognitive learning disorder or schizophrenia-like phenotypes1)2)3)4). | 1) Neurosci Lett. 2020 Jan 18;716:134677. 2) Cell Rep. 2017 Dec 26;21(13):3637-3645. 3) Neuroscience. 2012 Jun 1;211:136-64. 4) Dev Dyn. 2011 Jan;240(1):96-107. |
| 21.09.01 | Usher syndrome type 2C (OMIM:605472) responsible gene Adgrv1(Vlgr1,Gpr98) KO mice | RBRC09313 (KO) RBRC09315 (KO) RBRC09314 (EYFP KI) | These strains were reported to show auditory abnormalities1)2)3)4)5). | 1) Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):7765-7774. 2) J Clin Endocrinol Metab. 2012 Apr;97(4):E565-74. 3) Neurosci Lett. 2009 Sep 18;461(2):190-5. 4) J Neurosci. 2007 Jun 13;27(24):6478-88. 5) J Neurochem. 2005 Jan;92(1):191-202. |
| 21.09.01 | Prader-Willi syndrome (OMIM:176270) responsible gene Necdin(Ndn) KO mice | RBRC09382 (B6) RBRC09363 (ICR) RBRC02316 (ICR and B6 mixed) | These strains were reported to show behavioral and neuromorphological abnormalities1)2)3)4)5). | 1) Nat Commun. 2016 Mar 14;7:10943. 2) PLoS One. 2014 Jan 2;9(1):e84460. 3) J Neurosci. 2013 Jun 19;33(25):10362-73. 4) J Neurosci. 2012 Apr 18;32(16):5562-72. 5) J Neurosci. 2005 Jul 27;25(30):7090-9. |
| 21.09.01 | Congenital stationary night blindness responsible gene Trpm1 KO mice | RBRC05509 (B6) RBRC05138 (129) | These strains were reported to show vision abnormalities1)2)3)4)5). | 1) Mol Brain. 2021 Mar 30;14(1):61. 2) J Neurosci. 2017 Oct 11;37(41):9889-9900. 3) PLoS One. 2013 Nov 25;8(11):e81507. 4) Eur J Neurosci. 2013 Sep;38(6):2823-31. 5) Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):332-7. |
| 21.09.01 | SNARE protein family Snap25 gene amino acid substitution mice | RBRC09306 | This strain was reported to show behavioral disorders1)2)3)4). | 1) Sci Rep. 2017 Aug 11;7(1):7996. 2) Epilepsy Res. 2015 Sep;115:30-44. 3) J Neurosci. 2012 Nov 28;32(48):17186-96. 4) PLoS One. 2011;6(9):e25158. |
| 21.07.01 | One subunit of NMDA receptor Grin2a gene KO mice1) | RBRC01195 (C57BL/6J) RBRC02256 (B6 and 129 mixed) | These strains were used for research of neural mechanism2)3) or NMDA receptor-related neural disorders4). | 1) J Neurosci. 1996 Dec 15;16(24):7859-67. 2) Proc Natl Acad Sci U S A. 2019 Oct 15;116(42):21207-21212. 3) Nat Neurosci. 2011 Mar;14(3):338-44. 4) Cell Rep. 2020 Jan 14;30(2):381-396.e4. |
| 21.07.01 | Synaptic protein Stxbp1 (Munc18-1) gene floxed mice | RBRC05604 | Analysis of this strain revealed a novel mechanism to trigger epilepsy1)2). | 1) Nat Commun. 2019 Apr 23;10(1):1917. 2) Hum Mol Genet. 2017 Dec 15;26(24):4961-4974. |
| 21.07.01 | Serine protease Klk8 (Neuropsin) gene KO mice1) | RBRC02740 | The relationship between some behavior disorders (social discrimination behavior2), cognitive disorders3), stress disorders4), etc.) and Neuropsin was indicated by analysis of this strain. | 1) Mol Cell Neurosci. 2001 Mar;17(3):600-10. 2) Neurobiol Learn Mem. 2019 Jul;162:47-58. 3) Transl Psychiatry. 2017 Mar 7;7(3):e1052. 4) PLoS Genet. 2016 Oct 4;12(10):e1006356. |
| 21.07.01 | Secreted glycoprotein Reln (Reelin) gene C-terminal deficient mice1) | RBRC03079 | This strain was reported to show several neuropsychiatric or behavior disorders2)3). | 1) J Neurosci. 2015 Mar 18;35(11):4776-87. 2) Neuroscience. 2016 Nov 12;336:20-29. 3) Sci Rep. 2016 Jun 27;6:28636. |
| 21.04.27 | Downstream factor of IL-17 signaling pathway Nfkbiz (IκB-ζ) floxed mice1) | RBRC06410 | This strain is useful for Nfkbiz functional analyisis in various kinds of cells2)3)4)5). Recently, the relationship between ulcerative colitis and NHKBIZ was indicated by using this strain6). | 1) Immunity. 2013 Mar 21;38(3):450-60. 2) J Immunol. 2020 Apr 15;204(8):2033-2042. 3) JCI Insight. 2019 Nov 14;4(22):e130835. 4) Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):10088-10093. 5) Mouse of the Month Apr 2017 6) Nature. 2020 Jan;577(7789):260-265. |
| 21.04.27 | Tyrosine kinase receptor family EphB6 KO mice1) | RBRC02280 | The relationship between metastatic process of colorectal cancer and EPHB6 was indicated by analysis of this strain2). | 1) Biochem Biophys Res Commun. 2002 Oct 18;298(1):87-94. 2) Sci Rep. 2017 Mar 6;7:43702. |
| 21.04.27 | ROS1-fusion positive lung cancer model mice | RBRC09696 (CD74-ROS1 Tg) RBRC09697 (SDC4-ROS1 Tg) | These strains are Tg mice expressing CD74-ROS1 or SDC4-ROS1 fusion proteins which have been reported in human lung cancer cases1). | 1) Carcinogenesis. 2016 May;37(5):452-60. |
| 21.04.27 | Glycolysis enzyme PKM (pyruvate kinase M) mutant mice | RBRC10481 (PKM1 KI) RBRC10482 (PKM2 KI) | These strains selectively expressing PKM splicing isoforms (PKM1 or PKM2) were developed to analyze glycolytic enzyme PKM function for cancer glucose metabolism (Warburg effect)1). | 1) Cancer Cell. 2018 Mar 12;33(3):355-367.e7. |
| 21.03.01 | Autism spectrum disorder model mice | RBRC05954 | This strain is a mouse model of human 15q11–13 duplication1)2)3)4). Using functional MRI, neural circuit dysfunction in this strain was reported5). | 1) Sci Rep. 2018 Sep 12;8(1):13675. 2) Sci Rep. 2017 Aug 29;7(1):9902. 3) Mouse of the Month April 2015. 4) Cell. 2009 Jun 26;137(7):1235-46. 5) Sci Adv. 2020 Feb 5;6(6):eaav4520. |
| 21.03.01 | Ednrb (endothelin receptor type B) KO mice1) | RBRC06163 | This strain was reported as a Hirschsprung's disease2), melanoma3) or Waardenburg syndrome4) model. | 1) Cell. 1994 Dec 30;79(7):1267-76. 2) Development. 1998 Mar;125(5):825-36. 3) Cancer Res. 2010 Jan 1;70(1):24-9. 4) J Biol Chem. 2011 Aug 26;286(34):29621-6. |
| 21.03.01 | Lymphoedema-distichiasis syndrome responsible gene Foxc2 floxed mice | RBRC10306 | The phenotype analysis results of Foxc2 conditionally deleted mice in kidneys were reported1). | 1) Mamm Genome. 2016 Feb;27(1-2):62-9. |
| 21.03.01 | TPST2 enzymatic activity deficient mice | RBRC05261 | This strain is reported to show a growth retardation with hypothyroidism1)2)3). | 1) Biomed Res. 2010 Jun;31(3):207-11. 2) J Vet Med Sci. 2008 Oct;70(10):1043-9. 3) Mol Endocrinol. 2007 Jul;21(7):1713-21. |
| 21.01.04 | Vitamin D receptor VDR KO mice1)2) | RBRC05885 | This strain shows osteoporosis and rickets-like phenotypes. Therefore, it is utilized to reveal the relationship between vitamin D and osteogenesis3)4)5). | 1) Endocrinology. 2000 Apr;141(4):1317-24. 2) Nat Genet. 1997 Aug;16(4):391-6. 3) Biochem Biophys Res Commun. 2017 Jan 29;483(1):359-365. 4) Endocrinology. 2017 Jun 1;158(6):1951-1963. 5) Sci Rep. 2017 Aug 10;7(1):7786. |
| 21.01.04 | A kind of GPCR GPRC5B KO mice1) | RBRC10166 | Analysis of this strain suggested that GPRC5B is related with obesity-associated inflammatory signaling and synapse formation in Purkinje cells2)3). | 1) Biochem Biophys Res Commun. 2011 Sep 2;412(3):460-5. 2) Sci Signal. 2012 Nov 20;5(251):ra85. 3) Neurosci Res. 2018 Nov;136:33-47. |
| 21.01.04 | ACAM(CLMP) Tg mice controlled by adipocyte P2 promoter | RBRC06443 RBRC06444 RBRC06445 | In response to high fat-high sucrose diet feeding, these strains show resistance to obesity and diabetes1)2)3). | 1) J Lipid Res. 2000 Oct;41(10):1615-22. 2) Biochem J. 2005 Apr 15;387(Pt 2):343-53. 3) Diabetes. 2016 May;65(5):1255-67. |
| 21.01.04 | Phosphatidylcholine biosynthetic enzyme Pemt KO mice | RBRC06436 | In response to high fat-high sucrose diet feeding, these strains show not only resistance to obesity and diabetes but also non-alcoholic steatohepatitis1)2). | 1) Sci Rep. 2016 Feb 17;6:21721. 2) PLoS One. 2014 Mar 25;9(3):e92647. |
| 20.10.23 | Human renin・human angiotensinogen double Tg mice | RBRC01122 (hRN Tg) RBRC01123 (hAG Tg) RBRC02432 (F1(hRN × hAG)) | These strains were contributed to some results as Tsukuba Hypertensive mice1)2)3). Additionally, these are known as pregnancy-induced hypertension models4)5). | 1) Eur J Histochem. 2018 Jul 24;62(3):2930. 2) Mouse of the Month May 2012 3) Biochem Biophys Res Commun. 1991 Oct 31;180(2):1103-9.v 4) Sleep. 2018 Mar 1;41(3). 5) Sci Signal. 2017 May 16;10(479):eaam5711. |
| 20.10.23 | Prolin isomerase Pin1-KO mice1)2) | RBRC10368 | Analysis of this strain suggested the relationship between PIN1 and various biological phenomenon and diseases3)4)5). | 1) Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1335-40. 2) Biochem Biophys Res Commun. 1999 Nov 30;265(3):658-63. 3) Hum Mol Genet. 2018 Nov 15;27(22):3827-3839. 4) Biochem Biophys Res Commun. 2018 Feb 26;497(1):388-393. 5) Biochem Biophys Res Commun. 2017 Nov 18;493(2):946-951. |
| 20.10.23 | p53-target gene Tigar-KO mice | RBRC10981 | Analysis of this strain suggested the relationship between TIGAR and cardiac metabolism1)2). | 1) Am J Physiol Heart Circ Physiol. 2019 Jun 1;316(6):H1366-H1377. 2) J Mol Cell Cardiol. 2012 Jan;52(1):175-84. |
| 20.10.23 | Endogenous membrane protein Aqp7-KO mice | RBRC06294 | Analysis of this strain suggested the relationship between AQP7 and various metabolism pathways1)2)3). | 1) Cardiovasc Res. 2009 Jul 1;83(1):34-41. 2) Proc Natl Acad Sci U S A. 2005 Aug 2;102(31):10993-8. 3) Proc Natl Acad Sci U S A. 2004 Dec 21;101(51):17801-6. |
| 20.03.02 | Endoplasmic reticulum (ER) transmembrane protein IRE1α(ERN1)-KO/cKO mice1)| RBRC05515 | (floxed) RBRC05516 (KO) These strains are utilized to reveal the relationship between ER stress and some diseases2)3)4). | 1) Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16657-62. |
2) Nat Commun. 2018 Dec 17;9(1):5340. 3) Nature. 2018 Oct;562(7727):423-428. 4) J Cell Biol. 2018 Apr 2;217(4):1287-1301. |
| 20.03.02 | Tumor necrosis factor (TNF) receptor-associated factor TRAF6-KO mice1) | RBRC04950 (C57BL/6) RBRC05386 (BALB/c) | These strains show various disorders like ectodermal dysplasia, osteopertrosis, autoimmunity and so on2)3)4)5). | 1) Genes Cells. 1999 Jun;4(6):353-62. 2) Commun Biol. 2019 Aug 6;2:292. 3) Proc Natl Acad Sci U S A. 2017 Aug 22;114(34):E7140-E7149. 4) J Biol Chem. 2017 Jun 16;292(24):10169-10179. 5) Mouse of the Month Sep 2012 |
| 20.03.02 | Tubulin glutamylation enzyme TTLL1-KO mice | RBRC03327 | This strain shows primary ciliary dyskinesia-like phenotype1)2)3). | 1) Sci Rep. 2018 Feb 13;8(1):2904. 2) PLoS One. 2015 Nov 18;10(11):e0141823. 3) Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10490-5. |
| 20.03.02 | Apoptosis-related transmembrane receptor FAS-KO mice | RBRC01474 (C57BL/6) RBRC01476 (MRL) | These strains show autoimmune lymphoproliferative syndrome (OMIM: 601859)-like phenotype1)2)3)4). | 1) Proc Natl Acad Sci U S A. 1996 Mar 5;93(5):2131-6. 2) Nat Genet. 1995 Nov;11(3):294-300. 3) Eur J Immunol. 2013 Jul;43(7):1789-98. 4) J Exp Med. 2013 Sep 23;210(10):2087-103. |
| 20.01.06 | Spinal and bulbar muscular atrophy (SBMA) model mice | RBRC00344 | This strain shows some phenotypes similar to human patients. It is utilized to explore molecular mechanisms and therapeutic agents1) 2) 3). | 1) Hum Mol Genet. 2018 Jul 15;27(14):2425-2442. 2) J Neurosci. 2016 May 4;36(18):5094-106. 3) Neuron. 2002 Aug 29;35(5):843-54. |
| 20.01.06 | Limb-girdle muscular dystrophy type 2A (LGMD2A) model mice | RBRC04787 | CAPN3 protease activity-deficient mice show muscular disease-like phenotypes1) 2) 3). | 1) Hum Mol Genet. 2018 May 1;27(9):1642-1653. 2) J Clin Invest. 2010 Aug;120(8):2672-83. 3) J Biol Chem. 2010 Jul 23;285(30):22986-98. |
| 20.01.06 | Sporadic amyotrophic lateral sclerosis (ALS) model mice | RBRC09428 | This strain shows some phenotypes similar to human patients. It is utilized to explore molecular mechanisms and therapeutic agents1) 2) 3) 4). | 1) Sci Rep. 2017 Jan 3;7:39994. 2) Sci Rep. 2016 Jun 28;6:28649. 3) J Neurosci. 2010 Sep 8;30(36):11917-25. 4) Mouse of the Month Nov 2015. |
| 20.01.06 | Familial amyotrophic lateral sclerosis (ALS) model mice | RBRC09642 RBRC09643 RBRC09644 | Tg mice harboring mutated human SOD1 show progressive motor neuron disease-like phenotypes1). | 1) Hum Mol Genet. 2015 Jun 15;24(12):3427-39. |
| 19.11.06 | Disc1 point mutated (L100P) mice with schizophrenia-like phenotypes | RBRC06364 | This strain is a schizophrenia model, which established by ENU mutagenesis 1) 2) 3) 4). | 1) Neuron. 2007 May 3;54(3):387-402. 2) Front Cell Neurosci. 2018 Aug 2;12:238. 3) Behav Brain Res. 2017 Mar 1;320:113-118. 4) Schizophr Bull. 2017 Jan;43(1):214-225. |
| 19.11.06 | Disc1 point mutated (Q13L) mice with depression-like phenotypes | RBRC06365 | This strain is a endogenous depression model, which established by ENU mutagenesis 1) 2) 3). | 1) Neuron. 2007 May 3;54(3):387-402. 2) Neuroscience. 2016 May 3;321:99-107. 3) PLoS One. 2014 Oct 1;9(10):e108088. |
| 19.11.06 | CaMKIIα point mutated (K42R) mice with learning and memory deficits | RBRC05821 RBRC05636 | CaMKIIα kinase activity-deficient mice shows hippocampus-dependent learning and memory deficits 1) 2) 3). | 1) eNeuro. 2018 Aug 21;5(4). pii: ENEURO.0133-18.2018. 2) Genes Dev. 2014 May 15;28(10):1101-10. 3) J Neurosci. 2009 Jun 10;29(23):7607-18. |
| 19.11.06 | Metabotropic glutamate receptor 2 (mGluR2)-KO mice 1) | RBRC01351 | Analysis of this strain suggested the relationship between mGluR2 and schizophrenia 2) 3) 4). | 1) Science. 1996 Aug 2;273(5275):645-7. 2) Sci Signal. 2016 Jan 12;9(410):ra5. 3) J Neurosci. 2016 Nov 9;36(45):11521-11531. 4) PLoS One. 2015 May 7;10(5):e0125523. |
| 19.09.03 | GPI-anchored protein CD109-KO mice1) 2) | RBRC05911 | This strain shows osteopenia3) and psoriasis-like epidermal hyperplasia4). In addition, CD109 is known to be a regulator of tumor progression5). | 1) Pathol Int. 2019 May;69(5):249-259. 2) Mouse of the Month Nov 2013. 3) Genes Cells. 2018 Jul;23(7):590-598. 4) Am J Pathol. 2012 Oct;181(4):1180-9. 5) J Pathol. 2017 Dec;243(4):468-480. |
| 19.09.03 | G protein-coupled receptor BLT2-KO mice | RBRC04741 RBRC04742 | This strain shows not only DSS-induced colitis exacerbation1) but also delayed skin or corneal wound healing 2) 3) 4). | 1) FASEB J. 2010 Dec;24(12):4678-90. 2) Sci Rep. 2017 Oct 16;7(1):13267. 3) FASEB J. 2016 Feb;30(2):933-47. 4) J Exp Med. 2014 Jun 2;211(6):1063-78. |
| 19.09.03 | Scott syndrome (OMIM: 262890) disease gene Ano6 (Tmem16F) floxed mice1) | RBRC09797 | Platelet-specific Ano6-null mice shows a mild bleeding disorder similar to the human condition2). | 1) J Biol Chem. 2013 May 10;288(19):13305-16. 2) Proc Natl Acad Sci U S A. 2015 Oct 13;112(41):12800-5. |
| 19.09.03 | Winchester syndrome (OMIM: 277950) disease gene Mmp14 (MT1-MMP) KO/LacZ KI mice | RBRC05977 | Mmp14-null mice shows severve osteolysis. In addition, this strain is useful for Mmp14 expression analysis1) 2) 3) 4) 5). | 1) Development. 2013 Jan 15;140(2):343-52. 2) Dev Cell. 2013 May 28;25(4):402-16. 3) Diabetes. 2010 Oct;59(10):2484-94. 4) Genes Cells. 2009 May;14(5):617-26. 5) J Cell Sci. 2007 May 1;120(Pt 9):1607-14. |
| 19.07.01 | ATR-X syndrome (OMIM: 301040) model mice | RBRC04937 | This is a Atrx (disease gene) knockout mouse strain, which shows some abnormal phenotypes similar to the human condition1) 2) and is utilized to explore therapeutic agents3). | 1) J Neurosci. 2011 Jan 5;31(1):346-58. 2) Hippocampus. 2011 Jun;21(6):678-87. 3) Nat Med. 2018 Jun;24(6):802-813. |
| 19.07.01 | Cardio-facio-cutaneous syndrome-1 (OMIM: 115150) model mice | RBRC09730 RBRC09731 RBRC09907 RBRC09908 | This is a Braf (disease gene) point mutation knockin mouse strain, which shows some abnormal phenotypes similar to the human condition1) 2) 3) 4). | 1) Hum Mol Genet. 2019 Jan 1;28(1):74-83. 2) Hum Mol Genet. 2017 Dec 1;26(23):4715-4727. 3) Hum Mol Genet. 2015 Dec 20;24(25):7349-60. 4) Hum Mol Genet. 2014 Dec 15;23(24):6553-66. |
| 19.07.01 | Chédiak-Higashi syndrome (OMIM: 214500) model mice | RBRC00134 | This is a Lyst (disease gene) spontaneous mutation mouse strain, which shows some abnormal phenotypes similar to the human condition1) and is utilized to analyze the mechanism2) 3). | 1) Nature. 1996 Jul 18;382(6588):262-5. 2) Mol Genet Metab. 2010 Apr;99(4):389-95. 3) J Biol Chem. 1997 Nov 21;272(47):29790-4. |
| 19.07.01 | Griscelli syndrome cutaneous and neurologic type (OMIM: 214450) model mice | RBRC02978 | This is a Myo5a (disease gene) spontaneous point mutation mouse strain, which shows abnormal pigmentation and neurological impairment similar to the human condition1) 2). | 1) J Neurosci. 2011 Apr 20;31(16):6067-78. 2) Genetics. 1998 Apr;148(4):1963-72. |
