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Cryopreservation of Mouse Embryos by Ethylene Glycol-Based Vitrification
JoVE 3155 11/18/2011

Today’s tool for functional analysis / Today’s model for human disease





DateTitleBRC No.DescriptionReferences
19.12.02Cre-driver mice for CRF neuronRBRC06520Crh (corticotropin-releasing hormone) Cre KI strain is useful for stress response research 1) 2).1) Sci Adv. 2016 Aug 17;2(8):e1501723.
2) Endocrinology. 2014 Oct;155(10):4054-60.
19.12.02Crh gene reporter miceRBRC09893Crh (corticotropin-releasing hormone) Venus KI strain allows the visualization of CRF neurons 1) 2) 3).1) Biol Sex Differ. 2019 Jan 28;10(1):6.
2) Brain Struct Funct. 2017 May;222(4):1705-1732.
3) Endocrinology. 2014 Oct;155(10):4054-60.
19.12.02Cre-driver mice for Oligodendrocyte lineage and motoneuronRBRC01507Olig2-tamoxifen inducible Cre KI strain is frequently used in neuroscience 1) 2) 3) 4) 5).1) Nat Neurosci. 2018 May;21(5):696-706.
2) Science. 2014 Sep 26;345(6204):1254927.v
3) Mouse of the Month July 2006
4) Dev Biol. 2006 May 15;293(2):358-69.
5) Curr Biol. 2002 Jul 9;12(13):1157-63.
19.12.02Transcription factor Olig2 reporter miceRBRC06017
RBRC06018
RBRC06022
This strain express Venus, mCherry or luciferase-OLIG2 fusion protein 1).1) Science. 2013 Dec 6;342(6163):1203-8.
19.12.02Cre-driver mice for dorsal telencephalonRBRC01345Emx1 (empty spiracles homeobox 1) Cre KI strain is frequently used in neuroscience 1) 2) 3) 4) 5).1) Nat Commun. 2019 Aug 8;10(1):3581.
2) Nat Commun. 2017 May 23;8:15488.
3) Mouse of the Month July 2006
4) Genesis. 2004 Mar;38(3):130-8.
5) Nature. 2000 Aug 17;406(6797):726-31.
19.12.02Cre-driver mice for developing cochleaeRBRC02272Emx2 (empty spiracles homeobox 2) Cre KI strain 1) is useful for inner ear development research 2) 3) 4).1) J Neurosci. 2005 May 25;25(21):5097-108.
2) J Neurosci. 2019 Oct 9;39(41):8013-8023.
3) Dev Biol. 2018 May 1;437(1):17-26.
4) Development. 2018 Jun 14;145(12).
19.10.01Cellualar oxidative stress imaging miceRBRC057041)
RBRC061612)
Nrf2 (oxidative stress-responsive transcription factor) reporter mice were utilized for the elucidation of oxidative stress sensing mechanism3).1) Sci Rep. 2012;2:229.
2) Free Radic Biol Med. 2014 Jul;72:124-33.
3) Cell Rep. 2019 Jul 16;28(3):746-758.e4.
19.10.01ROS production conditionally regulatable mice1)RBRC09859This strain expresses SDAD (ROS homeostasis-related enzyme) defective mutants according to Cre recombinase.1) Eur J Immunol. 2017 Feb;47(2):406-418.
19.10.01Sperm-egg fusion imaging mice1)RBRC05763Izumo1 (sperm acrosomal gene) reporter strain is useful for the elucidation of gamete fusion mechanism2) 3).1) J Cell Sci. 2012 Nov 1;125(Pt 21):4985-90.
2) Cell Cycle. 2018;17(11):1279-1285.
3) Nat Commun. 2015 Nov 16;6:8858.
19.10.01Sperm acrosome−GFP:
sperm mitochondria−DsRed
dual reporter mice1)
RBRC03743
RBRC05861
This strain is useful for the elucidation of fertilization or acrosome reaction mechanism2) 3) 4).1) Exp Anim. 2010;59(1):105-7.
2) J Cell Biol. 2018 Jun 4;217(6):2103-2119.
3) J Biol Chem. 2018 Jul 27;293(30):11796-11808.
4) Biol Reprod. 2016 Apr;94(4):80.
19.08.01Cre-driver mice for orexin neuronsRBRC06806This strain expresses Cre recombinase and EGFP in orexin neurons1) 2).1) Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):E10740-E10747.
2) Neuropharmacology. 2014 Oct;85:451-60.
19.08.01Full maturated OSN (olfactory sensory neuron) reporter mice1)RBRC02092OMP (olfactory marker protein) gene-GFP KI mice are broadly utilized for olfactory analysis2) 3) 4).1) J Neurosci. 2001 Dec 15;21(24):9713-23.
2) J Neurosci. 2019 Jan 30;39(5):814-832.
3) Cell Stem Cell. 2017 Dec 7;21(6):761-774.e5.
4) Cell. 2016 Jun 16;165(7):1734-1748.
19.08.01Selenocysteine-tRNA (Trsp) floxed mice1)RBRC02681This strain was utilized for an oxidative stress model2) 3).1) J Biol Chem. 2008 Jan 25;283(4):2021-30.
2) Cell Rep. 2017 Feb 21;18(8):2030-2044.
3) Blood. 2011 Jan 20;117(3):986-96.
19.08.01Neuronally enriched Rufy3 KO-first miceRBRC05780Analysis of this strain revealed that RUFY3 is essential for caspase-mediated axon degeneration1).1) Neuron. 2019 Jun 7. pii: S0896-6273(19)30483-0. 
19.06.03Cre-driver mice for postnatal somatic motor neuronsRBRC01515
RBRC01516
These strain express Cre recombinase in slow type motor neurons1) 2).1) Genesis. 2016 Nov;54(11):568-572.
2) Brain Res. 2014 Mar 6;1550:36-46.
19.06.03Mitochondria-EGFP labeled mice1) 2)RBRC02250This transgenic strain is utilized to identify and monitor the mitochondorial morphology3) 4).1) Exp Anim. 2010;59(1):99-103.
2) FEBS Lett. 2001 Jun 29;500(1-2):7-11.
3) Sci Transl Med. 2017 Oct 25;9(413).
4) PLoS One. 2012;7(6):e36850.
19.06.03Zinc transporter Slc39a10 (Zip10) floxed miceRBRC06221Analysis of this strain revealed novel functions of Slc39a10 in humoral immune system1) 2) and epidermal development3).1) Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):11786-91.
2) Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):11780-5.
3) Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):12243-12248.
19.06.03Cell adhesion molecule Cadm1 (SynCAM1) KO miceRBRC04062This strain was utilized for analysis of not only nervous system1) 2) 3) but also bone turnover4).1) J Neurosci. 2016 Jul 13;36(28):7464-75.
2) Neuron. 2010 Dec 9;68(5):894-906.
3) Biochem Biophys Res Commun. 2010 Jun 4;396(3):703-8.
4) PLoS One. 2017 Apr 17;12(4):e0175632.
19.04.01Cre-driver mice for myelinating cells of the central nervous system1)RBRC01461This strain is useful for the elucidation of gene function in oligodendrocyte myelination2).1) Genesis. 2000 Feb;26(2):127-9.
2) Nat Commun. 2016 Nov 23;7:13478.
19.04.01Oct3/4 (Pou5f1) reporter miceRBRC007711)
RBRC060372)
These strains are useful for stem cell research because they express EGFP under the control of pluripotency marker Oct3/43) 4) 5).1) Dev Biol. 2003 Jun 1;258(1):209-25.
2) Development. 2008 Mar;135(5):909-18.
3) Cell Res. 2011 Jan;21(1):196-204.
4) Dev Biol. 2010 Oct 1;346(1):90-101.
5) Stem Cells. 2009 Feb;27(2):383-9.
19.04.01Fgf5 spontaneous mutant miceRBRC05894
RBRC05895
This strain shows abnormal hair follicle cycle1). In addition, it contributed to the research about spermatogenic stem cells2).1) Exp Anim. 2011;60(2):161-7.
2) Cell Stem Cell. 2019 Jan 3;24(1):79-92. e6.
19.04.01Fstl4 (Mahya) reporter miceRBRC04952This strain is useful for revolutionary genetic research1)In addition, it was used to monitor specific subtypes of retinal ganglion cells2).1) Dev Genes Evol. 2005 Nov;215(11):564-74.
2) Curr Eye Res. 2016 Apr;41(4):558-68.


DateTitleBRC No.DescriptionReferences
20.01.06Spinal and bulbar muscular atrophy (SBMA) model miceRBRC00344This strain shows some phenotypes similar to human patients. It is utilized to explore molecular mechanisms and therapeutic agents1) 2) 3).1) Hum Mol Genet. 2018 Jul 15;27(14):2425-2442.
2) J Neurosci. 2016 May 4;36(18):5094-106.
3) Neuron. 2002 Aug 29;35(5):843-54.
20.01.06Limb-girdle muscular dystrophy type 2A (LGMD2A) model miceRBRC04787CAPN3 protease activity-deficient mice show muscular disease-like phenotypes1) 2) 3).1) Hum Mol Genet. 2018 May 1;27(9):1642-1653.
2) J Clin Invest. 2010 Aug;120(8):2672-83.
3) J Biol Chem. 2010 Jul 23;285(30):22986-98.
20.01.06Sporadic amyotrophic lateral sclerosis (ALS) model mice RBRC09428This strain shows some phenotypes similar to human patients. It is utilized to explore molecular mechanisms and therapeutic agents1) 2) 3) 4).1) Sci Rep. 2017 Jan 3;7:39994.
2) Sci Rep. 2016 Jun 28;6:28649.
3) J Neurosci. 2010 Sep 8;30(36):11917-25.
4) Mouse of the Month Nov 2015.
20.01.06Familial amyotrophic lateral sclerosis (ALS) model mice RBRC09642
RBRC09643
RBRC09644
Tg mice harboring mutated human SOD1 show progressive motor neuron disease-like phenotypes1).1) Hum Mol Genet. 2015 Jun 15;24(12):3427-39.
19.11.06Disc1 point mutated (L100P) mice with schizophrenia-like phenotypesRBRC06364This strain is a schizophrenia model, which established by ENU mutagenesis 1) 2) 3) 4).1) Neuron. 2007 May 3;54(3):387-402.
2) Front Cell Neurosci. 2018 Aug 2;12:238.
3) Behav Brain Res. 2017 Mar 1;320:113-118.
4) Schizophr Bull. 2017 Jan;43(1):214-225.
19.11.06Disc1 point mutated (Q13L) mice with depression-like phenotypesRBRC06365This strain is a endogenous depression model, which established by ENU mutagenesis 1) 2) 3).1) Neuron. 2007 May 3;54(3):387-402.
2) Neuroscience. 2016 May 3;321:99-107.
3) PLoS One. 2014 Oct 1;9(10):e108088.
19.11.06CaMKIIα point mutated (K42R) mice with learning and memory deficits RBRC05821
RBRC05636
CaMKIIα kinase activity-deficient mice shows hippocampus-dependent learning and memory deficits 1) 2) 3).1) eNeuro. 2018 Aug 21;5(4). pii: ENEURO.0133-18.2018.
2) Genes Dev. 2014 May 15;28(10):1101-10.
3) J Neurosci. 2009 Jun 10;29(23):7607-18.
19.11.06Metabotropic glutamate receptor 2 (mGluR2)-KO mice 1)RBRC01351Analysis of this strain suggested the relationship between mGluR2 and schizophrenia 2) 3) 4).1) Science. 1996 Aug 2;273(5275):645-7.
2) Sci Signal. 2016 Jan 12;9(410):ra5.
3) J Neurosci. 2016 Nov 9;36(45):11521-11531.
4) PLoS One. 2015 May 7;10(5):e0125523.
19.09.03GPI-anchored protein CD109-KO mice1) 2)RBRC05911This strain shows osteopenia3) and psoriasis-like epidermal hyperplasia4). In addition, CD109 is known to be a regulator of tumor progression5).1) Pathol Int. 2019 May;69(5):249-259.
2) Mouse of the Month Nov 2013.
3) Genes Cells. 2018 Jul;23(7):590-598.
4) Am J Pathol. 2012 Oct;181(4):1180-9.
5) J Pathol. 2017 Dec;243(4):468-480.
19.09.03G protein-coupled receptor BLT2-KO miceRBRC04741
RBRC04742
This strain shows not only DSS-induced colitis exacerbation1) but also delayed skin or corneal wound healing 2) 3) 4). 1) FASEB J. 2010 Dec;24(12):4678-90.
2) Sci Rep. 2017 Oct 16;7(1):13267.
3) FASEB J. 2016 Feb;30(2):933-47.
4) J Exp Med. 2014 Jun 2;211(6):1063-78.
19.09.03Scott syndrome
(OMIM: 262890)
disease gene Ano6 (Tmem16F) floxed mice1)
RBRC09797Platelet-specific Ano6-null mice shows a mild bleeding disorder similar to the human condition2).1) J Biol Chem. 2013 May 10;288(19):13305-16.
2) Proc Natl Acad Sci U S A. 2015 Oct 13;112(41):12800-5.
19.09.03Winchester syndrome
(OMIM: 277950)
disease gene Mmp14 (MT1-MMP) KO/LacZ KI mice
RBRC05977Mmp14-null mice shows severve osteolysis. In addition, this strain is useful for Mmp14 expression analysis1) 2) 3) 4) 5).1) Development. 2013 Jan 15;140(2):343-52.
2) Dev Cell. 2013 May 28;25(4):402-16.
3) Diabetes. 2010 Oct;59(10):2484-94.
4) Genes Cells. 2009 May;14(5):617-26.
5) J Cell Sci. 2007 May 1;120(Pt 9):1607-14.
19.07.01ATR-X syndrome
(OMIM: 301040)
model mice
RBRC04937This is a Atrx (disease gene) knockout mouse strain, which shows some abnormal phenotypes similar to the human condition1) 2) and is utilized to explore therapeutic agents3).1) J Neurosci. 2011 Jan 5;31(1):346-58.
2) Hippocampus. 2011 Jun;21(6):678-87.
3) Nat Med. 2018 Jun;24(6):802-813.
19.07.01Cardio-facio-cutaneous syndrome-1
(OMIM: 115150)
model mice
RBRC09730
RBRC09731
RBRC09907
RBRC09908
This is a Braf (disease gene) point mutation knockin mouse strain, which shows some abnormal phenotypes similar to the human condition1) 2) 3) 4).1) Hum Mol Genet. 2019 Jan 1;28(1):74-83.
2) Hum Mol Genet. 2017 Dec 1;26(23):4715-4727.
3) Hum Mol Genet. 2015 Dec 20;24(25):7349-60.
4) Hum Mol Genet. 2014 Dec 15;23(24):6553-66.
19.07.01Chédiak-Higashi syndrome
(OMIM: 214500)
model mice
RBRC00134This is a Lyst (disease gene) spontaneous mutation mouse strain, which shows some abnormal phenotypes similar to the human condition1) and is utilized to analyze the mechanism2) 3).1) Nature. 1996 Jul 18;382(6588):262-5.
2) Mol Genet Metab. 2010 Apr;99(4):389-95.
3) J Biol Chem. 1997 Nov 21;272(47):29790-4.
19.07.01Griscelli syndrome
cutaneous and neurologic type
(OMIM: 214450)
model mice
RBRC02978This is a Myo5a (disease gene) spontaneous point mutation mouse strain, which shows abnormal pigmentation and neurological impairment similar to the human condition1) 2).1) J Neurosci. 2011 Apr 20;31(16):6067-78.
2) Genetics. 1998 Apr;148(4):1963-72.
19.05.08Ehlers-Danlos syndorome spondylodysplastic type 3
(OMIM: 612350)
model mice
RBRC06217This is a Slc39a13 (disease gene) knockout mouse strain, which shows defect of connective tissue similar to the human condition1) 2).1) PLoS Genet. 2017 Aug 30;13(8):e1006950.
2) PLoS One. 2008;3(11):e3642.
19.05.08Myoclonic epilepsy of Lafora
(OMIM: 254780)
model mice
RBRC02715This is a Epm2a (disease gene) knockout mouse strain, which shows progressive eurodegeneration similar to the human condition1) 2) 3).1) Hum Mol Genet. 2017 Dec 15;26(24):4778-4785.
2) Brain. 2014 Mar;137(Pt 3):806-18.
3) Hum Mol Genet. 2002 May 15;11(11):1251-62.
19.05.08Hirschsprung disease susceptibility to 1
(OMIM: 142623)
model mice
RBRC06249This is a Ret (disease gene) point mutation knockin mouse strain, which shows megacolon and deafness similar to the human condition1) 2) 3).1) Dev Biol. 2011 Jan 15;349(2):160-8.
2) Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13051-6.
3) Mol Cell Biol. 2004 Sep;24(18):8026-36.
19.05.08Mowat-Wilson syndrome
(OMIM: 235730)
model mice
RBRC01925This is a Zeb2 (disease gene) knockout mouse strain, which shows some abnormal phenotypes similar to the human condition1) 2) 3).1) Hum Mol Genet. 2007 Jun 15;16(12):1423-36.
2) Am J Hum Genet. 2003 Feb;72(2):465-70.
3) Genesis. 2002 Feb;32(2):82-4.