Today’s tool for functional analysis / Today’s model for human disease




DateTitleBRC No.DescriptionReferences
24.12.04ARMC12-targeted BioID Tg miceRBRC11045This strain expresses ARMC12 and biotin ligase BioID2 fusion protein under the control of the Clgn promoter.1)1) Proc Natl Acad Sci U S A. 2021 Feb 9;118(6):e2018355118.
24.12.04TESMIN-targeted BioID Tg miceRBRC11222This strain expresses TESMIN and biotin ligase TurboID fusion protein under the control of the Clgn promoter.1)1) Sci Rep. 2022 Dec 23;12(1):22198.
24.12.04TESMIN-targeted BioID Tg miceRBRC11665This strain expresses TESMIN and biotin ligase BioID2 fusion protein under the control of the Clgn promoter, and also has deletion of Tesmin gene.1)1) Sci Rep. 2022 Dec 23;12(1):22198.
24.04.01Cma1(Mcpt5)-DTR KI miceRBRC11317This strain is capable of inducing mast cell depletion by administration of DT (diphtherial toxin). 1)1) Biochem Biophys Res Commun. 2021 Apr 30:551:127-132.
24.04.01Msr1(Cd204)-DTR KI miceRBRC06357This strain is capable of inducing CD204-positive macrophages depletion by administration of DT (diphtherial toxin). 1)1) Biochem Biophys Rep. 2020 Aug 7:23:100791.
24.04.01Ly75(Cd205)-DTR KI miceRBRC05659This strain is capable of inducing mast CD205-positive cDCs (conventional dendritic cells) depletion by administration of DT (diphtherial toxin). 1)1) Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11288-93.
24.04.01Lyz2(Lysm)-DTR KI miceRBRC04394This strain is capable of inducing alveolar epithelial type II (AE2) cells and macrophages depletion by administration of DT (diphtherial toxin). 1)2)3)1) iScience. 2023 Jan 5;26(2):105934.
2) Nat Immunol. 2014 Nov;15(11):1064-9.
3) J Immunol. 2007 Apr 15;178(8):5001-9.
23.12.01p16<INK4a>(CDKN2A) luminescent reporter miceRBRC05271
(ICR)
RBRC09236
(B6)
These Tg strains carry the entire human p16<INK4a>(CDKN2A) gene locus tagged with luciferase.1)1) J Cell Biol. 2009 Aug 10;186(3):393-407.
23.12.01p21(CDKN1A) luminescent reporter miceRBRC09237This Tg strain expresses luciferase under the human p21(CDKN1A) promoter.1)1) Proc Natl Acad Sci U S A. 2007 Sep 18;104(38):15034-9.
23.12.01Arc luminescent reporter miceRBRC06053This BAC Tg strain expresses luciferase under the exogenous Arc promoter.1)1) Brain Struct Funct. 2011 Jun;216(2):91-104.
23.12.01Bdnf luminescent reporter miceRBRC11093This BAC Tg strain expresses luciferase under the exogenous Bdnf promoter. 1)2)1) Sci Rep. 2017 Jul 10;7(1):4949.
2) J Neurosci. 2015 Apr 8;35(14):5606-24.
23.10.02The clock gene
Bmal1(Arntl) floxed mice
RBRC11399Analysis of crosses with various Cre driver mice has been reported.1)2)3)4)5)1) Mol Metab. 2021 Jul;49:101202.
2) Cell Rep. 2021 Jul 6;36(1):109336.
3) JCI Insight. 2019 Mar 7;4(5):e121798.
4) Sci Rep. 2018 Jan 31;8(1):1996.
5) PLoS One. 2011;6(9):e25231.
23.10.02The clock gene Bmal1(Arntl) luminescent reporter miceRBRC09717This Tg strain expresses luciferase after Cre-mediated recombination under the exogenous Bmal1(Arnt).1)1) Biochemistry. 2010 Sep 21;49(37):8053-61.
23.10.02The clock gene Per1 luminescent reporter miceRBRC09608This Tg strain expresses luciferase under the exogenous Per1 promoter. 1)2)1) Sci Rep. 2015 Jul 21;5:12310.
2) Proc Natl Acad Sci U S A. 2007 May 1;104(18):7664-9.
23.10.02The clock genes Bmal1(Arntl) and Per1 luminescent reporter miceRBRC02670This Tg strain expresses different luciferases under the exogenous Bmal1(Arntl) and Per1 promoter, respectively.1)1) Genes Cells. 2006 Oct;11(10):1173-82.
23.08.03
Zeb2 (SIP1, Zfhx1b) gene fluorescent reporter miceRBRC09239
(ICR)
RBRC09240
(ICR and B6 mixed)
These KI strains express a EGFP under the control of endogenous Zeb2 promoter.1)2)3)4)5)1) Cell Rep. 2023 Mar 20;112276.
2) Cardiovasc Res. 2022 Mar 25;118(5):1262-1275.
3) Immunity. 2021 Jul 13;54(7):1417-1432.e7.
4) Elife. 2019 Aug 8;8:e47605.
5) Genesis. 2014 Jan;52(1):56-67.
23.08.03
Sox9 gene fluorescent reporter miceRBRC05651This KI strain expresses a EGFP under the control of endogenous Sox9 promoter.1)2)3)4)5)1) Front Cell Dev Biol. 2020 Oct 22;8:585640.
2) Endocrinology. 2019 Feb 1;160(2):387-398.
3) Nat Commun. 2018 Aug 22;9(1):3356.
4) PLoS One. 2017 Nov 30;12(11):e0188705.
5) Dev Dyn. 2009 May;238(5):1100-10.
23.08.03
Tg mice for conditional overexpression of SOX9RBRC05654This Tg strain overexpresses SOX9 after Cre-mediated recombination.1)2)3)4)5)1) Proc Natl Acad Sci U S A. 2019 Jan 29;116(5):1704-1713.
2) Elife. 2018 Apr 3;7:e32358.
3) J Clin Invest. 2018 Aug 1;128(8):3475-3489.
4) Gastroenterology. 2018 Jul;155(1):194-209.e2.
5) J Bone Miner Metab. 2011 Jan;29(1):123-9.
23.08.03
Tg mice for misexpression of SOX9 in limb bud mesenchymeRBRC05525This Tg strain misexpresses SOX9 under the control of Prrx1 promoter.1)2)1) Development. 2009 Apr;136(8):1263-72.
2) Matrix Biol. 2007 May;26(4):224-33.
23.06.01Neuronal cells Cre-driver miceRBRC11130This KI strain expresses a Cre under the control of endogenous Tubb3 promoter.1)1) Cell Rep. 2021 Jul 27;36(4):109427.
23.06.01Spleen TLX1 expressing cells Cre-driver miceRBRC11118This KI strain expresses CreERT2 and Venus under the control of endogenous Tlx1 promoter.1)2)3)1) Sci Rep. 2019 Dec 31;9(1):20408.
2) Sci Rep. 2018 May 29;8(1):8308.
3) Genesis. 2014 Nov;52(11):916-23.
23.06.01Glucagon-producing α-cells Cre-driver miceRBRC10958This KI strain expresses Cre under the control of Gcg promoter.1)1) Exp Anim. 2020 Apr 24;69(2):178-188.
23.06.01KRT19 expressing cells Cre-driver miceRBRC10923This BAC Tg strain expresses iCre under the control of Krt19 promoter.1)1) PLoS One. 2019 Aug 8;14(8):e0220818.
23.04.03Orexin neurons FLP driver miceRBRC11555This KI strain expresses FLP and GFP under the control of endogenous Hcrt promoter.1)1) Elife. 2019 Jun 4;8:e44927.
23.04.03FLPe driver miceRBRC10708
RBRC10707
RBRC01834
These Tg strains express FLPe under the control of CAG promoter in C57BL/6J background.1)1) Exp Anim. 2006 Apr;55(2):137-41.
23.04.03FLPo driver miceRBRC09982
RBRC06479
RBRC06470
These Tg strains express FLPo under the control of CAG promoter.1)1) J Cell Sci. 2016 May 1;129(9):1940-9.
23.02.03Notch signaling fluorescent reporter miceRBRC06137This Tg strain expresses Venus depend on activation of Notch signaling via RBP-jk-binding sequence.1)2)3)4)1) Stem Cells. 2016 Aug;34(8):2169-82.
2) Nat Commun. 2015 Jul 23;6:7739.
3) Development. 2011 Jan;138(1):55-64.
4) Dev Biol. 2005 Oct 1;286(1):311-25.
23.02.03 A transcriptional co-activator in the Notch signaling Maml1 KO miceRBRC10002This strain has been used for analysis of the Notch signaling pathway.1)2)3)4)1) PLoS Genet. 2016 Dec 27;12(12):e1006514.
2) PLoS Genet. 2013;9(1):e1003132.
3) Development. 2011 Dec;138(23):5235-46.
4) Proc Natl Acad Sci U S A. 2007 Jun 5;104(23):9764-9.
23.02.03Notch2 floxed miceRBRC09647This strain has been used for analysis of the Notch signaling pathway.1)2)3)4)1) Nat Commun. 2019 Jan 14;10(1):190.
2) PLoS Biol. 2019 May 9;17(5):e3000262.
3) Nat Med. 2015 Jan;21(1):55-61.
4) Immunity. 2003 May;18(5):675-85.
22.12.06RAG2 expressing cells fluorescent reporter miceRBRC09497This KI strain expresses a EGFP under the control of endogenous Rag2 promoter.1)1) Int Immunol. 2003 Mar;15(3):393-402.
22.12.06GATA1 expressing cells fluorescent reporter miceRBRC09400This BAC Tg strain expresses GFP under the control of Gata1 promoter.1)1) Mol Cell Biol. 2009 Mar;29(5):1163-75.
22.12.06Inhibitory neurons fluorescent reporter miceRBRC09645This BAC Tg strain expresses YFP under the control of VGAT(Slc32a1) promoter.1)1) Neuroscience. 2009 Dec 15;164(3):1031-43.
22.12.06Inhibitory neurons fluorescent reporter miceRBRC10799
RBRC10800
These BAC Tg strains express tdTomato under the control of VGAT(Slc32a1) promoter.1) 1) J Comp Neurol. 2018 Feb 15;526(3):373-396.
22.10.03PDGFRα expressing cells Cre-driver miceRBRC09616This KI strain expresses a GFP-CreERT2 fucion protein under the control of endogenous Pdgfra promoter.1)2)3)4)5)1) Sci Rep. 2021 Apr 21;11(1):8683.
2) Nat Commun. 2020 May 8;11(1):2303.
3) Development. 2018 Jan 29;145(2):dev155879.
4) Genesis. 2015 May;53(5):329-36.
5) Mouse of the Month September 2016.
22.10.03Astrocytes Cre-driver miceRBRC10705This Tg strain expresses Cre under the control of S100b promoter.1)2)3)1) J Neurosci. 2017 Oct 18;37(42):10052-10062.
2) Front Neurosci. 2008 Dec 15;2(2):225-33.
3) Front Behav Neurosci. 2008 Apr 23;2:1.
22.10.03Specific excitatory neurons Cre-driver miceRBRC10626This Tg strain expresses CreERT2 under the control of Atoh1 promoter.1)1) Science. 2015 Nov 20;350(6263):957-61.
22.10.03Testicular germ cells Cre-driver miceRBRC06480This Tg strain expresses Cre under the control of Stra8 promoter.1)1) Sci Rep. 2015 Sep 21;5:14254.
22.08.01Lateral nucleus of the amygdala Cre-driver miceRBRC10694This KI strain expresses iCre under the control of endogenous Grp( Gastrin-releasing peptide) promoter.1)1) Elife. 2018 Jun 26;7:e34135.
22.08.01Vesicular GABA transporters Cre-driver miceRBRC10606This BAC Tg strain expresses Cre under the control of Slc32a1 promoter.1)2)3)4)5)1) Hum Mol Genet. 2021 May 28;30(9):758-770.
2) Nat Commun. 2020 Oct 9;11(1):5113.
3) Nat Commun. 2019 Apr 23;10(1):1917.
4) Mol Autism. 2019 Mar 28;10:15.
5) Hum Mol Genet. 2013 Dec 1;22(23):4784-804.
22.08.01Osteoblasts Cre-driver miceRBRC05603This Tg strain expresses Cre under the control of Col1a1 promoter.1)2)3)4)5)1) Bone. 2021 Sep;150:116010.
2) JBMR Plus. 2021 May 17;5(6):e10496.
3) Cell. 2020 Aug 6;182(3):609-624.e21.
4) Genes Cells. 2018 May;23(5):345-356.
5) Dev Dyn. 2002 Jun;224(2):245-51.
22.08.01Osteoblasts Cre-driver miceRBRC05524This Tg strain expresses Cre under the control of Col1a1 promoter.1)2)3)4)5)1) JCI Insight. 2020 May 7;5(9):e135355.
2) Stem Cells. 2016 Aug;34(8):2145-56.
3) J Bone Miner Res. 2015 Apr;30(4):715-22.
4) EMBO J. 2015 Jun 12;34(12):1648-60.
5) J Bone Miner Res. 2008 Feb;23(2):271-7.
22.06.01Rspo2-Cre BAC Tg miceRBRC10754Cre expression is detected
in basolateral amygdala (BLA)1).
(BAC clone ID:RP23-39M21)
1) Nat Neurosci. 2016 Dec;19(12):1636-1646.
22.06.01Gpr151-Cre BAC Tg miceRBRC10728Cre expression is detected
in cholinergic neurons of medial habenula (mHb)1)2).
(BAC clone ID:MSMg01-81G4)
1) J Comp Neurol. 2017 Oct 15;525(15):3227-3250.
2) Front Behav Neurosci. 2013 Mar 12;7:17.
22.06.01Prkcd-Cre BAC Tg miceRBRC10725Cre expression is detected
in almost the entire dorsal thalamus1).
(BAC clone ID:RP23-220I83)
1) Sci Rep. 2016 Jun 27;6:28750.
22.06.01VGAT(Slc32a1)-Cre BAC Tg miceRBRC10723Cre expression is detected
in inhibitory neurons1)2).
(BAC clone ID:RP23-392P11)
1) Sci Rep. 2016 Jun 27;6:28750.
2) Hum Mol Genet. 2013 Dec 1;22(23):4784-804.
22.03.30Otx2-tdTomato KI mice1)RBRC10897This strain expresses tdTomato under the control of ectoderm marker Otx2.1) Exp Anim. 2019 Nov 6;68(4):499-509
22.03.30Sox17-EGFP KI mice1)RBRC10898This strain expresses EGFP under the control of endoderm marker Sox17.1) Exp Anim. 2019 Nov 6;68(4):499-509
22.03.30Tppp3-EGFP KI mice1)RBRC10145This strain expresses EGFP under the control of Tppp3.1) Nat Commun. 2019 Sep 5;10(1):3999
22.03.30Tppp3-CreERT2 KI mice1)RBRC10144This strain expresses CreERT2 under the control of Tppp3.1) Nat Commun. 2019 Sep 5;10(1):3999
22.03.30Sox10-CreERT2 KI mice1)RBRC10143This strain expresses CreERT2 under the control of Sox10.1) Nat Commun. 2019 Sep 5;10(1):3999
22.01.31Actin-tTS Tg mice1)2)RBRC05447This strain express tTS in whole body 3)4)5).1) Genomics. 2003 Apr;81(4):356-60
2) Biol Psychiatry. 2010 Apr 15;67(8):770-3
3) Sci Rep. 2019 Mar 4;9(1):3422
4) Sci Rep. 2017 Oct 19;7(1):13605
5) Neuron. 2015 May 6;86(3):813-26
22.01.31Gad1-tTA KI mice1)RBRC11365tTA expression is detected in GABAergic neurons.1) Mol Brain. 2021 Jan 7;14(1):5
22.01.31 Gad1-Stop-tetO KI mice1)RBRC11364This strain is used for Gad1 gene expression control by Tet on/off system.1) Mol Brain. 2021 Jan 7;14(1):5
22.01.31 Nkcc1-tetO KI mice1)RBRC11202This strain is used for Nkcc1 (Slc12a2) gene expression control by Tet on/off system.1) Sci Rep. 2017 Oct 19;7(1):13605
22.01.31CatC-tetO KI mice1)RBRC10854This strain is used for Cathepsin C gene expression control by Tet on/off system.1) Glia. 2017 Jun;65(6):917-930
21.12.01Sox9-CreERT2 KI mice1)RBRC05522This strain is useful for research of embryonic development and cell differentiation2)3)4)5).1) Genesis. 2010 Nov;48(11):635-44.
2) Development. 2021 Jul 1;148(13):dev199543.
3) Nat Commun. 2021 May 4;12(1):2509.
4) Proc Natl Acad Sci U S A. 2021 Feb 16;118(7):e2017115118.
5) Proc Natl Acad Sci U S A. 2020 Jun 2;117(22):12182-12191.
21.12.01Sox9-Cre KI mice1)RBRC05523This strain is useful for research of embryonic development and cell differentiation2)3)4)5). 1) Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14665-70.
2) Elife. 2020 May 12;9:e53688.
3) Development. 2019 Oct 4;146(20):dev182782.
4) J Neurosci. 2018 Jun 6;38(23):5429-5440.
5) Development. 2018 Dec 18;145(24):dev165381.
21.12.01Sox1-Cre KI mice1)RBRC05065This strain is useful for research of embryonic development and cell differentiation2)3)4)5).1) Cell. 2007 Jun 29;129(7):1377-88.
2) Genes Cells. 2021 Feb;26(2):45-55.
3) PLoS Genet. 2020 Feb 24;16(2):e1008300.
4) Dev Biol. 2020 Dec 1;468(1-2):101-109.
5) Nat Commun. 2020 Nov 11;11(1):5709.
21.12.01Dkk3-Cre BAC Tg mice1)RBRC10900
(C57BL/6)
RBRC05427
(129)
Theses strains are useful for eye development research2)3)4)5).1) Genesis. 2007 Aug;45(8):502-7.
2) Genes Cells. 2020 Jun;25(6):402-412.
3) Elife. 2020 Feb 25;9:e51275.
4) Invest Ophthalmol Vis Sci. 2020 Sep 1;61(11):43.
5) Invest Ophthalmol Vis Sci. 2017 Apr 1;58(4):1916-1929.
21.10.01Plp1-tTA Tg miceRBRC05446tTA expression is detected in oligodendrocytes1). It was contributed to some results2)3)4)5).1) Genesis. 2012 May;50(5):424-8.
2) J Neurosci. 2019 May 22;39(21):4036-4050.
3) J Neurochem. 2019 Jul;150(2):158-172.
4) Nat Neurosci. 2018 Apr;21(4):625-637.
5) Cell Rep. 2018 Aug 21;24(8):2196-2210.e9.
21.10.01Htr5b-tTA KI miceRBRC05445tTA expression is detected in 5-hydroxytryptamine (serotonin) receptor 5B positive cells1). It was contributed to some results2)3)4).1) Cell Rep. 2012 Aug 30;2(2):397-406.
2) Nat Neurosci. 2019 May;22(5):770-777.
3) Cell Rep. 2018 Aug 21;24(8):2196-2210.e9.
4) Cell Rep. 2017 Nov 21;21(8):2066-2073.
21.10.01Pmch-tTA BAC Tg miceRBRC05844tTA expression is detected in MCH (melanin-concentrating hormone) neurons1). It was contributed to some results2)3).1) J Neurosci. 2014 May 14;34(20):6896-909.
2) Science. 2019 Sep 20;365(6459):1308-1313.
3) Elife. 2020 Apr 21;9:e54275.
21.10.01Tph2-tTA BAC Tg miceRBRC05846tTA expression is detected in serotonergic neurons1). It was contributed to some results2)3)4). 1) Int J Neuropsychopharmacol. 2014 Nov;17(11):1777-83.
2) Nat Neurosci. 2019 May;22(5):770-777.
3) Neuropharmacology. 2020 May 1;167:107703.
4) Nat Commun. 2018 Jun 1;9(1):2048.
21.08.02Cre-driver mice for inner earRBRC09434Pax2-Cre Tg strain is utilized as Cre-driver mice for inner ear1)2)3).1) Elife. 2020 Jan 8;9:e52160.
2) PLoS Genet. 2017 Oct 23;13(10):e1007048.
3) Genesis. 2004 Apr;38(4):195-9.
21.08.02Cre-driver mice for olfactory sensory neuronsRBRC06339Olfr1507(MOR28)-Cre Tg strain is utilized as Cre-driver mice for a part of olfactory sensory neurons1)2)3).1) Science. 2019 Jul 5;365(6448):eaaw5030.
2) Mouse of the Month October 2015.
3) Cell. 2010 Jun 11;141(6):1056-67.
21.08.02Cre-driver mice for olfactory sensory neuronsRBRC06346Ascm4(OMACS)-Cre KI strain is utilized as Cre-driver mice for dorsal zone olfactory sensory neurons1)2)3).1) Commun Biol. 2019 Jan 8;2:14.
2) Sci Rep. 2015 Sep 11;5:14073.
3) Nature. 2007 Nov 22;450(7169):503-8.
21.08.02Cre-driver mice for retinal photoreceptor cells and progenitor cells RBRC05426Crx-Cre Tg strain is utilized as Cre-driver mice for retinal photoreceptor cells and progenitor cells1)2)3).1) Sci Rep. 2018 Jun 4;8(1):8543.
2) Hum Mol Genet. 2018 Sep 15;27(18):3137-3153.
3) Nat Neurosci. 2003 Dec;6(12):1255-63.
21.08.02CreERT2-driver mice for retinal photoreceptor cells and progenitor cells RBRC05559Crx-CreERT2 Tg strain is utilized as tamoxifen-inducible Cre-driver mice for retinal photoreceptor cells and progenitor cells1)2)3).1) Exp Eye Res. 2018 Aug;173:32-43.
2) Cell Rep. 2015 Nov 3;13(5):990-1002.
3) J Neurosci. 2011 Nov 16;31(46):16792-807.
21.03.31G-CaMP7 Tg mice controlled by Thy1 promoterRBRC06579Using this strain, longitudina imaging of large-scale functional hippocampal cellular maps was performed1)2).1) Cell Rep. 2020 Jul 7;32(1):107864.
2) PLoS One. 2012;7(12):e51286.
21.03.31G-CaMP7 Tg mice controlled by Slc1a2 (GLT1) promoterRBRC09650This strain expresses G-CaMP7 in astrocytes and a subpopulation of cortical neurons1)2)3)4). It contributed to elucidation of the recovery mechanism after acute ischemic stroke5).1) Nat Commun. 2016 Mar 22;7:11100.
2) Mouse of the Month August 2017.
3) J Neurosci. 2007 Jun 20;27(25):6607-19.
4) PLoS One. 2012;7(12):e51286.
5) Proc Natl Acad Sci U S A. 2019 May 28;116(22):11010-11019.
21.03.31G-CaMP6 Tg mice controlled by Thy1 promoterRBRC10611This strain expresses G-CaMP6 in brain1)2).1) Neurosci Res. 2020 Feb;151:53-60.
2) PLoS One. 2012;7(12):e51286.
21.03.31G-CaMP7 expression conditionally controllable Tg miceRBRC06510This strain is reported to show a growth retardation with hypothyroidism1)2)3).1) PLoS One. 2015 May 6;10(5):e0125354.
2) Mouse of the Month June 2015.
3) PLoS One. 2012;7(12):e51286.
21.02.01A member of formin protein family mDia1 floxed miceRBRC02595This strain contributed to elucidation of actin cytokine-mediated T cell activation mechanism1)2)3).1) Sci Adv6 (1) 2020 eaay2432
2) Cell Rep 2016 17 (9) 2405-2417
3) J Exp Med 2007 204 (9) 2031-8
21.02.01Oncostatin M (a member of IL-6 family of cytokines) receptor KO mice1)2)RBRC02711This strain is widely used for variety research fields including immunology3)4)5).1) Blood 2003 102 (9) 3154-62
2) Hepatology 2004 39 (3) 635-44
3) Proc Natl Acad Sci U S A 2020 117 (9) 5028-5038
4) Nat Commun 2017 8 13946
5) J Lipid Res 2017 58 (5) 895-906
21.02.01Cytokine TNFα KO mice1)2)RBRC05118
(C57BL/6)
RBRC05119
(BALB/c)
These strains are widely used for elucidation of immune mechanism3)4).1) J Immunol 1997 159 (3) 1418-28
2) Lab Invest 1997 77 (6) 647-58
3) J Immunol 2019 203 (4) 783-788
4) Front Immunol 2018 9 2619
20.12.01Endogenous membrane protein Mavs (IPS-1) KO mice1)RBRC04546Mavs (IPS-1) is related to the cytokine production as adaptor to recognize cytoplasmic RNA virus. This strain contributed to elucidate some findings 2)3)4)5). 1) J Immunol. 2011 Nov 15;187(10):5320-7.
2) Cancer Sci. 2018 Apr;109(4):956-965.
3) Cell Rep. 2017 May 30;19(9):1874-1887.
4) Cell Rep. 2015 May 26;11(8):1193-207.
5) Immunity. 2015 Dec 15;43(6):1148-59.
20.12.01Ubiquitin ligase Efp (Trim25) KO mice1)RBRC02844Analysis of this strain revealed that Efp (Trim25) is related to the breast tumor growth2), neuroinflammation pathogenesis3) and inhibition of virus infection4)5).1) Proc Natl Acad Sci U S A. 1999 Oct 12;96(21):12027-32.
2) Nature. 2002 Jun 20;417(6891):871-5.
3) Nat Immunol. 2017 Jan;18(1):54-63.
4) Nat Immunol. 2010 Jan;11(1):63-9.
5) Nature. 2007 Apr 19;446(7138):916-920.
20.12.01Itgal (LFA-1, Cd11a) KO mice1)RBRC00850Analysis of this strain revealed several type I interferon secretion
mechanism by plasmacytoid dendritic cells2).
1) J Exp Med. 1996 Apr 1;183(4):1415-26.
2) Nat Commun. 2017 Nov 17;8(1):1592.
20.12.01Agt (angiotensinogen) KO mice1)RBRC01120This strain is widely used for functional analysis of renin-angiotensin system2)3).1) J Biol Chem. 1994 Dec 16;269(50):31334-7.
2) PLoS One. 2015 Jun 24;10(6):e0129484.
3) Circ Res. 2014 Jul 7;115(2):263-72.
20.10.01Pro-inflammatory cytokine IL-6 KO mice1)RBRC04918
(C57BL/6)
RBRC04919
(BALB/c)
RBRC05131
(DBA/1)
IL-6 (interleukin-6) is a cytokine that has multifunction, including inflammatory response, in many kinds of cells. These strains were utilized for IL-6 functional analysis2)3)4).1) Nature. 1994 Mar 24;368(6469):339-42.
2) Sci Rep. 2019 Jul 25;9(1):10842.
3) Sci Adv. 2018 Jul 11;4(7):eaas9944. 
4) Sci Rep. 2018 Oct 25;8(1):15783.
20.10.01IL-6-related inflammatory status in vivo imaging miceRBRC09487This BAC-based human IL-6-luciferase Tg strain is useful for evaluation of inflammatory status in vivo by luciferase luminescence1)2)3)4)5).1) Sci Rep. 2018 May 23;8(1):8037. 
2) Eur J Pharmacol. 2017 May 5;802:76-84.
3) Nat Commun. 2016 May 23;7:11624.
4) Mouse of the Month May 2016
5) Mol Cell Biol. 2015 Oct;35(20):3590-601. 
20.10.01Human IL-6 expression conditionally controllable miceRBRC09734
RBRC09735
This strain expresses human IL-6 according to Cre recombinase1).1) Exp Anim. 2016 Nov 1;65(4):455-463.
20.04.01Cre reporter mice showing green-to-red fluorescent conversion1)2)3)RBRC04874This ROSA26-KI strain express EGFP signal before and tdsRed signal after Cre-mediated recombination. It was contributed to some results4)5)6).1) Exp Anim. 2013;62(4):295-304.
2) Mouse of the Month October 2018
3) Mouse of the Month March 2014
4) iScience. 2019 Oct 25;20:337-347.
5) Dev Cell. 2019 Jul 22;50(2):139-154.e5.
6) PLoS One. 2018 Jan 11;13(1):e0190800.
20.04.01Cre reporter mice expressing EGFP signal1)RBRC09806This Tg strain express EGFP signal after Cre-mediated recombination. It was contributed to some results2)3)4).1) FEBS Lett. 2000 Mar 31;470(3):263-8.
2) Dev Cell. 2019 Jan 28;48(2):151-166.e7.
3) Cell Stem Cell. 2018 Mar 1;22(3):384-397.e6.
4) Nat Commun. 2018 Apr 24;9(1):1623.
20.04.01Cre reporter mice expressing LacZ signal1)2)RBRC02657This ROSA26-KI strain express LacZ signal after Cre-mediated recombination. It was contributed to some results3)4)5).1) Front Behav Neurosci. 2013 Mar 12;7:17.
2) Mouse of the Month March 2013
3) Transgenic Res. 2018 Apr;27(2):193-201.
4) J Neurosci. 2017 Aug 9;37(32):7682-7699.
5) Genesis. 2016 Nov;54(11):568-572.
20.02.03Siglec-H gene
DTR-EGFP KI mice
RBRC05658
(C57BL/6)
RBRC09688
(BALB/c)
In this strain, plasmacytoid dendritic cells (pDCs) can be depleted by injection of diphtheria toxin 1)2)3). User reported that pDCs are related with acute liver injury4). 1) Glia. 2017 Dec;65(12):1927-1943.
2) Sci Rep. 2016 Apr 14;6:24477.
3) Immunity. 2011 Dec 23;35(6):958-71.
4) J Clin Invest. 2019 Jul 2;129(8):3201-3213.
20.02.03Xcr1 gene
KikGR KI mice
RBRC09928This is a photoconvertible KikGR reporter mice for Xcr1 gene, which express chemokine receptor at one subset of dendritic cells1).1) Proc Natl Acad Sci U S A. 2016 Jan 26;113(4):1044-9.
20.02.03Xcr1 gene
DTR-Venus KI mice
RBRC09485
(C57BL/6)
RBRC10391
(BALB/c)
In this strain, XCR1-positive dendritic cells can be depleted by injection of diphtheria toxin 1) 2) 3). 1) Nat Microbiol. 2018 May;3(5):611-621.
2) J Immunol. 2017 Dec 15;199(12):4165-4179.
3) Mouse of the Month January 2016
20.02.03Relb gene
Venus KI mice
RBRC09496This is a Venus reporter strain for Nf-κB family gene Relb, which is related with immune cell maturation 1).1) J Biochem. 2015 Dec;158(6):485-95.
19.12.02Cre-driver mice for CRF neuronRBRC06520Crh (corticotropin-releasing hormone) Cre KI strain is useful for stress response research 1) 2).1) Sci Adv. 2016 Aug 17;2(8):e1501723.
2) Endocrinology. 2014 Oct;155(10):4054-60.
19.12.02Crh gene reporter miceRBRC09893Crh (corticotropin-releasing hormone) Venus KI strain allows the visualization of CRF neurons 1) 2) 3).1) Biol Sex Differ. 2019 Jan 28;10(1):6.
2) Brain Struct Funct. 2017 May;222(4):1705-1732.
3) Endocrinology. 2014 Oct;155(10):4054-60.
19.12.02Cre-driver mice for Oligodendrocyte lineage and motoneuronRBRC01507Olig2-tamoxifen inducible Cre KI strain is frequently used in neuroscience 1) 2) 3) 4) 5).1) Nat Neurosci. 2018 May;21(5):696-706.
2) Science. 2014 Sep 26;345(6204):1254927.v
3) Mouse of the Month July 2006
4) Dev Biol. 2006 May 15;293(2):358-69.
5) Curr Biol. 2002 Jul 9;12(13):1157-63.
19.12.02Transcription factor Olig2 reporter miceRBRC06017
RBRC06018
RBRC06022
This strain express Venus, mCherry or luciferase-OLIG2 fusion protein 1).1) Science. 2013 Dec 6;342(6163):1203-8.
19.12.02Cre-driver mice for dorsal telencephalonRBRC01345Emx1 (empty spiracles homeobox 1) Cre KI strain is frequently used in neuroscience 1) 2) 3) 4) 5).1) Nat Commun. 2019 Aug 8;10(1):3581.
2) Nat Commun. 2017 May 23;8:15488.
3) Mouse of the Month July 2006
4) Genesis. 2004 Mar;38(3):130-8.
5) Nature. 2000 Aug 17;406(6797):726-31.
19.12.02Cre-driver mice for developing cochleaeRBRC02272Emx2 (empty spiracles homeobox 2) Cre KI strain 1) is useful for inner ear development research 2) 3) 4).1) J Neurosci. 2005 May 25;25(21):5097-108.
2) J Neurosci. 2019 Oct 9;39(41):8013-8023.
3) Dev Biol. 2018 May 1;437(1):17-26.
4) Development. 2018 Jun 14;145(12).
19.10.01Cellualar oxidative stress imaging miceRBRC057041)
RBRC061612)
Nrf2 (oxidative stress-responsive transcription factor) reporter mice were utilized for the elucidation of oxidative stress sensing mechanism3).1) Sci Rep. 2012;2:229.
2) Free Radic Biol Med. 2014 Jul;72:124-33.
3) Cell Rep. 2019 Jul 16;28(3):746-758.e4.
19.10.01ROS production conditionally regulatable mice1)RBRC09859This strain expresses SDAD (ROS homeostasis-related enzyme) defective mutants according to Cre recombinase.1) Eur J Immunol. 2017 Feb;47(2):406-418.
19.10.01Sperm-egg fusion imaging mice1)RBRC05763Izumo1 (sperm acrosomal gene) reporter strain is useful for the elucidation of gamete fusion mechanism2) 3).1) J Cell Sci. 2012 Nov 1;125(Pt 21):4985-90.
2) Cell Cycle. 2018;17(11):1279-1285.
3) Nat Commun. 2015 Nov 16;6:8858.
19.10.01Sperm acrosome−GFP:
sperm mitochondria−DsRed
dual reporter mice1)
RBRC03743
RBRC05861
This strain is useful for the elucidation of fertilization or acrosome reaction mechanism2) 3) 4).1) Exp Anim. 2010;59(1):105-7.
2) J Cell Biol. 2018 Jun 4;217(6):2103-2119.
3) J Biol Chem. 2018 Jul 27;293(30):11796-11808.
4) Biol Reprod. 2016 Apr;94(4):80.
19.08.01Cre-driver mice for orexin neuronsRBRC06806This strain expresses Cre recombinase and EGFP in orexin neurons1) 2).1) Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):E10740-E10747.
2) Neuropharmacology. 2014 Oct;85:451-60.
19.08.01Full maturated OSN (olfactory sensory neuron) reporter mice1)RBRC02092OMP (olfactory marker protein) gene-GFP KI mice are broadly utilized for olfactory analysis2) 3) 4).1) J Neurosci. 2001 Dec 15;21(24):9713-23.
2) J Neurosci. 2019 Jan 30;39(5):814-832.
3) Cell Stem Cell. 2017 Dec 7;21(6):761-774.e5.
4) Cell. 2016 Jun 16;165(7):1734-1748.
19.08.01Selenocysteine-tRNA (Trsp) floxed mice1)RBRC02681This strain was utilized for an oxidative stress model2) 3).1) J Biol Chem. 2008 Jan 25;283(4):2021-30.
2) Cell Rep. 2017 Feb 21;18(8):2030-2044.
3) Blood. 2011 Jan 20;117(3):986-96.
19.08.01Neuronally enriched Rufy3 KO-first miceRBRC05780Analysis of this strain revealed that RUFY3 is essential for caspase-mediated axon degeneration1).1) Neuron. 2019 Jun 7. pii: S0896-6273(19)30483-0. 
19.06.03Cre-driver mice for postnatal somatic motor neuronsRBRC01515
RBRC01516
These strain express Cre recombinase in slow type motor neurons1) 2).1) Genesis. 2016 Nov;54(11):568-572.
2) Brain Res. 2014 Mar 6;1550:36-46.
19.06.03Mitochondria-EGFP labeled mice1) 2)RBRC02250This transgenic strain is utilized to identify and monitor the mitochondorial morphology3) 4).1) Exp Anim. 2010;59(1):99-103.
2) FEBS Lett. 2001 Jun 29;500(1-2):7-11.
3) Sci Transl Med. 2017 Oct 25;9(413).
4) PLoS One. 2012;7(6):e36850.
19.06.03Zinc transporter Slc39a10 (Zip10) floxed miceRBRC06221Analysis of this strain revealed novel functions of Slc39a10 in humoral immune system1) 2) and epidermal development3).1) Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):11786-91.
2) Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):11780-5.
3) Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):12243-12248.
19.06.03Cell adhesion molecule Cadm1 (SynCAM1) KO miceRBRC04062This strain was utilized for analysis of not only nervous system1) 2) 3) but also bone turnover4).1) J Neurosci. 2016 Jul 13;36(28):7464-75.
2) Neuron. 2010 Dec 9;68(5):894-906.
3) Biochem Biophys Res Commun. 2010 Jun 4;396(3):703-8.
4) PLoS One. 2017 Apr 17;12(4):e0175632.
19.04.01Cre-driver mice for myelinating cells of the central nervous system1)RBRC01461This strain is useful for the elucidation of gene function in oligodendrocyte myelination2).1) Genesis. 2000 Feb;26(2):127-9.
2) Nat Commun. 2016 Nov 23;7:13478.
19.04.01Oct3/4 (Pou5f1) reporter miceRBRC007711)
RBRC060372)
These strains are useful for stem cell research because they express EGFP under the control of pluripotency marker Oct3/43) 4) 5).1) Dev Biol. 2003 Jun 1;258(1):209-25.
2) Development. 2008 Mar;135(5):909-18.
3) Cell Res. 2011 Jan;21(1):196-204.
4) Dev Biol. 2010 Oct 1;346(1):90-101.
5) Stem Cells. 2009 Feb;27(2):383-9.
19.04.01Fgf5 spontaneous mutant miceRBRC05894
RBRC05895
This strain shows abnormal hair follicle cycle1). In addition, it contributed to the research about spermatogenic stem cells2).1) Exp Anim. 2011;60(2):161-7.
2) Cell Stem Cell. 2019 Jan 3;24(1):79-92. e6.
19.04.01Fstl4 (Mahya) reporter miceRBRC04952This strain is useful for revolutionary genetic research1)In addition, it was used to monitor specific subtypes of retinal ganglion cells2).1) Dev Genes Evol. 2005 Nov;215(11):564-74.
2) Curr Eye Res. 2016 Apr;41(4):558-68.


DateTitleBRC No.DescriptionReferences
24.02.26
Sensory neurons Cre-driver miceRBRC10246This KI strain expresses Cre under the control of endogenous Advillin promoter.1)1) Proc Natl Acad Sci U S A. 2010 May 18;107(20):9424-9.
24.02.26
Homeobox gene Vsx2 Cre-driver miceRBRC09714This KI strain expresses CreERT2 under the control of endogenous Vsx2(Chx10) promoter.
24.02.26
Homeobox gene Vsx2 Cre-driver miceRBRC06574This BAC Tg strain expresses CreERT2 under the control of Vsx2(Chx10) promoter.1)2)1) Development. 2020 Sep 28;147(18):dev188730.
2) Cell Death Dis. 2020 Aug 18;11(8):655.
24.02.26
Homeobox gene Vsx2 Cre-driver miceRBRC05564This Tg strain expresses Cre under the control of Vsx2(Chx10) promoter.1)2)3)4)1) Dev Biol. 2020 Aug 15;464(2):137-144.
2) Development. 2017 Jul 1;144(13):2392-2401.
3) J Exp Med. 2016 Jun 27;213(7):1175-83.
4) J Neurosci. 2011 Nov 16;31(46):16792-807.
23.12.28.Kpna1(importin α5) gene KO miceRBRC06031
(KO)
RBRC06030
(floxed)
KPNA1 KO mice have been reported to have behavioral abnormalities and female functional incompetence in delivery.1)2)1) PLoS One. 2021 Nov 12;16(11):e0258364.
2) FEBS J. 2011 May;278(9):1561-72.
23.12.28.Kiss1 gene floxed miceRBRC10389This strain has been reported to be infertile when crossed with Cre driver strains.1)2)1) J Reprod Dev. 2020 Aug 20;66(4):359-367.
2) J Reprod Dev. 2020 Aug 20;66(4):369-375.
23.12.28.Prl gene KO miceRBRC06232Prolactin has been reported to be involved in a variety of physiological phenomena and diseases.1)2)3)4)5)1) Cell Rep. 2021 Jun 1;35(9):109204.
2) Cancer Res. 2019 Oct 15;79(20):5316-5327.
3) PLoS One. 2016 Nov 28;11(11):e0166416.
4) Biol Reprod. 2015 Sep;93(3):75.
5) EMBO J. 1997 Dec 1;16(23):6926-35.
23.11.02Il17rb gene KO miceRBRC10254
(C57BL/6 background)
RBRC10255
(BALB/c background)
IL17RB is a receptor for IL17B and IL17E (IL25) and has been studied in relation to inflammatory diseases.1)2)3)4)1) J Exp Med. 2023 Aug 7;220(8):e20221773.
2) J Immunol. 2017 Jan 15;198(2):669-680.
3) Immunity. 2015 Apr 21;42(4):692-703.
4) PLoS Biol. 2012 Feb;10(2):e1001255.
23.11.02Il22ra2gene KO miceRBRC10360IL22RA2(IL22BP) has been studied in relation to inflammatory cutaneous diseases. 1)1) Front Immunol. 2018 Jun 21:9:1418.
23.11.02Il33 gene KO miceRBRC09341IL33 has been studied in relation to various diseases. 1)2)3)4)5)1) Dis Model Mech. 2023 Sep 1;16(9):dmm050174.
2) Immunity. 2022 Jan 11;55(1):159-173.e9.
3) Sci Immunol. 2022 Jun 24;7(72):eabl7209.
4) Immunity. 2021 Jan 12;54(1):151-163.e6.
5) Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18581-6.
23.09.01A molecular chaperon Serpinh1(Hsp47) floxed miceRBRC10972Serpinh1 is essential for collagen synthesis and various phenotypes have been reported using this strain.1)2)3)4)1) JCI Insight. 2019 Aug 8;4(15):e128722.
2) Mol Cell. 2018 Jan 18;69(2):238-252.e7.
3) J Biol Chem. 2015 Feb 6;290(6):3639-46.
4) J Cell Sci. 2012 Mar 1;125(Pt 5):1118-28.
23.09.01A molecular chaperon Serpinh1(Hsp47) KO miceRBRC10971Serpinh1 is essential for collagen synthesis and it has been reported that null mutant mice do not survive beyond 11.5 dpc.1)2)3)1) Mol Biol Cell. 2006 May;17(5):2346-55.
2) J Cell Sci. 2004 Nov 15;117(Pt 24):5913-22.
3) J Cell Biol. 2000 Sep 18;150(6):1499-506.
23.09.01A TNF superfamily Tnfsf11 (RANKL) floxed miceRBRC06142Using this strain, Tnfsf11 mutations have been reported to result in bone abnormalities.1)2)1) J Bone Miner Res. 2014 Apr;29(4):830-42.
2) J Clin Invest. 2013 Sep;123(9):3914-24.
23.09.01A transmembrane protein Pmepa1 mutated miceRBRC11387This strain has been reported to show bone abnormalities.1)2)1) FASEB J. 2021 Feb;35(2):e21281.
2) FASEB J. 2019 Mar;33(3):4365-4375.
23.07.03Mad2l2 mutated miceRBRC09685This Mad2l2 (Rev7) mutated strain established by ENU mutagenesis has been reported that both male and female homozygotes exhibit infertility and female homozygotes develop ovarian tumors at a high frequencyto1)2)3.1) Mol Cell Endocrinol. 2015 Sep 5;412:19-25.
2) J Biol Chem. 2014 Feb 7;289(6):3811-24.
3) J Reprod Dev. 2008 Jun;54(3):225-8.
23.07.03Mad2l2 KO miceRBRC05473This strain has been reported that both male and female homozygotes lack germ cells1).1) J Biol Chem. 2013 Apr 12;288(15):10459-71.
23.07.03Tdrd12 mutated miceRBRC09686This Tdrd12 mutated strain established by ENU mutagenesis has been reported that male homozygotes exhibit infertility1)2).1) Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16492-7.
2) Exp Anim. 2009 Oct;58(5):525-32.
23.07.03Tdrd12(Ecat8) KO miceRBRC02326This strain has been reported that male homozygotes exhibit infertility1)2).1) Cell Rep. 2018 Sep 25;24(13):3423-3432.e4.
2) Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16492-7.
23.07.03Rnf212 mutated miceRBRC09687This Rnf212 mutated strain established by ENU mutagenesis has been reported that male homozygotes exhibit infertility1).1) Reproduction. 2015 Jan;149(1):67-74.
23.04.27Osteoarthritis (OMIM: 612400) model miceRBRC-GSC0080This Gdf5 mutated strain established by ENU mutagenesis has been reported to show brachypodism and ankylosis1)2)3)4)5).1) Sci Rep. 2016 Mar 31;6:23670.
2) Diabetes. 2014 Jan;63(1):162-75.
3) Biochem Biophys Res Commun. 2014 Jul 18;450(1):255-60.
4) Hum Mol Genet. 2007 Oct 1;16(19):2366-75.
5) Mouse of the Month September 2007
23.04.27Spondyloepimetaphyseal dysplasia (OMIM: 183900) model miceRBRC-GSC0164This Col2a1mutated strain established by ENU mutagenesis has been reported to show skeletal dysplasia-like phenotypes1).1) Mamm Genome. 2011 Jun;22(5-6):318-28.
23.04.27Spontaneous steoarthritis model miceRBRC06803This strain is an inbred line derived from STR/1N1)2).1) Osteoarthritis Cartilage. 2001 Feb;9(2):85-91.
2) Osteoarthritis Cartilage. 1994 Jun;2(2):103-9.
23.04.27Menkes disease (OMIM: 309400) model miceRBRC01261Menkes disease is an X-chromosome recessive genetic disorder caused by ATP7A gene mutations. This strain has a mutation in the Atp7a gene1).1) Genomics. 2006 Feb;87(2):191-9.
23.04.27Menkes disease (OMIM: 309400) model miceRBRC09617Menkes disease is an X-chromosome recessive genetic disorder caused by ATP7A gene mutations. This strain has a mutation in the Atp7a gene1)2)3).1) J Inherit Metab Dis. 1998 Jun;21(3):199-202.
2) Mamm Genome. 1997 Jun;8(6):407-10.
3) Nat Genet. 1994 Apr;6(4):369-73.
23.03.02Nasu-Hakola disease (OMIM: 221770)
responsible gene Tyrobp(DAP12) KO mice
RBRC11704This strain is reported to show the developmental arrest of osteoclasts and ligodendrocytes1)2)3)4)5).1) Cell Rep. 2021 Dec 14;37(11):110111.
2) EMBO J. 2020 Nov 16;39(22):e104464.
3) Sci Signal. 2019 Jan 15;12(564):eaar5514.
4) J Biol Chem. 2018 Mar 9;293(10):3793-3805.
5) J Clin Invest. 2003 Feb;111(3):323-32.
23.03.02NGLY1 deficiency (OMIM: 615273)
responsible gene Ngly1 KO mice
RBRC11332By crossing this strain JF1/Ms Ngly1-/+ mice with C57BL/6 Ngly1-/+ mice (RBRC06293), we can partially avoid embryonic lethality and obtain JF1/B6F1 Ngly1-/- mice1).1) Proc Jpn Acad Ser B Phys Biol Sci. 2021;97(2):89-102.
23.03.02Fgf9 spontaneous mutant miceRBRC09906This strain was reported to show elbow knee synostosis1)2)3)4).1) Histochem Cell Biol. 2020 Apr;153(4):215-223.
2) Hum Mol Genet. 2020 Aug 3;29(13):2148-2161.
3) Nat Genet. 2009 Mar;41(3):289-98.
4) Mamm Genome. 2002 Jul;13(7):341-4.
23.03.02Vimentin phosphorylated Site amino acid substitution miceRBRC11719This strain was reported to show some premature aging phenotypes1)2).1) Cells. 2019 Sep 1;8(9):1016.
2) J Biol Chem. 2013 Dec 13;288(50):35626-35.
23.01.05A receptor of cytokine BAFFTnfrsf13c floxed miceRBRC10245BAFF-R(Tnfrsf13c) gene encodes a receptor for the cytokine TNF family member BAFF. This strain has been used for analysis of B cell functions and autoimmun diseases1)2)1) Blood. 2011 Mar 17;117(11):3104-12.
2) J Immunol. 2004 Aug 15;173(4):2245-52.
23.01.05A CDM family molecule DOCK2 KO miceRBRC10168This strain is widely utilized in basic immunology and basic disease research1)2)3)4)5)1) Am J Pathol. 2022 Feb;192(2):226-238.
2) J Allergy Clin Immunol. 2019 Nov;144(5):1377-1390.e4.
3) J Immunol. 2018 Sep 1;201(5):1442-1451.
4) Nat Genet. 2017 Oct;49(10):1437-1449.
5) Nature. 2001 Aug 23;412(6849):826-31.
23.01.05A cadherin superfamily CDH17 KO miceRBRC09896This strain has been reported to show development of B cells and dysfunction of memory B cells1)2)1) PLoS One. 2015 Jan 22;10(1):e0117566.
2) Eur J Immunol. 2005 Mar;35(3):957-63.
22.09.01Skin melanoma(OMIM:608035, 612263)
model mice
RBRC00694This KRT14-Kitl Tg strain has been reported to show epidermal pigmentation1)2)3)4)5).1) J Invest Dermatol. 2017 May;137(5):1126-1134.
2) Cell Rep. 2017 Jun 13;19(11):2177-2184.
3) J Invest Dermatol. 2015 Jul;135(7):1829-1838.
4) Development. 1998 Aug;125(15):2915-23.
5) J Exp Med. 1998 May 18;187(10):1565-73.
22.09.01Atopic dermatitis(OMIM:603165)
model mice
RBRC06233
(Coisogenic strain)
RBRC06234
(C57BL/6J background)
RBRC06235
(BALB/c background)
These Trpv3 point mutation strains have been reported to show both non-hair and atopic dermatitis-like phenotypes1)2)3)4)5).1) J Invest Dermatol. 2009 Mar;129(3):714-22.
2) Immunology. 2007 May;121(1):51-61.
3) Biochem Biophys Res Commun. 2007 Nov 23;363(3):479-83.
4) Exp Anim. 2003 Oct;52(5):419-23.
5) Exp Anim. 1997 Jul;46(3):225-9.
22.09.01IL4 KO miceRBRC04920
(C57BL/6J background)
RBRC04921
(BALB/c background)
RBRC05130
(DBA/1 background)
This strain has been reported to show increased susceptibility to infection of parasites. In addition, this strain has been used for some immunology research1)2)3)4).1) Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):13057-13062.
2) Immunity. 2014 May 15;40(5):758-71.
3) Microbiol Immunol. 2000;44(12):971-9.
4) Nature. 1993 Mar 18;362(6417):245-8.
22.07.01Cytokine signal inhibitor Socs1 floxed miceRBRC04753This strain has been used for analysis of anti-inflammatory mechanism in some kind of cells (endothelial cells, hepatic cells, neurons, etc.)1)2)3)4)5).1) FASEB J. 2021 Apr;35(4):e21388.
2) J Immunol. 2018 Jan 1;200(1):177-185.
3) J Immunol. 2017 Jul 1;199(1):149-158.
4) Nat Immunol. 2017 Jan;18(1):54-63.
5) J Immunol. 2008 Mar 15;180(6):3746-56.
22.07.01Cytokine signal inhibitor Socs3 floxed miceRBRC04754This strain has been used for analysis of anti-inflammatory mechanism in some kind of cells (endothelial cells, hematopoietic cells, neurons, etc.) 1)2)3)4)5).1) J Biol Chem. Jan-Jun 2021;296:100239.
2) Neuron. 2021 Apr 21;109(8):1333-1349.e6.
3) EBioMedicine. 2021 Nov;73:103632.
4) JCI Insight. 2021 Jul 22;6(14):e147280.
5) Nat Immunol. 2003 Jun;4(6):551-6.
22.07.01NF-κB negative regulator Tnfaip3(A20) floxed miceRBRC05494
(Tnfaip3 floxed)
RBRC05495
(Tnfaip3 KO)
These strains have been used for analysis of anti-inflammatory mechanism in some kind of cells (immune cells, hematopoietic cells, etc.)1)2)3).1) Int J Mol Sci. 2020 Apr 18;21(8):2830.
2) J Immunol. 2017 Jan 15;198(2):820-831.
3) PLoS One. 2014 Jan 31;9(1):e87425.
22.05.06Angiogenic factor Angpt1 floxed miceRBRC09330This strain has been used for some research such as various retinal diseases and diabetes mellitus1)2)3)4)5).1) Diabetes. 2019 Apr;68(4):774-786.
2) Sci Adv. 2019 Feb 13;5(2):eaau6732.
3) Nat Commun. 2018 Jun 22;9(1):2448.
4) Nat Commun. 2017 May 16;8:15296.
5) Sci Transl Med. 2013 Sep 18;5(203):203ra127.
22.05.06Src point mutated (S75D) mice with progressive optic neuropathy-like phenotypesRBRC10208The age-related retinal ganglion cell number reduction have been reported1)2).1) Sci Rep. 2017 Dec 1;7(1):16779.
2) J Biochem. 2003 May;133(5):563-9.
22.05.06Mef2d KO mice with retinitis pigmentosa like phenotypesRBRC09366
(Mef2d floxed)
RBRC09367
(Mef2d KO)
Progressive retinal photoreceptor cell loss, abnormal retinal electroretinogram, shortening of the photoreceptor outer segment, and abnormal formation of photoreceptor ribbon synapses have been reported1)2).1) Cells. 2020 Apr 10;9(4):931.
2) Genes Cells. 2015 May;20(5):408-26.
22.05.06Membrane scaffold protein
Epb4.1l2 (4.1G) KO mice
RBRC09370Mislocalization of photoreceptor terminals in retinas and visual acuity impairments in an optokinetic response have been reported 1).1) Cell Rep. 2015 Feb 10;10(5):796-808.
22.03.01Infantile-onset leukoencephalopathy model miceRBRC10267
( Mlc1-STOPtetO KI)
RBRC10268
( Mlc1-tetO KI)
These strains are capable of inducing KO or overexpression of Mlc1 gene. They reported to exhibit a phenotype similar to that of human pathology1).1) Glia. 2017 Jan;65(1):150-168.
22.03.01Early infantile epileptic encephalopathy model miceRBRC036547 repeats of the GCG triple is knocked into codon 330 of Arx gene1)2)3)4)5).1) Neurobiol Dis. 2021 Jun;153:105329.
2) Neuroscience. 2017 Aug 15;357:220-231.
3) Neurobiol Dis. 2017 Sep;105:245-256.
4) Hum Mol Genet. 2016 Dec 15;25(24):5433-5443.
5) Hum Mol Genet. 2009 Oct 1;18(19):3708-24.
22.03.01Lissencephaly model miceRBRC03438
RBRC03435
Using these Arx KO strains, various results were reported1)2)3)4).1) Biol Open. 2017 Oct 15;6(10):1552-1568.
2) PLoS One. 2013 Jun 28;8(6):e68050.
3) Development. 2005 Feb;132(4):751-62.
4) Nat Genet. 2002 Nov;32(3):359-69.
22.03.01Protrudin (Zfyve27) KO miceRBRC10084Some behavioral abnormalities containig a depression-like phenotype were reported1).1) Mol Brain. 2020 Nov 10;13(1):146.
22.01.05Cloned mice lines derived from antigen-specific CD4+ T cellsRBRC10902
RBRC10903
These strains are useful for allergic-related research as animal model with allergic predisposition1).1) EMBO Rep. 2017 Jun;18(6):885-893.
22.01.05Ca2+-dependent modulator Cys proteases Capn6 gene KO miceRBRC06237
(C57BL/6)
RBRC06238
(ICR)
Capn6 expression is observed in embryonic skeletal muscle and adult regenerated skeletal muscle. These strains are useful for research related with development and regeneration of skeletal muscle1)2).1) J Clin Invest. 2016 Sep 1;126(9):3417-32.
2) PLoS Genet. 2013;9(8):e1003668.
22.01.05Axon guidance molecule Sema4d gene KO miceRBRC10202
(C.B17/Icr-+/+Jcl)
This strain has been reported to have high reproducibility of focal cerebral infarction by middle cerebral artery occlusion1)2)3)4)5).1) Biochem Biophys Res Commun. 2020 Jan 22;521(4):827-832.
2) Neuroscience. 2019 May 15;406:420-431.
3) Glia. 2015 Dec;63(12):2249-59.
4) J Exp Stroke Transl Med. 2010 Mar;3(1):28-33.
5) J Neurosci Res. 2009 Oct;87(13):2833-41.
22.01.05Sema4D receptor Plxnb1 gene KO miceRBRC10201
(C.B17/Icr-+/+Jcl)
This strain has been reported to have high reproducibility of focal cerebral infarction by middle cerebral artery occlusion1)2)3).1) J Exp Stroke Transl Med. 2010 Mar;3(1):28-33.
2) Development. 2008 Oct;135(20):3333-43.
3) Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13188-93.
21.11.01Major components of stratum corneum Flg (filaggrin) gene KO mice1)RBRC05850
(C57BL/6J)

RBRC05851
(BALB/c)
These strains were used for research of skin diseases2)3)4).1) J Allergy Clin Immunol. 2012 Jun;129(6):1538-46.e6.
2) J Dermatol Sci. 2019 Jun;94(3):346-349.
3) Immunity. 2015 Apr 21;42(4):756-66.
4) Sci Rep. 2013;3:1731.
21.11.01GPI-anchored membrane protein Cd109 gene KO mice1)RBRC09599CD109 is highly expressed in several types of human cancers. Analysis of this strains indicated the relationship between Cd109 and some diseases2)3)4)5).1) Am J Pathol. 2012 Oct;181(4):1180-9.
2) Cell Rep. 2019 Oct 8;29(2):391-405.e5.
3) Genes Cells. 2018 Jul;23(7):590-598.
4) J Pathol. 2017 Dec;243(4):468-480.
21.11.01Foxp2[R552H] KI miceRBRC04059
RBRC04060
These strains carry a Foxp2[R552H] mutation related to human speech-language disorder1)2)3)4)5).1) Cereb Cortex. 2017 Jul 1;27(7):3648-3659.
2) Neurosci Lett. 2014 Apr 30;566:162-6.
3) J Neurochem. 2012 Jul;122(1):72-80.
4) Neurosci Lett. 2012 Jan 11;506(2):277-80.
21.11.01GPI-anchored membrane protein Mdga1 KO miceRBRC05286
RBRC10977
RBRC10978
These strains were reported to show several cognitive learning disorder or schizophrenia-like phenotypes1)2)3)4).1) Neurosci Lett. 2020 Jan 18;716:134677.
2) Cell Rep. 2017 Dec 26;21(13):3637-3645.
3) Neuroscience. 2012 Jun 1;211:136-64.
4) Dev Dyn. 2011 Jan;240(1):96-107.
21.09.01Usher syndrome type 2C (OMIM:605472) responsible gene Adgrv1(Vlgr1,Gpr98) KO miceRBRC09313
(KO)
RBRC09315
(KO)
RBRC09314
(EYFP KI)
These strains were reported to show auditory abnormalities1)2)3)4)5).1) Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):7765-7774.
2) J Clin Endocrinol Metab. 2012 Apr;97(4):E565-74.
3) Neurosci Lett. 2009 Sep 18;461(2):190-5.
4) J Neurosci. 2007 Jun 13;27(24):6478-88.
5) J Neurochem. 2005 Jan;92(1):191-202.
21.09.01Prader-Willi syndrome (OMIM:176270) responsible gene Necdin(Ndn) KO miceRBRC09382
(B6)
RBRC09363
(ICR)
RBRC02316
(ICR and B6 mixed)
These strains were reported to show behavioral and neuromorphological abnormalities1)2)3)4)5).1) Nat Commun. 2016 Mar 14;7:10943.
2) PLoS One. 2014 Jan 2;9(1):e84460.
3) J Neurosci. 2013 Jun 19;33(25):10362-73.
4) J Neurosci. 2012 Apr 18;32(16):5562-72.
5) J Neurosci. 2005 Jul 27;25(30):7090-9.
21.09.01Congenital stationary night blindness responsible gene Trpm1 KO miceRBRC05509
(B6)
RBRC05138
(129)
These strains were reported to show vision abnormalities1)2)3)4)5).1) Mol Brain. 2021 Mar 30;14(1):61.
2) J Neurosci. 2017 Oct 11;37(41):9889-9900.
3) PLoS One. 2013 Nov 25;8(11):e81507.
4) Eur J Neurosci. 2013 Sep;38(6):2823-31.
5) Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):332-7.
21.09.01SNARE protein family Snap25 gene amino acid substitution miceRBRC09306
This strain was reported to show behavioral disorders1)2)3)4).1) Sci Rep. 2017 Aug 11;7(1):7996.
2) Epilepsy Res. 2015 Sep;115:30-44.
3) J Neurosci. 2012 Nov 28;32(48):17186-96.
4) PLoS One. 2011;6(9):e25158.
21.07.01One subunit of NMDA receptor
Grin2a gene KO mice1)
RBRC01195
(C57BL/6J)
RBRC02256
(B6 and 129 mixed)
These strains were used for research of neural mechanism2)3) or NMDA receptor-related neural disorders4).1) J Neurosci. 1996 Dec 15;16(24):7859-67.
2) Proc Natl Acad Sci U S A. 2019 Oct 15;116(42):21207-21212.
3) Nat Neurosci. 2011 Mar;14(3):338-44.
4) Cell Rep. 2020 Jan 14;30(2):381-396.e4.
21.07.01Synaptic protein
Stxbp1 (Munc18-1) gene
floxed mice
RBRC05604Analysis of this strain revealed a novel mechanism to trigger epilepsy1)2).1) Nat Commun. 2019 Apr 23;10(1):1917.
2) Hum Mol Genet. 2017 Dec 15;26(24):4961-4974.
21.07.01Serine protease
Klk8 (Neuropsin) gene
KO mice1)
RBRC02740The relationship between some behavior disorders (social discrimination behavior2), cognitive disorders3), stress disorders4), etc.) and Neuropsin was indicated by analysis of this strain.1) Mol Cell Neurosci. 2001 Mar;17(3):600-10.
2) Neurobiol Learn Mem. 2019 Jul;162:47-58.
3) Transl Psychiatry. 2017 Mar 7;7(3):e1052.
4) PLoS Genet. 2016 Oct 4;12(10):e1006356.
21.07.01Secreted glycoprotein
Reln (Reelin) gene
C-terminal deficient mice1)
RBRC03079This strain was reported to show several neuropsychiatric or behavior disorders2)3).1) J Neurosci. 2015 Mar 18;35(11):4776-87.
2) Neuroscience. 2016 Nov 12;336:20-29.
3) Sci Rep. 2016 Jun 27;6:28636.
21.04.27Downstream factor of IL-17 signaling pathway Nfkbiz (IκB-ζ) floxed mice1)RBRC06410This strain is useful for Nfkbiz functional analyisis in various kinds of cells2)3)4)5). Recently, the relationship between ulcerative colitis and NHKBIZ was indicated by using this strain6). 1) Immunity. 2013 Mar 21;38(3):450-60.
2) J Immunol. 2020 Apr 15;204(8):2033-2042.
3) JCI Insight. 2019 Nov 14;4(22):e130835.
4) Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):10088-10093.
5) Mouse of the Month Apr 2017
6) Nature. 2020 Jan;577(7789):260-265.
21.04.27Tyrosine kinase receptor family EphB6 KO mice1)RBRC02280The relationship between metastatic process of colorectal cancer and EPHB6 was indicated by analysis of this strain2).1) Biochem Biophys Res Commun. 2002 Oct 18;298(1):87-94.
2) Sci Rep. 2017 Mar 6;7:43702.
21.04.27ROS1-fusion positive lung cancer model miceRBRC09696
(CD74-ROS1 Tg)
RBRC09697
(SDC4-ROS1 Tg)
These strains are Tg mice expressing CD74-ROS1 or SDC4-ROS1 fusion proteins which have been reported in human lung cancer cases1).1) Carcinogenesis. 2016 May;37(5):452-60.
21.04.27Glycolysis enzyme PKM (pyruvate kinase M) mutant miceRBRC10481
(PKM1 KI)
RBRC10482
(PKM2 KI)
These strains selectively expressing PKM splicing isoforms (PKM1 or PKM2) were developed to analyze glycolytic enzyme PKM function for cancer glucose metabolism (Warburg effect)1).1) Cancer Cell. 2018 Mar 12;33(3):355-367.e7.
21.03.01Autism spectrum disorder model miceRBRC05954This strain is a mouse model of human 15q11–13 duplication1)2)3)4).
Using functional MRI, neural circuit dysfunction in this strain
was reported5).
1) Sci Rep. 2018 Sep 12;8(1):13675.
2) Sci Rep. 2017 Aug 29;7(1):9902.
3) Mouse of the Month April 2015.
4) Cell. 2009 Jun 26;137(7):1235-46.
5) Sci Adv. 2020 Feb 5;6(6):eaav4520.
21.03.01Ednrb (endothelin receptor type B) KO mice1)RBRC06163This strain was reported as a Hirschsprung's disease2), melanoma3) or Waardenburg syndrome4) model.1) Cell. 1994 Dec 30;79(7):1267-76.
2) Development. 1998 Mar;125(5):825-36.
3) Cancer Res. 2010 Jan 1;70(1):24-9.
4) J Biol Chem. 2011 Aug 26;286(34):29621-6.
21.03.01 Lymphoedema-distichiasis syndrome responsible gene Foxc2 floxed miceRBRC10306The phenotype analysis results of Foxc2 conditionally deleted mice in kidneys were reported1).1) Mamm Genome. 2016 Feb;27(1-2):62-9.
21.03.01TPST2 enzymatic activity deficient mice RBRC05261This strain is reported to show a growth retardation with hypothyroidism1)2)3).1) Biomed Res. 2010 Jun;31(3):207-11.
2) J Vet Med Sci. 2008 Oct;70(10):1043-9.
3) Mol Endocrinol. 2007 Jul;21(7):1713-21.
21.01.04Vitamin D receptor VDR KO mice1)2)RBRC05885This strain shows osteoporosis and rickets-like phenotypes. Therefore, it is utilized to reveal the relationship between vitamin D and osteogenesis3)4)5).1) Endocrinology. 2000 Apr;141(4):1317-24.
2) Nat Genet. 1997 Aug;16(4):391-6.
3) Biochem Biophys Res Commun. 2017 Jan 29;483(1):359-365.
4) Endocrinology. 2017 Jun 1;158(6):1951-1963.
5) Sci Rep. 2017 Aug 10;7(1):7786.
21.01.04A kind of GPCR GPRC5B KO mice1)RBRC10166Analysis of this strain suggested that GPRC5B is related with obesity-associated inflammatory signaling and synapse formation in Purkinje cells2)3).1) Biochem Biophys Res Commun. 2011 Sep 2;412(3):460-5.
2) Sci Signal. 2012 Nov 20;5(251):ra85.
3) Neurosci Res. 2018 Nov;136:33-47.
21.01.04ACAM(CLMP) Tg mice controlled by adipocyte P2 promoter RBRC06443
RBRC06444
RBRC06445
In response to high fat-high sucrose diet feeding, these strains show resistance to obesity and diabetes1)2)3).1) J Lipid Res. 2000 Oct;41(10):1615-22.
2) Biochem J. 2005 Apr 15;387(Pt 2):343-53.
3) Diabetes. 2016 May;65(5):1255-67.
21.01.04Phosphatidylcholine biosynthetic enzyme Pemt KO miceRBRC06436In response to high fat-high sucrose diet feeding, these strains show not only resistance to obesity and diabetes but also non-alcoholic steatohepatitis1)2).1) Sci Rep. 2016 Feb 17;6:21721.
2) PLoS One. 2014 Mar 25;9(3):e92647.
20.10.23Human renin・human angiotensinogen double Tg miceRBRC01122
(hRN Tg)
RBRC01123
(hAG Tg)
RBRC02432
(F1(hRN × hAG))
These strains were contributed to some results as Tsukuba Hypertensive mice1)2)3). Additionally, these are known as pregnancy-induced hypertension models4)5).1) Eur J Histochem. 2018 Jul 24;62(3):2930.
2) Mouse of the Month May 2012
3) Biochem Biophys Res Commun. 1991 Oct 31;180(2):1103-9.v
4) Sleep. 2018 Mar 1;41(3).
5) Sci Signal. 2017 May 16;10(479):eaam5711.
20.10.23Prolin isomerase Pin1-KO mice1)2)RBRC10368Analysis of this strain suggested the relationship between PIN1 and various biological phenomenon and diseases3)4)5).1) Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1335-40.
2) Biochem Biophys Res Commun. 1999 Nov 30;265(3):658-63.
3) Hum Mol Genet. 2018 Nov 15;27(22):3827-3839.
4) Biochem Biophys Res Commun. 2018 Feb 26;497(1):388-393.
5) Biochem Biophys Res Commun. 2017 Nov 18;493(2):946-951.
20.10.23p53-target gene Tigar-KO miceRBRC10981Analysis of this strain suggested the relationship between TIGAR and cardiac metabolism1)2).1) Am J Physiol Heart Circ Physiol. 2019 Jun 1;316(6):H1366-H1377.
2) J Mol Cell Cardiol. 2012 Jan;52(1):175-84.
20.10.23Endogenous membrane protein Aqp7-KO miceRBRC06294Analysis of this strain suggested the relationship between AQP7 and various metabolism pathways1)2)3).1) Cardiovasc Res. 2009 Jul 1;83(1):34-41.
2) Proc Natl Acad Sci U S A. 2005 Aug 2;102(31):10993-8.
3) Proc Natl Acad Sci U S A. 2004 Dec 21;101(51):17801-6.
20.03.02Endoplasmic reticulum (ER) transmembrane protein IRE1α(ERN1)-KO/cKO mice1)RBRC05515
(floxed)
RBRC05516
(KO)
These strains are utilized to reveal the relationship between ER stress and some diseases2)3)4).1) Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16657-62.
2) Nat Commun. 2018 Dec 17;9(1):5340.
3) Nature. 2018 Oct;562(7727):423-428.
4) J Cell Biol. 2018 Apr 2;217(4):1287-1301.
20.03.02Tumor necrosis factor (TNF) receptor-associated factor TRAF6-KO mice1)RBRC04950
(C57BL/6)
RBRC05386
(BALB/c)
These strains show various disorders like ectodermal dysplasia, osteopertrosis, autoimmunity and so on2)3)4)5).1) Genes Cells. 1999 Jun;4(6):353-62.
2) Commun Biol. 2019 Aug 6;2:292.
3) Proc Natl Acad Sci U S A. 2017 Aug 22;114(34):E7140-E7149.
4) J Biol Chem. 2017 Jun 16;292(24):10169-10179.
5) Mouse of the Month Sep 2012
20.03.02Tubulin glutamylation enzyme TTLL1-KO miceRBRC03327This strain shows primary ciliary dyskinesia-like phenotype1)2)3).1) Sci Rep. 2018 Feb 13;8(1):2904.
2) PLoS One. 2015 Nov 18;10(11):e0141823.
3) Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10490-5.
20.03.02Apoptosis-related transmembrane receptor FAS-KO miceRBRC01474
(C57BL/6)
RBRC01476
(MRL)
These strains show autoimmune
lymphoproliferative syndrome (OMIM: 601859)-like phenotype1)2)3)4).
1) Proc Natl Acad Sci U S A. 1996 Mar 5;93(5):2131-6.
2) Nat Genet. 1995 Nov;11(3):294-300.
3) Eur J Immunol. 2013 Jul;43(7):1789-98.
4) J Exp Med. 2013 Sep 23;210(10):2087-103.
20.01.06Spinal and bulbar muscular atrophy (SBMA) model miceRBRC00344This strain shows some phenotypes similar to human patients. It is utilized to explore molecular mechanisms and therapeutic agents1) 2) 3).1) Hum Mol Genet. 2018 Jul 15;27(14):2425-2442.
2) J Neurosci. 2016 May 4;36(18):5094-106.
3) Neuron. 2002 Aug 29;35(5):843-54.
20.01.06Limb-girdle muscular dystrophy type 2A (LGMD2A) model miceRBRC04787CAPN3 protease activity-deficient mice show muscular disease-like phenotypes1) 2) 3).1) Hum Mol Genet. 2018 May 1;27(9):1642-1653.
2) J Clin Invest. 2010 Aug;120(8):2672-83.
3) J Biol Chem. 2010 Jul 23;285(30):22986-98.
20.01.06Sporadic amyotrophic lateral sclerosis (ALS) model mice RBRC09428This strain shows some phenotypes similar to human patients. It is utilized to explore molecular mechanisms and therapeutic agents1) 2) 3) 4).1) Sci Rep. 2017 Jan 3;7:39994.
2) Sci Rep. 2016 Jun 28;6:28649.
3) J Neurosci. 2010 Sep 8;30(36):11917-25.
4) Mouse of the Month Nov 2015.
20.01.06Familial amyotrophic lateral sclerosis (ALS) model mice RBRC09642
RBRC09643
RBRC09644
Tg mice harboring mutated human SOD1 show progressive motor neuron disease-like phenotypes1).1) Hum Mol Genet. 2015 Jun 15;24(12):3427-39.
19.11.06Disc1 point mutated (L100P) mice with schizophrenia-like phenotypesRBRC06364This strain is a schizophrenia model, which established by ENU mutagenesis 1) 2) 3) 4).1) Neuron. 2007 May 3;54(3):387-402.
2) Front Cell Neurosci. 2018 Aug 2;12:238.
3) Behav Brain Res. 2017 Mar 1;320:113-118.
4) Schizophr Bull. 2017 Jan;43(1):214-225.
19.11.06Disc1 point mutated (Q13L) mice with depression-like phenotypesRBRC06365This strain is a endogenous depression model, which established by ENU mutagenesis 1) 2) 3).1) Neuron. 2007 May 3;54(3):387-402.
2) Neuroscience. 2016 May 3;321:99-107.
3) PLoS One. 2014 Oct 1;9(10):e108088.
19.11.06CaMKIIα point mutated (K42R) mice with learning and memory deficits RBRC05821
RBRC05636
CaMKIIα kinase activity-deficient mice shows hippocampus-dependent learning and memory deficits 1) 2) 3).1) eNeuro. 2018 Aug 21;5(4). pii: ENEURO.0133-18.2018.
2) Genes Dev. 2014 May 15;28(10):1101-10.
3) J Neurosci. 2009 Jun 10;29(23):7607-18.
19.11.06Metabotropic glutamate receptor 2 (mGluR2)-KO mice 1)RBRC01351Analysis of this strain suggested the relationship between mGluR2 and schizophrenia 2) 3) 4).1) Science. 1996 Aug 2;273(5275):645-7.
2) Sci Signal. 2016 Jan 12;9(410):ra5.
3) J Neurosci. 2016 Nov 9;36(45):11521-11531.
4) PLoS One. 2015 May 7;10(5):e0125523.
19.09.03GPI-anchored protein CD109-KO mice1) 2)RBRC05911This strain shows osteopenia3) and psoriasis-like epidermal hyperplasia4). In addition, CD109 is known to be a regulator of tumor progression5).1) Pathol Int. 2019 May;69(5):249-259.
2) Mouse of the Month Nov 2013.
3) Genes Cells. 2018 Jul;23(7):590-598.
4) Am J Pathol. 2012 Oct;181(4):1180-9.
5) J Pathol. 2017 Dec;243(4):468-480.
19.09.03G protein-coupled receptor BLT2-KO miceRBRC04741
RBRC04742
This strain shows not only DSS-induced colitis exacerbation1) but also delayed skin or corneal wound healing 2) 3) 4). 1) FASEB J. 2010 Dec;24(12):4678-90.
2) Sci Rep. 2017 Oct 16;7(1):13267.
3) FASEB J. 2016 Feb;30(2):933-47.
4) J Exp Med. 2014 Jun 2;211(6):1063-78.
19.09.03Scott syndrome
(OMIM: 262890)
disease gene Ano6 (Tmem16F) floxed mice1)
RBRC09797Platelet-specific Ano6-null mice shows a mild bleeding disorder similar to the human condition2).1) J Biol Chem. 2013 May 10;288(19):13305-16.
2) Proc Natl Acad Sci U S A. 2015 Oct 13;112(41):12800-5.
19.09.03Winchester syndrome
(OMIM: 277950)
disease gene Mmp14 (MT1-MMP) KO/LacZ KI mice
RBRC05977Mmp14-null mice shows severve osteolysis. In addition, this strain is useful for Mmp14 expression analysis1) 2) 3) 4) 5).1) Development. 2013 Jan 15;140(2):343-52.
2) Dev Cell. 2013 May 28;25(4):402-16.
3) Diabetes. 2010 Oct;59(10):2484-94.
4) Genes Cells. 2009 May;14(5):617-26.
5) J Cell Sci. 2007 May 1;120(Pt 9):1607-14.
19.07.01ATR-X syndrome
(OMIM: 301040)
model mice
RBRC04937This is a Atrx (disease gene) knockout mouse strain, which shows some abnormal phenotypes similar to the human condition1) 2) and is utilized to explore therapeutic agents3).1) J Neurosci. 2011 Jan 5;31(1):346-58.
2) Hippocampus. 2011 Jun;21(6):678-87.
3) Nat Med. 2018 Jun;24(6):802-813.
19.07.01Cardio-facio-cutaneous syndrome-1
(OMIM: 115150)
model mice
RBRC09730
RBRC09731
RBRC09907
RBRC09908
This is a Braf (disease gene) point mutation knockin mouse strain, which shows some abnormal phenotypes similar to the human condition1) 2) 3) 4).1) Hum Mol Genet. 2019 Jan 1;28(1):74-83.
2) Hum Mol Genet. 2017 Dec 1;26(23):4715-4727.
3) Hum Mol Genet. 2015 Dec 20;24(25):7349-60.
4) Hum Mol Genet. 2014 Dec 15;23(24):6553-66.
19.07.01Chédiak-Higashi syndrome
(OMIM: 214500)
model mice
RBRC00134This is a Lyst (disease gene) spontaneous mutation mouse strain, which shows some abnormal phenotypes similar to the human condition1) and is utilized to analyze the mechanism2) 3).1) Nature. 1996 Jul 18;382(6588):262-5.
2) Mol Genet Metab. 2010 Apr;99(4):389-95.
3) J Biol Chem. 1997 Nov 21;272(47):29790-4.
19.07.01Griscelli syndrome
cutaneous and neurologic type
(OMIM: 214450)
model mice
RBRC02978This is a Myo5a (disease gene) spontaneous point mutation mouse strain, which shows abnormal pigmentation and neurological impairment similar to the human condition1) 2).1) J Neurosci. 2011 Apr 20;31(16):6067-78.
2) Genetics. 1998 Apr;148(4):1963-72.



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