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Today’s tool for functional analysis / Today’s model for human disease

▶ Today’s tool for functional analysis▶ Today’s model for human disease

Date	Title	BRC No.	Description	References
19.08.01	Cre-driver mice for orexin neurons	RBRC06806	This strain expresses Cre recombinase and EGFP exclusively in orexin neurons^{1) 2)}.	1) Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):E10740-E10747. 2) Neuropharmacology. 2014 Oct;85:451-60.
19.08.01	Full maturated OSN (olfactory sensory neuron) reporter mice¹⁾	RBRC02092	OMP (olfactory marker protein) gene-GFP KI mice are broadly utilized for olfactory analysis^{2) 3) 4)}.	1) J Neurosci. 2001 Dec 15;21(24):9713-23. 2) J Neurosci. 2019 Jan 30;39(5):814-832. 3) Cell Stem Cell. 2017 Dec 7;21(6):761-774.e5. 4) Cell. 2016 Jun 16;165(7):1734-1748.
19.08.01	Selenocysteine-tRNA (Trsp) floxed mice¹⁾	RBRC02681	This strain was utilized for an oxidative stress model^{2) 3)}.	1) J Biol Chem. 2008 Jan 25;283(4):2021-30. 2) Cell Rep. 2017 Feb 21;18(8):2030-2044. 3) Blood. 2011 Jan 20;117(3):986-96.
19.08.01	Neuronally enriched Rufy3 KO-first mice	RBRC05780	Analysis of this strain revealed that RUFY3 is essential for caspase-mediated axon degeneration¹⁾.	1) Neuron. 2019 Jun 7. pii: S0896-6273(19)30483-0.
19.06.03	Cre-driver mice for postnatal somatic motor neurons	RBRC01515 RBRC01516	These strain express Cre recombinase selectively in slow type motor neurons^{1) 2)}.	1) Genesis. 2016 Nov;54(11):568-572. 2) Brain Res. 2014 Mar 6;1550:36-46.
19.06.03	Mitochondria-EGFP labeled mice^{1) 2)}	RBRC02250	This transgenic strain is utilized to identify and monitor the mitochondorial morphology^{3) 4)}.	1) Exp Anim. 2010;59(1):99-103. 2) FEBS Lett. 2001 Jun 29;500(1-2):7-11. 3) Sci Transl Med. 2017 Oct 25;9(413). 4) PLoS One. 2012;7(6):e36850.
19.06.03	Zinc transporter Slc39a10 (Zip10) floxed mice	RBRC06221	Analysis of this strain revealed novel functions of Slc39a10 in humoral immune system^{1) 2)} and epidermal development³⁾.	1) Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):11786-91. 2) Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):11780-5. 3) Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):12243-12248.
19.06.03	Cell adhesion molecule Cadm1 (SynCAM1) KO mice	RBRC04062	This strain was utilized for analysis of not only nervous system^{1) 2) 3)} but also bone turnover⁴⁾.	1) J Neurosci. 2016 Jul 13;36(28):7464-75. 2) Neuron. 2010 Dec 9;68(5):894-906. 3) Biochem Biophys Res Commun. 2010 Jun 4;396(3):703-8. 4) PLoS One. 2017 Apr 17;12(4):e0175632.
19.04.01	Cre-driver mice for myelinating cells of the central nervous system¹⁾	RBRC01461	This strain is useful for the elucidation of gene function in oligodendrocyte myelination²⁾.	1) Genesis. 2000 Feb;26(2):127-9. 2) Nat Commun. 2016 Nov 23;7:13478.
19.04.01	Oct3/4 (Pou5f1) reporter mice	RBRC00771¹⁾ RBRC06037²⁾	These strains are useful for stem cell research because they express EGFP under the control of pluripotency marker Oct3/4^{3) 4) 5)}.	1) Dev Biol. 2003 Jun 1;258(1):209-25. 2) Development. 2008 Mar;135(5):909-18. 3) Cell Res. 2011 Jan;21(1):196-204. 4) Dev Biol. 2010 Oct 1;346(1):90-101. 5) Stem Cells. 2009 Feb;27(2):383-9.
19.04.01	Fgf5 spontaneous mutant mice	RBRC05894 RBRC05895	This strain shows abnormal hair follicle cycle¹⁾. In addition, it contributed to the research about spermatogenic stem cells²⁾.	1) Exp Anim. 2011;60(2):161-7. 2) Cell Stem Cell. 2019 Jan 3;24(1):79-92. e6.
19.04.01	Fstl4 (Mahya) reporter mice	RBRC04952	This strain is useful for revolutionary genetic research¹⁾In addition, it was used to monitor specific subtypes of retinal ganglion cells²⁾.	1) Dev Genes Evol. 2005 Nov;215(11):564-74. 2) Curr Eye Res. 2016 Apr;41(4):558-68.

Date	Title	BRC No.	Description	References
19.07.01	ATR-X syndrome (OMIM: 301040) model mice	RBRC04937	This is a Atrx (disease gene) knockout mouse strain, which shows some abnormal phenotypes similar to the human condition^{1) 2)} and is utilized to explore therapeutic agents³⁾.	1) J Neurosci. 2011 Jan 5;31(1):346-58. 2) Hippocampus. 2011 Jun;21(6):678-87. 3) Nat Med. 2018 Jun;24(6):802-813.
19.07.01	Cardio-facio-cutaneous syndrome-1 (OMIM: 115150) model mice	RBRC09730 RBRC09731 RBRC09907 RBRC09908	This is a Braf (disease gene) point mutation knockin mouse strain, which shows some abnormal phenotypes similar to the human condition^{1) 2) 3) 4)}.	1) Hum Mol Genet. 2019 Jan 1;28(1):74-83. 2) Hum Mol Genet. 2017 Dec 1;26(23):4715-4727. 3) Hum Mol Genet. 2015 Dec 20;24(25):7349-60. 4) Hum Mol Genet. 2014 Dec 15;23(24):6553-66.
19.07.01	Chédiak-Higashi syndrome (OMIM: 214500) model mice	RBRC00134	This is a Lyst (disease gene) spontaneous mutation mouse strain, which shows some abnormal phenotypes similar to the human condition¹⁾ and is utilized to analyze the mechanism^{2) 3)}.	1) Nature. 1996 Jul 18;382(6588):262-5. 2) Mol Genet Metab. 2010 Apr;99(4):389-95. 3) J Biol Chem. 1997 Nov 21;272(47):29790-4.
19.07.01	Griscelli syndrome cutaneous and neurologic type (OMIM: 214450) model mice	RBRC02978	This is a Myo5a (disease gene) spontaneous point mutation mouse strain, which shows abnormal pigmentation and neurological impairment similar to the human condition^{1) 2)}.	1) J Neurosci. 2011 Apr 20;31(16):6067-78. 2) Genetics. 1998 Apr;148(4):1963-72.
19.05.08	Ehlers-Danlos syndorome spondylodysplastic type 3 (OMIM: 612350) model mice	RBRC06217	This is a Slc39a13 (disease gene) knockout mouse strain, which shows defect of connective tissue similar to the human condition^{1) 2)}.	1) PLoS Genet. 2017 Aug 30;13(8):e1006950. 2) PLoS One. 2008;3(11):e3642.
19.05.08	Myoclonic epilepsy of Lafora (OMIM: 254780) model mice	RBRC02715	This is a Epm2a (disease gene) knockout mouse strain, which shows progressive eurodegeneration similar to the human condition^{1) 2) 3)}.	1) Hum Mol Genet. 2017 Dec 15;26(24):4778-4785. 2) Brain. 2014 Mar;137(Pt 3):806-18. 3) Hum Mol Genet. 2002 May 15;11(11):1251-62.
19.05.08	Hirschsprung disease susceptibility to 1 (OMIM: 142623) model mice	RBRC06249	This is a Ret (disease gene) point mutation knockin mouse strain, which shows megacolon and deafness similar to the human condition^{1) 2) 3)}.	1) Dev Biol. 2011 Jan 15;349(2):160-8. 2) Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13051-6. 3) Mol Cell Biol. 2004 Sep;24(18):8026-36.
19.05.08	Mowat-Wilson syndrome (OMIM: 235730) model mice	RBRC01925	This is a Zeb2 (disease gene) knockout mouse strain, which shows some abnormal phenotypes similar to the human condition^{1) 2) 3)}.	1) Hum Mol Genet. 2007 Jun 15;16(12):1423-36. 2) Am J Hum Genet. 2003 Feb;72(2):465-70. 3) Genesis. 2002 Feb;32(2):82-4.