RIKEN BioResource Center Mouse E-mail News No. 140

RIKEN BioResource Center Mouse E-mail News No. 140

RIKEN BioResource Center (BRC) is pleased to update you with the latest

======= Contents ===============================================
- 2017 RIKEN MARC KMPC Mouse Workshop
- 2017 AMMRA & AMPC Meeting
- User publications
- Newly deposited mouse strains

| 2017 RIKEN MARC KMPC Mouse Workshop

 RIKEN BRC, Model Animal Research Center (MARC) and Korea Mouse Phenotyping 
Consortium (KMPC) will hold a joint Mouse Workshop "From Breeding Mouse to 
Editing Mouse Genome" at NEST Hotel, Incheon in Korea from August 28th 
through to 29th.


| The 64th Annual Meeting of the Japanese Association for Laboratory Animal

 The 64th Annual Meeting of the Japanese Association for Laboratory Animal 
will be held at Big Palette Fukushima from May 25th through to 27th.


| User publications

 The following result has been newly reported by users. We are
honored to introduce new publications to the science community.
Therefore, we look forward to receiving your publications too.

RBRC00806  GFP-LC3#53
Fujimoto C, Iwasaki S, Urata S, Morishita H, Sakamaki Y, 
Fujioka M, Kondo K, Mizushima N, Yamasoba T. Autophagy is 
essential for hearing in mice. 
Cell Death Dis. ;8(5):e2780, 2017.

RBRC00858  B6;129S6-Bcl2l12/Irf3<tm1Ttg>/TtgRbrc [IRF-3 KO/B6, C57BL/6]
Ishii T, Hosoki K, Nikura Y, Yamashita N, Nagase T, Yamashita N.
IFN Regulatory Factor 3 Potentiates Emphysematous Aggravation by 
Lipopolysaccharide. J. Immunol. ;198(9):3637-3649, 2017.

RBRC00872  XO
Miura K, Murata C, Harikae K, Suzuki H, Kanai-Azuma M, 
Kurohmaru M, Tsunekawa N, Kanai Y. Defects in the first 
wave of folliculogenesis in mouse XO ovaries.
J. Reprod. Dev., doi: 10.1262/jrd.2017-033, 2017.

RBRC01071  Floxed RBP-J [Floxed RBP-J]
RBRC04495  B6.Cg-Tg(Tek-cre)1Ywa [Tie2-Cre, B6-TekCre Tg]
Sawaguchi S, Varshney S, Ogawa M, Sakaidani Y, Yagi H, 
Takeshita K, Murohara T, Kato K, Sundaram S, Stanley P, 
Okajima T. O-GlcNAc on NOTCH1 EGF repeats regulates 
ligand-induced Notch signaling and vascular development 
in mammals. Elife., doi: 10.7554/eLife.24419, 2017.

RBRC01934  C3.NSY-(D11Mit74-D11Mit229) [C3H.NSY-Nidd1n R1 Congenic]
Ohno T, Maegawa T, Katoh H, Miyasaka Y, Suzuki M, Kobayashi M, 
Horio F. A new missense mutation in the paired domain of the 
mouse Pax3 gene. Exp. Anim., doi: 10.1538/expanim.17-0013, 2017.

RBRC01965  B6;129S4-Fbxo15<tm1Yam>
Donato V, Bonora M, Simoneschi D, Sartini D, Kudo Y, Saraf A, 
Florens L, Washburn MP Stadtfeld M, Pinton P, Pagano M. 
The TDH-GCN5L1-Fbxo15-KBP axis limits mitochondrial biogenesis 
in mouse embryonic stem cells. Nat. Cell Biol. ;19(4):341-351, 2017.

RBRC02422   B6.129S2-Mdk<tm1Tmu> [Mdk-KO/C57BL/6J]
Chen H, He D, Lasek AW. Midkine in the Mouse Ventral 
Tegmental Area Limits Ethanol Intake and Ccl2 Gene 
Expression. Genes Brain Behav., doi: 10.1111/gbb.12384, 2017.

RBRC02759  B6.Cg-Atg7<tm1Tchi> [C57BL/6-Atg7 flox/flox]
RBRC02975  B6.129S-Atg5<tm1Myok> [Atg5flox]
Zhang Y, Cross SD, Stanton JB, Marmorstein AD, Le YZ, 
Marmorstein LY. Early AMD-like defects in the RPE and 
retinal degeneration in aged mice with RPE-specific 
deletion of Atg5 or Atg7. Mol Vis. ;23:228-241, 2017.

RBRC02796  B6.Cg-Stab2<tm1> [Stab2-KO]
Donner AJ, Wancewicz EV, Murray HM, Greenlee S, Post N, 
Bell M, Lima WF, Swayze EE, Seth PP. Co-Administration 
of an Excipient Oligonucleotide Helps Delineate Pathways 
of Productive and Nonproductive Uptake of Phosphorothioate 
Antisense Oligonucleotides in the Liver. Nucleic Acid Ther.,
doi: 10.1089/nat.2017.0662, 2017. 

RBRC04395  B6;129-Siglec1<tm1(HBEGF)Mtka> [CD169-DTR KO]
Wang D, Li Q, Yang Y, Hao S, Han X, Song J, Yin Y, Li X, 
Tanaka M, Qiu CH. Macrophage Subset Expressing CD169 in 
Peritoneal Cavity-Regulated Mucosal Inflammation Together 
with Lower Levels of CCL22. Inflammation. 
doi: 10.1007/s10753-017-0562-0, 2017.

RBRC04841  B6N.129P2-Bhlhe40<tm1Homy> [Dec1 KO]
Jinhua H, Zhao M, Shuangcheng H, Yuanran Z, Rui N, Wei L, 
Bingfang Y, Jian Y. Icariin protects against glucocorticoid 
induced osteoporosis, increases the expression of the bone 
enhancer DEC1 and modulates the PI3K/Akt/GSK3β/β-catenin 
integrated signaling pathway. Biochem Pharmacol.,
doi: 10.1016/j.bcp.2017.04.010, 2017.

RBRC04950  B6;129P2-Traf6<tm1Jino> [B6-Traf6 KO]
Ismail HM, Didangelos A, Vincent TL, Saklatvala J.
Rapid Activation of Transforming Growth Factor β-Activated 
Kinase 1 in Chondrocytes by Phosphorylation and K63 -Linked 
Polyubiquitination Upon Injury to Animal Articular Cartilage. 
Arthritis. Rheumatol. ;69(3):565-575, 2017.

RBRC-GSC0247  M100366
Yamamoto H, Takada T, Yamanashi Y, Ogura M, Masuo Y, 
Harada-Shiba M, Suzuki H. VLDL/LDL acts as a drug 
carrier and regulates the transport and metabolism 
of drugs in the body. Sci Rep. ;7(1):633, 2017.

| Newly deposited mouse strains

Dr. Masahito Ikawa, Osaka University
RBRC06470  B6D2-Tg(CAG-FLPo)1Osb
RBRC06471  STOCK Adam18<tm1Osb>/30
RBRC06472  C57BL/6N-Capn11<tm1Osb>/5B
RBRC06476  C57BL/6N-Adam18<tm1Osb>/2
RBRC06479  B6D2-Tg(CAG-FLPo)2Osb
RBRC06480  B6D2-Tg(Stra8-Cre)1Osb
RBRC09938  B6D2-1110017D15Rik<em1Osb>
RBRC09939  B6D2-Spaca7<em1Osb>
RBRC09940  B6D2-2900092C05Rik<em1Osb>
RBRC09941  B6D2-Stpg4<em1Osb>
RBRC09944  B6D2-Lyzl1<em1Osb>
RBRC09948  B6D2-Pinlyp<em1Osb>
RBRC09950  B6D2-Tmco5<em1Osb>
RBRC09951  B6D2-1700015F17Rik<em1Osb>
RBRC09955  B6D2-Tmem247<em1Osb>
RBRC09957  B6D2-Col20a1<em1Osb>
RBRC09963  B6D2-C1qtnf4<em1Osb>
RBRC09964  B6D2-4930522H14Rik<em1Osb>
RBRC09968  B6D2-Ubqlnl<em1Osb>
RBRC09972  B6D2-Smim23<em1Osb>
RBRC09973  B6D2-Ms4a13<em1Osb>
RBRC09982  B6.Cg-Tg(CAG-FLPo)1Osb
RBRC09983  B6D2-Gm5617<em1Osb>
RBRC09984  B6D2-Gm5617<em2Osb>

Dr. Yoshihiro Miwa, University of Tsukuba
RBRC09257  C.Cg-Tg(CAG-tdKaede)15Utr

Dr. Masanori Miyanishi, Stanford University School of Medicine
RBRC09733  B6.Cg-Hoxb5<em1.1Ilw>

Dr. Mitsuo Tagaya, Tokyo University of Pharmacy and Life Sciences
RBRC09738  B6;B6CB-Ddhd1<tm1a(KOMP)Katn>
RBRC09740  B6.Cg-Ddhd1<tm1b(KOMP)Katn>

Dr. Naoki Itano, Kyoto Sangyo University
RBRC09904  B6.129-Has1<tm1Nita>Has2<tm1.1Nita>

Dr. Katsuhiko Itoh, Kyoto University
RBRC09931  C57BL/6-Prm2<em1(S56A)Kyot>
RBRC09932  C57BL/6-Prm2<em2(S56D)Kyot>


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RIKEN BioResource Center
Experimental Animal Division
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Ibaraki, 305-0074 Japan

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