RIKEN BioResource Research Center Mouse E-mail News No. 156

RIKEN BioResource Research Center Mouse E-mail News No. 156

RIKEN BioResource Research Center (BRC) is pleased to update you with the 
latest information.

======= Contents =======================================================
- Special topic: Mouse of the Month 
  "A novel Down syndrome mouse model by chromosome engineering technique"
- Today's model for human disease
- User publications
- Newly deposited mouse strains

| Special topic: Mouse of the Month

A novel Down syndrome mouse model by chromosome engineering technique
  RBRC05796 STOCK Tc(HSA21q-MAC1)
Depositor: Yasuhiro Kazuki, Ph.D.
           Chromosome Engineering Research Center, Tottori University

Mouse of the Month archive

| Today's model for human disease

Autism spectrum disorder model mice
RBRC05954 B6.129S7-Dp(7Herc2-Mkrn3)1Taku

Ednrb (endothelin receptor type B) KO mice
RBRC06163 B6;129-Ednrb<tm1Ywa>

Lymphoedema-distichiasis syndrome responsible geneFoxc2 floxed mice
RBRC10306 C57BL/6-Foxc2<tm1.1Motoj>

TPST2 enzymatic activity deficient mice
RBRC05261 DW/J-Tpst2<grt>/Hkv

Today's model for human disease

| User publications

 The following result has been newly reported by users. We are
honored to introduce new publications to the science community.
Therefore, we look forward to receiving your publications too.

RBRC01680 B6.Cg-Smoc1<Tn(sb-lacZ,GFP)PV384Jtak>/JtakRbrc
Delgado Lagos FA, Elgheznawy A, Kyselova A, Meyer Zu Heringdorf D, Ratiu C, 
Randriamboavonjy V, Mann AW, Fisslthaler B, Siragusa M, Fleming I.
Secreted modular calcium binding protein 1 binds/activates thrombin to account 
for platelet hyper-reactivity in diabetes.
Blood. 2021 Feb 2;blood.2020009405. doi: 10.1182/blood.2020009405.

RBRC02370 B6.129-Grn<tm1Mni>
Murakoshi M, Gohda T, Adachi E, Ichikawa S, Hagiwara S, Suzuki Y.
Differential organ-specific inflammatory response to progranulin 
in high-fat diet-fed mice.
Sci Rep. 2021 Jan 13;11(1):1194. doi: 10.1038/s41598-020-80940-8.

RBRC01390 B6.129P2-Nfe2l2<tm1Mym>/MymRbrc
Liao K, Su X, Lei K, Liu Z, Lu L, Wu Q, Pan H, Huang Q, Zhao Y, Wang M, 
Cai J, Liu L, Li T.
Sinomenine protects bone from destruction to ameliorate arthritis 
via activating p62Thr269/Ser272-Keap1-Nrf2 feedback loop.
Biomed Pharmacother. 2021 Jan 1;135:111195. doi: 10.1016/j.biopha.2020.111195.

RBRC06344 C57BL/6-App<tm3(NL-G-F)Tcs>
Biechele G, Wind K, Blume T, Sacher C, Beyer L, Eckenweber F, Franzmeier N, Ewers M, Zott B, 
Lindner S, Gildehaus FJ, von Ungern-Sternberg B, Tahirovic S, Willem M, Bartenstein P, 
Cumming P, Rominger A, Herms J, Brendel M.
Microglial activation in the right amygdala-entorhinal-hippocampal complex is associated with 
preserved spatial learning in AppNL-G-F mice.
Neuroimage. 2020 Dec 29;230:117707. doi: 10.1016/j.neuroimage.2020.117707.

| Newly deposited mouse strains

Dr. Kenji Tanaka, Keio University
RBRC11201 STOCK Gria2<em1(tetO)Kftnk>
RBRC11202 STOCK Slc12a2<tm1.1(tetO)Kftnk>

Dr. Masahito Ikawa, Osaka University
RBRC11217 STOCK Kif9<em2Osb> Tg(CAG/Acr-EGFP)C3-N01-FJ002Osb
RBRC11222 B6D2-Tg(Clgn-Tesmin/TurboID/3xFLAG)1Osb
RBRC11223 STOCK Del(2Cstl1-Cstdc2)1Osb
RBRC11232 Stock Llcfc1<em2Osb> Tg(Clgn-Llcfc1/PA)1Osb
RBRC11237 B6D2-Rsph6a<em3Osb>
RBRC11238 B6D2-Cib4<em1Osb>
RBRC11241 B6D2-Spata24<em1Osb>
RBRC11251 B6D2-Tmem114<em1Osb>
RBRC11258 B6D2-Tmem168<em1(R539Q)Osb>
RBRC11261 B6D2-Lelp1<em1Osb>
RBRC11268 B6D2-Iqca<em1Osb>

Dr. Kazuhiro Morishita, University of Miyazaki
RBRC11271 C57BL/6N-Tg(Cd4-CADM1)#Kmori

Dr. Takehiko Yokomizo, Juntendo University
RBRC11285 C57BL/6-Ltb4r1<tm1c(EUCOMM)Hmgu>/Tyoko
RBRC11286 C57BL/6J-Lta4h<em1Tyoko>

Dr. Kazuyoshi Kawakami, Tohoku University
RBRC11314 C57BL/6JJcl-Tg(CnCda2-TCR)Tukk


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RIKEN BioResource Research Center
Experimental Animal Division
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