************************************************************************ RIKEN BioResource Research Center Mouse E-mail News No. 160 ************************************************************************ RIKEN BioResource Research Center (BRC) is pleased to update you with the latest information. ======= Contents ======================================================= - Today's model for human disease - User publications - Newly deposited mouse strains ======================================================================== +----------------------------------------------------------------------- | Today's model for human disease +----------------------------------------------------------------------- One subunit of NMDA receptor Grin2a gene KO mice RBRC01195 B6.129S6-Grin2a<tm1Nak>/NakRbrc RBRC02256 B6;129S-Grin2a<tm1Nak> Synaptic protein Stxbp1 (Munc18-1) gene floxed mice RBRC05604 C57BL/6N-Stxbp1<tm1Ksak> Serine protease Klk8 (Neuropsin) gene KO mice RBRC02740 B6.129P2-Klk8<tm1Shio> Secreted glycoprotein Reln (Reelin) gene C-terminal deficient mice RBRC03079 C57BL/6-Reln<tm1.1Mhat> Today's model for human disease https://mus.brc.riken.jp/en/todays_tool_and_model +----------------------------------------------------------------------- | User publications +----------------------------------------------------------------------- The following result has been newly reported by users. We are honored to introduce new publications to the science community. Therefore, we look forward to receiving your publications too. RBRC00144 C57BL/6-Ly5.1 Kondo T, Ikegawa S, Fukumi T, Sumii Y, Sugiura H, Sando Y, Nakamura M, Meguri Y, Iwamoto M, Maeda Y, Matsuoka KI. Pretransplant Short-Term Exposure of Donor Graft Cells to ITK Selective Inhibitor Ameliorates Acute Graft-versus-Host Disease by Inhibiting Effector T Cell Differentiation while Sparing Regulatory T Cells. Immunohorizons. 2021 Jun 10;5(6):424-437. doi: 10.4049/immunohorizons.2100042. https://doi.org/10.4049/immunohorizons.2100042 RBRC01828 B6.Cg-Tg(CAG-Cre)CZ-MO2Osb Tanimizu N, Ichinohe N, Sasaki Y, Itoh T, Sudo R, Yamaguchi T, Katsuda T, Ninomiya T, Tokino T, Ochiya T, Miyajima A, Mitaka T. Generation of functional liver organoids on combining hepatocytes and cholangiocytes with hepatobiliary connections ex vivo. Nat Commun. 2021 Jun 7;12(1):3390. doi: 10.1038/s41467-021-23575-1. https://doi.org/10.1038/s41467-021-23575-1 RBRC01544 B6.129P2-Sirpa<tm1Nog>/Rbrc Sarute N, Cheng H, Yan Z, Salas-Briceno K, Richner J, Rong L, Ross SR. Signal-regulatory protein alpha is an anti-viral entry factor targeting viruses using endocytic pathways. PLoS Pathog. 2021 Jun 7;17(6):e1009662. doi: 10.1371/journal.ppat.1009662. https://doi.org/10.1371/journal.ppat.1009662 RBRC01059 NC Chiu YH, Wu YW, Hung JI, Chen MC. Epigallocatechin Gallate/L-Ascorbic Acid-Loaded Poly-γ-Glutamate Microneedles with Antioxidant, Anti-inflammatory, and Immunomodulatory Effects for the Treatment of Atopic Dermatitis. Acta Biomater. 2021 Jun 1;S1742-7061(21)00342-1. doi: 10.1016/j.actbio.2021.05.032. https://doi.org/10.1016/j.actbio.2021.05.032 RBRC06240 B6.129P2-Hmgb1<tm1Ttg> Lu J, Yue Y, Xiong S. Extracellular HMGB1 augments macrophage inflammation by facilitating the endosomal accumulation of ALD-DNA via TLR2/4-mediated endocytosis. Biochim Biophys Acta Mol Basis Dis. 2021 Jun 1;1867(10):166184. doi: 10.1016/j.bbadis.2021.166184. https://doi.org/10.1016/j.bbadis.2021.166184 RBRC01868 FVB.Cg-Ptgds<tm1(cre)Gvn>/GvnRbrc Wang TA, Chen C, Huang F, Feng S, Tien J, Braz JM, Basbaum AI, Jan YN, Jan LY. TMEM16C is involved in thermoregulation and protects rodent pups from febrile seizures. Proc Natl Acad Sci USA. 2021 May 18;118(20):e2023342118. doi: 10.1073/pnas.2023342118. https://doi.org/10.1073/pnas.2023342118 RBRC01710 B6.129S-Ahr<tm1Yfk> Kimura E, Kohda M, Maekawa F, Fujii-Kuriyama Y, Tohyama C. Neurons expressing the aryl hydrocarbon receptor in the locus coeruleus and island of Calleja major are novel targets of dioxin in the mouse brain. Histochem Cell Biol. 2021 May 8. doi: 10.1007/s00418-021-01990-1. https://doi.org/10.1007/s00418-021-01990-1 RBRC09616 B6.Cg-Pdgfra<tm1.1(EGFP/cre/ERT2)Hyma> Kimura K, Ramirez K, Nguyen TAV, Yamashiro Y, Sada A, Yanagisawa H. Contribution of PDGFRα-positive cells in maintenance and injury responses in mouse large vessels. Sci Rep. 2021 Apr 21;11(1):8683. doi: 10.1038/s41598-021-88126-6. https://doi.org/10.1038/s41598-021-88126-6 RBRC03163 B6J.129P2-Hmox1<tm1Mym> Alves de Souza RW, Gallo D, Lee GR, Katsuyama E, Schaufler A, Weber J, Csizmadia E, Tsokos GC, Koch LG, Britton SL, Wisløff U, Brum PC, Otterbein LE. Skeletal muscle heme oxygenase-1 activity regulates aerobic capacity. Cell Rep. 2021 Apr 20;35(3):109018. doi: 10.1016/j.celrep.2021.109018. https://doi.org/10.1016/j.celrep.2021.109018 RBRC01390 B6.129P2-Nfe2l2<tm1Mym>/MymRbrc Alharthy SA, Hardej D. The role of transcription factor Nrf2 in the toxicity of perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) in C57BL/6 mouse astrocytes. Environ Toxicol Pharmacol. 2021 Apr 1;86:103652. doi: 10.1016/j.etap.2021.103652. https://doi.org/10.1016/j.etap.2021.103652 +----------------------------------------------------------------------- | Newly deposited mouse strains +----------------------------------------------------------------------- Dr. Itaru Imayoshi, Kyoto University RBRC11178 C57BL/6-Gt(ROSA)26Sor<tm1(CAG-tdTomato)Imayo> RBRC11179 C57BL/6-Gt(ROSA)26Sor<tm1.1(CAG-tdTomato)Imayo> RBRC11180 C57BL/6-Gt(ROSA)26Sor<tm1.2(CAG-tdTomato)Imayo> RBRC11184 C57BL/6-Gt(ROSA)26Sor<tm1(CAG-tdiRFP713NLS)Imayo> RBRC11185 C57BL/6-Gt(ROSA)26Sor<tm1.1(CAG-tdiRFP713NLS)Imayo> RBRC11186 C57BL/6-Gt(ROSA)26Sor<tm1.2(CAG-tdiRFP713NLS)Imayo> RBRC11187 C57BL/6-Gt(ROSA)26Sor<tm1.3(CAG-tdiRFP713NLS)Imayo> Dr. Ryuta Koyama, The University of Tokyo RBRC11346 B6.Cg-Actb<tm1.1(tetO-GFP/bPAC)Yksk> Dr. Takashi Nagasawa, Osaka University RBRC11390 B6.Cg-Cxcl12<tm4.1Tng> RBRC11393 B6.Cg-Ebf3<tm2.1Tng> Dr. Arinobu Tojo, The University of Tokyo RBRC11394 C57BL/6J-Was<em1(I292T)Imsmt> Dr. Akio Kihara, Hokkaido University RBRC11423 B6-Tg(IVL-Cyp4f39)6Akih Dr. Yumiko Saga, National Institute of Genetics Research Organization of Information and Systems RBRC11438 B6;B6D2-Tg(CAG-OsTIR1-P2A-mAID-EGFP-nanoluc)#16Ysa RBRC11439 B6;B6D2-Tg(CAG-OsTIR1-P2A-mAID-EGFP-nanoluc)#19Ysa Dr. Masahide Asano, Kyoto University RBRC11441 B6;129P2-Kdm6b<tm1.1Masn> RBRC11442 B6;B6D2-Kdm6b<em1Masn> Dr. Yumi Mizuno, Saitama Medical University RBRC11443 B6-Tysnd1<tm1Yuzu> https://mus.brc.riken.jp/en/mailnews/kitaku_list/20210618_k __________________________________________________________________ *We hope you find the contents of this message of interest. However, if you would prefer to unsubscribe from future e-mails, please send an e-mail to animal.brc@riken.jp. *If you have any questions or comments, please send an e-mail to animal.brc@riken.jp. *Content is subject to change without notice. *All Rights Reserved. __________________________________________________________________ RIKEN BioResource Research Center Experimental Animal Division 3-1-1 Koyadai, Tsukuba-shi Ibaraki, 305-0074 Japan animal.brc@riken.jp https://mus.brc.riken.jp/en/ __________________________________________________________________ 2021.07.13.
