RIKEN BioResource Research Center Mouse E-mail News No. 160

RIKEN BioResource Research Center Mouse E-mail News No. 160

RIKEN BioResource Research Center (BRC) is pleased to update you with the 
latest information.

======= Contents =======================================================
- Today's model for human disease
- User publications
- Newly deposited mouse strains

| Today's model for human disease

One subunit of NMDA receptor Grin2a gene KO mice
RBRC01195 B6.129S6-Grin2a<tm1Nak>/NakRbrc
RBRC02256 B6;129S-Grin2a<tm1Nak>

Synaptic protein Stxbp1 (Munc18-1) gene floxed mice
RBRC05604 C57BL/6N-Stxbp1<tm1Ksak>

Serine protease Klk8 (Neuropsin) gene KO mice
RBRC02740 B6.129P2-Klk8<tm1Shio>

Secreted glycoprotein Reln (Reelin) gene C-terminal deficient mice
RBRC03079 C57BL/6-Reln<tm1.1Mhat>

Today's model for human disease

| User publications

 The following result has been newly reported by users. We are
honored to introduce new publications to the science community.
Therefore, we look forward to receiving your publications too.

RBRC00144 C57BL/6-Ly5.1
Kondo T, Ikegawa S, Fukumi T, Sumii Y, Sugiura H, Sando Y, Nakamura M, 
Meguri Y, Iwamoto M, Maeda Y, Matsuoka KI.
Pretransplant Short-Term Exposure of Donor Graft Cells to ITK Selective 
Inhibitor Ameliorates Acute Graft-versus-Host Disease by Inhibiting Effector 
T Cell Differentiation while Sparing Regulatory T Cells.
Immunohorizons. 2021 Jun 10;5(6):424-437. doi: 10.4049/immunohorizons.2100042.

RBRC01828 B6.Cg-Tg(CAG-Cre)CZ-MO2Osb
Tanimizu N, Ichinohe N, Sasaki Y, Itoh T, Sudo R, Yamaguchi T, Katsuda T, 
Ninomiya T, Tokino T, Ochiya T, Miyajima A, Mitaka T.
Generation of functional liver organoids on combining hepatocytes and 
cholangiocytes with hepatobiliary connections ex vivo.
Nat Commun. 2021 Jun 7;12(1):3390. doi: 10.1038/s41467-021-23575-1.

RBRC01544 B6.129P2-Sirpa<tm1Nog>/Rbrc
Sarute N, Cheng H, Yan Z, Salas-Briceno K, Richner J, Rong L, Ross SR.
Signal-regulatory protein alpha is an anti-viral entry factor targeting viruses 
using endocytic pathways.
PLoS Pathog. 2021 Jun 7;17(6):e1009662. doi: 10.1371/journal.ppat.1009662.

RBRC01059 NC
Chiu YH, Wu YW, Hung JI, Chen MC.
Epigallocatechin Gallate/L-Ascorbic Acid-Loaded Poly-γ-Glutamate Microneedles with Antioxidant, 
Anti-inflammatory, and Immunomodulatory Effects for the Treatment of Atopic Dermatitis.
Acta Biomater. 2021 Jun 1;S1742-7061(21)00342-1. doi: 10.1016/j.actbio.2021.05.032.

RBRC06240 B6.129P2-Hmgb1<tm1Ttg>
Lu J, Yue Y, Xiong S.
Extracellular HMGB1 augments macrophage inflammation by facilitating the 
endosomal accumulation of ALD-DNA via TLR2/4-mediated endocytosis.
Biochim Biophys Acta Mol Basis Dis. 2021 Jun 1;1867(10):166184. doi: 10.1016/j.bbadis.2021.166184.

RBRC01868 FVB.Cg-Ptgds<tm1(cre)Gvn>/GvnRbrc
Wang TA, Chen C, Huang F, Feng S, Tien J, Braz JM, Basbaum AI, Jan YN, Jan LY.
TMEM16C is involved in thermoregulation and protects rodent pups from febrile seizures.
Proc Natl Acad Sci USA. 2021 May 18;118(20):e2023342118. doi: 10.1073/pnas.2023342118.

RBRC01710 B6.129S-Ahr<tm1Yfk>
Kimura E, Kohda M, Maekawa F, Fujii-Kuriyama Y, Tohyama C.
Neurons expressing the aryl hydrocarbon receptor in the locus coeruleus and 
island of Calleja major are novel targets of dioxin in the mouse brain.
Histochem Cell Biol. 2021 May 8. doi: 10.1007/s00418-021-01990-1.

RBRC09616 B6.Cg-Pdgfra<tm1.1(EGFP/cre/ERT2)Hyma>
Kimura K, Ramirez K, Nguyen TAV, Yamashiro Y, Sada A, Yanagisawa H.
Contribution of PDGFRα-positive cells in maintenance and injury responses 
in mouse large vessels.
Sci Rep. 2021 Apr 21;11(1):8683. doi: 10.1038/s41598-021-88126-6.

RBRC03163 B6J.129P2-Hmox1<tm1Mym>
Alves de Souza RW, Gallo D, Lee GR, Katsuyama E, Schaufler A, Weber J, 
Csizmadia E, Tsokos GC, Koch LG, Britton SL, Wisløff U, Brum PC, Otterbein LE.
Skeletal muscle heme oxygenase-1 activity regulates aerobic capacity.
Cell Rep. 2021 Apr 20;35(3):109018. doi: 10.1016/j.celrep.2021.109018.

RBRC01390 B6.129P2-Nfe2l2<tm1Mym>/MymRbrc
Alharthy SA, Hardej D.
The role of transcription factor Nrf2 in the toxicity of perfluorooctane sulfonate 
(PFOS) and perfluorooctanoic acid (PFOA) in C57BL/6 mouse astrocytes.
Environ Toxicol Pharmacol. 2021 Apr 1;86:103652. doi: 10.1016/j.etap.2021.103652.

| Newly deposited mouse strains

Dr. Itaru Imayoshi, Kyoto University
RBRC11178 C57BL/6-Gt(ROSA)26Sor<tm1(CAG-tdTomato)Imayo>
RBRC11179 C57BL/6-Gt(ROSA)26Sor<tm1.1(CAG-tdTomato)Imayo>
RBRC11180 C57BL/6-Gt(ROSA)26Sor<tm1.2(CAG-tdTomato)Imayo>
RBRC11184 C57BL/6-Gt(ROSA)26Sor<tm1(CAG-tdiRFP713NLS)Imayo>
RBRC11185 C57BL/6-Gt(ROSA)26Sor<tm1.1(CAG-tdiRFP713NLS)Imayo>
RBRC11186 C57BL/6-Gt(ROSA)26Sor<tm1.2(CAG-tdiRFP713NLS)Imayo>
RBRC11187 C57BL/6-Gt(ROSA)26Sor<tm1.3(CAG-tdiRFP713NLS)Imayo>

Dr. Ryuta Koyama, The University of Tokyo
RBRC11346 B6.Cg-Actb<tm1.1(tetO-GFP/bPAC)Yksk>

Dr. Takashi Nagasawa, Osaka University
RBRC11390 B6.Cg-Cxcl12<tm4.1Tng>
RBRC11393 B6.Cg-Ebf3<tm2.1Tng>

Dr. Arinobu Tojo, The University of Tokyo
RBRC11394 C57BL/6J-Was<em1(I292T)Imsmt>

Dr. Akio Kihara, Hokkaido University
RBRC11423 B6-Tg(IVL-Cyp4f39)6Akih

Dr. Yumiko Saga, National Institute of Genetics
Research Organization of Information and Systems
RBRC11438 B6;B6D2-Tg(CAG-OsTIR1-P2A-mAID-EGFP-nanoluc)#16Ysa
RBRC11439 B6;B6D2-Tg(CAG-OsTIR1-P2A-mAID-EGFP-nanoluc)#19Ysa

Dr. Masahide Asano, Kyoto University
RBRC11441 B6;129P2-Kdm6b<tm1.1Masn>
RBRC11442 B6;B6D2-Kdm6b<em1Masn>

Dr. Yumi Mizuno, Saitama Medical University
RBRC11443 B6-Tysnd1<tm1Yuzu>


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RIKEN BioResource Research Center
Experimental Animal Division
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