RIKEN BioResource Research Center Mouse E-mail News No. 166

RIKEN BioResource Research Center Mouse E-mail News No. 166

RIKEN BioResource Research Center (BRC) is pleased to update you with the 
latest information.

======= Contents =======================================================
- Today's model for human disease
- User publications
- Newly deposited mouse strains

| Today's model for human disease

Cloned mice lines derived from antigen-specific CD4+ T cells
RBRC10902 C.CD2-Tcra-V10<Df> Tcrb-V5<Df>/Ogu
RBRC10903 C.CD2-Tcra-V10<Dp1> Tcrb-V31<Dp1>/Ogu

Ca2+-dependent modulator Cys proteases Capn6 gene KO mice
RBRC06237 B6.Cg-Capn6<tm1Hiso>
RBRC06238 ICR.Cg-Capn6<tm1Hiso>

Axon guidance molecule Sema4d gene KO mice
RBRC10202 CB17.Cg-Sema4D<tm1In>

Sema4D receptor Plxnb1 gene KO mice
RBRC10201 CB17.Cg-Plxnb1<tm1Matl>

Today's model for human disease

| User publications

 The following result has been newly reported by users. We are
honored to introduce new publications to the science community.
Therefore, we look forward to receiving your publications too.

RBRC00897 B6.Cg-Aicda<tm1Hon> (N10)/HonRbrc
Luo Y, Zhang X, Chen R, Li R, Liu Y, Zhang J, Liu Q, Si M, Liu J, Wu B, Wang X, 
Wu S, Zhang Y, Zhang X, Guo D, He X, Pan T, Zhang H.
USP10 regulates B cell response to SARS-CoV-2 or HIV-1 nanoparticle vaccines 
through deubiquitinating AID.
Signal Transduct Target Ther. 2022 Jan 4;7(1):7. doi: 10.1038/s41392-021-00858-z.

RBRC00806 GFP-LC3#53
Andrea K. H. Stavoe, Erika L. F. Holzbaur.
Live Imaging of Autophagosome Biogenesis and Maturation in Primary Neurons.
Neuromethods. 2022 Jan 1;23-40. doi: 10.1007/978-1-0716-1589-8_3.

RBRC01390 B6.129P2-Nfe2l2<tm1Mym>/MymRbrc
Fotini Filippopoulou, George I. Habeos, Vagelis Rinotas, Antonia Sophocleous, 
Gerasimos P. Sykiotis, Eleni Douni, Dionysios V. Chartoumpekis.
Dexamethasone Administration in Mice Leads to Less Body Weight Gain over Time, 
Lower Serum Glucose, and Higher Insulin Levels Independently of NRF2.
Antioxidants. 2021 Dec 21 ;11(1):4. doi: 10.3390/antiox11010004.

RBRC00639 JF1/Msf
Matsuzaki H, Miyajima Y, Fukamizu A, Tanimoto K.
Orientation of mouse H19 ICR affects imprinted H19 gene expression through promoter
 methylation-dependent and -independent mechanisms.
Commun Biol. 2021 Dec 17;4(1):1410. doi: 10.1038/s42003-021-02939-9.

RBRC02706 B6.Cg-Tg(FucciS/G2/M)#504Bsi
RBRC02707 B6.Cg-Tg(FucciG1)#596Bsi
Zotos D, Quast I, Li-Wai-Suen CSN, McKenzie CI, Robinson MJ, Kan A, Smyth GK, 
Hodgkin PD, Tarlinton DM.
The concerted change in the distribution of cell cycle phases and zone composition 
in germinal centers is regulated by IL-21.
Nat Commun. 2021 Dec 9;12(1):7160. doi: 10.1038/s41467-021-27477-0.

RBRC02332 B6.Cg-Tg(Drd2-YFP)364-5
RBRC03111 C57BL/6J-Tg(mDrd1-YFP)680-1Koba
Faruk MO, Tsuboi D, Yamahashi Y, Funahashi Y, Lin YH, Ahammad RU, Hossen E, 
Amano M, Nishioka T, Tzingounis AV, Yamada K, Nagai T, Kaibuchi K.
Muscarinic signaling regulates voltage-gated potassium channel KCNQ2 phosphorylation 
in the nucleus accumbens via protein kinase C for aversive learning.
J Neurochem. 2021 Dec 8. doi: 10.1111/jnc.15555.

RBRC01253 B6;129S4-Gopc<tm1.1Tno>/Rbrc
Bizkarguenaga M, Gomez-Santos L, Madrid JF, Sáez FJ, Alonso E.
Zona Pellucida sperm-binding protein 3 receptor distribution during Gopc-/- 
globozoospermic spermatogenesis.
Microsc Res Tech. 2021 Dec 6. doi: 10.1002/jemt.24009.

RBRC02290 STOCK Tg(Nanog-GFP,Puro)1Yam
Evgeniia Borisova, Ken Nishimura, Yuri An, Miho Takami, Jingyue Li, Dan Song, 
Mami Matsuo-Takasaki, Dorian Luijkx, Shiho Aizawa, Akihiro Kuno, Eiji Sugihara, 
Taka-aki Sato, Fumiaki Yumoto, Tohru Terada, Koji Hisatake, Yohei Hayashi.
Structurally-discovered KLF4 variants accelerate and stabilize reprogramming to pluripotency.
iScience. 2021 Dec 14;103525. doi: 10.1016/j.isci.2021.103525.

RBRC06344 C57BL/6-App<tm3(NL-G-F)Tcs>
Liu X, Zhou Q, Zhang JH, Wang KY, Saito T, Saido TC, Wang X, Gao X, Azuma K.
Microglia-Based Sex-Biased Neuropathology in Early-Stage Alzheimer's Disease Model Mice 
and the Potential Pharmacologic Efficacy of Dioscin.
Cells. 2021 Nov 22;10(11):3261. doi: 10.3390/cells10113261.

RBRC01151 B6;129S7-Hey1<tm1Kkb>/YsaRbrc
RBRC02707 B6.Cg-Tg(FucciG1)#596Bsi
Harada Y, Yamada M, Imayoshi I, Kageyama R, Suzuki Y, Kuniya T, Furutachi S, Kawaguchi D, Gotoh Y.
Cell cycle arrest determines adult neural stem cell ontogeny by an embryonic Notch-nonoscillatory Hey1 module.
Nat Commun. 2021 Nov 12;12(1):6562. doi: 10.1038/s41467-021-26605-0.

RBRC04895  B6(Cg)-Timd4<tm1Osa>
Lee SA, Kim D, Min C, Moon B, Lee J, Moon H, Yang S, Lee CS, Lee G, Park D.
Phagocyte Chemoattraction Is Induced through the Mcp-1-Ccr2 Axis during Efferocytosis.
Cells. 2021 Nov 10;10(11):3115. doi: 10.3390/cells10113115.

| Newly deposited mouse strains

Dr. Tadashi Okamura, Research Institute National Center for Global Health and Medicine
RBRC11565 C.Cg-Ace2<em1(ACE2)Okt>

Dr. Yoshitaka Fujihara, National Cerebral and Cardiovascular Center
RBRC11576 B6D2-Smim8<em1Ncvc>
RBRC11577 B6D2-Smim9<em1Ncvc>

Dr. Yoko Aoki, Tohoku University
RBRC11578 C.Cg-Hras<tm1.1(G12S)Tumg>


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RIKEN BioResource Research Center
Experimental Animal Division
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