RIKEN BioResource Research Center Mouse E-mail News No. 170

RIKEN BioResource Research Center Mouse E-mail News No. 170

RIKEN BioResource Research Center (BRC) is pleased to update you with the 
latest information.

======= Contents =======================================================
- Today's model for human disease
- The 69th Annual Meeting of the Japanese Association for Laboratory 
  Animal Science
- User publications
- Newly deposited mouse strains

| Today's model for human disease

Angiogenic factor Angpt1 floxed mice
RBRC09330 Angpt1(Acc.No.CDB0627K)

Src point mutated (S75D) mice with progressive optic neuropathy-like phenotypes
RBRC10208 B6.129-Src<tm1(S75D)Goka>

Mef2d KO mice with retinitis pigmentosa like phenotypes
RBRC09366 C3;B6-Mef2d<tm1a-flox-tfur> (Mef2d floxed)
RBRC09367 C3;B6-Mef2d<tm1.2Tfur> (Mef2d KO)

Membrane scaffold protein Epb4.1l2 (4.1G) KO mice
RBRC09370 129S6/SvEvtac-Epb4.1l2<tm1Tfur>

Today's model for human disease

| The 69th Annual Meeting of the Japanese Association for Laboratory 
| Animal Science

 The 69th Annual Meeting of the Japanese Association for Laboratory 
Animal Science will be held at Sendai International Center from 
May 18th through 20th.

The 69th Annual Meeting of the Japanese Association for Laboratory 
Animal Science

| User publications

 The following result has been newly reported by users. We are
honored to introduce new publications to the science community.
Therefore, we look forward to receiving your publications too.

RBRC00858 B6;129S6-Bcl2l12/Irf3<tm1Ttg>/TtgRbrc
Foss MH, Stevens SL, Jin H, Allen EM, Nelson D, DeFilippis V, 
Nilsen A, Stenzel-Poore MP.
Identification and Characterization of Small-Molecule 
IRF3-Dependent Immune Activators for Pharmaceutical Development.
ACS Chem Biol. 2022 Apr 26. doi: 10.1021/acschembio.1c00912. 

RBRC01726 B6;129-Mfge8<tm1Osa>/OsaRbrc
Chiang HY, Chu PH, Chen SC, Lee TH.
MFG-E8 promotes osteogenic transdifferentiation of smooth muscle cells 
and vascular calcification by regulating TGF-β1 signaling.
Commun Biol. 2022 Apr 19;5(1):364. doi: 10.1038/s42003-022-03313-z.

RBRC05637 B6D2;129S2-Igsf8<tm1.1Osb>
Jimbo K, Nakajima-Takagi Y, Ito T, Koide S, Nannya Y, Iwama A, 
Tojo A, Konuma T.
Immunoglobulin superfamily member 8 maintains myeloid leukemia stem cells 
through inhibition of β-catenin degradation.
Leukemia. 2022 Apr 13. doi: 10.1038/s41375-022-01564-7.

RBRC03327 B6.129-Ttll1<tm1Seto>/SetoRbrc
RBRC03328 B6.129-Ttll5<tm1Seto>/SetoRbrc
RBRC03329 B6;129-Ttll7<tm1Seto>/SetoRbrc
RBRC03337 C57BL/6N-Ttll11<tm1Seto>/SetoRbrc
Wu HY, Rong Y, Bansal PK, Wei P, Guo H, Morgan JI.
TTLL1 and TTLL4 polyglutamylases are required for the 
neurodegenerative phenotypes in pcd mice.
PLoS Genet. 2022 Apr 11;18(4):e1010144. doi: 10.1371/journal.pgen.1010144.

RBRC01084 B6.129-Drd5<tm1Mok>
Sasamori H, Asakura T, Sugiura C, Bouchekioua Y, Nishitani N, Sato M, 
Yoshida T, Yamasaki M, Terao A, Watanabe M, Ohmura Y, Yoshioka M.
Behavioral characteristics of dopamine D5 receptor knockout mice.
Sci Rep. 2022 Apr 10;12(1):6014. doi: 10.1038/s41598-022-10013-5.

RBRC00145 B6.Cg-Kitl<Sl-t>/Rbrc
Kanatsu-Shinohara M, Lee J, Miyazaki T, Morimoto H, Shinohara T.
Adeno-associated-virus-mediated gene delivery to ovaries restores 
fertility in congenital infertile mice.
Cell Reports Medicine. 27 April 2022. doi:10.1016/j.xcrm.2022.100606.

RBRC06342 C57BL/6-App<tm1(NL)Tcs>
RBRC06343 C57BL/6-App<tm2(NL-F)Tcs>
RBRC06344 C57BL/6-App<tm3(NL-G-F)Tcs>
RBRC09995 B6.Cg-Mapt<tm1.1(MAPT)Tcs>
RBRC10041 B6.Cg-Mapt<tm1.1(MAPT)Tcs> App<tm1(NL)Tcs>
RBRC10042 B6.Cg-Mapt<tm1.1(MAPT)Tcs> App<tm2(NL-F)Tcs>
RBRC10043 B6.Cg-Mapt<tm1.1(MAPT)Tcs> App<tm3(NL-G-F)Tcs>
Sasaguri H, Hashimoto S, Watamura N, Sato K, Takamura R, Nagata K, Tsubuki S, 
Ohshima T, Yoshiki A, Sato K, Kumita W, Sasaki E, Kitazume S, Nilsson P, 
Winblad B, Saito T, Iwata N, C. Saido T.
Recent Advances in the Modeling of Alzheimer’s Disease.
Front Neurosci. 2022 Mar 31;16:807473. doi: 10.3389/fnins.2022.807473.

RBRC05808 B6.129P2-Aldh2<tm1Kaw>
Kasai A, Jee E, Tamura Y, Kouzaki K, Kotani T, Nakazato K.
Aldehyde dehydrogenase 2 deficiency promotes skeletal muscle atrophy in aged mice.
Am J Physiol Regul Integr Comp Physiol. 2022 Jun 1;322(6):R511-R525. 
doi: 10.1152/ajpregu.00304.2021.

| Newly deposited mouse strains

Dr. Yoichiro Iwakura, Tokyo University of Science
RBRC11350 B6-Ang4<em1Yiw>
RBRC11351 B6-Clec12a<em1Yiw>
RBRC11352 B6-Clec7a<em1Yiw>
RBRC11353 B6-Clec4n<em1Yiw>
RBRC11354 B6-Clec3b<em1Yiw>
RBRC11355 B6.Cg-Clec7a<tm1Yiw> Card9<em1Yiw>

Dr. Takaomi C. Saido, RIKEN CBS
RBRC11518 C57BL/6-App<tm2(NL-F)Tcs> Psen1<em1(P117L)Tcs>

Dr. Masahito Ikawa, Osaka University
RBRC11628 B6D2-Kctd19<em1Osb> Tg(Clgn-Kctd19/3xHA)1Osb
RBRC11629 B6D2-Kctd19<em2Osb>
RBRC11630 STOCK Zfp541<em1Osb>
RBRC11631 B6D2.B6-Tg(Zp3-EGFP/Cd9)1Osb
RBRC11637 B6D2-Kctd19<em1Osb> Tg(Clgn-3xFLAG-Kctd19)1Osb Tg(Clgn-Kctd19/3xHA)2Osb
RBRC11645 B6D2-Tg(Clgn-Spata33/PA)1Osb
RBRC11647 B6D2-Tg(Clgn-Fam71f1/PA)1Osb
RBRC11657 B6D2-Spaca4<tm1Osb>
RBRC11663 B6D2-Fam209<em1Osb>
RBRC11664 B6D2-Lrrc23<em1Osb> Tg(Clgn-Lrrc23/FLAG)1Osb Tg(Clgn-Lrrc23/1D4)1Osb
RBRC11665 B6D2-Mtl5<em1Osb> Tg(Clgn-Tesmin/BioID2/3xFLAG)1Osb

Dr. Kyoko Matsuzaki, Tokyo Medical and Dental University
RBRC11670 C57BL/6J-Rassf6<em1Kymt>

Dr. Yasuhiro Yamada, The University of Tokyo
RBRC11673 C57BL/6J-Cdkn2a<em1(HA)Yasu>
RBRC11674 C57BL/6J-Mycl<em1Yasu>
RBRC11675 C57BL/6J-Mycl<em2Yasu>

Dr. Yusaku Nakabeppu, Kyushu University
RBRC11676 B6.129S-Fosb<tm1.1Yun>
RBRC11677 B6.129S-Fosb<tm2.1Yun>
RBRC11678 B6.129S-Fosb<tm3.1Yun>
RBRC11679 B6.129S-Nudt1<tm1Yun>
RBRC11680 B6.129S-Mutyh<tm1Yun>
RBRC11681 B6.129S-Ogg1<tm1Yun>

Dr. Takayoshi Inoue, National Institute of Neuroscience
RBRC11686 B6;Cg-Oxtr<em1(1xPA/T2A/tdTomato)Yinn>
RBRC11687 B6;Cg-Oxtr<em2(1xPA/T2A/icre)Yinn>
RBRC11688 B6;Cg-Oxtr<em3(3xPA)Yinn>
RBRC11689 B6;Cg-Oxtr<em4(3xHA/T2A/icre/ERT2)Yinn>


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RIKEN BioResource Research Center
Experimental Animal Division
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Ibaraki, 305-0074 Japan

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