************************************************************************ RIKEN BioResource Research Center Mouse E-mail News No. 170 ************************************************************************ RIKEN BioResource Research Center (BRC) is pleased to update you with the latest information. ======= Contents ======================================================= - Today's model for human disease - The 69th Annual Meeting of the Japanese Association for Laboratory Animal Science - User publications - Newly deposited mouse strains ======================================================================== +----------------------------------------------------------------------- | Today's model for human disease +----------------------------------------------------------------------- Angiogenic factor Angpt1 floxed mice RBRC09330 Angpt1(Acc.No.CDB0627K) Src point mutated (S75D) mice with progressive optic neuropathy-like phenotypes RBRC10208 B6.129-Src<tm1(S75D)Goka> Mef2d KO mice with retinitis pigmentosa like phenotypes RBRC09366 C3;B6-Mef2d<tm1a-flox-tfur> (Mef2d floxed) RBRC09367 C3;B6-Mef2d<tm1.2Tfur> (Mef2d KO) Membrane scaffold protein Epb4.1l2 (4.1G) KO mice RBRC09370 129S6/SvEvtac-Epb4.1l2<tm1Tfur> Today's model for human disease https://mus.brc.riken.jp/en/todays_tool_and_model +----------------------------------------------------------------------- | The 69th Annual Meeting of the Japanese Association for Laboratory | Animal Science +----------------------------------------------------------------------- The 69th Annual Meeting of the Japanese Association for Laboratory Animal Science will be held at Sendai International Center from May 18th through 20th. The 69th Annual Meeting of the Japanese Association for Laboratory Animal Science https://jalas69.jp/english/index.html +----------------------------------------------------------------------- | User publications +----------------------------------------------------------------------- The following result has been newly reported by users. We are honored to introduce new publications to the science community. Therefore, we look forward to receiving your publications too. https://rrc.nbrp.jp/references/register RBRC00858 B6;129S6-Bcl2l12/Irf3<tm1Ttg>/TtgRbrc Foss MH, Stevens SL, Jin H, Allen EM, Nelson D, DeFilippis V, Nilsen A, Stenzel-Poore MP. Identification and Characterization of Small-Molecule IRF3-Dependent Immune Activators for Pharmaceutical Development. ACS Chem Biol. 2022 Apr 26. doi: 10.1021/acschembio.1c00912. https://doi.org/10.1021/acschembio.1c00912 RBRC01726 B6;129-Mfge8<tm1Osa>/OsaRbrc Chiang HY, Chu PH, Chen SC, Lee TH. MFG-E8 promotes osteogenic transdifferentiation of smooth muscle cells and vascular calcification by regulating TGF-β1 signaling. Commun Biol. 2022 Apr 19;5(1):364. doi: 10.1038/s42003-022-03313-z. https://doi.org/10.1038/s42003-022-03313-z RBRC05637 B6D2;129S2-Igsf8<tm1.1Osb> Jimbo K, Nakajima-Takagi Y, Ito T, Koide S, Nannya Y, Iwama A, Tojo A, Konuma T. Immunoglobulin superfamily member 8 maintains myeloid leukemia stem cells through inhibition of β-catenin degradation. Leukemia. 2022 Apr 13. doi: 10.1038/s41375-022-01564-7. https://doi.org/10.1038/s41375-022-01564-7 RBRC03327 B6.129-Ttll1<tm1Seto>/SetoRbrc RBRC03328 B6.129-Ttll5<tm1Seto>/SetoRbrc RBRC03329 B6;129-Ttll7<tm1Seto>/SetoRbrc RBRC03337 C57BL/6N-Ttll11<tm1Seto>/SetoRbrc Wu HY, Rong Y, Bansal PK, Wei P, Guo H, Morgan JI. TTLL1 and TTLL4 polyglutamylases are required for the neurodegenerative phenotypes in pcd mice. PLoS Genet. 2022 Apr 11;18(4):e1010144. doi: 10.1371/journal.pgen.1010144. https://doi.org/10.1371/journal.pgen.1010144 RBRC01084 B6.129-Drd5<tm1Mok> Sasamori H, Asakura T, Sugiura C, Bouchekioua Y, Nishitani N, Sato M, Yoshida T, Yamasaki M, Terao A, Watanabe M, Ohmura Y, Yoshioka M. Behavioral characteristics of dopamine D5 receptor knockout mice. Sci Rep. 2022 Apr 10;12(1):6014. doi: 10.1038/s41598-022-10013-5. https://doi.org/10.1038/s41598-022-10013-5 RBRC00145 B6.Cg-Kitl<Sl-t>/Rbrc Kanatsu-Shinohara M, Lee J, Miyazaki T, Morimoto H, Shinohara T. Adeno-associated-virus-mediated gene delivery to ovaries restores fertility in congenital infertile mice. Cell Reports Medicine. 27 April 2022. doi:10.1016/j.xcrm.2022.100606. https://doi.org/10.1016/j.xcrm.2022.100606 RBRC06342 C57BL/6-App<tm1(NL)Tcs> RBRC06343 C57BL/6-App<tm2(NL-F)Tcs> RBRC06344 C57BL/6-App<tm3(NL-G-F)Tcs> RBRC09995 B6.Cg-Mapt<tm1.1(MAPT)Tcs> RBRC10041 B6.Cg-Mapt<tm1.1(MAPT)Tcs> App<tm1(NL)Tcs> RBRC10042 B6.Cg-Mapt<tm1.1(MAPT)Tcs> App<tm2(NL-F)Tcs> RBRC10043 B6.Cg-Mapt<tm1.1(MAPT)Tcs> App<tm3(NL-G-F)Tcs> Sasaguri H, Hashimoto S, Watamura N, Sato K, Takamura R, Nagata K, Tsubuki S, Ohshima T, Yoshiki A, Sato K, Kumita W, Sasaki E, Kitazume S, Nilsson P, Winblad B, Saito T, Iwata N, C. Saido T. Recent Advances in the Modeling of Alzheimer’s Disease. Front Neurosci. 2022 Mar 31;16:807473. doi: 10.3389/fnins.2022.807473. https://doi.org/10.3389/fnins.2022.807473 RBRC05808 B6.129P2-Aldh2<tm1Kaw> Kasai A, Jee E, Tamura Y, Kouzaki K, Kotani T, Nakazato K. Aldehyde dehydrogenase 2 deficiency promotes skeletal muscle atrophy in aged mice. Am J Physiol Regul Integr Comp Physiol. 2022 Jun 1;322(6):R511-R525. doi: 10.1152/ajpregu.00304.2021. https://doi.org/10.1152/ajpregu.00304.2021 +----------------------------------------------------------------------- | Newly deposited mouse strains +----------------------------------------------------------------------- Dr. Yoichiro Iwakura, Tokyo University of Science RBRC11350 B6-Ang4<em1Yiw> RBRC11351 B6-Clec12a<em1Yiw> RBRC11352 B6-Clec7a<em1Yiw> RBRC11353 B6-Clec4n<em1Yiw> RBRC11354 B6-Clec3b<em1Yiw> RBRC11355 B6.Cg-Clec7a<tm1Yiw> Card9<em1Yiw> Dr. Takaomi C. Saido, RIKEN CBS RBRC11518 C57BL/6-App<tm2(NL-F)Tcs> Psen1<em1(P117L)Tcs> Dr. Masahito Ikawa, Osaka University RBRC11628 B6D2-Kctd19<em1Osb> Tg(Clgn-Kctd19/3xHA)1Osb RBRC11629 B6D2-Kctd19<em2Osb> RBRC11630 STOCK Zfp541<em1Osb> RBRC11631 B6D2.B6-Tg(Zp3-EGFP/Cd9)1Osb RBRC11637 B6D2-Kctd19<em1Osb> Tg(Clgn-3xFLAG-Kctd19)1Osb Tg(Clgn-Kctd19/3xHA)2Osb RBRC11645 B6D2-Tg(Clgn-Spata33/PA)1Osb RBRC11647 B6D2-Tg(Clgn-Fam71f1/PA)1Osb RBRC11657 B6D2-Spaca4<tm1Osb> RBRC11663 B6D2-Fam209<em1Osb> RBRC11664 B6D2-Lrrc23<em1Osb> Tg(Clgn-Lrrc23/FLAG)1Osb Tg(Clgn-Lrrc23/1D4)1Osb RBRC11665 B6D2-Mtl5<em1Osb> Tg(Clgn-Tesmin/BioID2/3xFLAG)1Osb Dr. Kyoko Matsuzaki, Tokyo Medical and Dental University RBRC11670 C57BL/6J-Rassf6<em1Kymt> Dr. Yasuhiro Yamada, The University of Tokyo RBRC11673 C57BL/6J-Cdkn2a<em1(HA)Yasu> RBRC11674 C57BL/6J-Mycl<em1Yasu> RBRC11675 C57BL/6J-Mycl<em2Yasu> Dr. Yusaku Nakabeppu, Kyushu University RBRC11676 B6.129S-Fosb<tm1.1Yun> RBRC11677 B6.129S-Fosb<tm2.1Yun> RBRC11678 B6.129S-Fosb<tm3.1Yun> RBRC11679 B6.129S-Nudt1<tm1Yun> RBRC11680 B6.129S-Mutyh<tm1Yun> RBRC11681 B6.129S-Ogg1<tm1Yun> Dr. Takayoshi Inoue, National Institute of Neuroscience RBRC11686 B6;Cg-Oxtr<em1(1xPA/T2A/tdTomato)Yinn> RBRC11687 B6;Cg-Oxtr<em2(1xPA/T2A/icre)Yinn> RBRC11688 B6;Cg-Oxtr<em3(3xPA)Yinn> RBRC11689 B6;Cg-Oxtr<em4(3xHA/T2A/icre/ERT2)Yinn> https://mus.brc.riken.jp/en/mailnews/kitaku_list/20220420_k __________________________________________________________________ *We hope you find the contents of this message of interest. However, if you would prefer to unsubscribe from future e-mails, please send an e-mail to animal.brc@riken.jp. *If you have any questions or comments, please send an e-mail to animal.brc@riken.jp. *Content is subject to change without notice. *All Rights Reserved. __________________________________________________________________ RIKEN BioResource Research Center Experimental Animal Division 3-1-1 Koyadai, Tsukuba-shi Ibaraki, 305-0074 Japan animal.brc@riken.jp https://mus.brc.riken.jp/en/ __________________________________________________________________ 2022.05.17.
