************************************************************************ RIKEN BioResource Research Center Mouse E-mail News No. 172 ************************************************************************ RIKEN BioResource Research Center (BRC) is pleased to update you with the latest information. ======= Contents ======================================================= - BRC Current Technology "Successful increase of the litter size in mice by 1.4 times" - Today's model for human disease - A collaborative paper with Dr. Gen Yamada, Wakayama Medical University has been published on Reproductive Medicine and Biology - A review article on the importance of the genetic quality for reproducible experiments in mice has been published online in Transgenic Research - User publications - Newly deposited mouse strains ======================================================================== +----------------------------------------------------------------------- | BRC Current Technology +----------------------------------------------------------------------- Successful increase of the litter size in mice by 1.4 times https://mus.brc.riken.jp/en/current_tech/jun_2022 BRC Current Technology archive https://mus.brc.riken.jp/en/current_tech +----------------------------------------------------------------------- | Today's model for human disease +----------------------------------------------------------------------- Cytokine signal inhibitor Socs1 floxed mice RBRC04753 B6;129S4(Cg)-Socs1<tm1Ayos> Cytokine signal inhibitor Socs3 floxed mice RBRC04754 B6;129S4-Socs3<tm1Ayos> NF-κB negative regulator Tnfaip3(A20) floxed mice RBRC05494 B6;129P2-Tnfaip3<tm1Homy> RBRC05495 B6;129P2-Tnfaip3<tm1.1Homy> Today's model for human disease https://mus.brc.riken.jp/en/todays_tool_and_model +----------------------------------------------------------------------- | A collaborative paper with Dr. Gen Yamada, Wakayama Medical University | has been published on Reproductive Medicine and Biology +----------------------------------------------------------------------- Hashimoto D, Fujimoto K, Morioka S, Ayabe S, Kataoka T, Fukumura R, Ueda Y, Kajimoto M, Hyuga T, Suzuki K, Hara I, Asamura S, Wakana S, Yoshiki A, Gondo Y, Tamura M, Sasaki T, Yamada G. Establishment of mouse line showing inducible priapism-like phenotypes. Reprod. Med. Biol. ;21(1):e12472. doi: 10.1002/rmb2.12472. https://doi.org/10.1002/rmb2.12472 +----------------------------------------------------------------------- | A review article on the importance of the genetic quality for reproducible | experiments in mice has been published online in Transgenic Research +----------------------------------------------------------------------- Yoshiki A, Ballard G, Perez A.V. Genetic quality: a complex issue for experimental study reproducibility. Transgenic Res. doi: 10.1007/s11248-022-00314-w. https://doi.org/10.1007/s11248-022-00314-w +----------------------------------------------------------------------- | User publications +----------------------------------------------------------------------- The following result has been newly reported by users. We are honored to introduce new publications to the science community. Therefore, we look forward to receiving your publications too. https://rrc.nbrp.jp/references/register RBRC10791 B6.Cg-Prox1<tm1.1Ykaw> Lin Q, Wu L, Chatla S, Chowdhury FA, Atale N, Joseph J, Du W. Hematopoietic stem cell regeneration through paracrine regulation of the Wnt5a/Prox1 signaling axis. J Clin Invest. 2022 Jun 15;132(12):e155914. doi: 10.1172/JCI155914. https://doi.org/10.1172/JCI155914 RBRC01828 B6.Cg-Tg(CAG-Cre)CZ-MO2Osb Gleixner AM, Verdone BM, Otte CG, Anderson EN, Ramesh N, Shapiro OR, Gale JR, Mauna JC, Mann JR, Copley KE, Daley EL, Ortega JA, Cicardi ME, Kiskinis E, Kofler J, Pandey UB, Trotti D, Donnelly CJ. NUP62 localizes to ALS/FTLD pathological assemblies and contributes to TDP-43 insolubility. Nat Commun. 2022 Jun 13;13(1):3380. doi: 10.1038/s41467-022-31098-6. https://doi.org/10.1038/s41467-022-31098-6 RBRC06344 C57BL/6-App<tm3(NL-G-F)Tcs> Gannon M, Wang B, Stringfellow SA, Quintin S, Mendoza I, Srikantha T, Roberts AC, Saito T, Saido TC, Roberson E, Yacoubian TA. 14-3-3θ does not protect against behavioral or pathological deficits in Alzheimer's disease mouse models. eNeuro. 2022 Jun 10;ENEURO.0368-21.2022. doi: 10.1523/ENEURO.0368-21.2022. https://doi.org/10.1523/ENEURO.0368-21.2022 RBRC02711 B6.129S-Osmr<tm1Mtan> Hermans D, Houben E, Baeten P, Slaets H, Janssens K, Hoeks C, Hosseinkhani B, Duran G, Bormans S, Gowing E, Hoornaert C, Beckers L, Fung WK, Schroten H, Ishikawa H, Fraussen J, Thoelen R, de Vries HE, Kooij G, Zandee S, Prat A, Hellings N, Broux B. Oncostatin M triggers brain inflammation by compromising blood-brain barrier integrity. Acta Neuropathol. 2022 Jun 6. doi: 10.1007/s00401-022-02445-0. https://doi.org/10.1007/s00401-022-02445-0 RBRC00886 B6;B6C3-Tg(Acro3-EGFP)01Osb Hirano K, Nonami Y, Nakamura Y, Sato T, Sato T, Ishiguro KI, Ogawa T, Yoshida S. Temperature sensitivity of DNA double-strand break repair underpins heat-induced meiotic failure in mouse spermatogenesis. Commun Biol. 2022 May 26;5(1):504. doi: 10.1038/s42003-022-03449-y. https://doi.org/10.1038/s42003-022-03449-y +----------------------------------------------------------------------- | Newly deposited mouse strains +----------------------------------------------------------------------- Dr. Hiroshi Kiyonari, RIKEN BDR RBRC11333 LPCAT2 (loxP) (Acc.No.CDB0649K) RBRC11334 LPCAT3 (loxP) (Acc.No.CDB0653K) RBRC11335 Ppp6c (Acc.No.CDB0850K) RBRC11336 PKN3 (-) (Acc.No.CDB0457K) RBRC11337 CLPABP (Acc No. CDB0582K) RBRC11338 Arf4 (loxP)(Acc No.CDB0884K) RBRC11339 Arf5 (loxP)(Acc No.CDB0885K) RBRC11340 Dullard (lacZ)(Acc No. CDB0474K) RBRC11341 mDia2 (Acc No. CDB0419K) RBRC11342 Epac2 (Acc No. CDB0570K) RBRC11343 Tdrd5 (Acc No. CDB0603K) RBRC11344 CNOT6 (loxP)(Acc No.CDB0794K) RBRC11345 CNOT8 (loxP)(Acc No.CDB0584K) Dr. Noriyuki Sugo, Osaka University RBRC11713 B6.129-Polb<tm1Koy> Dr. Kenji Tanaka, Keio University RBRC11714 STOCK Actb<tm4.1(tetO-KR2/EYFP)Kftnk> Tg(Pvalb-tTA)1Kftnk Dr. Satoru Takahashi, University of Tsukuba RBRC11716 Crl:CD1(ICR)-Tg(UAS-cre/T2A/miRFP670)216Staka Dr. Tamio Ohno, Nagoya University RBRC11717 D2.B6-Cpox<Rgsc0129>/Ohnot Dr. Daishi Yamakawa, Mie University RBRC11718 B6.129S-Tchp<tm1Inag> RBRC11719 B6.129S-Vim<tm1Sibg> Dr. Akira Ishikawa, Nagoya University RBRC11723 B6.Cg-Pbwg1/1Nga-bt3 https://mus.brc.riken.jp/en/mailnews/kitaku_list/20220620_k __________________________________________________________________ *We hope you find the contents of this message of interest. However, if you would prefer to unsubscribe from future e-mails, please send an e-mail to animal.brc@riken.jp. *If you have any questions or comments, please send an e-mail to animal.brc@riken.jp. *Content is subject to change without notice. *All Rights Reserved. __________________________________________________________________ RIKEN BioResource Research Center Experimental Animal Division 3-1-1 Koyadai, Tsukuba-shi Ibaraki, 305-0074 Japan animal.brc@riken.jp https://mus.brc.riken.jp/en/ __________________________________________________________________ 2022.07.12.
