************************************************************************ BRC Mouse E-mail News No. 183 ************************************************************************ RIKEN BioResource Research Center (BRC) is pleased to update you with the latest information. ======= Contents ======================================================= - Today's tool for functional analysis - User publications - Newly deposited mouse strains ======================================================================== +----------------------------------------------------------------------- | Today's tool for functional analysis +----------------------------------------------------------------------- Neuronal cells Cre-driver mice RBRC11130 C57BL/6N-Tubb3<tm1.1(Cre)Ksak> Spleen TLX1 expressing cells Cre-driver mice RBRC11118 B6-Tlx1<tm1.1(cre/ERT2/ires2/Venus)Rygo> Glucagon-producing α-cells Cre-driver mice RBRC10958 C57BL/6-Gcg<em1(cre)Utr> KRT19 expressing cells Cre-driver mice RBRC10923 B6.B6D2-Tg(Krt19-icre)2Hirt https://mus.brc.riken.jp/en/todays_tool_and_model +----------------------------------------------------------------------- | User publications +----------------------------------------------------------------------- The following result has been newly reported by users. We are honored to introduce new publications to the science community. Therefore, we look forward to receiving your publications too. https://rrc.nbrp.jp/references/register RBRC04944 B6.129S4-Il5<tm1.1Ktk> Yamada T, Tatematsu M, Takasuga S, Fuchimukai A, Yamagata K, Seki S, Kuba K, Yoshida H, Taniuchi I, Bernhardt G, Shibuya K, Shibuya A, Yamada T, Ebihara T. TIGIT mediates activation-induced cell death of ILC2s during chronic airway allergy. J Exp Med. 2023 Jul 3;220(7):e20222005. doi: 10.1084/jem.20222005. https://doi.org/10.1084/jem.20222005 RBRC00144 B6.SJL-Ptprc<a>/Rbrc Suga K, Suto A, Tanaka S, Sugawara Y, Kageyama T, Ishikawa J, Sanayama Y, Ikeda K, Furuta S, Kagami SI, Iwata A, Hirose K, Suzuki K, Ohara O, Nakajima H. TAp63, a methotrexate target in CD4+ T cells, suppresses Foxp3 expression and exacerbates autoimmune arthritis. JCI Insight. 2023 May 22;8(10):e164778. doi: 10.1172/jci.insight.164778. https://doi.org/10.1172/jci.insight.164778 RBRC09497 C57BL/6-Rag2<tm1Tgi> Naito Y, Koyama S, Masuhiro K, Hirai T, Uenami T, Inoue T, Osa A, Machiyama H, Watanabe G, Sax N, Villa J, Kinugasa-Katayama Y, Nojima S, Yaga M, Hosono Y, Okuzaki D, Satoh S, Tsuda T, Nakanishi Y, Suga Y, Morita T, Fukushima K, Nishide M, Shiroyama T, Miyake K, Iwahori K, Hirata H, Nagatomo I, Yano Y, Tamiya M, Kumagai T, Takemoto N, Inohara H, Yamasaki S, Yamashita K, Aoshi T, Akbay EA, Hosen N, Shintani Y, Takamatsu H, Mori M, Takeda Y, Kumanogoh A. Tumor-derived semaphorin 4A improves PD-1-blocking antibody efficacy by enhancing CD8+ T cell cytotoxicity and proliferation. Sci Adv. 2023 May 19;9(20):eade0718. doi: 10.1126/sciadv.ade0718. https://doi.org/10.1126/sciadv.ade0718 RBRC01834 C57BL/6-Tg(CAG-flpe)36Ito/ItoRbrc Fujinuma S, Nakatsumi H, Shimizu H, Sugiyama S, Harada A, Goya T, Tanaka M, Kohjima M, Takahashi M, Izumi Y, Yagi M, Kang D, Kaneko M, Shigeta M, Bamba T, Ohkawa Y, Nakayama KI. FOXK1 promotes nonalcoholic fatty liver disease by mediating mTORC1-dependent inhibition of hepatic fatty acid oxidation. Cell Rep. 2023 May 30;42(5):112530. doi: 10.1016/j.celrep.2023.112530. https://doi.org/10.1016/j.celrep.2023.112530 RBRC05555 B6;B6129-Ezh2<tm1Yugo>/Hko Fukui Y, Hirota Y, Aikawa S, Sakashita A, Shimizu-Hirota R, Takeda N, Ishizawa C, Iida R, Kaku T, Hirata T, Hiraoka T, Akaeda S, Matsuo M, Osuga Y. The EZH2-PRC2-H3K27me3 axis governs the endometrial cell cycle and differentiation for blastocyst invasion. Cell Death Dis. 2023 May 18;14(5):320. doi: 10.1038/s41419-023-05832-x. https://doi.org/10.1038/s41419-023-05832-x RBRC00897 B6.Cg-Aicda<tm1Hon>(N10)/HonRbrc Bello A, Müller A, Hirth G, Giebeler LN, Böttcher K, Voigt S, Jungnickel B. Cell Cycle-Mediated Regulation of Secondary Ig Diversification. J Immunol. 2023 May 15;210(10):1508-1518. doi: 10.4049/jimmunol.2100880. https://doi.org/10.4049/jimmunol.2100880 RBRC10053 B6(Cg)-Aqp4<tm1.1Tsna> Serizawa K, Miyake S, Katsura Y, Yorozu K, Kurasawa M, Tomizawa-Shinohara H, Yasuno H, Matsumoto Y. Intradermal AQP4 peptide immunization induces clinical features of neuromyelitis optica spectrum disorder in mice. J Neuroimmunol. doi: 10.1016/j.jneuroim.2023.578109. https://doi.org/10.1016/j.jneuroim.2023.578109 RBRC02711 B6.129S-Osmr<tm1Mtan> Feng Y, Yuan Y, Xia H, Wang Z, Che Y, Hu Z, Deng J, Li F, Wu Q, Bian Z, Zhou H, Shen D, Tang Q. OSMR deficiency aggravates pressure overload-induced cardiac hypertrophy by modulating macrophages and OSM/LIFR/STAT3 signalling. J Transl Med. 2023 Apr 29;21(1):290. doi: 10.1186/s12967-023-04163-x. https://doi.org/10.1186/s12967-023-04163-x RBRC00144 B6.SJL-Ptprc<a>/Rbrc Sumii Y, Kondo T, Ikegawa S, Fukumi T, Iwamoto M, Nishimura MF, Sugiura H, Sando Y, Nakamura M, Meguri Y, Matsushita T, Tanimine N, Kimura M, Asada N, Ennishi D, Maeda Y, Matsuoka KI. Hematopoietic stem cell-derived Tregs are essential for maintaining favorable B cell lymphopoiesis following posttransplant cyclophosphamide. JCI Insight. 2023 Apr 24;8(8):e162180. doi: 10.1172/jci.insight.162180. https://doi.org/10.1172/jci.insight.162180 RBRC01346 C57BL/6-Prkdc<scid>/Rbrc Kawase K, Kawashima S, Nagasaki J, Inozume T, Tanji E, Kawazu M, Hanazawa T, Togashi Y. High Expression of MHC Class I Overcomes Cancer Immunotherapy Resistance Due to IFNγ Signaling Pathway Defects. Cancer Immunol Res. 2023 Apr 16;OF1-OF14. doi: 10.1158/2326-6066.CIR-22-0815. https://doi.org/10.1158/2326-6066.CIR-22-0815 RBRC10014 B6D2;B6-Plcz1<em1Osb> Hirose N, Kikuchi Y, Kageyama A, Sugita H, Sakurai M, Kawata Y, Terakawa J, Wakayama T, Ito J, Kashiwazaki N. Successful Production of Offspring Derived from Phospholipase C Zeta-Deficient Sperm by Additional Artificial Activation. Life (Basel). 2023 Apr 10;13(4):980. doi: 10.3390/life13040980. https://doi.org/10.3390/life13040980 RBRC05582 C.Cg-Cpox<nct>/JmsRbrc Read KA, Jones DM, Pokhrel S, Hales EDS, Varkey A, Tuazon JA, Eisele CD, Abdouni O, Saadey A, Leonard MR, Warren RT, Powell MD, Boss JM, Hemann EA, Yount JS, Xin G, Ghoneim HE, Lio CJ, Freud AG, Collins PL, Oestreich KJ. Aiolos represses CD4+ T cell cytotoxic programming via reciprocal regulation of TFH transcription factors and IL-2 sensitivity. Nat Commun. 2023;14:1652. doi: 10.1038/s41467-023-37420-0. https://doi.org/10.1038/s41467-023-37420-0 +----------------------------------------------------------------------- | Newly deposited mouse strains +----------------------------------------------------------------------- Dr. Hiroshi Hamada, RIKEN BDR RBRC11908 B6;Cg-Pycr2<tm1Hmd> RBRC11941 B6;Cg-Pkd1l1<em1(mScarletI)Hmd> RBRC11942 B6;Cg-Pkd1l1<em2(mScarletI)Hmd> https://mus.brc.riken.jp/en/mailnews/kitaku_list/20230522_k __________________________________________________________________ *We hope you find the contents of this message of interest. However, if you would prefer to unsubscribe from future e-mails, please send an e-mail to animal.brc@riken.jp. *If you have any questions or comments, please send an e-mail to animal.brc@riken.jp. *Content is subject to change without notice. *All Rights Reserved. __________________________________________________________________ RIKEN BioResource Research Center Experimental Animal Division 3-1-1 Koyadai, Tsukuba-shi Ibaraki, 305-0074 Japan animal.brc@riken.jp https://mus.brc.riken.jp/en/ __________________________________________________________________ 2023.06.15.
