************************************************************************ BRC Mouse E-mail News No. 187 ************************************************************************ RIKEN BioResource Research Center (BRC) is pleased to update you with the latest information. ======= Contents ======================================================= - Today's tool for functional analysis - Today's model for human disease - Official X account of BRC - User publications - Newly deposited mouse strains ======================================================================== +----------------------------------------------------------------------- | Today's tool for functional analysis +----------------------------------------------------------------------- p16<INK4a>(CDKN2A) luminescent reporter mice RBRC05271 ICR-Tg(p16-luc)53Eiha/Rbrc RBRC09236 B6.ICR-Tg(CDKN2A-luc)53Eiha/EihaRbrc p21(CDKN1A) luminescent reporter mice RBRC09237 B6.ICR-Tg(Cdkn1a-luc)34Eiha/EihaRbrc Arc luminescent reporter mice RBRC06053 C57BL/6-Tg(RP24-388I10-luc)1Himo Bdnf luminescent reporter mice RBRC11093 C57BL/6-Tg(RP24-310A6/Luc)2MftymMfuku https://mus.brc.riken.jp/en/todays_tool_and_model +----------------------------------------------------------------------- | Today's model for human disease +----------------------------------------------------------------------- Il17rbgene KO mice RBRC10254 C57BL/6-Il17rb<tm1Tgi> RBRC10255 C.B6-Il17rb<tm1Tgi> Il22ra2gene KO mice RBRC10360 C57BL/6-Il22ra2<tm1.1Ksat> Il33gene KO mice RBRC09341 B6.Cg-Il33<tm1Snak> https://mus.brc.riken.jp/en/todays_tool_and_model +----------------------------------------------------------------------- | Official X account of BRC +----------------------------------------------------------------------- The BRC Official X (formerly Twitter) account is now open. We will send out information and announcements about BioResource. Please follow us. https://x.com/RIKEN_BRC_en +----------------------------------------------------------------------- | User publications +----------------------------------------------------------------------- The following result has been newly reported by users. We are honored to introduce new publications to the science community. Therefore, we look forward to receiving your publications too. https://rrc.nbrp.jp/references/register RBRC06344 C57BL/6-App<tm3(NL-G-F)Tcs> Akasaka T, Watanabe H, Ono M. In Vivo Near-Infrared Fluorescence Imaging Selective for Soluble Amyloid β Aggregates Using y-Shaped BODIPY Derivative. J Med Chem. 2023 Oct 26;66(20):14029-14046. doi: 10.1021/acs.jmedchem.3c01057. https://doi.org/10.1021/acs.jmedchem.3c01057 RBRC10390 STOCK Actb<tm3.1(tetO-GCaMP6)Kftnk>Tg(Pvalb-tTA)1Kftnk Mitsui R, Miwa-Nishimura K, Hashitani H. Roles of endothelial prostaglandin I2 in maintaining synchronous spontaneous Ca2+ transients in rectal capillary pericytes. J Physiol. 2023 Oct 11. doi: 10.1113/JP284284. https://doi.org/10.1113/JP284284 RBRC04415 STOCK Tg(Lefty1-Cre/ERT2)8Hmd Tsubosaka A, Komura D, Kakiuchi M, Katoh H, Onoyama T, Yamamoto A, Abe H, Seto Y, Ushiku T, Ishikawa S. Stomach encyclopedia: Combined single-cell and spatial transcriptomics reveal cell diversity and homeostatic regulation of human stomach. Cell Rep. 2023 Oct 31;42(10):113236. doi: 10.1016/j.celrep.2023.113236. https://doi.org/10.1016/j.celrep.2023.113236 RBRC02388 B6.129P2-Ly96<tm1Kmiy> Wang M, Zhang Q, Lou S, Jin L, Wu G, Wu W, Tang Q, Wang Y, Long X, Huang P, Luo W, Liang G. Inhibition of MD2 by natural product-drived JM-9 attenuates renal inflammation and diabetic nephropathy in mice. Biomed Pharmacother. 2023 Dec:168:115660. doi: 10.1016/j.biopha.2023.115660. https://doi.org/10.1016/j.biopha.2023.115660 RBRC09240 STOCK Zeb2<tm2.1Yhi> Kim S, Chen J, Jo S, Ou F, Ferris ST, Liu TT, Ohara RA, Anderson DA, Wu R, Chen MY, Gillanders WE, Gillanders WE, Murphy TL, Murphy KM. IL-6 selectively suppresses cDC1 specification via C/EBPβ. J Exp Med. 2023 Oct 2;220(10):e20221757. doi: 10.1084/jem.20221757. https://doi.org/10.1084/jem.20221757 RBRC03390 B6;129-Apoe<tm>/3SfuRbrc, RBRC03418 B6;129-Apoe<tm(APOE4)Sfu>/SfuRbrc, RBRC06344 C57BL/6-App<tm3(NL-G-F)Tcs> Takebayashi Y, Yamazaki Y, Yamada H, Yazawa K, Nakamori M, Kurashige T, Morino H, Takahashi T, Sotomaru Y, Maruyama H. Apolipoprotein E genotype-dependent accumulation of amyloid β in APP-knock-in mouse model of Alzheimer's disease Biochem Biophys Res Commun. 2023 Nov 26:683:149106. doi: 10.1016/j.bbrc.2023.10.038. https://doi.org/10.1016/j.bbrc.2023.10.038 RBRC02370 B6.129-Grn<tm1Mni> Sasaki T, Kuse Y, Nakamura S, Shimazawa M, Hara H. Progranulin deficiency exacerbates cardiac remodeling after myocardial infarction. FASEB Bioadv. 2023 Sep 20;5(10):395-411. doi: 10.1096/fba.2023-00084. https://doi.org/10.1096/fba.2023-00084 +----------------------------------------------------------------------- | Newly deposited mouse strains +----------------------------------------------------------------------- Dr. Tomomi Shimogori, RIKEN CBS RBRC12151 B6;Cg-Fgf8<tm1.1(cre)Itl>/ Tshim RBRC12152 B6;Cg-Shh<tm1.1(cre)Itl>/ Tshim https://mus.brc.riken.jp/en/mailnews/kitaku_list/20231120_k Dr. Kenichi Kobayashi, National Institute of Occupational Safety and Health RBRC12088 DW/J-Tpst2<grt>/Jnios Dr. Hiroyuki Sasaki, Kyushu University RBRC12100 B6;Cg-Dnmt3a<em1(ADA)Hsas> RBRC12101 B6.Cg-Dnmt3a<em2(D329A)Hsas> RBRC12102 B6.129-H3f3b<em1.1(K36M)Hsas> Dr. Michihiro Mieda, Kanazawa University RBRC12109 B6(Cg)-Vip<em1(tTA2)Miem> https://mus.brc.riken.jp/en/mailnews/kitaku_list/20231020_k __________________________________________________________________ *We hope you find the contents of this message of interest. However, if you would prefer to unsubscribe from future e-mails, please send an e-mail to animal.brc@riken.jp. *If you have any questions or comments, please send an e-mail to animal.brc@riken.jp. *Content is subject to change without notice. *All Rights Reserved. __________________________________________________________________ RIKEN BioResource Research Center Experimental Animal Division 3-1-1 Koyadai, Tsukuba-shi Ibaraki, 305-0074 Japan animal.brc@riken.jp https://mus.brc.riken.jp/en/ https://x.com/RIKEN_BRC_en __________________________________________________________________ 2023.12.13.
