BRC Moue E-mail News No. 187

BRC Mouse E-mail News No. 187

RIKEN BioResource Research Center (BRC) is pleased to update you with the 
latest information.

======= Contents =======================================================
- Today's tool for functional analysis
- Today's model for human disease
- Official X account of BRC
- User publications
- Newly deposited mouse strains

| Today's tool for functional analysis

p16<INK4a>(CDKN2A) luminescent reporter mice
RBRC05271 ICR-Tg(p16-luc)53Eiha/Rbrc
RBRC09236 B6.ICR-Tg(CDKN2A-luc)53Eiha/EihaRbrc

p21(CDKN1A) luminescent reporter mice
RBRC09237 B6.ICR-Tg(Cdkn1a-luc)34Eiha/EihaRbrc

Arc luminescent reporter mice
RBRC06053 C57BL/6-Tg(RP24-388I10-luc)1Himo

Bdnf luminescent reporter mice
RBRC11093 C57BL/6-Tg(RP24-310A6/Luc)2MftymMfuku

| Today's model for human disease

Il17rbgene KO mice
RBRC10254 C57BL/6-Il17rb<tm1Tgi>
RBRC10255 C.B6-Il17rb<tm1Tgi>

Il22ra2gene KO mice
RBRC10360 C57BL/6-Il22ra2<tm1.1Ksat>

Il33gene KO mice
RBRC09341 B6.Cg-Il33<tm1Snak>

| Official X account of BRC

 The BRC Official X (formerly Twitter) account is now open.
We will send out information and announcements about BioResource.
Please follow us.

| User publications

 The following result has been newly reported by users. We are
honored to introduce new publications to the science community.
Therefore, we look forward to receiving your publications too.

RBRC06344 C57BL/6-App<tm3(NL-G-F)Tcs>
Akasaka T, Watanabe H, Ono M.
In Vivo Near-Infrared Fluorescence Imaging Selective for Soluble Amyloid β Aggregates Using y-Shaped BODIPY Derivative.
J Med Chem. 2023 Oct 26;66(20):14029-14046. doi: 10.1021/acs.jmedchem.3c01057.

RBRC10390 STOCK Actb<tm3.1(tetO-GCaMP6)Kftnk>Tg(Pvalb-tTA)1Kftnk
Mitsui R, Miwa-Nishimura K, Hashitani H.
Roles of endothelial prostaglandin I2 in maintaining synchronous spontaneous Ca2+ transients in rectal capillary pericytes.
J Physiol. 2023 Oct 11. doi: 10.1113/JP284284.

RBRC04415 STOCK Tg(Lefty1-Cre/ERT2)8Hmd
Tsubosaka A, Komura D, Kakiuchi M, Katoh H, Onoyama T, Yamamoto A, Abe H, Seto Y, Ushiku T, Ishikawa S.
Stomach encyclopedia: Combined single-cell and spatial transcriptomics reveal cell diversity and homeostatic regulation of human stomach.
Cell Rep. 2023 Oct 31;42(10):113236. doi: 10.1016/j.celrep.2023.113236.

RBRC02388 B6.129P2-Ly96<tm1Kmiy>
Wang M, Zhang Q, Lou S, Jin L, Wu G, Wu W, Tang Q, Wang Y, Long X, Huang P, Luo W, Liang G.
Inhibition of MD2 by natural product-drived JM-9 attenuates renal inflammation and diabetic nephropathy in mice.
Biomed Pharmacother. 2023 Dec:168:115660. doi: 10.1016/j.biopha.2023.115660.

RBRC09240 STOCK Zeb2<tm2.1Yhi>
Kim S, Chen J, Jo S, Ou F, Ferris ST, Liu TT, Ohara RA, Anderson DA, Wu R, Chen MY, Gillanders WE, Gillanders WE, Murphy TL, Murphy KM.
IL-6 selectively suppresses cDC1 specification via C/EBPβ.
J Exp Med. 2023 Oct 2;220(10):e20221757. doi: 10.1084/jem.20221757.

RBRC03390 B6;129-Apoe<tm>/3SfuRbrc, RBRC03418 B6;129-Apoe<tm(APOE4)Sfu>/SfuRbrc, RBRC06344 C57BL/6-App<tm3(NL-G-F)Tcs>
Takebayashi Y, Yamazaki Y, Yamada H, Yazawa K, Nakamori M, Kurashige T, Morino H, Takahashi T, Sotomaru Y, Maruyama H.
Apolipoprotein E genotype-dependent accumulation of amyloid β in APP-knock-in mouse model of Alzheimer's disease
Biochem Biophys Res Commun. 2023 Nov 26:683:149106. doi: 10.1016/j.bbrc.2023.10.038.

RBRC02370 B6.129-Grn<tm1Mni>
Sasaki T, Kuse Y, Nakamura S, Shimazawa M, Hara H.
Progranulin deficiency exacerbates cardiac remodeling after myocardial infarction.
FASEB Bioadv. 2023 Sep 20;5(10):395-411. doi: 10.1096/fba.2023-00084.

| Newly deposited mouse strains
Dr. Tomomi Shimogori, RIKEN CBS
RBRC12151 B6;Cg-Fgf8<tm1.1(cre)Itl>/ Tshim
RBRC12152 B6;Cg-Shh<tm1.1(cre)Itl>/ Tshim

Dr. Kenichi Kobayashi, National Institute of Occupational Safety and Health
RBRC12088 DW/J-Tpst2<grt>/Jnios

Dr. Hiroyuki Sasaki, Kyushu University
RBRC12100 B6;Cg-Dnmt3a<em1(ADA)Hsas>
RBRC12101 B6.Cg-Dnmt3a<em2(D329A)Hsas>
RBRC12102 B6.129-H3f3b<em1.1(K36M)Hsas>

Dr. Michihiro Mieda, Kanazawa University
RBRC12109 B6(Cg)-Vip<em1(tTA2)Miem>

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RIKEN BioResource Research Center
Experimental Animal Division
3-1-1 Koyadai, Tsukuba-shi
Ibaraki, 305-0074 Japan

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