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April 2005 Mouse of the Month |
A Model for Congenital Alopecia
Novel hairless allele created by ENU mutagenesis in Korea |
Chemically-induced mutation, hairless, recessive, Chr 14
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| Research Application: Dermatology, Immunology and Inflammation Research, Cancer Research, Toxicology ResearchThis strain was created by ENU mutagenesis program in Korea Institute of Toxicology (KIT) in Korea Research Institute of Chemical Tech. Mice resembles hairless rhino mice in which no hair regeneration occurs and skin tissue is extensively folded as shown in the Figure. A mutation in the human homolog of Hr (HR; OMIM602302) , are known to cause congenital hairless disease, alopecia universalis congenita (OMIM602302). The Depositors are welcome to collaborate further detailed analyses on this mutant mouse. Series of other ENU-mutant mice with interesting phenotypes have also been deposited to RIKEN BRC.
DEPOSITOR: Drs. Chang-Woo Song and Jae-Woo Cho For further information: |
