BRC facility Health Report
Update information
IMPC Search IMPC database

Frequently used strains and publications


Quality Control

Technical information

Customer service


  Order Form


Video protocol

Cryopreservation of Mouse Embryos by Ethylene Glycol-Based Vitrification
JoVE 3155 11/18/2011

Apr 2008 PRAT4A KO Mouse


A Key Molecule for Innate and Adaptive Immunity

BRC No. RBRC02399_C57BL/6-PRAT4A<tm1Kmiy>
Research Application:Immunology and Inflammation Research

PRAT4A KO mouse & its Litter Mate

Bone Marrow derived DCs lacking PRAT4A are impaired in TLR-dependent responses


   Immune cells such as dendric cells (DCs) and macrophages express multiple Toll-like receptors (TLRs) which recognize a variety of pathogen products. A protein associated with TLR4 (PRAT4A) has been found to bind TLR4, and regulate the expression of TLR4 and the response to LPS. Using PRAT4A-deficient mice, there are defective cytokine production against bacteria and activation of Th1 responses. DCs, macrophages and B cells lacking PRAT4A have impaired responses to a variety of TLR ligands. The PRAT4A-deficient bone marrow chimera mice are resistant to lethal-dose LPS administration in the LPS-induced sepsis model to analyze in vivo immune response. This mutant mouse is useful for the study of PRAT4A in innate and adaptive immunity.


Depositor :  Dr. Kensuke Miyake (The University of Tokyo)
Reference : J Exp Med. 204, 2963-2976 (2007)