Semaphorin III/D gene targeting mice

RIKEN BRC August 2006
Mouse of the Month
Semaphorin III/D gene targeting mice

an essential cue for axon guidance

BRC No. 01104_semaphorin III/D (null) Targeting mice
BRC No. 01105_semaphorin III/D (lacZ) Targeting mice
BRC No. 01106_semaphorin III/D (conditional) Targeting mice
Targeted mutation:Semaphorin III/D, Chr 5
Gene Symbol:Sema3a (OMIM603961)
Research Application:Neurobiology
BRC No. 01105
semaphorin III/D (lacZ) Targeting mice


Semaphorin III/D (also called Sema3a) is a member of the collapsin/semaphorin family and functions as the repulsive and attractive cues of axon guidance during nervous system development. Semaphorin III/D is well characterized neural chemorepellents and regulates nerve fiber projection in vivo. The body weight of homozygous mutant mice is only half of wild-type mice at 4 weeksof age, and the peripheral nerve projection is also affected. This strain is useful for elucidating the mechanism of axon guidance.


Depositor : Dr. Takeshi Yagi
(Graduate School of Frontier Biosciences, Osaka University)
Reference : Taniguch,i M., Yuasa, S., Fujisawa, H., Naruse, I., Saga, S., Mishina, M., Yagi, T.
Disruption of semaphorin III/D gene causes severe abnormality in peripheral nerve projection.
Neuron 19, 519-530 (1997)



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