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RECS1 knockout mouse

RIKEN BRC January 2007
Mouse of the Month
RECS1 knockout mouse
A key molecule for vascular remodeling

BRC No. 01773_ RECS1 knockout mouse line26
BRC No. 01772_ RECS1 knockout mouse line41
Spontaneous mutation:RECS1, Chr. 1
Gene Symbol:Tmbim1(OMIM610364)
Research Application:Cardiovasular Research
Figure (A)Spatial pattern analysis of gelatinolytic activity, cystic medial degeneration (CMD) and MMP-9 protein levels in throracic aortas from old RECS1 KO mice. Arrowheads indicate large CMD foci.
(B)A representative large CMD focus in KO mouse. Scale bar=100μm.
ISZ: In situ zymography
AB/PAS: Alician Blue/Periodic Acid Schiff.
In detail, please see Circulation Journal. 2006; 70 (5): 615-624.

 

  RECS1 is one of the mechanical stress responsive genes and functions as a negative regulator of matrix metalloprotease 9 (MMP-9). RECS1 deficient mice are prone to aortic dilation and cystic medial degeneration (CMD) when the mice ages (older than 14 months). Aortic dilation and CMD are frequently encountered pathological findings in aortic aneurysms as well as in normal aging aorta. This strain is useful for study of the function of RECS1 gene and as a mouse model for aortic dilation and CMD.

 

Depositor : Dr. Hiroshi Nojima (Osaka University)
References : [1] Zhao H, Ito A, Kimura SH, Yabuta N, Sakai N, Ikawa M, Okabe M, Matsuzawa Y, Yamashita S and Nojima H.
RECS1 deficiency in mice induces susceptibility to cystic medial degeneration.
Genes Genet Syst. 2006; Feb;81(1):41-50.
[2] Zhao H, Ito A, Sakai N, Matsuzawa Y, Yamashita S and Nojima H
RECS1 is a Negative Regulator of Matrix Metalloproteinase-9 Production and Aged RECS1 Knockout Mice are Prone to Aortic Dilation
Circulation Journal. 2006; 70 (5): 615-624.


 

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