BRC facility Health Report
Update information
IMPC Search IMPC database

Frequently used strains and publications


Quality Control

Technical information

Customer service


  Order Form


Video protocol

Cryopreservation of Mouse Embryos by Ethylene Glycol-Based Vitrification
JoVE 3155 11/18/2011

Jan 2008 mDomino KO Mouse


mDomino KO Mouse
An essential molecule for embryonic hematopoiesis

BRC No. RBRC01774_mDomino knockout mouse
Research Application : Developmental Biology
Defect in primitive hematopoiesis in mDom-mutated embryos (E9.5)
(o-dianisidine staining for hemoglobin)


The SWI2/SNF2 family protein, p400/mDomino (mammalian Domino), is an Swr1-class DNA-dependent ATPase that is a core subunit of a large chromatin-remodeling complex, and is suggested to play a unique function in histone variant exchange. The mDomino-mutated mice are embryonic lethal by day 11.5 (E11.5), and show a defect in embryonic hematopoiesis. The gene expression profile revealed that erythroid-specific genes were reduced in mDomino-mutated embryo (E8.5). The mDomino mutation also enhanced the expression of Hox genes, including Hoxa7, Hoxa9 and Hoxb9, in the yolk sac.


Depositor : Dr. Rikiro Fukunaga (Kyoto University)
Reference : Genes Cells. (2007) May;12(5):581-92.